Article
Biochemistry & Molecular Biology
Erica S. Martins-Duarte, Juliana de Araujo Portes, Ramon Borges da Silva, Hugo Silva Pires, Simon J. Garden, Wanderley de Souza
Summary: Toxoplasma gondii is a common parasitic disease worldwide, with limited therapy options. Chemical modification of 1,10-phenanthroline to new derivatives has significantly improved anti-T. gondii activity, potentially serving as lead compounds for the treatment of acute and chronic phases of toxoplasmosis.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Iti Saraav, Luisa Cervantes-Barragan, Philipp Olias, Yong Fu, Qiuling Wang, Leran Wang, Yi Wang, Matthias Mack, Megan T. Baldridge, Thaddeus Stappenbeck, Marco Colonna, L. David Sibley
Summary: Oral infection with Toxoplasma gondii exacerbates damage to the colon caused by chemical irritant and impairs wound healing by suppressing stem cell regeneration. Enhanced tissue damage is due to inflammatory monocytes releasing inflammatory mediators.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Food Science & Technology
Pablo-Jesus Marin-Garcia, Nuria Planas, Lola Llobat
Summary: This article reviews the detection methods, prevalence, and control measures of Toxoplasma gondii in the food industry. T. gondii is a common parasite that causes infection through food contamination, but standardized detection methods are currently lacking in the industry. The main detection methods include bioassays, cell culture, molecular and microscopic techniques, and serological methods. Due to the high prevalence of T. gondii in many food products, standardized detection methods and control measures are necessary.
Article
Immunology
Mohammad Mahdi Jafari, Zahra Azimzadeh Tabrizi, Mohammad Saaid Dayer, Nazanin Atieh Kazemi-Sefat, Mahshid Mohtashamifard, Rahimeh Mohseni, Atefeh Bagheri, Saeed Bahadory, Amir Karimipour-Saryazdi, Fatemeh Ghaffarifar
Summary: Toxoplasma gondii infection is associated with immune response, which can be used as prognosis markers. Immunotherapy has become a new approach for toxoplasmosis treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Parasitology
Jiaofeng Huang, Jiaolong Zheng, Bang Liu, Lingling Lu, Haicong Wu, Su Lin, Dongliang Li
Summary: This study found that Toxoplasma gondii infection is associated with higher mortality in the general population, and this association is related to age and sex. This suggests that Toxoplasma gondii infection may be an important public health issue.
PARASITES & VECTORS
(2022)
Article
Multidisciplinary Sciences
Syrian G. Sanchez, Emilie Bassot, Aude Cerutti, Hoa Mai Nguyen, Amel Aida, Nicolas Blanchard, Sebastien Besteiro
Summary: Toxoplasma gondii is responsible for toxoplasmosis, a disease that can be serious when contracted during pregnancy, but can also be a threat for immunocompromised individuals. The study finds that targeting the apicoplast in bradyzoites, the latent form of the parasite, leads to a loss of long-term viability, suggesting the apicoplast as a potential therapeutic target.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Geriatrics & Gerontology
Hira Mohyuddin, Blanca Laffon, Joao P. Teixeira, Solange Costa, Armanda Teixeira-Gomes, Eduardo Pasaro, Niel Constantine, Aline Dagdag, Heidi K. Ortmeyer, Boris Tizenberg, Liubov Afram, Poyu Yen, Christopher Marano, Christopher A. Lowry, Andrew J. Hoisington, Jill A. Rachbeisel, Vanessa Valdiglesias, Carlota Lema-Arranz, Natalia Fernandez-Bertolez, Ana Maseda, Jose C. Millan-Calenti, Elizabeth J. Kovacs, Johanna M. Gostner, Dietmar Fuchs, Lisa A. Brenner, Laura Lorenzo-Lopez, Teodor T. Postolache
Summary: This study revealed an association between Toxoplasma gondii and frailty, but further research is needed for validation. Certain biomarkers related to inflammaging were associated with both Toxoplasma gondii and frailty, but they did not fully mediate the association between the two.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Immunology
Amy C. Schumacher, Lina Elbadawi, Traci DeSalvo, Anne Straily, Daniel Ajzenberg, David Letzer, Ellen Moldenhauer, Tammy L. Handly, Dolores Hill, Marie-Laure Darde, Christelle Pomares, Karine Passebosc-Faure, Kristine Bisgard, Carlos A. Gomez, Cindy Press, Stephanie Smiley, Jose G. Montoya, James J. Kazmierczak
Summary: In 2017, an outbreak of toxoplasmosis was linked to undercooked venison served at a retreat in Wisconsin. Most of the attendees experienced illness, with laboratory results showing atypical features for toxoplasmosis. The strain of T. gondii found in the venison was a unique genotype, highlighting the potential risks of consuming undercooked game meat in North America.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Thais Cabral Monica, Fernanda Evers, Beatriz Souza Lima Nino, Fernanda Pinto-Ferreira, Jose Wander Bregano, Mariana Ragassi Urbano, Guita Rubinsky-Elefant, Roberta Lemos Freire, Italmar Teodorico Navarro, Regina Mitsuka-Bregano
Summary: The study examined the seroprevalence and risk factors of toxoplasmosis and toxocariasis in schoolchildren in Jataizinho, Parana, revealing associations with factors such as the mother's education level, age, presence of cats in the household, income, and presence of dogs. There was also an association between the two zoonoses, highlighting the importance of implementing control measures to reduce the incidence and risks of sequelae in children.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Ragab M. Fereig, Yoshifumi Nishikawa
Summary: In this study, the cyto-nuclear and mitochondrial localization of TgPrx1 and TgPrx3 proteins in Toxoplasma gondii were revealed. Knocking out TgPrx1 and TgPrx3 genes in T. gondii resulted in decreased survival rate in mice infected with TgPrx3KO strain compared to TgPrx1KO and control strains. Additionally, TgPrx1KO and TgPrx3KO induced high levels of interferon gamma (IFN-gamma) and increased IL-6 and IL-12p40 production in infected mice and murine macrophages. These findings suggest that TgPrx3 may be a potential sub-unit vaccine candidate for controlling toxoplasmosis in susceptible humans and animals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Lokman Galal, Frederic Ariey, Meriadeg Ar Gouilh, Marie-Laure Darde, Azra Hamidovic, Franck Letourneur, Franck Prugnolle, Aurelien Mercier
Summary: This study analyzes 156 genomes of Toxoplasma gondii and provides estimates of the parasite's mutation rate and generation time. It reveals that a specific haplotype is associated with the spread of the parasite through cats, indicating its role in sexual reproduction.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Rajib Acharjee, Keith K. Talaam, Endah D. Hartuti, Yuichi Matsuo, Takaya Sakura, Bundutidi M. Gloria, Shinya Hidano, Yasutoshi Kido, Mihoko Mori, Kazuro Shiomi, Masakazu Sekijima, Tomoyoshi Nozaki, Kousuke Umeda, Yoshifumi Nishikawa, Shinjiro Hamano, Kiyoshi Kita, Daniel K. Inaoka
Summary: Toxoplasma gondii is a protozoan parasite that infects a large portion of the global human population. A new potential drug target, TgMQO, has been identified in this study, and a novel expression system was developed to study its characteristics. Ferulenol, an MQO inhibitor, showed promising inhibitory effects on TgMQO, with distinct binding sites from other known inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Veterinary Sciences
Ningbo Xia, Nuo Ji, Longjiao Li, Yuan Huang, Congshan Yang, Xuefang Guo, Qinghong Guo, Bang Shen, Lihua Xiao, Yaoyu Feng
Summary: This study investigated the seroprevalence and risk factors of T. gondii infection in cats across China. The study found higher infection rates in Sichuan, Chongqing, and Hunan, and reported the seroprevalence in Qinghai, Anhui, Jiangxi, Shaanxi, and Ningxia for the first time. Age and lifestyle (stray or pet) of cats were identified as risk factors for T. gondii infection.
BMC VETERINARY RESEARCH
(2022)
Review
Infectious Diseases
Tahereh Mikaeili Galeh, Shahabeddin Sarvi, Seyed Abdollah Hosseini, Ahmad Daryani
Summary: Toxoplasmosis, caused by Toxoplasma gondii, is a common food-borne infection in humans. In rodent populations, atypical genotypes are dominant, while clonal strains circulate with low genetic diversity in this mammal species.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Yazhen Ma, Xinru Cao, Hui Wang, Xingju Song, Dandan Hu
Summary: Tilmicosin and acetylisovaleryltylosin tartrate (ATLL) have potent anti-Toxoplasma activities, inhibiting the growth and proliferation of the parasite. ATLL shows strong inhibitory effects on intracellular parasites, while tilmicosin suppresses extracellular parasites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Ruben R. Ben-Harari, Mark P. Connolly
POSTGRADUATE MEDICINE
(2019)
Article
Genetics & Heredity
Mark P. Connolly, Saswat Panda, Julien Patris, Bouke P. C. Hazenberg
ORPHANET JOURNAL OF RARE DISEASES
(2019)
Review
Medicine, General & Internal
Paula J. Lapinskas, Ruben R. Ben-Harari
POSTGRADUATE MEDICINE
(2019)
Review
Infectious Diseases
Ruben R. Ben-Harari
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2019)
Article
Health Care Sciences & Services
Nikolaos Kotsopoulos, Gertruud Haitsma, Mark P. Connolly, Baudouin Standaert
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
(2020)
Article
Economics
Nikolaos Kotsopoulos, Mark P. Connolly, Thibaut Dort, Andrius Kavaliunas
JOURNAL OF MEDICAL ECONOMICS
(2020)
Article
Immunology
Mark P. Connolly, Nikolaos Kotsopoulos
Article
Economics
Baudouin Standaert, Christophe Sauboin, Quentin J. Leclerc, Mark P. Connolly
Summary: This study evaluated the use of a modified Social Accounting Matrix (SAM) to analyze the impact of medical intervention policies on economic transactions. Results showed that the SAM approach provides a more detailed assessment of indirect non-medical costs and financial interactions between agents, disclosing useful information for different stakeholders.
Article
Economics
Nikolaos Kotsopoulos, Mark P. Connolly, Jinjing Li
Summary: The study evaluated the fiscal consequences of atherosclerotic cardiovascular disease (ASCVD) patients, showing that treating with evolocumab may lead to additional tax revenues and savings in disability payments. Evolocumab can improve patients' work capacity and tax contributions by reducing cardiovascular events.
JOURNAL OF MEDICAL ECONOMICS
(2021)
Article
Genetics & Heredity
Mark P. Connolly, Nikos Kotsopoulos, Sebastian Vermeersch, Julien Patris, David Cassiman
Summary: The study demonstrates that individuals with Acute Hepatic Porphyria (AHP) incur significant public costs due to frequent attacks, with reduced lifetime earnings, taxes paid, and increased disability benefit support compared to the general population. Eliminating AHP attacks can result in fiscal benefits for the government, including reduced healthcare costs, disability payments, and improved tax revenue.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Article
Endocrinology & Metabolism
Nikolaos Kotsopoulos, Mark P. Connolly, Michael Willis, Andreas Nilsson, Asa Ericsson, James Baker-Knight
Summary: This study estimated the fiscal burden for taxpayers in Sweden associated with type 2 diabetes and its complications. It found that failure to meet HbA1c targets resulted in significant tax revenue losses and excess disability payments for the government.
DIABETES OBESITY & METABOLISM
(2022)
Article
Engineering, Biomedical
Goran Medic, Nikos Kotsopoulos, Mark P. Connolly, Jennifer Lavelle, Vincent Norlock, Manish Wadhwa, Belinda A. Mohr, Wayne M. Derkac
Summary: This study compared the costs and outcomes of MCOT patch followed by ILR and ILR alone in cryptogenic stroke patients, finding that the MCOT patch arm detected more cases of AF and resulted in significant cost savings. The cost per patient with detected AF was significantly lower in the MCOT patch arm compared to the ILR only arm.
MEDICAL DEVICES-EVIDENCE AND RESEARCH
(2021)
Article
Obstetrics & Gynecology
Rui Martins, Mark P. Connolly
Summary: Infertility can be overcome through medically assisted reproductive technologies, but measuring the cost-effectiveness of these treatments raises ethical and methodological questions, presenting challenges for decision-makers. Infertility and infertility treatments differ significantly from other health conditions and treatments.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2022)
Article
Immunology
Simon van der Schans, Marcel H. Schottler, Jurjen van der Schans, Mark P. Connolly, Maarten J. Postma, Cornelis Boersma
Summary: This study assessed the fiscal impact of the COVID-19 outbreak in the Netherlands using two different approaches. The results showed significant losses in terms of tax income and GDP due to the pandemic. The study provides important insights into the relationship between disease outbreaks and government public accounts.
Article
Medicine, Research & Experimental
Nikos Kotsopoulos, Mark P. Connolly
Summary: The study estimated the fiscal burden of obesity in Canada, including revenue losses and increased government spending, with an average cost of CAD$752 per capita in 2021. Reductions in obesity prevalence can lead to significant annual fiscal gains for the government.
ADVANCES IN THERAPY
(2023)