Cellular Targets for the Treatment of Flavivirus Infections

Dengue Virus Selectively Annexes Endoplasmic Reticulum-Associated Translation Machinery as a Strategy for Co-opting Host Cell Protein Synthesis

(2018) David W. Reid et al.   JOURNAL OF VIROLOGY

Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects

(2017) Elena Bekerman et al.   JOURNAL OF CLINICAL INVESTIGATION

Screening of FDA-Approved Drugs for Inhibitors of Japanese Encephalitis Virus Infection

(2017) Shaobo Wang et al.   JOURNAL OF VIROLOGY

A MicroRNA Screen Identifies the Wnt Signaling Pathway as a Regulator of the Interferon Response during Flavivirus Infection

(2017) Jessica L. Smith et al.   JOURNAL OF VIROLOGY

An update on Zika virus infection

(2017) David Baud et al.   LANCET

N -Methyl-d-Aspartate (NMDA) Receptor Blockade Prevents Neuronal Death Induced by Zika Virus Infection

(2017) Vivian V. Costa et al.   mBio

Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses

(2017) Hanna Roth et al.   mBio

Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus

(2017) Keiko Rausch et al.   Cell Reports

A Small-Molecule Oligosaccharyltransferase Inhibitor with Pan-flaviviral Activity

(2017) Andreas S. Puschnik et al.   Cell Reports

Optimizing celgosivir therapy in mouse models of dengue virus infection of serotypes 1 and 2: The search for a window for potential therapeutic efficacy

(2016) Satoru Watanabe et al.   ANTIVIRAL RESEARCH

An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target

(2016) Matthew K. Howe et al.   ANTIVIRAL RESEARCH

A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection

(2016) Nicholas J. Barrows et al.   Cell Host & Microbe

Dynamics of Human and Viral RNA Methylation during Zika Virus Infection

(2016) Gianluigi Lichinchi et al.   Cell Host & Microbe

N6 -Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection

(2016) Nandan S. Gokhale et al.   Cell Host & Microbe

Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection

(2016) Nicholas S. Heaton et al.   IMMUNITY

Rab8b Regulates Transport of West Nile Virus Particles from Recycling Endosomes

(2016) Shintaro Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RPLP1 and RPLP2 Are Essential Flavivirus Host Factors That Promote Early Viral Protein Accumulation

(2016) Rafael K. Campos et al.   JOURNAL OF VIROLOGY

A CRISPR screen defines a signal peptide processing pathway required by flaviviruses

(2016) Rong Zhang et al.   NATURE

Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens

(2016) Caleb D. Marceau et al.   NATURE

Zika virus cell tropism in the developing human brain and inhibition by azithromycin

(2016) Hanna Retallack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arginine methylation enhances the RNA chaperone activity of the West Nile virus host factor AUF1 p45

(2016) Susann Friedrich et al.   RNA

Identification of Proteins Bound to Dengue Viral RNA In Vivo Reveals New Host Proteins Important for Virus Replication

(2016) Stacia L. Phillips et al.   mBio

Dengue Virus Genome Uncoating Requires Ubiquitination

(2016) Laura A. Byk et al.   mBio

Unique Requirement for ESCRT Factors in Flavivirus Particle Formation on the Endoplasmic Reticulum

(2016) Keisuke Tabata et al.   Cell Reports

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics

(2016) George Savidis et al.   Cell Reports

The Golgi associated ERI3 is a Flavivirus host factor

(2016) Alex Michael Ward et al.   Scientific Reports

Modification of the Host Cell Lipid Metabolism Induced by Hypolipidemic Drugs Targeting the Acetyl Coenzyme A Carboxylase Impairs West Nile Virus Replication

(2015) Teresa Merino-Ramos et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection

(2015) Shuhei Taguwa et al.   CELL

Lovastatin for the Treatment of Adult Patients With Dengue: A Randomized, Double-Blind, Placebo-Controlled Trial

(2015) James Whitehorn et al.   CLINICAL INFECTIOUS DISEASES

Dengue virus requires the CC-chemokine receptor CCR5 for replication and infection development

(2015) Rafael E. Marques et al.   IMMUNOLOGY

From non-A, non-B hepatitis to hepatitis C virus cure

(2015) Jean-Michel Pawlotsky et al.   JOURNAL OF HEPATOLOGY

Dengue-3 Virus Entry into Vero Cells: Role of Clathrin-Mediated Endocytosis in the Outcome of Infection

(2015) Luana E. Piccini et al.   PLoS One

Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness

(2015) G. Manokaran et al.   SCIENCE

Dengue Virus Uses a Non-Canonical Function of the Host GBF1-Arf-COPI System for Capsid Protein Accumulation on Lipid Droplets

(2015) Nestor G. Iglesias et al.   TRAFFIC

Dengue virus NS1 protein interacts with the ribosomal protein RPL18: This interaction is required for viral translation and replication in Huh-7 cells

(2015) Margot Cervantes-Salazar et al.   VIROLOGY

KDEL Receptors Assist Dengue Virus Exit from the Endoplasmic Reticulum

(2015) Ming Yuan Li et al.   Cell Reports

RNASEK Is a V-ATPase-Associated Factor Required for Endocytosis and the Replication of Rhinovirus, Influenza A Virus, and Dengue Virus

(2015) Jill M. Perreira et al.   Cell Reports

Proteasome Inhibition Suppresses Dengue Virus Egress in Antibody Dependent Infection

(2015) Milly M. Choy et al.   PLoS Neglected Tropical Diseases

Cissampelos pareira Linn: Natural Source of Potent Antiviral Activity against All Four Dengue Virus Serotypes

(2015) Ruchi Sood et al.   PLoS Neglected Tropical Diseases

Nitazoxanide: A first-in-class broad-spectrum antiviral agent

(2014) Jean-François Rossignol   ANTIVIRAL RESEARCH

Repurposing of Prochlorperazine for Use Against Dengue Virus Infection

(2014) Yogy Simanjuntak et al.   JOURNAL OF INFECTIOUS DISEASES

The Stress Granule Component TIA-1 Binds Tick-Borne Encephalitis Virus RNA and Is Recruited to Perinuclear Sites of Viral Replication To Inhibit Viral Translation

(2014) A. Albornoz et al.   JOURNAL OF VIROLOGY

AUF1 p45 Promotes West Nile Virus Replication by an RNA Chaperone Activity That Supports Cyclization of the Viral Genome

(2014) S. Friedrich et al.   JOURNAL OF VIROLOGY

Efficacy and safety of celgosivir in patients with dengue fever (CELADEN): a phase 1b, randomised, double-blind, placebo-controlled, proof-of-concept trial

(2014) Jenny G Low et al.   LANCET INFECTIOUS DISEASES

Lovastatin Delays Infection and Increases Survival Rates in AG129 Mice Infected with Dengue Virus Serotype 2

(2014) Marlen Martinez-Gutierrez et al.   PLoS One

Heat shock protein 90 controls HIV-1 reactivation from latency

(2014) I. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membranous Replication Factories Induced by Plus-Strand RNA Viruses

(2014) Inés Romero-Brey et al.   Viruses-Basel

Correction: The Mannose Receptor Mediates Dengue Virus Infection of Macrophages

(2014) Joanna L Miller et al.   PLoS Pathogens

G3BP1, G3BP2 and CAPRIN1 Are Required for Translation of Interferon Stimulated mRNAs and Are Targeted by a Dengue Virus Non-coding RNA

(2014) Katell Bidet et al.   PLoS Pathogens

A new paradigm: innate immune sensing of viruses via the unfolded protein response

(2014) Judith A. Smith   Frontiers in Microbiology

The Small Molecules AZD0530 and Dasatinib Inhibit Dengue Virus RNA Replication via Fyn Kinase

(2013) M. de Wispelaere et al.   JOURNAL OF VIROLOGY

Three-Dimensional Architecture of Tick-Borne Encephalitis Virus Replication Sites and Trafficking of the Replicated RNA

(2013) L. Miorin et al.   JOURNAL OF VIROLOGY

Heat Shock Protein 70 Is Associated with Replicase Complex of Japanese Encephalitis Virus and Positively Regulates Viral Genome Replication

(2013) Jing Ye et al.   PLoS One

HIV-1 transcription and latency: an update

(2013) Carine Van Lint et al.   Retrovirology

Flavivirus Entry Receptors: An Update

(2013) Manuel Perera-Lecoin et al.   Viruses-Basel

Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus

(2012) Kylie M. Wagstaff et al.   BIOCHEMICAL JOURNAL

The TIM and TAM Families of Phosphatidylserine Receptors Mediate Dengue Virus Entry

(2012) Laurent Meertens et al.   Cell Host & Microbe

Effects of Short-Course Oral Corticosteroid Therapy in Early Dengue Infection in Vietnamese Patients: A Randomized, Placebo-Controlled Trial

(2012) D. T. H. Tam et al.   CLINICAL INFECTIOUS DISEASES

Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug

(2012) E. Mastrangelo et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Japanese Encephalitis Virus Infects Neuronal Cells through a Clathrin-Independent Endocytic Mechanism

(2012) M. Kalia et al.   JOURNAL OF VIROLOGY

The helicase activity of DDX56 is required for its role in assembly of infectious West Nile virus particles

(2012) Zaikun Xu et al.   VIROLOGY

G Protein-Coupled Receptor Kinase 2 Promotes Flaviviridae Entry and Replication

(2012) Caroline Le Sommer et al.   PLoS Neglected Tropical Diseases

Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes and protects against lethal challenge mouse model

(2011) Abhay P.S. Rathore et al.   ANTIVIRAL RESEARCH

Competitive inhibitor of cellular α-glucosidases protects mice from lethal dengue virus infection

(2011) Jinhong Chang et al.   ANTIVIRAL RESEARCH

Class II ADP-ribosylation Factors Are Required for Efficient Secretion of Dengue Viruses

(2011) Mateusz Kudelko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

The Kinase Inhibitor SFV785 Dislocates Dengue Virus Envelope Protein from the Replication Complex and Blocks Virus Assembly

(2011) Azlinda Anwar et al.   PLoS One

Quantitative mass spectrometry of DENV-2 RNA-interacting proteins reveals that the DEAD-box RNA helicase DDX6 binds the DB1 and DB2 3’ UTR structures

(2011) Alex Michael Ward et al.   RNA Biology

Formation of membrane-defined compartments by tick-borne encephalitis virus contributes to the early delay in interferon signaling

(2011) Lisa Miorin et al.   VIRUS RESEARCH

Interferon-stimulated genes and their antiviral effector functions

(2011) John W Schoggins et al.   Current Opinion in Virology

Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo

(2010) Jinhong Chang et al.   ANTIVIRAL RESEARCH

Tick-Borne Encephalitis Virus Delays Interferon Induction and Hides Its Double-Stranded RNA in Intracellular Membrane Vesicles

(2010) A. K. Overby et al.   JOURNAL OF VIROLOGY

The Endoplasmic Reticulum Provides the Membrane Platform for Biogenesis of the Flavivirus Replication Complex

(2010) Leah K. Gillespie et al.   JOURNAL OF VIROLOGY

Molecular mechanisms involved in the early steps of flavivirus cell entry

(2010) Bärbel Kaufmann et al.   MICROBES AND INFECTION

A Randomized Controlled Trial of Chloroquine for the Treatment of Dengue in Vietnamese Adults

(2010) Vianney Tricou et al.   PLoS Neglected Tropical Diseases

Cyclosporine Inhibits Flavivirus Replication through Blocking the Interaction between Host Cyclophilins and Viral NS5 Protein

(2009) M. Qing et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites

(2009) Sonja Welsch et al.   Cell Host & Microbe

Alternative infectious entry pathways for dengue virus serotypes into mammalian cells

(2009) Eliana G. Acosta et al.   CELLULAR MICROBIOLOGY

Poly(A)-binding protein binds to the non-polyadenylated 3' untranslated region of dengue virus and modulates translation efficiency

(2009) C. Polacek et al.   JOURNAL OF GENERAL VIROLOGY

Discovery of insect and human dengue virus host factors

(2009) October M. Sessions et al.   NATURE

Cholesterol biosynthesis modulation regulates dengue viral replication

(2009) Christopher Rothwell et al.   VIROLOGY

Dengue Virus Capsid Protein Usurps Lipid Droplets for Viral Particle Formation

(2009) Marcelo M. Samsa et al.   PLoS Pathogens

Closing the door on flaviviruses: Entry as a target for antiviral drug design

(2008) Rushika Perera et al.   ANTIVIRAL RESEARCH

Novel binding between pre-membrane protein and vacuolar ATPase is required for efficient dengue virus secretion

(2008) Xiaoqun Duan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Highly Structured, Nuclease-Resistant, Noncoding RNA Produced by Flaviviruses Is Required for Pathogenicity

(2008) Gorben P. Pijlman et al.   Cell Host & Microbe

RNA interference screen for human genes associated with West Nile virus infection

(2008) Manoj N. Krishnan et al.   NATURE