Article
Clinical Neurology
Zhenxing Zhang, Yi Wang, Tao Luo, Huaguang Qi, Lin Cai, Yang Yuan, Jingfeng Li
Summary: The aim of this study was to assess the value of dermatomal somatosensory evoked potentials (DSEPs) and cortical somatosensory evoked potentials (SSEPs) in monitoring spinal cord function for patients with congenital scoliosis (CS). The study found that DSEPs are more sensitive to microscopic posterior column dysfunction in CS patients that cannot be detected by either radiology or routine clinical examination. Therefore, preoperative DSEPs assessment is recommended for intraoperative monitoring.
Article
Clinical Neurology
Angelo Insola, Paolo Mazzone, Eugenio Scarnati, Domenico Restuccia, Massimiliano Valeriani
Summary: This study investigated the subcortical somatosensory evoked potentials in Parkinson's disease patients. Results showed different responses to muscle or cutaneous afferent stimulation, providing insights into subcortical processing of somatosensory input.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Edyta Dziadkowiak, Marta Waliszewska-Prosol, Malgorzata Wieczorek, Joanna Bladowska, Slawomir Budrewicz, Maria Ejma
Summary: The study identified significant changes in multiple parameters of visually evoked potentials, brainstem auditory evoked potentials, and somatosensory evoked potentials in patients with myasthenia gravis, suggesting disturbances in the bioelectric activities of the central and peripheral nervous system.
Article
Pediatrics
Maria Arriaga-Redondo, Dorotea Blanco Bravo, Alejandra Aguado del Hoyo, Ana Polo Arrondo, Yolanda Ruiz Martin, Manuel Sanchez-Luna
Summary: The study demonstrated the good predictive capacity of somatosensory-evoked potentials (SEPs) in newborns with hypoxic-ischemic encephalopathy (HIE) and therapeutic hypothermia (TH) to detect an increased risk of neuroimaging lesions and neurodevelopmental impairment at two years of age.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Anesthesiology
Xiang Bingbing, Jiao Shulan, Zhang Yulong, Wang Lu, Yao Yuting, Yuan Feng, Chen Rui, Zhou Qijun
Summary: Studies have shown that both desflurane and sevoflurane have a dose-dependent inhibitory effect on SEPs and MEPs during neurosurgery, with desflurane appearing to have a stronger inhibitory effect at the same MAC concentration compared to sevoflurane.
BMC ANESTHESIOLOGY
(2021)
Article
Clinical Neurology
Mustafa Ahmed Mahmutoglu, Andre Rupp, Ulf Baumgaertner
Summary: This study investigated the cortical activity in response to tactile and nociceptive stimuli using simultaneous EEG and MEG recordings. The results showed that MEG was superior in detecting early nociceptive components, while EEG was better at detecting late nociceptive components.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Engineering, Biomedical
Priscella Asman, Sujit Prabhu, Dhiego Bastos, Sudhakar Tummala, Shreyas Bhavsar, Thomas Michael McHugh, Nuri Firat Ince
Summary: The study investigated the feasibility of unsupervised delineation of the central sulcus (CS) using spatiotemporal patterns of SSEP captured with ECoG grids, vividly outlining the CS based on SSEP amplitude distribution as a spatial 2D heat map. Unsupervised clustering method separated anterior and posterior channels with 96.3% accuracy, automatically delineating the CS location with high precision.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Clinical Neurology
Davide Rossi Sebastiano, Daniele Cazzato, Elisa Visani, Eleonora Dalla Bella, Laura Brambilla, Grazia Devigili, Paola Caroppo, Lorenzo Maggi, Lorenzo Nanetti, Ettore Salsano, Laura Canafoglia, Isabella Canavero, Elena Anghileri, Deborah Bonfoco, Paola Lanteri
Summary: This study aims to investigate the relationship between N20-P25 peak-to-peak amplitude (N20p-P25p) of somatosensory evoked potentials (SEPs) and abnormalities of the sensory pathways and myoclonus/epilepsy. The results showed no significant differences in N20p-P25p among different age-dependent groups and patients with or without abnormalities of sensory pathways. However, myoclonic/epileptic patients showed higher N20p-P25p than other groups. Cluster analysis identified four clusters of patients including myoclonus/epilepsy, central sensory abnormalities, peripheral sensory abnormalities, and absence of myoclonus and sensory abnormalities. Increased N20p-P25p may indicate different pathophysiological substrates.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Andreas Nowacki, David Zhang, Jonathan Wermelinger, Pablo Abel Alvarez Abut, Jan Rosner, Claudio Pollo, Kathleen Seidel
Summary: This study investigated the properties of median nerve somatosensory evoked potential (SEPs) recorded from segmented Deep Brain Stimulation (DBS) leads in the sensory thalamus (VP), and their relation to clinical and anatomical findings. The results showed that SEP amplitudes differed along different recording directions and correlated with the contacts of lowest effect-threshold to induce paraesthesia.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Noelle Aalberts, Erik Westhall, Birger Johnsen, Katrin Hahn, Martin Kenda, Tobias Cronberg, Hans Friberg, Sandra Preuss, Christoph J. Ploner, Christian Storm, Jens Nee, Christoph Leithner, Christian Endisch
Summary: Bilaterally absent cortical somatosensory evoked potentials (SSEPs) reliably predict poor outcome in comatose cardiac arrest (CA) patients. However, the thresholds, agreement between recordings, and agreement between raters of cortical SSEP amplitudes remain uncertain.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Hongli Yue, Man Zhou, Yingzi Chong, Miao Cheng, Hui Qiao, Yu Lu, Weihua Cui
Summary: This study aims to evaluate the effects of intravenous infusion of lidocaine on SEPs and MEPs during intraspinal tumour resection to determine whether electrophysiological monitoring can accurately reflect the integrity of nerve functions while infusing lidocaine, and explore the possibility of lidocaine use as an anaesthesia option during intraspinal tumour resection.
JOURNAL OF PAIN RESEARCH
(2022)
Article
Neurosciences
Andrea Victoria Arciniegas-Villanueva, Eva Maria Fernandez-Diaz, Emilio Gonzalez-Garcia, Javier Sancho-Pelluz, David Mansilla-Lozano, Tomas Segura
Summary: This study evaluated the utility of somatosensory evoked potentials (SSEP) in predicting the prognosis of patients who experienced coma following cardiac arrest or acute structural brain injury. The results showed that N20 and N70 SSEP were useful in predicting the long-term prognosis of these patients, with high specificity and sensitivity.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Vanesa Soto-Leon, Mabel Torres-Llacsa, Laura Mordillo-Mateos, Carmen Carrasco-Lopez, Jose A. Pineda-Pardo, Ana Velasco, Laura Abad-Toribio, Jesus Tornero, Guglielmo Foffani, Bryan A. Strange, Antonio Oliviero
Summary: Focal application of transcranial static magnetic field stimulation (tSMS) over the human motor cortex induces reductions in functional connectivity within the stimulated sensori-motor network, with time-dependency.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Maria Pyasik, Irene Ronga, Dalila Burin, Adriana Salatino, Pietro Sarasso, Francesca Garbarini, Raffaella Ricci, Lorenzo Pia
Summary: Studies have shown that sensory attenuation triggered by the own hand and by the embodied fake hand have similar behavioral and neurophysiological signatures, indicating that body ownership plays a crucial role in distinguishing the source of perceived sensations.
Article
Neurosciences
John K. Hermann, Ashley Borseth, Francesco G. Pucci, Carmen Toth, Olivia Hogue, Hugh H. Chan, Andre G. Machado, Kenneth B. Baker
Summary: Research has shown that deep brain stimulation (DBS) can enhance cortical excitability and promote motor rehabilitation. In this study using a rat model, the effects of DBS on the lateral cerebellar nucleus (LCN) were examined. The results indicate that LCN DBS can influence thalamocortical somatosensory pathways. However, further research is needed to better understand the potential role of SSEPs in optimizing therapy.
NEUROSCIENCE LETTERS
(2022)
Review
Neurosciences
Marta C. Antonelli, Martin G. Frasch, Mercedes Rumi, Ritika Sharma, Peter Zimmermann, Maria S. Molinet, Silvia M. Lobmaier
Summary: Exposure to stress during gestation and early childhood may increase the risk of functional developmental impairments. Non-invasively obtainable physiological signals and epigenetic biomarkers can predict neurodevelopmental outcomes and identify children who would benefit from early intervention programs. Early family-centered intervention programs can improve parental attachment and contribute to healthy socio-emotional adulthood. Biomarker-guided early intervention strategies are crucial in preventing future neuropsychiatric problems and reducing their impact.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Cell Biology
Marie-Luise Ederer, Madlen Guenther, Lena Best, Julia Lindner, Christoph Kaleta, Otto W. Witte, Rowena Simon, Christiane Frahm
Summary: Inflammation is believed to play a role in cognitive decline during aging. This study examines the impact of physical activity and social isolation on cognitive function and inflammation in old mice. The results show that voluntary wheel running improves cognitive function, while social isolation has negative effects. Inflammatory markers increase in both the hippocampus and colon during aging, and voluntary wheel running specifically attenuates intestinal inflammation.
Article
Cell Biology
Diana M. Morales-Prieto, Jose M. Murrieta-Coxca, Milan Stojiljkovic, Celia Diezel, Priska E. Streicher, Julian A. Henao-Restrepo, Franziska Roestel, Julia Lindner, Otto W. Witte, Sebastian Weis, Christian Schmeer, Manja Marz
Summary: Extracellular vesicles, specifically small EVs, are involved in neuroinflammation and neurodegenerative diseases. Aging brains show increased neuroinflammation and glial activation, which can be influenced by EVs. Our study demonstrates that sEVs from aged mice can cross the blood-brain barrier and induce glial cell activation in young animals.
Article
Biochemistry & Molecular Biology
Quratul Ain, Christian W. Schmeer, Diane Wengerodt, Yvonne Hofmann, Otto W. Witte, Alexandra Kretz
Summary: This article presents a practical workflow for the efficient purification of viable neural cells from the mature CNS. The protocol is suitable for acquiring and phenomapping CNS neural cells at different states, including health, physiological and precocious aging, and genetically provoked neurodegeneration. It is a rapid and efficient method that preserves physiological cell proportions and can be applied in various downstream applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Computer Science, Interdisciplinary Applications
M. G. Frasch
Summary: Sampling rate has an impact on the quality of HRV estimates. This article systematically examines the sensitivity of different HRV metrics to sampling rate errors and proposes a methodology for comprehensive validation of the effect of sampling rate on HRV.
JOURNAL OF BIOMEDICAL INFORMATICS
(2022)
Editorial Material
Immunology
Martin G. Frasch
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Peter Zimmermann, Marta C. Antonelli, Ritika Sharma, Alexander Mueller, Camilla Zelgert, Bibiana Fabre, Natasha Wenzel, Hau-Tieng Wu, Martin G. Frasch, Silvia M. Lobmaier
Summary: This study reveals the adverse effects of maternal prenatal stress on fetal iron homeostasis and neurodevelopment. Specifically, the study found lower transferrin saturation and a 15% decrease in fetal ferritin in stressed male neonates. Additionally, the study showed higher fetal stress index in the stressed group compared to the control group, suggesting the potential for early intervention strategies.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Sidra Gull, Christian Gaser, Karl-Heinz Herrmann, Anja Urbach, Marcus Boehme, Samia Afzal, Juergen R. Reichenbach, Otto W. Witte, Silvio Schmidt
Summary: By using MRI and DBM, we examined the structural changes in the brains of male RccHan:WIST rats. The study found that the overall brain volume increased with age, but there were also divergent local morphologic alterations. The visual, auditory, and somatosensory cortical areas showed shrinkage, while the higher-order brain areas such as the ectorhinal, entorhinal, retrosplenial, and cingulate cortical regions were preserved and grew with age.
Letter
Obstetrics & Gynecology
Martin G. Frasch
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Biology
Martin G. Frasch, Byung-Jun Yoon, Dario Lucas Helbing, Gal Snir, Marta C. Antonelli, Reinhard Bauer
Summary: According to CDC data, ASD was diagnosed in one of every 36 children in the US in 2020. A model explaining the etiology of ASD based on common gene network features involving glial and neuronal cells during fetal development is proposed, with implications for understanding the causes of ASD, early detection, and new treatments. Fetal neuroinflammation and prenatal stress may contribute to lifelong neurological disabilities. Through genomic data analysis and statistical network analysis, the study supports the hypothesis of glial-neuronal interplay in ASD and discusses its implications for etiology, early detection, and therapeutic approaches. The proposed model is of interest for ASD research, treatment development, prevention, and policy-making.
Review
Biotechnology & Applied Microbiology
Martin Gerbert Frasch
Summary: A code, defined as a system of signals or symbols, has been found in heart rate variability (HRV) to reflect information flow and physiological responses. HRV shows features of time structure, phase space structure, specificity to organs and pathophysiological syndromes, and species independence universality. This code forms a spatiotemporal structure that is not fully understood. Physiological examples such as fetal systemic inflammatory response, organ-specific inflammatory responses, chronic hypoxia, allostatic load, and vagotomy provide evidence of the existence and utility of the HRV code.
BIOENGINEERING-BASEL
(2023)
Article
Obstetrics & Gynecology
Colin Wakefield, Lena Yao, Steve Self, Martin G. Frasch
Summary: This study evaluated the perception of women of child-bearing age towards remote fetal ECG monitoring technologies. The results of an online survey showed a high willingness among pregnant women to use wearable ECG devices for increased monitoring of maternal and fetal health.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Medicine, General & Internal
Colin Wakefield, Mingju Cao, Patrick Burns, Gilles Fecteau, Andre Desrochers, Martin G. Frasch
Summary: The experience level of the team was found to be the single variable determining the success of experiment outcomes using the CINAFS model.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Martin G. Frasch
Summary: NeuroKit2 is a Python Toolbox for Neurophysiological Signal Processing that simplifies and automates the computation of various mathematical estimates of heart rate variability (HRV) or similar time series. It can handle different types of input data and provides 124 HRV measures, including the estimation of temporal fluctuations of the HRV estimates themselves. The methodology is demonstrated in a sleep dataset, showcasing its potential applications in studying the dynamic relationships between sleep state architecture and multi-dimensional HRV metrics.
Meeting Abstract
Obstetrics & Gynecology
Moira Barbieri, Tamara Stampalija, Martin Gerbert Frasch, Roberto Sassi, Massimo Walter Rivolta
REPRODUCTIVE SCIENCES
(2022)
Review
Physiology
Minyu Zhang, Biyang Xiao, Xiaoqi Chen, Bingming Ou, Songtao Wang
Summary: Non-alcoholic fatty liver disease (NAFLD) is closely related to bile acid and gut microbiota disorders. Exercise plays an important role in maintaining the homeostasis of the enterohepatic circulation and the health of the host gut microbiota by regulating the composition and function of the bile acid pool in the enterohepatic axis. Exercise has been recommended as a first-line intervention for NAFLD, and regulating bile acids through exercise may be a promising treatment strategy.