Journal
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
Volume 46, Issue -, Pages S564-S570Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/21691401.2018.1501381
Keywords
Exosomes; nanoparticle; tumor; drug carrier; chemotherapy; radiotherapy
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Funding
- national Key R&D project of the Chinese Ministry of Science and Technology [2016YFC0904600]
- National Natural Science Foundation of China [U1432248, U1632270, 11675234, 11575262]
- Natural Science Foundation of Gansu [17JR5RA310]
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Exosomes are nanoscale vesicles shed from all cell types and play a major role in communication and transportation of materials between cells due to their ability to transfer proteins and nucleic acids from one cell to another. Analogous in size and function to synthetic nanoparticles, exosomes offer many advantages, rendering them the most promising candidates for targeted drug or gene delivery vehicles. Exosomes can also induce chemoresistance or radioresistance of tumor cells. Studies about the related mechanisms help overcome cancer therapy resistance to some extent. In this review, we focus on the application of exosomes as nanocarriers and the current status of the application of exosomes to cancer therapy.
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