Aggregatibacter actinomycetemcomitans Leukotoxin Is Delivered to Host Cells in an LFA-1-Indepdendent Manner When Associated with Outer Membrane Vesicles

Association of Vibrio cholerae 569B outer membrane vesicles with host cells occurs in a GM1-independent manner

(2018) Elnaz S. Rasti et al.   CELLULAR MICROBIOLOGY

Receptor-Based Peptides for Inhibition of Leukotoxin Activity

(2018) Eric Krueger et al.   ACS Infectious Diseases

Use of a Cholesterol Recognition Amino Acid Consensus Peptide To Inhibit Binding of a Bacterial Toxin to Cholesterol

(2016) Evan Koufos et al.   BIOCHEMISTRY

LFA-1-targeting Leukotoxin (LtxA; Leukothera®) causes lymphoma tumor regression in a humanized mouse model and requires caspase-8 and Fas to kill malignant lymphocytes

(2015) Kristina M. DiFranco et al.   LEUKEMIA RESEARCH

Inhibition of LtxA toxicity by blocking cholesterol binding with peptides

(2015) A.C. Brown et al.   Molecular Oral Microbiology

Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions

(2015) Carmen Schwechheimer et al.   NATURE REVIEWS MICROBIOLOGY

Proteomics of Aggregatibacter actinomycetemcomitans Outer Membrane Vesicles

(2015) Thomas Kieselbach et al.   PLoS One

Aggregatibacter actinomycetemcomitans Outer Membrane Vesicles Are Internalized in Human Host Cells and Trigger NOD1- and NOD2-Dependent NF-κB Activation

(2014) Bernard Thay et al.   INFECTION AND IMMUNITY

Protein selection and export via outer membrane vesicles

(2013) K.E. Bonnington et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Aggregatibacter actinomycetemcomitansLeukotoxin Utilizes a Cholesterol Recognition/Amino Acid Consensus Site for Membrane Association

(2013) Angela C. Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane association and destabilization byAggregatibacter actinomycetemcomitansleukotoxin requires changes in secondary structures

(2013) M.J. Walters et al.   Molecular Oral Microbiology

Enterohemorrhagic Escherichia coli Hemolysin Employs Outer Membrane Vesicles to Target Mitochondria and Cause Endothelial and Epithelial Apoptosis

(2013) Martina Bielaszewska et al.   PLoS Pathogens

Aggregatibacter actinomycetemcomitans leukotoxin cytotoxicity occurs through bilayer destabilization

(2012) Angela C. Brown et al.   CELLULAR MICROBIOLOGY

Delivery ofBordetella pertussisadenylate cyclase toxin to target cells via outer membrane vesicles

(2012) Gina M. Donato et al.   FEBS LETTERS

Campylobacter jejuni Outer Membrane Vesicles Play an Important Role in Bacterial Interactions with Human Intestinal Epithelial Cells

(2012) Abdi Elmi et al.   INFECTION AND IMMUNITY

Leukotoxin (Leukothera®) Targets Active Leukocyte Function Antigen-1 (LFA-1) Protein and Triggers a Lysosomal Mediated Cell Death Pathway

(2012) Kristina M. DiFranco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vibrio choleraeO395 Outer Membrane Vesicles Modulate Intestinal Epithelial Cells in a NOD1 Protein-dependent Manner and Induce Dendritic Cell-mediated Th2/Th17 Cell Responses

(2012) Debashree Chatterjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Moraxella catarrhalisOuter Membrane Vesicles Carry β-Lactamase and Promote Survival ofStreptococcus pneumoniaeandHaemophilus influenzaeby Inactivating Amoxicillin

(2011) Viveka Schaar et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Perinuclear Localization of Internalized Outer Membrane Vesicles Carrying Active Cytolethal Distending Toxin from Aggregatibacter actinomycetemcomitans

(2011) Pramod Kumar Rompikuntal et al.   INFECTION AND IMMUNITY

Cytotoxic effects of Kingella kingae outer membrane vesicles on human cells

(2011) R. Maldonado et al.   MICROBIAL PATHOGENESIS

Aggregatibacter actinomycetemcomitans Leukotoxin: A Powerful Tool with Capacity to Cause Imbalance in the Host Inflammatory Response

(2011) Anders Johansson   Toxins

Biological Functions and Biogenesis of Secreted Bacterial Outer Membrane Vesicles

(2010) Adam Kulp et al.   Annual Review of Microbiology

Outer membrane vesicles of Vibrio vulnificus deliver cytolysin–hemolysin VvhA into epithelial cells to induce cytotoxicity

(2010) Young Ran Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multicomponent Moraxella catarrhalis outer membrane vesicles induce an inflammatory response and are internalized by human epithelial cells

(2010) Viveka Schaar et al.   CELLULAR MICROBIOLOGY

Uptake of Helicobacter pylori Outer Membrane Vesicles by Gastric Epithelial Cells

(2010) H. Parker et al.   INFECTION AND IMMUNITY

Outer membrane vesicles function as offensive weapons in host–parasite interactions

(2010) Atsuo Amano et al.   MICROBES AND INFECTION

Virulence and Immunomodulatory Roles of Bacterial Outer Membrane Vesicles

(2010) T. N. Ellis et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Comparison of the osteolytic activity of surface-associated proteins of bacteria implicated in periodontal disease

(2010) K Reddi et al.   ORAL DISEASES

Response of chronic and aggressive periodontitis to treatment

(2010) David E. Deas et al.   PERIODONTOLOGY 2000

Bacterial outer membrane vesicles in disease and preventive medicine

(2010) Can M. Ünal et al.   Seminars in Immunopathology

Bordetella Adenylate Cyclase Toxin Mobilizes Its β2 Integrin Receptor into Lipid Rafts to Accomplish Translocation across Target Cell Membrane in Two Steps

(2010) Ladislav Bumba et al.   PLoS Pathogens

Aggregatibacter actinomycetemcomitans LtxC is required for leukotoxin activity and initial interaction between toxin and host cells

(2009) Nataliya V. Balashova et al.   GENE

Porphyromonas gingivalis Outer Membrane Vesicles Enter Human Epithelial Cells via an Endocytic Pathway and Are Sorted to Lysosomal Compartments

(2009) N. Furuta et al.   INFECTION AND IMMUNITY

Cytolethal Distending Toxin-induced Cell Cycle Arrest of Lymphocytes Is Dependent upon Recognition and Binding to Cholesterol

(2009) Kathleen Boesze-Battaglia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long-Distance Delivery of Bacterial Virulence Factors by Pseudomonas aeruginosa Outer Membrane Vesicles

(2009) Jennifer M. Bomberger et al.   PLoS Pathogens