Article
Infectious Diseases
Mar Sanchez-Somolinos, Marta Diaz-Navarro, Antonio Benjumea, Jose Matas, Javier Vaquero, Patricia Munoz, Pablo Sanz-Ruiz, Maria Guembe
Summary: By comparing the anti-biofilm activity of dalbavancin and vancomycin over a 3-month period, this study found that dalbavancin showed sustained activity and maintained a higher percentage reduction in cfu/mL counts compared to vancomycin. The concentration of dalbavancin decreased significantly after 2 weeks, while the concentration of vancomycin gradually increased, leading to lower anti-biofilm activity. The study also observed that dalbavancin exhibited stronger anti-biofilm activity against S. epidermidis compared to S. aureus, particularly at the higher concentration of 5% and after 3 months.
Article
Engineering, Biomedical
Sumana Ghosh, Mau Sinha, Ritwik Samanta, Suresh Sadhasivam, Anamika Bhattacharyya, Ashis Nandy, Swamini Saini, Nupur Tandon, Himanshi Singh, Swati Gupta, Anjali Chauhan, Keerthi Kumar Aavula, Sneha Susan Varghese, Pujie Shi, Sudip Ghosh, Mukesh Kumar Garg, Tanmoy Saha, Aparna Padhye, Shamik Ghosh, Hae Lin Jang, Shiladitya Sengupta
Summary: By using molecular-docking simulations and screening, a new antibiotic effective against bone infection is designed, showing potent antimicrobial activity, reducing bacterial resistance, and suitable for localized delivery.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Materials Science, Biomaterials
Lei Chen, Yufei Tang, Kang Zhao, Xiang Zha, Min Wei, Quanchang Tan, Zixiang Wu
Summary: In this study, gentamicin sulfate (GS)/alendronate (ALN)-dual-loaded gelatin modified PMMA bone cement (GAPBC) was successfully fabricated to provide rapid and continuous antibiotic release and long-term anti-osteoporotic therapy. The sequential release of GS and ALN from the modified bone cement showed significantly higher drug release ratios compared to standard PMMA bone cement, demonstrating potential for future clinical applications.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Review
Orthopedics
Hyrum Judd, Jorge Benito, Tejbir S. Pannu, Jesus M. Villa, Carlos A. Higuera, Arturo Corces
Summary: Data on the safety and dosage of antibiotic-loaded bone cement (ALBC) spacers are heterogeneous. Risk factors for acute kidney injury (AKI) include antibiotic concentration greater than 3 or 3.6 g per cement batch, comorbidities, chronic kidney disease, and hypovolemia. Despite similar spacer antibiotic dosing, there is variability in serum concentrations. Until more evidence surfaces, it is suggested to use antibiotic dose below 3 g per cement batch to be relatively safe. Appropriate antibiotic use in 2-stage revision should consider the risk factors for AKI.
Article
Chemistry, Multidisciplinary
Yazan Al Thaher, Raida Khalil, Sharif Abdelghany, Mutaz S. Salem
Summary: This study investigated the release of gentamicin from carbon nanotubes incorporated in polymethyl methacrylate bone cement to prevent prosthetic joint infections. The results showed prolonged release of gentamicin from CNT-loaded bone cements over several weeks without affecting their mechanical and antimicrobial properties.
Article
Chemistry, Physical
Martin Luedemann, Axel Jakuscheit, Andrea Ewald, Leena Fruehmann, Stefanie Hoelscher-Doht, Maximilian Rudert, Sebastian Philipp von Hertzberg-Boelch
Summary: The study showed that the topical application of tranexamic acid during total joint arthroplasty did not significantly affect antibiotic release, activity against S. aureus, or compressive strength of the cement.
Article
Orthopedics
Zhe Gao, Yang Xu, Yuchen Kan, Hailong Li, Rui Guo, Luyang Han, Wenhan Bu, Jianjun Chu
Summary: Non-leaching antibacterial bone cement can provide long-term antibacterial activity, but it cannot treat serious infections that have already occurred like antibiotic-loaded bone cement. The antibacterial activity and biocompatibility of non-leaching cement when loaded with antibiotics have not been determined yet.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Sebastian Philipp von Hertzberg-Boelch, Martin Luedemann, Maximilian Rudert, Andre F. Steinert
Summary: This literature review explores the use of antibiotic loaded polymethylmethacrylate bone cements in arthroplasty. It outlines the clinically relevant differences that need to be considered when using antibiotic loaded bone cements for long-term implant fixation or as spacers for treating periprosthetic joint infections. In vitro findings on antibiotic elution and material properties are summarized and their clinical applications are discussed.
Article
Orthopedics
Joshua A. Parry, Joseph Chavarria, Sara Giddins, David Rojas, Cyril Mauffrey, Todd Baldini, Yang Lv
Summary: The aim of this study was to compare cefazolin versus vancomycin high-dose antibiotic cement spacers. The results showed that cefazolin had shorter setting time, greater compressive strength, and compression modulus compared to vancomycin-loaded spacers. The antimicrobial and antibiotic release properties of cefazolin spacers were significantly superior to vancomycin spacers. Therefore, cefazolin could be used in the treatment of infected bone defects with high-dose antibiotic PMMA spacers.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2023)
Article
Orthopedics
Andre Lunz, Kevin Knappe, Georg W. Omlor, Mareike Schonhoff, Tobias Renkawitz, Sebastian Jaeger
Summary: This study compares the mechanical characteristics of six dual antibiotic-loaded bone cement preparations made from three different PMMA bone cements. The results show that the mechanical strength of antibiotic-loaded PMMA bone cement decreases even over the short time period of six weeks.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Review
Orthopedics
Surena Namdari, Suleiman Y. Sudah, Mariano E. Menendez, Patrick J. Denard
Summary: This study contextualizes the use of antibiotic spacers in the treatment of periprosthetic joint infection in shoulder arthroplasty. It reviews the history, types, antibiotic composition and dosage, efficacy, and complications of shoulder spacers.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2022)
Article
Multidisciplinary Sciences
Yazan Al Thaher, Hadil Faris Alotaibi, Lirong Yang, Polina Prokopovich
Summary: The successful development of chlorhexidine-coated silica nanoparticles capable of prolonged drug release, incorporated into commercial formulation PMMA bone cement, showed superior antimicrobial activity and cytocompatibility, highlighting a potential solution for prosthetic joint infections.
Article
Microbiology
Willemijn Boot, Tanja Schmid, Matteo D'Este, Olivier Guillaume, Andrew Foster, Laurent Decosterd, Robert G. Richards, David Eglin, Stephan Zeiter, Thomas F. Moriarty
Summary: The study introduces a clinically relevant large animal model of chronic MRSA ODRI, demonstrating that an injectable, thermoresponsive, hyaluronic acid-based hydrogel loaded with gentamicin and vancomycin outperforms current clinical practice treatment. These results suggest that local antibiotic delivery with an injectable hydrogel can significantly increase treatment success rates beyond current clinical practice in a robust animal model.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Orthopedics
Jian Wei, Siqi Zhou, Hanwen Gu, Kai Tong
Summary: This study suggests that low-dose antibiotic-loaded acrylic cement commonly used in patients with periprosthetic joint infections does not adversely affect compressive strength and effectively kills gram-negative bacteria, with meropenem-loaded cement showing the best results. In the animal study, meropenem-loaded cement improves body weight, temperature, and inflammatory markers.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Omar Faruq, Kaushik Sarkar, Byong-Taek Lee
Summary: The aim of this study was to investigate the effect of PMMA bone cement in the presence of a gel phase on its mechanical and cellular properties. Porous PMMA cement was prepared using hyaluronic acid and polyethylene glycol as a gel phase, which resulted in decreased compressive strength and elastic modulus. The gel phase also reduced the polymerization temperature and did not affect apatite formation or pH. In vitro cellular tests confirmed the biocompatibility and osteogenic potential of the PMMA-10%HyA-10%PEG cement. These findings suggest that PMMA-10%HyA-10%PEG bone cements have distinctive mechanical and physicochemical properties and are suitable for cellular functionalities.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Orthopedics
Bernhard Springer, Ulrich Bechler, Wenzel Waldstein, Kilian Rueckl, Friedrich Boettner
JOURNAL OF ARTHROPLASTY
(2020)
Article
Orthopedics
Kilian Rueckl, Alina Liebich, Ulrich Bechler, Bernhard Springer, Maximilian Rudert, Friedrich Boettner
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2020)
Review
Orthopedics
Manuel Weissenberger, Tizian Heinz, Kilian Rueckl, Maximilian Rudert, Alexander Klug, Reinhard Hoffmann, Kay Schmidt-Horlohe
BMC MUSCULOSKELETAL DISORDERS
(2020)
Article
Orthopedics
F. Boettner, P. Sculco, M. Faschingbauer, K. Rueckl, R. Windhager, M. F. Kasparek
BONE & JOINT JOURNAL
(2020)
Article
Health Care Sciences & Services
Manuel Weissenberger, Alexander Klug, Tizian Heinz, Kilian Rueckl, Hans Kollenda, Maximilian Rudert, Reinhard Hoffmann, Kay Schmidt-Horlohe
Summary: This study evaluated the outcomes of anatomical distal biceps tendon refixation using one or two suture anchors, with no significant differences found between the two groups. Both techniques resulted in good outcomes for patients with distal biceps brachii tendon ruptures.
TECHNOLOGY AND HEALTH CARE
(2021)
Article
Orthopedics
Ulrich Bechler, Bernhard Springer, Kilian Rueckl, Tim Rolvien, Friedrich Boettner
Summary: The software app used in this study enabled simple and accurate measurement of cup position and leg length in direct anterior THA. A strong correlation was observed between intraoperative and postoperative measurements for anteversion, inclination, and leg length discrepancy.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2021)
Article
Orthopedics
Kilian Rueckl, Armin Runer, Anna Jungwirth-Weinberger, Maximilian F. Kasparek, Martin Faschingbauer, Friedrich Boettner
Summary: The study found that the degree of valgus deformity and the grade of osteoarthritis do not predict the outcome of total knee arthroplasty in patients with advanced valgus osteoarthritis. Surgery appears to be justified in patients who failed nonoperative treatment, regardless of the degree of deformity.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2021)
Article
Orthopedics
Anna Jungwirth-Weinberger, Tom Schmidt-Braekling, Kilian Rueckl, Bernhard Springer, Friedrich Boettner
Summary: This study compared the postoperative dislocation rates of the direct anterior and posterior approaches in total hip arthroplasty within a one-year follow-up. The results showed that the direct anterior approach had a significantly lower dislocation rate in the first year after surgery.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2022)
Article
Orthopedics
Kilian Rueckl, Bernhard Springer, Anna Jungwirth-Weinberger, Ulrich Bechler, Maximillian F. Kasparek, Friedrich Boettner
Summary: The routine release of the conjoined tendon (CTR group) during direct anterior approach (DAA) total hip arthroplasty (THA) decreases shear forces on the greater trochanter tip and eliminates the risk of greater trochanter fractures. This release did not increase the risk of postoperative dislocations.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2022)
Article
Orthopedics
Richard Lass, Ulrich Bechler, Bernhard Springer, Kilian Rueckl, Carola Hanreich, Friedrich Boettner
Summary: This study compares outcomes in terms of adverse local tissue reactions, elevated metal ion levels, and survival rates between low-risk and high-risk Birmingham hip resurfacing (BHR) patients at a minimum 5-year follow-up. The results show that BHR has good mid-term survival rates in the low-risk group, but should not be considered for patients with a femoral head size less than 48 mm.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Article
Orthopedics
Laura Elisa Streck, Lothar Seefried, Franca Genest, Thomas Reichel, Maximilian Rudert, Kilian Rueckl
Summary: This article presents a rare case of clavicle fracture following reverse shoulder arthroplasty (RSA), which may be caused by increased tension of the deltoid muscle after RSA, similar to stress fractures of the acromion. Associated bone disease, such as osteoporosis, may contribute to this complication. Previous case reports have shown significant functional impairments in affected patients. In this particular case, the fracture was addressed with plate fixation, but ultimately resulted in osteosynthesis failure with secondary dislocation.
Review
Orthopedics
Carola Hanreich, Bernhard Springer, Wenzel Waldstein, Kilian Rueckl, Ulrich Bechler, Friedrich Boettner
Summary: With an increasing number of younger patients undergoing total knee replacement surgery, it is important to understand their desire to participate in sports activities while expecting the implant to last. Current literature suggests that most patients engage in low impact activities both before and after surgery. However, recent studies indicate that high-impact sports may be possible with appropriate techniques and patient-specific factors, such as using conforming bearing surfaces and avoiding certain alignment and resurfacing procedures. This review paper provides insights on the sport habits of total knee replacement patients, biomechanical loads during different activities, and considerations for implant selection and technical approaches for active patients.
ZEITSCHRIFT FUR ORTHOPADIE UND UNFALLCHIRURGIE
(2023)
Article
Biotechnology & Applied Microbiology
Sebastian Philipp Boelch, Kilian Rueeckl, Laura Elisa Streck, Viktoria Szewczykowski, Manuel Weissenberger, Axel Jakuscheit, Maximilian Rudert
Summary: The study found that the definition of PJI significantly affects the prevalence of diagnosed PJIs at THA revision. Different PJI definitions resulted in different rates of PJI prevalence. Synovial fluid white blood cell count is a reliable means to rule out PJI.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Laura Elisa Streck, Chiara Gaal, Johannes Forster, Christian Konrads, Sebastian Philipp von Hertzberg-Boelch, Kilian Rueckl
Summary: This study aimed to determine the threshold for synovial fluid white blood cell count (WBC) and evaluate the reliability of microbiological cultures in predicting periprosthetic shoulder infection (PSI). The results showed that a threshold of 2800 leucocytes/mm(3) in synovial fluid had high sensitivity and specificity in predicting PSI, and microbiological cultures had excellent specificity. Therefore, joint aspiration is an important method for diagnosing PSI.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
Laura Elisa Streck, Johannes Forster, Sebastian Philipp von Hertzberg-Boelch, Thomas Reichel, Maximilian Rudert, Kilian Rueckl
Summary: Preoperative joint aspiration cannot definitively diagnose shoulder joint infections, but it can assist in targeted antibiotic therapy. Interstage aspiration does not have sufficient diagnostic value for routine use.
BMC MUSCULOSKELETAL DISORDERS
(2022)
