The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro

Dynamic Ligand Discrimination in the Notch Signaling Pathway

(2018) Nagarajan Nandagopal et al.   CELL

Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity

(2017) Vincent C. Luca et al.   SCIENCE

Context-Dependent Sensitivity to Mutations Disrupting the Structural Integrity of Individual EGF Repeats in the Mouse Notch Ligand DLL1

(2016) K. Schuster-Gossler et al.   GENETICS

Identification of Domains for Efficient Notch Signaling Activity in Immobilized Notch Ligand Proteins

(2016) Ledi Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Notch signalling in context

(2016) Sarah J. Bray   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Notch ligand delta-like1: X-ray crystal structure and binding affinity

(2015) Nadia J. Kershaw et al.   BIOCHEMICAL JOURNAL

The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis

(2015) Z. Liu et al.   DEVELOPMENT

Structural basis for Notch1 engagement of Delta-like 4

(2015) V. C. Luca et al.   SCIENCE

Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo

(2015) Kristina Preuße et al.   PLoS Genetics

Spatiotemporal oscillations of Notch1, Dll1 and NICD are coordinated across the mouse PSM

(2014) R. A. Bone et al.   DEVELOPMENT

S/T Phosphorylation of DLL1 Is Required for Full Ligand Activity In Vitro but Dispensable for DLL1 Function In Vivo during Embryonic Patterning and Marginal Zone B Cell Development

(2014) E.-B. Braune et al.   MOLECULAR AND CELLULAR BIOLOGY

O-fucosylation of the Notch Ligand mDLL1 by POFUT1 Is Dispensable for Ligand Function

(2014) Julia Müller et al.   PLoS One

The Extracellular Domain of Notch2 Increases Its Cell-Surface Abundance and Ligand Responsiveness during Kidney Development

(2013) Zhenyi Liu et al.   DEVELOPMENTAL CELL

Intrinsic Selectivity of Notch 1 for Delta-like 4 Over Delta-like 1

(2013) Marie Blanke Andrawes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands

(2013) Chandramouli R. Chillakuri et al.   Cell Reports

A Mutation in EGF Repeat-8 of Notch Discriminates Between Serrate/Jagged and Delta Family Ligands

(2012) S. Yamamoto et al.   SCIENCE

Notch and disease: A growing field

(2012) Angeliki Louvi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Conformational Locking upon Cooperative Assembly of Notch Transcription Complexes

(2012) Sung Hee Choi et al.   STRUCTURE

Notch Signaling

(2012) R. Kopan   Cold Spring Harbor Perspectives in Biology

Mechanisms of T Cell Development and Transformation

(2011) Ute Koch et al.   Annual Review of Cell and Developmental Biology

Dll1- and Dll4-Mediated Notch Signaling Are Required for Homeostasis of Intestinal Stem Cells

(2011) Luca Pellegrinet et al.   GASTROENTEROLOGY

Cross-talk between endothelial cells and tumor via delta-like ligand4/Notch/PTEN signaling inhibits lung cancer growth

(2011) X-Y Ding et al.   ONCOGENE

Notch Signaling in the Immune System

(2010) Freddy Radtke et al.   IMMUNITY

Direct Comparison of Dll1- and Dll4-Mediated Notch Activation Levels Shows Differential Lymphomyeloid Lineage Commitment Outcomes

(2010) M. Mohtashami et al.   JOURNAL OF IMMUNOLOGY

DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries

(2009) I. Sorensen et al.   BLOOD

Notch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1 levels during early mouse development

(2009) Karin Schuster-Gossler et al.   BMC DEVELOPMENTAL BIOLOGY

Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formation

(2008) J. Feller et al.   GENES & DEVELOPMENT

A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition

(2008) Jemima Cordle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY