Article
Geriatrics & Gerontology
Elodie Bertrand, Valeska Marinho, Renata Naylor, Iris Bomilcar, Jerson Laks, Aimee Spector, Daniel C. Mograbi
Summary: This study explores the impact of a Brazilian adapted version of Cognitive Stimulation Therapy (CST-Brasil) on self-awareness in people with dementia. The results suggest that CST may improve metacognitive abilities in patients.
CLINICAL GERONTOLOGIST
(2023)
Article
Clinical Neurology
Zhitong Zeng, Linbin Wang, Weikun Shi, Lu Xu, Zhengyu Lin, Xinmeng Xu, Peng Huang, Yixin Pan, Zhonglue Chen, Yun Ling, Kang Ren, Chencheng Zhang, Bomin Sun, Dianyou Li
Summary: This study found that subthalamic nucleus (STN) deep brain stimulation (DBS) is more effective than unilateral globus pallidus interna (GPi) DBS in treating motor symptoms. STN DBS improves symptoms on both sides of the body, while GPi DBS mainly affects the contralateral side.
FRONTIERS IN NEUROLOGY
(2022)
Article
Chemistry, Multidisciplinary
Monica Spinola, Joana Camara, Luis Ferreira, Ana Lucia Faria, Sergi Bermudez Badia
Summary: This study presents a participatory design approach to develop a customized cognitive stimulation program for individuals with dementia using Musiquence. The program is based on preferences gathered from formal caregivers and individuals with dementia, and guidelines are provided for content development.
APPLIED SCIENCES-BASEL
(2022)
Article
Medicine, General & Internal
I. Daria Bogdan, D. L. Marinus Oterdoom, Teus van Laar, Rients B. Huitema, Vincent J. Odekerken, Judith A. Boel, Rob M. A. de Bie, J. Marc C. van Dijk
Summary: This study investigated the impact of unintentional high-frequency NBM-DBS on cognitive function in Parkinson's disease patients. The results showed that unintentional high-frequency NBM-DBS did not lead to significant cognitive decline. Further research is needed to determine the therapeutic role of NBM-DBS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Maria Jimenez Palomares, Maria Victoria Gonzalez Lopez-Arza, Elisa Maria Garrido Ardila, Trinidad Rodriguez Dominguez, Juan Rodriguez Mansilla
Summary: Occupational Therapy based on activities of daily living (ADL) cognitive stimulation showed positive effects in increasing the independence of institutionalized subjects with major neurocognitive disorder or dementia. However, these improvements were not maintained after the follow-up period.
Article
Geriatrics & Gerontology
Hsin-Hsuan Liu, Ray-Yau Wang, Shih-Jung Cheng, Kwong-Kum Liao, Jun-Hong Zhou, Yea-Ru Yang
Summary: This study investigated the effects of square-stepping exercise (SSE) on cognitive function, particularly executive function, in people with Parkinson's disease (PD). The results showed that SSE training significantly improved executive function in PD patients.
Article
Geriatrics & Gerontology
Serena Sabatini, Anthony Martyr, Obioha C. Ukoumunne, Clive Ballard, Rachel Collins, Claire Pentecost, Jennifer M. Rusted, Catherine Quinn, Kaarin J. Anstey, Sarang Kim, Anne Corbett, Helen Brooker, Linda Clare
Summary: This study investigated the attitudes toward own aging (ATOA) among people with dementia (PwD) and the factors influencing ATOA in PwD. The results showed that PwD had slightly more negative ATOA compared to individuals without dementia, but this relationship disappeared after controlling for depression and self-rated health. Among PwD, better visuospatial ability was the only factor associated with more positive ATOA. People with Parkinson's disease dementia and dementia with Lewy bodies reported the most negative ATOA.
Article
Neurosciences
Yusha Cui, Dongning Su, Junjiao Zhang, Joyce S. T. Lam, Shuangshuang Cao, Yaqin Yang, Yingshan Piao, Zhan Wang, Junhong Zhou, Hua Pan, Tao Feng
Summary: This study aimed to explore the effects of different medications on tremor complexity in Parkinsonian tremor (PT) and how the underlying factors contribute to such tremor complexity. The results showed that tremor complexity was lower during a cognitive task compared to a task-free condition in resting and postural conditions. After taking levodopa and benzhexol, participants had increased and decreased tremor complexity, respectively. The tremor complexity and its changes as induced by medications were significantly correlated with clinical ratings and their changes.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Psychology, Multidisciplinary
Rosa Silva, Elzbieta Bobrowicz-Campos, Paulo Santos-Costa, Ana Rita Cruz, Joao Apostolo
Summary: The study found that the individual cognitive stimulation program implemented by caregivers showed promising results in improving the cognition of persons with cognitive impairment, but had no significant impact on caregivers' physical and mental health.
FRONTIERS IN PSYCHOLOGY
(2021)
Review
Psychology
Robin M. T. Cafferata, Ben Hicks, Claudia C. von Bastian
Summary: Cognitive stimulation shows medium-sized effect on global cognition, with most effects supported by substantial and strong Bayesian evidence, although methodological issues highlight the need for better controlled studies for more compelling evidence.
PSYCHOLOGICAL BULLETIN
(2021)
Article
Clinical Neurology
Jacqueline M. Torres, Karla Renata Flores Romero, Ashwin A. Kotwal, Ruijia Chen, Tanisha Hill-Jarrett, Uchechi A. Mitchell, Medellena Maria Glymour
Summary: Little is known about the population of individuals who live with a spouse with cognitive impairment or dementia.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Tim D. van Balkom, Henk W. Berendse, Ysbrand D. van der Werf, Jos W. R. Twisk, Carel F. W. Peeters, Adriaan W. Hoogendoorn, Rob H. Hagen, Tanja Berk, Odile A. van den Heuvel, Chris Vriend
Summary: This study found no beneficial effect of eight-week computerized cognitive training on the primary outcome (planning accuracy) and only minor improvements on secondary outcomes (processing speed) with limited clinical impact.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Geriatrics & Gerontology
Valeska Marinho, Elodie Bertrand, Renata Naylor, Iris Bomilcar, Jerson Laks, Aimee Spector, Daniel C. Mograbi
Summary: The study showed that Cognitive Stimulation Therapy (CST) is a feasible and effective intervention for improving mood and activities of daily living in people with mild to moderate dementia. It had good acceptance among participants and showed potential for broader application in the Brazilian context.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Health Care Sciences & Services
Pedro Gamito, Jorge Oliveira, Marcelo Matias, Elsa Cunha, Rodrigo Brito, Paulo Ferreira Lopes, Alberto Deus
Summary: This study aimed to investigate the feasibility of using VR-based cognitive training to improve the cognitive function of patients with AUD, as well as estimating the effect size for future RCTs. Results suggested that cognitive training using VR contributed to enhancing attention and cognitive flexibility in patients recovering from AUD.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Clinical Neurology
Alberto Benussi, Valentina Cantoni, Maria Sofia Cotelli, Maria Cotelli, Chiara Brattini, Abhishek Datta, Chris Thomas, Emiliano Santarnecchi, Alvaro Pascual-Leone, Barbara Borroni
Summary: Exposure to y-tACS over Pz area significantly improved memory performances and restored intracortical connectivity measures of cholinergic neurotransmission in MCI-AD patients compared to sham tACS.
Article
Clinical Neurology
Zubeyir Bayraktaroglu, Tuba Akturk, Gorsev Yener, Tom A. de Graaf, Lutfu Hanoglu, Ebru Yildirim, Duygu Hunerli Gunduz, Ilayda Kiyi, Alexander T. Sack, Claudio Babiloni, Bahar Guntekin
Summary: Parkinson's disease patients with mild cognitive impairment exhibit abnormal neurophysiological oscillatory mechanisms, primarily driven by delta frequencies, during cognitive tasks.
CLINICAL EEG AND NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Aline M. Dantas, Alexander T. Sack, Elisabeth Bruggen, Peiran Jiao, Teresa Schuhmann
Summary: This study investigated the effects of noninvasive brain stimulation on risk-taking behavior by stimulating the right dorsolateral prefrontal cortex (rDLPFC) and ventromedial prefrontal cortex (VMPFC). The results showed that stimulating either rDLPFC or VMPFC led to an increase in risk-taking behavior and the average value chosen, with no effect on probability choice. Additionally, inhibiting rDLPFC resulted in increased response time. These findings suggest a strong anatomical and functional interconnection between rDLPFC and VMPFC.
Article
Clinical Neurology
Marom Bikson, Ana Ganho- Avila, Abhishek Datta, Morten Goertz Joensson, Bernadette Gillick, Sungjin Kim, Jinuk Kim, Adam Kirton, Kiwon Lee, Timothy Marjenin, Balder Onarheim, Erik M. Rehn, Alexander T. Sack, Gozde Unal
Summary: The objective of the LOTES-2023 guidance is to update the previous LOTES-2017 guidance and provide a transparent framework for the design of limited output transcranial electrical stimulation devices. This updated guidance aligns with international standards and regulations and emphasizes the responsibility of manufacturers in conducting device-specific risk management within a constrained dose range. The warnings and precautions have been updated to align with current biomedical evidence and applications.
Editorial Material
Clinical Neurology
Chris Baeken, Martijn Arns, Jerome Brunelin, Lorena Chanes, Igor Filipcic, Ana Ganho-Avila, Marco Hirnstein, Fady Rachid, Alexander T. Sack, Jacinta O'shea, Giordano D'urso, Andrea Antal
Review
Geriatrics & Gerontology
Hannah Liebermann-Jordanidis, Mandy Roheger, Ann-Kristin Folkerts, Annegret Alfter, Fabian Krohm, Anne Adams, Elke Kalbe
Summary: As we age, cognitive abilities decline, which can negatively impact quality of life and increase depressive symptoms in older adults. Cognitive trainings have shown potential in improving cognition, quality of life, and mood. However, there is a lack of clarity regarding the prognostic factors associated with changes in quality of life and depression after cognitive trainings.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Review
Clinical Neurology
Hanna Johansson, Ann-Kristin Folkerts, Ida Hammarstrom, Elke Kalbe, Breiffni Leavy
Summary: This study investigated the effects of motor-cognitive training on dual-task performance in Parkinson's disease (PD). The findings showed that PD patients can improve their dual-task ability through motor-cognitive training, as evidenced by improved gait speed, cadence, stride length, and reduced cost on gait speed. The findings were based on high certainty evidence.
JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xueli Chen, Ru Ma, Wei Zhang, Ginger Qinghong Zeng, Qianying Wu, Ajiguli Yimiti, Xinzhao Xia, Jiangtian Cui, Qiongwei Liu, Xueer Meng, Junjie Bu, Qi Chen, Yu Pan, Nancy Xiaonan Yu, Shouyan Wang, Zhi-De Deng, Alexander T. Sack, Myles Mc Laughlin, Xiaochu Zhang
Summary: Previous studies have shown correlations between alpha oscillations and working memory (WM) retention, but causal evidence has been lacking. Conventional tACS cannot modulate brain oscillations within the short retention subprocess, making it unsuitable for demonstrating causal evidence for parietal alpha oscillations in WM retention. In this study, we developed an online phase-corrected tACS system that allowed precise modulation of brain oscillations and used it to show a causal link between parietal alpha oscillations and WM retention.
Letter
Clinical Neurology
Amourie Prentice, Ylka Kolken, Christina Tuttle, Joris van Neijenhof, Richard Pitch, Iris van Oostrom, Vera Kruiver, Jonathan Downar, Alexander T. Sack, Martijn Arns, Nikita van der Vinne
Article
Neurosciences
Amourie Prentice, Ana Rita Barreiros, Nikita van der Vinne, Sven Stuiver, Hanneke van Dijk, Jeroen Antonius van Waarde, Mayuresh Korgaonkar, Alexander T. Sack, Martijn Arns
Summary: This study found an association between high rostral anterior cingulate cortex (rACC) theta activity and treatment resistance, suggesting potential improvement in the usefulness of rACC-theta biomarker in treatment selection and prognosis.
NEUROPSYCHOBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Olof J. van der Werf, Teresa Schuhmann, Tom de Graaf, Sanne Ten Oever, Alexander T. Sack
Summary: It has been discovered that visuospatial attention operates rhythmically, with a low-frequency 7-8 Hz mechanism coordinating periodic windows of sampling. The relative importance of locations in a visual scene affects the rhythmic sampling process.
SCIENTIFIC REPORTS
(2023)
Article
Psychiatry
Theodoros Koutsomitros, Sandra A. Schwarz, Kenneth T. van der Zee, Teresa Schuhmann, Alexander T. Sack
Summary: This study assessed the feasibility and clinical effectiveness of home-administered transcranial direct current stimulation (tDCS) with asynchronous remote supervision in the treatment of depression. The results showed that the tDCS group had a significantly greater reduction in depression symptoms after 3 weeks of treatment compared to the treatment as usual (TAU) group.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Lauren Zwienenberg, Hanneke van Dijk, Stefanie Enriquez-Geppert, Nikita van der Vinne, Richard Gevirtz, Evian Gordon, Alexander T. Sack, Martijn Arns
Summary: Currently, major depressive disorder (MDD) treatment plans are based on trial-and-error, and remission rates remain low. A strategy to replace trial-and-error and increase remission rates could be treatment stratification using the heartbeat-evoked potential (HEP) as a biomarker. The study found that using HEP as a stratification biomarker can enhance treatment outcome prediction for venlafaxine and rTMS.
NEUROPSYCHOBIOLOGY
(2023)
Article
Clinical Neurology
Hannah Meijs, Helena Voetterl, Alexander T. Sack, Hanneke van Dijk, Bieke De Wilde, Jan Van Hecke, Peter Niemegeers, Evian Gordon, Jurjen J. Luykx, Martijn Arns
Summary: This study used a polygenic score (PGS) and electroencephalography (EEG) data analysis to identify potential predictors for treatment outcomes in major depressive disorder (MDD). The results suggest the existence of a stable EEG network related to antidepressant-response that has potential as a predictor for MDD treatment, particularly in the case of venlafaxine.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2024)
Article
Neurosciences
Aline M. Dantas, Alexander T. Sack, Elisabeth Bruggen, Peiran Jiao, Teresa Schuhmann
Summary: This study investigated the functional relevance of frontal theta-band activity in decision-making using transcranial alternating current stimulation (tACS) over right or left dorsolateral prefrontal cortex (DLPFC). The results showed that risk-taking behavior increased after left DLPFC stimulation and decreased after right DLPFC stimulation. Furthermore, stimulation intensity had an effect on behavioral responses.
Review
Behavioral Sciences
Ting Wang, Tom de Graaf, Joshua Williams, Zhihao Wang, Teresa Schuhmann, Felix Duecker, Alexander T. Sack
Summary: Spatial attention control involves specialized functions in both hemispheres of the brain, leading to hemispheric asymmetries. Neuropsychological models explain this lateralization mainly based on patient studies of hemineglect. Our meta-analysis assessed inhibitory TMS effects on PPC during visual detection tasks across ten studies (1994-2022). These results call for a re-evaluation of current theoretical models of attention and their application to novel brain stimulation-based therapeutic interventions.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)