Article
Materials Science, Multidisciplinary
Mina Aleemardani, Louis Johnson, Michael Zivojin Trikic, Nicola Helen Green, Frederik Claeyssens
Summary: In this study, photocurable (PGS-co-PEG)-M copolymers were successfully prepared by methacrylation of PGS-co-PEG. The methacrylation process enhanced the mechanical strength of the copolymers while reducing their bioadhesive properties. These photocurable copolymers have great potential for biomedical applications.
MATERIALS TODAY ADVANCES
(2023)
Article
Biotechnology & Applied Microbiology
Jiajia Luo, Fenglei Sun, Pinhua Rao, Tonghe Zhu, Yonghang Liu, Juan Du, Sihao Chen, Xiangyun Jin, Jiale Jin, Yi Chai
Summary: A bioactive, injectable, multifunctional composite hydrogel loaded with nanospheres was prepared for wound treatment. The hydrogel exhibited rapid gelation, good injectable abilities, and resistance to bacterial growth. In vitro experiments showed good biocompatibility and promotion of wound healing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ana Catarina Sousa, Sara Biscaia, Rui Alvites, Mariana Branquinho, Bruna Lopes, Patricia Sousa, Joana Valente, Margarida Franco, Jose Domingos Santos, Carla Mendonca, Luis Atayde, Nuno Alves, Ana Colette Mauricio
Summary: This study explores a new approach to produce synthetic bone grafts and successfully manufactures three different composition scaffolds. Through in vitro evaluation, it is demonstrated that these scaffolds, especially the one with PEGDA, show promising effects on bone regeneration, including higher cell viability and increased cell adhesion and proliferation.
Article
Materials Science, Multidisciplinary
Ruben Martin-Cabezuelo, Alicia Naderpour-Penalver, A. Sigen, Wenxin Wang, Guillermo Vilarino-Feltrer, Ana Valles-Lluch
Summary: Poly(glycerol sebacate) (PGS) is a hyperbranched polyester with tunable chemical and mechanical properties, along with biocompatibility and biodegradability. Understanding the synthesis parameters of PGS is crucial for controlling its synthesis and obtaining a scalable and reproducible final product. This study reveals the importance of hydroxyl affinity, water presence, and glycerol loss in determining the properties of the final PGS product.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Article
Polymer Science
Cynthia G. Flores-Hernandez, Maria de los Angeles Cornejo-Villegas, Abigail Moreno-Martell, Alicia Del Real
Summary: The study aimed to obtain a new biodegradable graft polymer through two chemical processes, FTIR and TGA analysis confirmed its structure and thermal properties, with strong impact on fungal growth.
Article
Materials Science, Multidisciplinary
Sara Rastegar, Mehdi Mehdikhani, Ashkan Bigham, Elahe Poorazizi, Mohammad Rafienia
Summary: In this study, a new nanocomposite scaffold consisting of PGS/PCL/CQDs was developed for cardiac muscle regeneration. The addition of CQDs led to an increase in electrical conductivity, while the optimized PGS/PCL/CQDs scaffold showed superior physical, chemical, and biological properties.
MATERIALS CHEMISTRY AND PHYSICS
(2021)
Article
Polymer Science
Shima Majidansari, Negin Vahedi, Mahmood Rekabgardan, Camellia Ganjoury, Najmeh Najmoddin, Mohammad Tabatabaei, Faraz Sigaroodi, Paniz Naraghi-Bagherpour, Seyed Amir Ali Taheri, Mohammad-Mehdi Khani
Summary: Cardiovascular diseases are a major cause of death worldwide, and tissue engineering offers promising strategies for their treatment. This study demonstrates that a nanofibrous scaffold produced through electrospinning can support and significantly promote endothelial differentiation of mesenchymal stem cells.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Polymer Science
Ruben Martin-Cabezuelo, Jose Carlos Rodriguez-Hernandez, Guillermo Vilarino-Feltrer, Ana Valles-Lluch
Summary: A novel spin-coating technique has been developed to obtain smooth, continuous polymeric surfaces from poly(glycerol sebacate) (PGS). Curing PGS pre-polymer under variable temperatures leads to networks with different chemical properties and topographies, making them suitable as biomaterials. Understanding material-protein interactions and cell behavior on PGS substrates is crucial for biological applications.
Article
Polymer Science
Zahra Fakhari, Saied Nouri Khorasani, Farzaneh Alihosseini, Mohamad Hossein Nasr Esfahani, Fereshteh Karamali, Shahla Khalili
Summary: In this research, biocompatible and biodegradable polymers PGS and POC were used to fabricate a core-shell structure, which showed increased fiber diameter, pore size, hydrophilicity, and degradation rate with the addition of POC. Mechanical testing and cell culture experiments indicated that the PGS/PCL-POC/PCL scaffold was suitable for retinal tissue engineering applications.
Article
Polymer Science
Daegyu Lim, Su-il Park
Summary: Solid state polymerization (SSP) was used to modify poly(butylene sebacate-co-terephthalate) (PBSeT) at different temperatures. The results showed that PBSeT had higher viscosity and crystallinity, and improved thermal stability after SSP at 90°C for 40 minutes. SSP is a facile and rapid method for improving the crystallinity and thermal stability of synthesized PBSeT.
Article
Polymer Science
Naofumi Naga, Mitsusuke Satoh, Tomoyuki Magara, Kumkum Ahmed, Tamaki Nakano
Summary: Michael-addition reaction between multifunctional-acetoacetate, meso-erythritol tetra-acetoacetate (ETAA) or dsorbitol hexa-acetoacetate (SHAA), and poly(ethylene glycol) diacrylate (PEGDA) has been investigated to obtain porous polymers with controllable diameter and morphology. The porous polymers are soft, flexible, and have high affinity with various solvents.
EUROPEAN POLYMER JOURNAL
(2022)
Review
Polymer Science
Liu Yu, Guanjie Zeng, Jie Xu, Mingying Han, Zihan Wang, Ting Li, Meng Long, Ling Wang, Wenhua Huang, Yaobin Wu
Summary: This article reviews the research progress of Poly(glycerol sebacate) (PGS) and its derivatives in the field of biomedicine over the past two decades, including material design, synthesis, and properties. In addition, a statistical analysis is presented to identify trends in this research. It is expected that this review and the design principles of PGS-based materials will promote further development and optimization of PGS and its derivatives for biomedical applications.
Review
Biotechnology & Applied Microbiology
Bruno Godinho, Nuno Gama, Artur Ferreira
Summary: Poly(glycerol sebacate) (PGS) is a biodegradable elastomer attracting attention in tissue engineering. New synthesis methods have been reported to reduce time and energy, and adjust properties for specific applications. This review compiles 20+ years of reports and proposes alternatives for faster production of PGS structures with desired properties.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Thermodynamics
Hui Zhu, Zhiguo Jiang, Zhaobin Qiu
Summary: Fully biodegradable PLLA/PTGA blends with different phase behaviors and significantly increased crystallization rate were successfully prepared for the first time in this research. Increasing the PTGA content remarkably improved the overall crystallization rate and spherulitic growth rate of PLLA, indicating the plasticization role of PTGA, while the crystallization mechanism and crystal structure of PLLA remained unchanged, regardless of the presence of PTGA.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Article
Polymer Science
Dongyong Sha, Zihan Wu, Jingjing Zhang, Yifan Ma, Zhaogang Yang, Yuan Yuan
Summary: In the past decade, PGS has gained significant attention in various biomedical fields due to its superior elasticity, biocompatibility, and biodegradability. To meet the increasing demands, different modification strategies and construction methods have been developed to expand the properties of PGS. Currently, PGS has been applied in areas such as hard tissue engineering, soft tissue engineering, drug delivery, and device design.
EUROPEAN POLYMER JOURNAL
(2021)