Article
Multidisciplinary Sciences
Calixte Ida Penda, Magaly Moukoko Mbonjo, Joseph Fokam, Armando Blondel Djiyou Djeuda, Ngondi Grace, Francis Ateba Ndongo, Serge Bilong, Bertrand Eyoum Bille, Paul Koki Ndombo, Avelin Aghokeng, Alexis Ndjolo, Carole Else Eboumbou Moukoko
Summary: This study aimed to investigate the rates of virological failure (VF) and HIV drug resistance (HIVDR) among adolescents with HIV on antiretroviral therapy (ART) in Cameroon. The study found that higher rates of VF were associated with suboptimal adherence, older age, living outside the city where they received ART, severe immunocompromise, and starting ART in infancy. The overall rate of HIVDR was high among participants who underwent genotyping resistance testing.
Article
Microbiology
Maria Pia Amanzo-Vargas, Tessy Arellano-Veintemilla, Elsa Gonzalez-Lagos, Juan Echevarria, Fernando Mejia, Ana Grana, Eduardo Gotuzzo
Summary: This study compared the socio-demographic and clinical characteristics, and mortality rates between HIV-infected and HIV/HTLV-1 co-infected patients in Peru. The results showed that HIV/HTLV-1 co-infected patients had a significantly shorter survival time compared to HIV-infected patients. This suggests that the immune alterations caused by HTLV-1 in CD4 cell count may have contributed to late initiation of antiretroviral treatment and prophylaxis against opportunistic infections over the decades, and thus reducing their benefits in these patients.
Article
Multidisciplinary Sciences
Vinie Kouamou, Rhoderick Machekano, Tichaona Mapangisana, Caroline Maposhere, Reggie Mutetwa, Justen Manasa, Tinei Shamu, Kathy McCarty, Shungu Munyati, Junior Mutsvangwa, Mampedi Bogoshi, Dennis Israelski, David Katzenstein
Summary: In rural Zimbabwe, the clinic-based SAMBA II assay provided faster confirmatory VL results than the standard of care assay at the provincial referral laboratory. However, this did not lead to more efficient treatment outcomes for CALWH.
Article
Immunology
Aude Christelle Ka'e, Aubin Joseph Nanfack, Georgia Ambada, Maria Mercedes Santoro, Desire Takou, Ezechiel Ngoufack Jagni Semengue, Alex Durand Nka, Marie Laure Mpouel Bala, Orphelie Ndoh Endougou, Elise Elong, Grace Beloumou, Sandrine Djupsa, Davy Hyacinthe Gouissi, Nadine Fainguem, Michel Carlos Tommo Tchouaket, Samuel Martin Sosso, Daniel Kesseng, Francis Ateba Ndongo, Nelson Sonela, Arnaud Cedric Lacmago Kamta, Hyppolite K. Tchidjou, Therese Ndomgue, Suzie Tetang Moyo Ndiang, Anne Esther Njom Nlend, Celine Nguefeu Nkenfou, Carla Montesano, Gregory Edie Halle-Ekane, Giulia Cappelli, Caroline T. Tiemessen, Vittorio Colizzi, Francesca Ceccherini-Silberstein, Carlo-Federico Perno, Joseph Fokam
Summary: Antiretroviral therapy (ART) has improved the lifespan of people living with HIV, but their immune system remains in a state of sustained activation/inflammation. This study investigated the inflammatory profile of adolescents living with perinatal HIV-1 infection (ALPHI) receiving ART in an African context.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Chao Zhang, Jin-Wen Song, Hui-Huang Huang, Xing Fan, Lei Huang, Jian-Ning Deng, Bo Tu, Kun Wang, Jing Li, Ming-Ju Zhou, Cui-Xian Yang, Qi-Wen Zhao, Tao Yang, Li-Feng Wang, Ji-Yuan Zhang, Ruo-Nan Xu, Yan-Mei Jiao, Ming Shi, Feng Shao, Rafick-Pierre Sekaly, Fu-Sheng Wang
Summary: Chronic HIV-1 infection leads to CD4(+) T cell loss, with distinct mechanisms affecting pyroptotic and apoptotic CD4(+) T cells. Pyroptosis is closely associated with inflammation and driven by NLRP3 inflammasome activation, while apoptosis is more related to T cell activation status.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Infectious Diseases
Yun Lan, Feng Li, Linghua Li, Xizi Deng, Liya Li, Junbin Li, Xiaoli Cai, Xuemei Ling, Fengyu Hu
Summary: This study comprehensively analyzed the prevalence of drug resistance and transmission characteristics of CRF59_01B strains in infected patients in Guangdong, China. The results showed a high prevalence of ADR among ART-experienced patients with CRF59_01B strains and a low prevalence of PDR among ART-naive patients with CRF59_01B strains. A total of 20 transmission networks were identified.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Emmanuel Sendaula, Michael Buwembo, Denis Opio
Summary: The holistic care model supports individuals living with HIV in various aspects of their lives, resulting in improved treatment outcomes. Age and adherence are significantly associated with viral load suppression in HIV-infected adults receiving a holistic approach of care.
Article
Infectious Diseases
Boris Revollo, Laura Vinuela, Lorena de la Mora, Federico Garcia, Marc Noguera-Julian, Mariona Parera, Roger Paredes, Josep M. Llibre
Summary: This article reports a case of integrase resistance in a patient treated with co-formulated dolutegravir/lamivudine. It highlights the importance of carefully considering and monitoring drug-drug interactions, even when they are regarded as having a low potential.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Immunology
Kang Li, Huanhuan Chen, Jianjun Li, Yi Feng, Guanghua Lan, Shujia Liang, Meiliang Liu, Abdur Rashid, Hui Xing, Zhiyong Shen, Yiming Shao
Summary: Disparities in immune reconstruction (IR) results among HIV-1 infected patients under combined antiretroviral therapy (cART) are influenced by both host polymorphisms and viral genetic subtypes. This study found that HIV-1 CRF01_AE cluster 1 is associated with a lower probability of achieving IR compared to cluster 2 and other subtypes. The impaired immune restoration in patients with CRF01_AE cluster 1 is attributed to the presence of a high proportion of CXCR4-tropic viruses. Early identification of HIV-1 subtypes/sub-clusters and monitoring of virus phenotypes are crucial for improving the effectiveness of cART.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Infectious Diseases
Barbara Rossetti, Massimiliano Fabbiani, Domenico Di Carlo, Francesca Incardona, Ana Abecasis, Perpetua Gomes, Anna Maria Geretti, Carole Seguin-Devaux, Federico Garcia, Rolf Kaiser, Sara Modica, Adrian Shallvari, Anders Sonnerborg, Maurizio Zazzi
Summary: This large multi-cohort study indicates high effectiveness of elvitegravir- or dolutegravir-based first-line ART in routine practice across Europe. Factors such as baseline viral load and CD4 cell count can affect the treatment outcomes.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Public, Environmental & Occupational Health
Peter Memiah, Lillian Nkinda, Mtebe Majigo, Felix Humwa, Zelalaem Haile, Kennedy Muthoka, Aisha Zuheri, Anne Kamau, Lucy Ochola, Gabriel Buluku
Summary: This study aimed to evaluate the association between mental health symptoms and inflammatory biomarkers in HIV infected individuals. The results indicated that self-reported mental health symptoms were significantly associated with inflammatory markers such as CRP, sTNFR II, and IL-18.
Article
Public, Environmental & Occupational Health
Christopher T. Andersen, Christopher P. Duggan, Karim Manji, George R. Seage, Donna Spiegelman, Nandita Perumal, Nzovu Ulenga, Wafaie W. Fawzi
Summary: This study found that iron supplementation in HIV-infected children may increase the risk of mortality and disease progression, while reducing the risk of anemia.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Immunology
Vincent H. Wu, Jayme M. L. Nordin, Son Nguyen, Jaimy Joy, Felicity Mampe, Perla M. del Rio Estrada, Fernanda Torres-Ruiz, Mauricio Gonzalez-Navarro, Yara Andrea Luna-Villalobos, Santiago Avila-Rios, Gustavo Reyes-Teran, Pablo Tebas, Luis J. Montaner, Katharine J. Bar, Laura A. Vella, Michael R. Betts
Summary: In this study, a single-cell strategy was developed to define the HIV-infected memory CD4(+) T cell reservoir in ART-treated people living with HIV (ART-PLWH) using integrated accessible proviral DNA, epigenetic and cell surface protein profiling. The study identified a profound reservoir heterogeneity within and between ART-PLWH, characterized by new and known surface markers within memory CD4(+) T cell subsets. Furthermore, new epigenetic profiles and transcription factor motifs enriched in HIV-infected cells were uncovered, suggesting a potential for reactivation during ART treatment. These findings establish an initial multiomic atlas for targeted reservoir elimination strategies.
Article
Immunology
Ibnu A. Ariyanto, Silvia Lee, Riwanti Estiasari, Jeanne Edmands, Budiman Bela, Amin Soebandrio, Patricia Price
Summary: The study investigated the impact of CMV on γδ T-cell profiles in Indonesian HIV patients and healthy controls, finding that CMV may lead to a decrease in a specific type of γδ T-cells in HIV patients starting ART, but there was no consistent evidence of a role for CMV in γδ T-cell activation or differentiation.
CLINICAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Ines Mendoza, Alicia Lazaro, Alfredo Espinosa, Lorenzo Sanchez, Ana Maria Horta, Miguel Torralba
Summary: This study shows that dolutegravir plus lamivudine (2-DR) is not as effective as bictegravir/emtricitabine/tenofovir alafenamide (3-DR) in treating HIV-1. However, the durability and safety of 2-DR are similar to 3-DR.
Article
Infectious Diseases
Jennifer A. Brown, Bienvenu L. Nsakala, Kuena Mokhele, Itumeleng Rakuoane, Josephine Muhairwe, Tracy R. Glass, Alain Amstutz, Nadine Tschumi, Jennifer M. Belus, Thomas Klimkait, Niklaus D. Labhardt
Summary: The transition from EFV to DTG did not have negative impacts on the mental health and HIV/ART-related symptoms of people living with HIV, and potentially showed moderate improvements, supporting the rollout of DTG.
Letter
Biophysics
Mihaela Sava, Veronika Battig, Sabine Gerull, Jakob R. Passweg, Nina Khanna, Christian Garzoni, Bernhard Gerber, Nicolas J. Mueller, Urs Schanz, Christoph Berger, Yves Chalandon, Christian van Delden, Dionysios Neofytos, Susanne Stampf, Fabian C. Franzeck, Maja Weisser
BONE MARROW TRANSPLANTATION
(2023)
Article
Parasitology
Khanh Pham, Gideon S. Mtalitinya, Christine Aristide, Efeose A. Airewele, Deborah K. Nyakaru, Paige McMahon, Gerald Mulaki Mulaki, Paul L. A. M. Corstjens, Claudia J. . de Dood, Govert J. van Dam, John M. Changalucha, Humphrey D. Mazigo, Myung Hee Lee, Hyasinta Jaka, Jennifer A. Downs
Summary: Schistosoma mansoni infection is associated with mild-to-moderate lower gastrointestinal mucosal abnormalities that are visible during sigmoidoscopy, and these abnormalities partially improve 6 months after effective praziquantel treatment.
Article
Immunology
Robert Ndege, Omary Ngome, Fiona Vanobberghen, Farida Bani, Yvan Temba, Herieth Wilson, Jerry Hella, Winfrid Gingo, Mohamed Sasamalo, Dorcas Mnzava, Namvua Kimera, Hellen Hiza, John Wigayi, Herry Mapesi, Irene B. Kato, Francis Mhimbira, Klaus Reither, Manuel Battegay, Daniel H. Paris, Maja Weisser, Martin Rohacek
Summary: In this randomized two-center trial, a diagnostic algorithm including Extended Focused Assessment with Sonography for Human Immunodeficiency Virus and Tuberculosis did not increase the proportion of correctly managed patients with suspected extrapulmonary tuberculosis versus control, but increased definite tuberculosis.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Health Care Sciences & Services
Ivana Di Salvo, Dorcas Mnzava, Giovanni Jacopo Nicoletti, Elizabeth Senkoro, Robert C. Ndege, Dorothy J. Huang, Nathalia Tobias Makunja, George I. Kassiga, Andreas M. Kaufmann, Maja Weisser, Andre B. Kind
Summary: This study aims to evaluate the upscaling of cervical cancer screening and treatment services in a rural referral hospital in Tanzania to meet the targets set by the World Health Organization. It also explores the performance of novel diagnostic tests and provides information about HPV prevalence and persistence in a high-risk cohort of women living with HIV.
BMC HEALTH SERVICES RESEARCH
(2023)
Letter
Biophysics
Gioele Capoferri, Carla Simone Walti, Pascal Urwyler, Silvio Ragozzino, Jakob R. Passweg, Joerg Halter, Manuel Battegay, Veronika Baettig, Maja Weisser, Brice Arnold, Benedict Morin, Yukino Guetlin, Diana Albertos Torres, Gueliz Tuba Barut, Volker Thiel, Adrian Egli, Beatrice Drexler, Nina Khanna
BONE MARROW TRANSPLANTATION
(2023)
Article
Multidisciplinary Sciences
Lucas Romann, Laura Werlen, Nikki Rommers, Anja Hermann, Isabelle Gisler, Stefano Bassetti, Roland Bingisser, Martin Siegemund, Tim Roloff, Maja Weisser, Veronika C. Muigg, Vladimira Hinic, Michael Osthoff, Fabian Franzeck, Adrian Egli
Summary: This study evaluated factors for non-adherence to recommended blood culture volumes and assessed their effects on diagnostic performance. The use of central venous and arterial catheter for blood drawing resulted in increased filling volumes compared to peripheral venipuncture. Each additional nursing staff working at the time of blood drawing was associated with a higher likelihood of achieving the recommended filling volume. There was no significant correlation between the filling volume and the positivity rate.
Article
Biology
Elias Kabbas-Pinango, Moses Arinaitwe, Govert J. J. van Dam, Adriko Moses, Annet Namukuta, Andrina Barungi Nankasi, Nicholas Khayinja Mwima, Fred Besigye, Joaquin M. Prada, Poppy H. L. Lamberton
Summary: Schistosomiasis affects over 240 million people worldwide. Detecting the parasite eggs using Kato-Katz method is specific but not sensitive, while the urine-based POC-CCA test is more sensitive but has specificity issues and interpretation challenges. This study explores the variation in test results and suggests different thresholds for accurate diagnosis and prevalence monitoring.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Aneth Vedastus Kalinjuma, Hannah Hussey, Getrud Joseph Mollel, Emilio Letang, Manuel Battegay, Tracy R. Glass, Daniel Paris, Fiona Vanobberghen, Maja Weisser
Summary: Underweight and overweight/obesity are common health issues among people living with HIV (PLHIV) in rural sub-Saharan Africa, with underweight being associated with a higher risk of mortality and loss to follow-up.
Article
Infectious Diseases
Francisca Chuwa, Bernard Kivuma, Robert Ndege, KIULARCO Study Grp
Summary: This is the second case report of false-negative HIV rapid test results in a patient with advanced HIV disease in Tanzania. Currently, there are no guidelines on which tests should be performed in adult patients with severe immunosuppression despite a negative HIV rapid test result.
Article
Parasitology
Mariana Silva Sousa, Gdayllon Cavalcante Meneses, Govert Jan van Dam, Paul Leo Albert Maria Corstjens, Rosangela Lima de Freitas Galvao, Marta Cristhiany Cunha Pinheiro, Alice Maria Costa Martins, Elizabeth de Francesco Daher, Fernando Schemelzer de Moraes Bezerra
Summary: The study aimed to investigate the baseline levels of Schistosoma mansoni-Circulating Anodic Antigen (CAA) and their association with kidney biomarkers in individuals with long-term schistosomiasis follow-up after praziquantel treatment. The results showed that CAA-positive patients had increased baseline albuminuria and proteinuria, and their CAA levels were only correlated with Vascular Endothelial Growth Factor (VEGF) levels. However, no significant differences were observed in kidney biomarkers between the groups and different periods during the follow-up analysis.
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
(2023)
Letter
Clinical Neurology
Florian Ebel, Sarah Tschudin-Sutter, Maja Weisser, Michel Roethlisberger
JOURNAL OF NEUROSURGERY
(2023)