Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition

eIF1 Loop 2 interactions with Met-tRNAicontrol the accuracy of start codon selection by the scanning preinitiation complex

(2018) Anil Thakur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Embraced by eIF3: structural and functional insights into the roles of eIF3 across the translation cycle

(2017) Leoš Shivaya Valášek et al.   NUCLEIC ACIDS RESEARCH

Eukaryotic aspects of translation initiation brought into focus

(2017) Christopher H. S. Aylett et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Rps3/uS3 promotes mRNA binding at the 40S ribosome entry channel and stabilizes preinitiation complexes at start codons

(2017) Jinsheng Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Insights into the Mechanism of Scanning and Start Codon Recognition in Eukaryotic Translation Initiation

(2017) Alan G. Hinnebusch   TRENDS IN BIOCHEMICAL SCIENCES

eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast

(2017) Pilar Martin-Marcos et al.   eLife

Large-Scale Movements of IF3 and tRNA during Bacterial Translation Initiation

(2016) Tanweer Hussain et al.   CELL

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition

(2016) Angelita Simonetti et al.   MOLECULAR CELL

Eukaryotic translation initiation factor 3 plays distinct roles at the mRNA entry and exit channels of the ribosomal preinitiation complex

(2016) Colin Echeverría Aitken et al.   eLife

Semi-automated selection of cryo-EM particles in RELION-1.3

(2015) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex

(2015) Jose L. Llácer et al.   MOLECULAR CELL

Structure of mammalian eIF3 in the context of the 43S preinitiation complex

(2015) Amedee des Georges et al.   NATURE

Structure of a Yeast 40S–eIF1–eIF1A–eIF3–eIF3j initiation complex

(2015) Christopher H S Aylett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sliding of a 43S ribosomal complex from the recognized AUG codon triggered by a delay in eIF2-bound GTP hydrolysis

(2015) Ilya M. Terenin et al.   NUCLEIC ACIDS RESEARCH

Structure of a Yeast 40S–eIF1–eIF1A–eIF3–eIF3j initiation complex

(2015) Christopher H S Aylett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sampling the conformational space of the catalytic subunit of human γ-secretase

(2015) Xiao-chen Bai et al.   eLife

Tools for macromolecular model building and refinement into electron cryo-microscopy reconstructions

(2015) Alan Brown et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Scanning Mechanism of Eukaryotic Translation Initiation

(2014) Alan G. Hinnebusch   Annual Review of Biochemistry

Initiation of Translation by Cricket Paralysis Virus IRES Requires Its Translocation in the Ribosome

(2014) Israel S. Fernández et al.   CELL

Structural Changes Enable Start Codon Recognition by the Eukaryotic Translation Initiation Complex

(2014) Tanweer Hussain et al.   CELL

Structure of the mammalian 80S initiation complex with initiation factor 5B on HCV-IRES RNA

(2014) Hiroshi Yamamoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

eIF5 and eIF5B together stimulate 48S initiation complex formation during ribosomal scanning

(2014) Vera P. Pisareva et al.   NUCLEIC ACIDS RESEARCH

Eukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating Pi release and conformational transitions of the preinitiation complex

(2014) Adesh K. Saini et al.   NUCLEIC ACIDS RESEARCH

Structure of the Yeast Mitochondrial Large Ribosomal Subunit

(2014) A. Amunts et al.   SCIENCE

Structure of the Mammalian Ribosomal 43S Preinitiation Complex Bound to the Scanning Factor DHX29

(2013) Yaser Hashem et al.   CELL

Coordinated Movements of Eukaryotic Translation Initiation Factors eIF1, eIF1A, and eIF5 Trigger Phosphate Release from eIF2 in Response to Start Codon Recognition by the Ribosomal Preinitiation Complex

(2013) Jagpreet S. Nanda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Hairpin Loop of Eukaryotic Initiation Factor 1 (eIF1) Mediates 40 S Ribosome Binding to Regulate Initiator tRNAMetRecruitment and Accuracy of AUG Selectionin Vivo

(2013) Pilar Martin-Marcos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The initiation of mammalian protein synthesis and mRNA scanning mechanism

(2013) Ivan B. Lomakin et al.   NATURE

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM

(2013) Xueming Li et al.   NATURE METHODS

Molecular Architecture of a Eukaryotic Translational Initiation Complex

(2013) I. S. Fernandez et al.   SCIENCE

New Universal Rules of Eukaryotic Translation Initiation Fidelity

(2013) Hadas Zur et al.   PLoS Computational Biology

Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles

(2013) Xiao-chen Bai et al.   eLife

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Prevention of overfitting in cryo-EM structure determination

(2012) Sjors H W Scheres et al.   NATURE METHODS

Yeast eIF4B binds to the head of the 40S ribosomal subunit and promotes mRNA recruitment through its N-terminal and internal repeat domains

(2012) S. E. Walker et al.   RNA

The C-Terminal Domain of Eukaryotic Initiation Factor 5 Promotes Start Codon Recognition by Its Dynamic Interplay with eIF1 and eIF2β

(2012) Rafael E. Luna et al.   Cell Reports

Functional Elements in Initiation Factors 1, 1A, and 2  Discriminate against Poor AUG Context and Non-AUG Start Codons

(2011) P. Martin-Marcos et al.   MOLECULAR AND CELLULAR BIOLOGY

Stringency of start codon selection modulates autoregulation of translation initiation factor eIF5

(2011) Gary Loughran et al.   NUCLEIC ACIDS RESEARCH

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The RNA Recognition Motif of Eukaryotic Translation Initiation Factor 3g (eIF3g) Is Required for Resumption of Scanning of Posttermination Ribosomes for Reinitiation on GCN4 and Together with eIF3i Stimulates Linear Scanning

(2010) L. Cuchalova et al.   MOLECULAR AND CELLULAR BIOLOGY

The C-Terminal Region of Eukaryotic Translation Initiation Factor 3a (eIF3a) Promotes mRNA Recruitment, Scanning, and, Together with eIF3j and the eIF3b RNA Recognition Motif, Selection of AUG Start Codons

(2010) W.-L. Chiu et al.   MOLECULAR AND CELLULAR BIOLOGY

The 5′-7-Methylguanosine Cap on Eukaryotic mRNAs Serves Both to Stimulate Canonical Translation Initiation and to Block an Alternative Pathway

(2010) Sarah F. Mitchell et al.   MOLECULAR CELL

The Bowen–Conradi syndrome protein Nep1 (Emg1) has a dual role in eukaryotic ribosome biogenesis, as an essential assembly factor and in the methylation of Ψ1191 in yeast 18S rRNA

(2010) Britta Meyer et al.   NUCLEIC ACIDS RESEARCH

Initiation context modulates autoregulation of eukaryotic translation initiation factor 1 (eIF1)

(2010) I. P. Ivanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Eukaryotic 40S Ribosomal Subunit in Complex with Initiation Factor 1

(2010) J. Rabl et al.   SCIENCE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

eIF1 Controls Multiple Steps in Start Codon Recognition during Eukaryotic Translation Initiation

(2009) Jagpreet S. Nanda et al.   JOURNAL OF MOLECULAR BIOLOGY

Ribosomal position and contacts of mRNA in eukaryotic translation initiation complexes

(2008) Andrey V Pisarev et al.   EMBO JOURNAL