Article
Medicine, General & Internal
Hideaki Kagami, Minoru Inoue, Hideki Agata, Izumi Asahina, Tokiko Nagamura-Inoue, Masataka Taguri, Arinobu Tojo
Summary: By optimizing the cell-processing protocol, stable bone regeneration can be achieved with comparable quality and less fluctuation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Izumi Asahina, Hideaki Kagami, Hideki Agata, Masaki J. Honda, Yoshinori Sumita, Minoru Inoue, Tokiko Nagamura-Inoue, Arinobu Tojo
Summary: This study evaluated the safety and efficacy of bone tissue engineering using BMSCs in patients with severe atrophic alveolar bone. The results showed good long-term stability and safety of the regenerated bone, suggesting potential application in clinical practice. However, individual variations were observed, highlighting the need for further studies with larger sample sizes to confirm the efficacy of BMSCs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Jie Zhou, Yanlin Zhu, Dongqing Ai, Mengjiao Zhou, Han Li, Yiru Fu, Jinlin Song
Summary: Low-intensity pulsed ultrasound (LIPUS) can improve orthodontic tooth movement and alveolar bone remodeling by promoting the interaction between osteoblasts and osteoclasts, thus enhancing the effectiveness of orthodontic treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Cell Biology
Wuyang Zhang, Zhiwei Dong, Dengke Li, Bei Li, Yuan Liu, Xueni Zheng, Hui Liu, Hongzhi Zhou, Kaijin Hu, Yang Xue
Summary: The study revealed that Ctsk knockout or inhibition could promote alveolar bone regeneration by enhancing JBMMSC regeneration via glycolysis. These findings provide new insights into the regulatory mechanism of CTSK on bone regeneration.
CELL PROLIFERATION
(2021)
Article
Health Care Sciences & Services
Michael Strug, Lusine Aghajanova
Summary: The uterus is a homeostatic organ that responds to ovarian steroid hormones and prepares the endometrium for embryo implantation. Dysfunction in endometrial repair and regeneration can lead to infertility and abnormal menses. Mesenchymal stem cells have regenerative and immunomodulatory properties and have been investigated for therapeutic purposes in abnormal endometrium.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cell & Tissue Engineering
Xuan Zheng, Dirk M. Hermann, Mathias Baehr, Thorsten R. Doeppner
Summary: The heart and brain form a functional axis that is disrupted under ischemic conditions, but stem cell-derived extracellular vesicles show potential for treating ischemic stroke and myocardial infarction, offering hope. Therapeutic actions of EVs in the brain and heart reciprocally influence each other, with EVs playing roles in promoting angiogenesis, parenchymal remodeling, and tissue recovery, and the therapeutic effects are dependent on the cargos within EVs.
Review
Biochemistry & Molecular Biology
Xing-An Wang, Ju-Pi Li, Kang-Hsi Wu, Shun-Fa Yang, Yu-Hua Chao
Summary: Aplastic anemia is a rare but life-threatening disease characterized by low blood cell count and reduced cellularity in the bone marrow. Mesenchymal stem cell dysfunction is believed to play a role in the development of the disease. This review provides a comprehensive understanding of the involvement of mesenchymal stem cells in acquired idiopathic aplastic anemia and discusses their clinical application. The pathophysiology of the disease, properties of mesenchymal stem cells, and results of mesenchymal stem cell therapy in animal models are also described. The authors anticipate that more patients with aplastic anemia can benefit from mesenchymal stem cell therapy in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Jose C. Pastor, Salvador Pastor-Idoate, Marina Lopez-Paniagua, Marta Para, Francisco Blazquez, Esther Murgui, Veronica Garcia, Rosa M. Coco-Martin
Summary: This study reports the results of a clinical trial on patients with acute non-arteritic optic neuropathy (NA-AION) treated with an intravitreal injection of allogeneic bone marrow-derived mesenchymal stem cells (BM-MSCs). The study found that the intravitreal application of allogeneic BM-MSCs appeared to be well tolerated and resulted in visual improvement in some patients.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Engineering, Biomedical
Jiaxin Luo, Hongyan Chen, Guifang Wang, Jiaxuan Lyu, Yulan Liu, Sihan Lin, Mingliang Zhou, Xinquan Jiang
Summary: This study developed CGRP-loaded porous microspheres (PMs) to protect bone marrow mesenchymal stem cells (BMSCs) against inflammatory mediators in periodontitis and promote periodontal bone regeneration. The released CGRP effectively ameliorated the inflammation-induced dysfunction of BMSCs by suppressing the ROS/NLRP3/Caspase-1 pathway. The PMs' porous architecture provided effective cell-carrying capacity and physical protection for BMSCs during transplantation. In vivo experiments demonstrated that CGRP/BMSC-loaded PMs effectively inhibited inflammation and improved osteogenic activity, leading to better periodontal bone regeneration. This study focuses on the protection of stem cell function in the inflammatory microenvironment, which is important for stem cell-mediated tissue regeneration and repair under inflammatory conditions.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Dongyuan Luo, Boying Chen, Yu Chen
Summary: The currently available biomaterials for alveolar cleft repair have poor mechanical properties and biocompatibility. In this study, a 3D printed biomimetic scaffold was developed using a mixture of beta-tricalcium phosphate (beta-TCP) and bone marrow mesenchymal stem cells (BMSCs). The hybrid scaffold showed good biocompatibility and mechanical properties, and supported the attachment, proliferation, survival, differentiation, and osteogenic induction of BMSCs for alveolar cleft reconstruction.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Dezheng Tang, Entang Wang, Yifan Xu, Chao Liang, Changying Liu, Xiao Lin, Jun Li
Summary: The study found higher failure rates among T2DM patients during the healing period, and identified multiple differentially expressed proteins between different groups. The results suggest that risk factors besides hyperglycemia may affect osseointegration during the healing period.
Retraction
Biochemistry & Molecular Biology
Sabine Wislet-Gendebien, Emerence Laudet, Virginie Neirinckx, Philippe Alix, Pierre Leprince, Aneta Glejzer, Christophe Poulet, Benoit Hennuy, Lukas Sommer, Olga Shakhova, Bernard Rogister
Summary: A correction to this paper has been published.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Orthopedics
Andrea Pintore, Donato Notarfrancesco, Arnaldo Zara, Antonio Oliviero, Filippo Migliorini, Francesco Oliva, Nicola Maffulli
Summary: The study found that autologous mesenchymal stem cell (MSC) injections can improve clinical and functional outcomes in knee osteoarthritis (KOA) patients, with similar results between autologous bone marrow cells (BMAC) and adipose-derived stromal cells (ADSCs). Measurements of Knee Injury and Osteoarthritis Outcome Score (KOOS), Oxford Knee Score (OKS), and visual analog scale (VAS) were collected from 102 patients with KOA before the procedures, at one month, and at six months post-injection.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Cell & Tissue Engineering
Alireza Hosseinpour, Fatemeh Kheshti, Asma Kazemi, Armin Attar
Summary: This study compared the effects of transplantation of bone-marrow mononuclear cells (BM-MNCs) and mesenchymal stem cells (MSCs) on ejection fraction (LVEF) in patients with acute myocardial infarction (AMI). The results showed that both types of cells significantly improved LVEF in the short term, with MSCs being more effective according to the ICEMAN criteria. The effect was even more pronounced in patients who received stem cell transplantation in the early course after AMI.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell Biology
Hitesh Chopra, Chen Cao, Celia Sommer, Alex Dahlkemper, James Sugai, James L. Sherley, Darnell Kaigler
Summary: This study quantifies the stem cell fractions of human mesenchymal stem cell preparations derived from oral tissues and finds significant differences in the stem cell fractions among donors. The stability of the stem cell fractions during serial cell culture shows inter-donor variation, with some patient preparations exhibiting sufficient stability to support long-term expansion of stem cells. These findings provide important insights for the clinical-scale expansion and biomanufacturing of MSCs, leading to more effective and predictable outcomes in clinical trials and treatments employing SCT.