Journal
ELIFE
Volume 7, Issue -, Pages -Publisher
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.38844
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Funding
- Council for Science, Technology and Innovation
- Japan Agency for Medical Research and Development
- Wellcome Trust
- Arthritis Research UK [21357]
- Ministry of Education, Culture, Sports, Science, and Technology [JP18dm0307008]
- Japan Society for the Promotion of Science [KAKENHI 26120002]
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Working memory deficits are present in many neuropsychiatric diseases with diagnosis-related severity. However it is unknown whether this common behavioral abnormality is a continuum explained by a neural mechanism shared across diseases or a set of discrete dysfunctions. Here we performed predictive modeling to examine working memory ability (WMA) as a function of normative whole-brain connectivity across psychiatric diseases. We built a quantitative model for letter three-back task performance in healthy participants using resting state functional magnetic resonance imaging (rs-fMRI). This normative model was applied to independent participants (N = 965) including four psychiatric diagnoses. Individual's predicted WMA significantly correlated with a measured WMA in both healthy population and schizophrenia. Our predicted effect size estimates on WMA impairment were comparable to previous meta-analysis results. These results suggest a general association between brain connectivity and working memory ability applicable commonly to health and psychiatric diseases
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