Article
Medicine, General & Internal
Wang Hui, Hu Xiao-feng, Li Song-guo, Wang Jing-jing, Huang Xuan, Tao Yong
Summary: This study found that using orthokeratology (OK) lenses can effectively control the axial growth and progression rate of myopia compared to frame glasses. Although wearing OK lenses may cause dry eye symptoms, there were no significant changes in ocular surface and meibomian gland function for each patient, indicating that the use of OK lenses is a relatively safe modality for myopia control in adolescents.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Li Yang, Ling Zhang, Ren Jian Hu, Ping Ping Yu, Xiuming Jin
Summary: The study found that wearing orthokeratology lenses may increase ocular surface disease index and damage to the meibomian glands, with significant differences in noninvasive tear breakup time and corneal fluorescein staining compared to the control group.
CONTACT LENS & ANTERIOR EYE
(2021)
Article
Ophthalmology
Jing Ruan, Yu Zhang, Yueguo Chen
Summary: This study investigated the effect of overnight orthokeratology lenses on tear film stability and meibomian gland status in children aged 8-15 years. The results showed that continuous use of orthokeratology lenses for 12 months had minimal effect on tear film and meibomian gland status. This finding can help guide the clinical management of tear film quality with respect to the use of orthokeratology contact lenses.
Article
Ophthalmology
Jing Zhai, Lijie Hou, Yixuan Yao, Hengli Lian, Siping Chen, Yeqing Xu, Qi Dai
Summary: This study tested the changes in meibomian gland morphology in asymptomatic children wearing overnight orthokeratology and soft contact lenses using an artificial intelligence analytic system. The results showed that MG width of the upper eyelid significantly increased and MG vagueness value significantly decreased after both treatments. The AI analytic system may be an effective method for quantitatively detecting MG morphological changes.
CONTACT LENS & ANTERIOR EYE
(2023)
Article
Ophthalmology
Saumya Yadav, Noopur Gupta, Tarjani Makwana, Murugesan Vanathi, Radhika Tandon
Summary: This study assessed the role of a noninvasive ocular surface analyzer (OSA) in diagnosing meibomian gland dysfunction (MGD) and found that MGD is a common disorder in adults attending a tertiary eye care hospital outpatient services. The use of OSA can aid in rapidly and reliably measuring MGD-related parameters.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Yuanfang Yang, Qinghui Wu, Wei Pan, Longbo Wen, Zhiwei Luo, Haoran Wu, Guangyao Ran, Zhikuan Yang, Xiaoning Li
Summary: This study investigated the characteristics of objective ocular surface parameters in children with myopia who are candidates for orthokeratology lens wear. The results showed that tear secretion increases and meibomian gland deficiency worsens with age. The dry eye diagnostic criteria for adults may be applicable to orthokeratology candidates aged 12-18 years but should be lower for younger candidates.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Medicine, General & Internal
Reiko Arita, Shima Fukuoka, Motoko Kawashima
Summary: Treatment selection for meibomian gland dysfunction (MGD) should be based on a comprehensive stage classification that includes ocular symptoms, lid margin abnormalities, meibum grade, and ocular surface staining. Different treatment modalities have varying efficacy based on the meiboscore determined by noncontact meibography, with intense pulsed light therapy showing improvement even in cases with high meiboscore. Prospective studies are needed to further validate these findings.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Kelvin H. Wan, Grace C. Y. Lui, Ken C. F. Poon, Susanna S. S. Ng, Alvin L. Young, David S. C. Hui, Clement C. Y. Tham, Paul K. S. Chan, Chi Pui Pang, Kelvin K. L. Chong
Summary: This study investigated ocular surface disturbances in COVID-19 patients after hospital discharge and found that meibomian gland dysfunction and ocular surface staining were more common and severe in these patients. Patients with higher viral loads had a greater risk of ocular surface symptoms.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Zengying Wang, Zuocheng Wang, Yifei Meng, Pengfei Wang, Shaniya Yibulayin, Bohua Jiang, Xufei Bian, Tianya Gao, Zhipeng Yan
Summary: The aim of this study was to investigate the changes in posterior corneal surface after 12 months of orthokeratology (ortho-k) treatment. Medical records of 37 Chinese children who wore ortho-k lenses over 12 months were reviewed. The results showed that the anterior corneal surface was significantly changed by ortho-k lens, while the posterior corneal surface did not show any changes during the 12-month follow up. Additionally, the anterior chamber depth, lens thickness, and ocular axis length were significantly changed during this period.
Review
Ophthalmology
Shokufeh Tavassoli, Nathan Wong, Elsie Chan
Summary: Ocular rosacea is a chronic inflammatory condition that primarily affects the eyes with symptoms such as chronic blepharoconjunctivitis and meibomian gland dysfunction. Corneal complications can include vascularization, ulceration, and scarring, and treatment options vary depending on disease severity. Ocular rosacea can also be associated with systemic disorders like cardiovascular disease.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Biology
Elena Diz-Arias, Elena Fernandez-Jimenez, Assumpta Peral, Jose A. Gomez-Pedrero
Summary: In this study, two different meibographers, using infrared and visible light, were used to obtain meibography images from normal and MGD population. The objective was to validate the use of visible light for observing and quantifying MG in clinical practice. The study found that VLNCM allowed for proper visualization and classification of MG in the upper eyelids.
Article
Medicine, General & Internal
Xiangjun Chen, Reza A. Badian, Havard Hynne, Behzod Tashbayev, Lene Hystad Hove, Janicke Liaaen Jensen, Tor Paaske Utheim
Summary: In this study, meibography of 65-year-old residents in Oslo, Norway was analyzed, and it was found that moderate meibomian gland atrophy was common and not gender-specific. Meibography alone cannot discriminate between meibomian gland dysfunction (MGD) and non-MGD, thus both morphological and functional tests are necessary for screening MGD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Hua Chen, Hui Gao, Hua-Tao Xie, Shu-Ting Liu, Yu-Kan Huang, Ming-Chang Zhang
Summary: The study revealed that treatment with Staphylococcus aureus crude extracts (SACEs) led to overexpression of keratin 1 (Krt1) in the ducts and acini of meibomian gland (MG) explants, along with decreased viability and increased cell death. SACEs treatment also dose-dependently increased levels of pro-inflammatory cytokines in MG explants and activated the NF-kappa B and AIM2/ASC signaling pathways.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Medicine, General & Internal
Reiko Arita, Shima Fukuoka
Summary: This study evaluated the efficacy and safety of intense pulsed light (IPL) combined with meibomian gland expression (MGX) for the treatment of refractory multiple and recurrent chalazia. The combination therapy significantly improved all parameters except meiboscore and the Schirmer value, while MGX alone only significantly improved meibum grade. No adverse events occurred in either group. IPL-MGX treatment was effective and safe for multiple and recurrent chalazia without surgery or curettage.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Ho Sik Hwang, Eric Mikula, Yilu Xie, Donald J. Brown, James V. Jester
Summary: A novel mouse transillumination meibography device was developed and successfully used to detect age-related changes in meibomian glands of young and old mice. Older mice exhibited meibomian gland dropout and irregular shapes.
Article
Ophthalmology
Xiu Wang, Xiaoxiao Lu, Jun Yang, Ruihua Wei, Liyuan Yang, Shaozhen Zhao, Xilian Wang
JOURNAL OF OPHTHALMOLOGY
(2016)
Letter
Ophthalmology
Xiu Wang, Patrick Glencer, Rui-Hua Wei
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2017)
Article
Ophthalmology
Jun Yang, Xiu Wang, Hong Zhang, Yi Pang, Rui-Hua Wei
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2017)
Letter
Ophthalmology
Xiu Wang, Elizabeth W. L. Lim, Li Lim, Rui-Hua Wei
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2017)
Review
Medical Laboratory Technology
Xiu Wang, Mianmian Wu, Yunshan Cao, Zhi Zhang, Fang Guo, Xiaorong Li, Yan Zhang
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2019)
Review
Chemistry, Medicinal
Siwei Cai, Qianhui Yang, Xiaorong Li, Yan Zhang
DRUG DESIGN DEVELOPMENT AND THERAPY
(2018)
Article
Multidisciplinary Sciences
Xiaoxiao Lu, Chenchen Chu, Xun Liu, Yichen Gao, Mianmian Wu, Fang Guo, Yahong Li, Chao Geng, Yue Huang, Yan Zhang, Shaozhen Zhao
Review
Medical Laboratory Technology
Yan Zhang, Mianmian Wu, Yunshan Cao, Fang Guo, Yahong Li
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2020)
Article
Ophthalmology
Xiu Wang, Xue Bai, Chengcheng Jin, Liqiong Zhao, Ruihua Wei
Summary: This study analyzed tear function outcomes in patients with ectatic corneas who underwent collagen cross-linking (CXL) treatment. The results showed that both epithelium-on (epi-on) and epithelium-off (epi-off) CXL improved best-corrected visual acuity (BCVA) and maximum keratometry value (Kmax), with no significant difference between the two methods. Both groups also showed a decrease in ocular surface disease index (OSDI), but only the change in tear meniscus height at 6 months postoperatively was statistically significant. This study concludes that both epi-on and epi-off CXL can control the progression of keratoconus and improve dry eye symptoms.
JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kai Wen, Yan Zhang, Yahong Li, Qing Wang, Jing Sun
Summary: The study assessed the m(6)A methylome in the anterior capsule of the lens of high myopia patients and found that upregulation of m(6)A methylation may change fundus anatomy by regulating the composition of the extracellular matrix through encoding protein.
Article
Biochemistry & Molecular Biology
Xiu Wang, Yan Zhang, Lei Zhou, Ruihua Wei, Lijie Dong