Article
Nutrition & Dietetics
Naoko Tsugawa, Mayu Nishino, Akiko Kuwabara, Honami Ogasawara, Maya Kamao, Shunjiro Kobayashi, Junichi Yamamura, Satoshi Higurashi
Summary: The study found that the low vitamin D status in recent lactating mothers may have decreased the concentrations of vitamin D and 25OHD in breast milk, compared to the 1980s. This has important implications for improving the vitamin D status of lactating mothers and infants.
Article
Obstetrics & Gynecology
Shu Qin Wei, Jean-Francois Bilodeau, Pierre Julien, Zhong-Cheng Luo, Haim A. Abenhaim, Wei Guang Bi, Anne Monique Nuyt, Line Leduc, Francois Audibert, William D. Fraser
Summary: The study revealed that maternal vitamin D deficiency was associated with increased oxidative stress levels during pregnancy, and both maternal vitamin D deficiency and increased oxidative stress levels were associated with the risk of pre-eclampsia.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Obstetrics & Gynecology
Ahmad I. Al-Shafei, Duria A. Rayis, Abdelmarouf H. Mohieldein, Ola A. El-Gendy, Ishag Adam
Summary: The study found that women with lower 25-hydroxyvitamin D levels in early pregnancy were at a higher risk of developing gestational diabetes mellitus, which could be useful in predicting GDM.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Biochemistry & Molecular Biology
Shufei Zeng, Chang Chu, Cornelia Doebis, Volker von Baehr, Berthold Hocher
Summary: There is a strong positive linear correlation between free 25(OH)D (f25(OH)D) and total 25(OH)D, making them useful for assessing vitamin D levels. The recommended threshold level for f25(OH)D is 8.499 pg/mL, corresponding to a target concentration of at least 30 ng/mL for t25(OH)D. The upper limit for vitamin D is still unclear, with most experts favoring a upper limit of 100 ng/mL for t25(OH)D.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Nutrition & Dietetics
Guowei Li, Likang Li, Jonathan D. Adachi, Ruoting Wang, Zebing Ye, Xintong Liu, Lehana Thabane, Gregory Y. H. Lip
Summary: This study found a quasi J-shaped relationship between serum circulating 25-hydroxyvitamin D (25(OH)D) level and risk of recurrent stroke in patients with a stroke history. The lowest risk of recurrent stroke was observed at a 25(OH)D level of approximately 60 nmol/L, which was associated with a 48% reduction in risk compared to a level of 10 nmol/L.
Article
Nutrition & Dietetics
RuTong Wang, Weijing Wang, Ping Hu, Ronghui Zhang, Xue Dong, Dongfeng Zhang
Summary: This study aimed to evaluate the association between dietary vitamin D intake and serum vitamin D concentrations with cognitive performance in older Americans. The results showed a positive association between dietary vitamin D intake, serum total 25-hydroxyvitamin D, and cognitive performance, with no significant gender differences in the associations. Further research is needed to clarify the effects of dietary vitamin D intake and specific serum D concentrations on cognitive performance.
Article
Nutrition & Dietetics
Eduardo Villamor, Henry Oliveros, Constanza Marin, Sandra Lopez-Arana, Samantha Agudelo-Canas
Summary: This randomized controlled trial examined the effects of providing cholecalciferol-fortified skim milk to Colombian adolescents and adult women. The results demonstrated that the provision of fortified milk increased serum total 25(OH)D concentrations in both groups, with varying effects depending on individual characteristics.
JOURNAL OF NUTRITION
(2023)
Article
Medical Laboratory Technology
Francesco Vierucci, Lara Fusani, Alessandro Saba, Tania Minucciani, Maria Paola Belluomini, Raffaele Domenici, Gian Luca Bracco, Angelina Vaccaro, Giovanni Federico
Summary: This study assessed the relationship between assumed risk factors for maternal vitamin D deficiency and levels of cord blood 25(OH)D-3 and C-3-epimer. The results showed that vitamin D deficiency was common in newborns, especially those born to mothers who did not receive vitamin D supplementation and had poor sun exposure.
CLINICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Lutfiye Karcioglu Batur, Ahmet Ozaydin, Murat Emrah Mavis, Gokce Goksu Gursu, Laurence Harbige, Nezih Hekim
Summary: The study investigated the impact of rs7041 and rs4588 polymorphisms in the GC gene on vitamin D parameters, with the most common genotypes of GT and AC found in Turkish individuals. This variation in genotypes may be linked to differences in free and bioavailable 25(OH)D levels.
Article
Multidisciplinary Sciences
Oleg Tsuprykov, Saban Elitok, Claudia Buse, Chang Chu, Bernhard Karl Kraemer, Berthold Hocher
Summary: This study compared the correlation of different vitamin D compounds in pregnant women, finding that total 1,25(OH)(2)D showed the best correlation with various health markers. Free 25(OH)D and bioavailable 25(OH)D are more precise indicators of vitamin D status than total 25(OH)D.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Huifeng Shi, Yuanhui Jiang, Pengbo Yuan, Lian Chen, Xiaoli Gong, Yike Yang, Yuanyuan Wang, Hai Jiang, You Li, Mengxing Sun, Yangyu Zhao, Yuan Wei
Summary: This study revealed a non-linear association between vitamin E concentrations in the first trimester and gestational vitamin E change with pre-eclampsia. The findings showed that vitamin E concentrations below 7.3 mg/L and gestational decrease were associated with increased risk of pre-eclampsia.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Sonja Soininen, Aino-Maija Eloranta, Ursula Schwab, Timo A. Lakka
Summary: The purpose of this study was to investigate the intake and sources of vitamin D, as well as the determinants of serum 25-hydroxyvitamin D (S-25(OH)D) in Finnish adolescents. The results showed that most adolescents had vitamin D intake at the recommended level, although a quarter did not meet the recommended intake and almost a third had low levels of S-25(OH)D. The main determinants of S-25(OH)D were vitamin D intake from supplements, consumption of milk products, consumption of meat products, travels to sunny countries, and average daylight time.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Vid Vicic, Andreja Kukec, Sasa Kugler, Ksenija Gersak, Josko Osredkar, Ruza Pandel Mikus
Summary: The objective of this study was to evaluate vitamin D status and its predictors in Slovenian premenopausal and postmenopausal women. The study found that vitamin D insufficiency and deficiency were common among both premenopausal and postmenopausal women, with vitamin D supplementation and sun exposure being important predictors of vitamin D status. Interestingly, the vitamin D status in Slovenian postmenopausal women was better than in premenopausal women, which differs from similar studies.
Article
Nutrition & Dietetics
Zhenyu Zhong, Guannan Su, Liping Du, Qingyun Zhou, Fuzhen Li, Wei Chi, Shengyun Liu, Meifen Zhang, Xianbo Zuo, Peizeng Yang
Summary: This study using Mendelian randomization found that genetically increased serum 25-hydroxyvitamin D levels were associated with a higher risk of Behcet's disease, with data from Chinese and Turkish cohorts supporting this conclusion. The contribution to Behcet's disease risk may increase with higher levels of vitamin D.
CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Frank Z. Stanczyk, Intira Sriprasert, Rachel Danis, Raj Pandian, Harpreet Matharu, Nicole Bender, Melissa Natavio
Summary: This study compared the effects of two combined oral contraceptive formulations on 25(OH)D levels and VDBP levels, revealing different impacts. LNG may have a suppressive effect on VDBP. Further research is needed to understand the influence of hormonal contraceptive formulations on vitamin D status and women's health.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Editorial Material
Medicine, General & Internal
Stefan Pilz, John P. A. Ioannidis
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Food Science & Technology
Spyridon N. Karras, Theocharis Koufakis, Lilian Adamidou, Georgios Dimakopoulos, Paraskevi Karalazou, Katerina Thisiadou, Pantelis Zebekakis, Kali Makedou, Kalliopi Kotsa
Summary: This study prospectively assessed changes in free 25-hydroxyvitamin D [25(OH)D] and vitamin D binding protein (VDBP) among overweight adults who followed a pescatarian Orthodox intermittent fasting regimen and controls who followed a low-fat 12:12 diet. The findings suggest that diet can affect free 25(OH)D concentrations, independently of exposure to sunlight, through variations in amino acid intake, providing novel mechanistic insights into the future planning of vitamin D supplementation strategies. However, larger studies are needed to test this hypothesis.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2023)
Article
Endocrinology & Metabolism
Natasha M. Appelman-Dijkstra, Stefan Pilz
Summary: Taking care of pregnant patients with parathyroid disorders requires consideration of changes in bone and mineral metabolism. The diagnostic and therapeutic approaches differ from the nonpregnant population. Parathyroidectomy is recommended for primary hyperparathyroidism before pregnancy to reduce complications. Conservative treatment and active surveillance are recommended for hypoparathyroidism. Postpartum monitoring is necessary, as there is an increased risk of hypercalcemia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Andreas Koster, Nikolai Hulde, Marcus-Andre Deutsch, Jan F. F. Gummert, Vera von Dossow, Armin Zittermann
Summary: We compared a moderate dose of tranexamic acid (TXA) protocol with a 1.5-g bolus-only protocol in 873 propensity score-matched pairs of valvular heart surgery patients. The number of transfused patients and transfused red blood cell concentrates was higher in the bolus-only protocol group. The risks of re-exploration and convulsive seizures were similar between the two groups.
THORACIC AND CARDIOVASCULAR SURGEON
(2023)
Review
Nutrition & Dietetics
Marios Anemoulis, Antonios Vlastos, Vasileios Kachtsidis, Spyridon N. Karras
Summary: This systematic review examined the impact of intermittent fasting (IF) on breast cancer patients. It found that IF may have positive effects on quality of life, radiological response, and cancer recurrence during chemotherapy, but the data quality was low and further research is needed for validation.
Article
Nutrition & Dietetics
Verena Theiler-Schwetz, Christian Trummer, Martin R. Gruebler, Martin H. Keppel, Armin Zittermann, Andreas Tomaschitz, Winfried Maerz, Andreas Meinitzer, Stefan Pilz
Summary: Accumulating evidence suggests an association of the TRP-KYN pathway with atherosclerosis and cardiovascular risk factors. Linear regression analyses showed significant associations between TRP, KYN, QUIN, and HDL, as well as smoking status and TRP/KYN pathway parameters. Further studies are needed to explore the diagnostic and therapeutic potential of the TRP-KYN pathway for cardiovascular diseases.
Review
Nutrition & Dietetics
Pawel Pludowski, Beata Kos-Kudla, Mieczyslaw Walczak, Andrzej Fal, Dorota Zozulinska-Ziolkiewicz, Piotr Sieroszewski, Jaroslaw Peregud-Pogorzelski, Ryszard Lauterbach, Tomasz Targowski, Andrzej Lewinski, Robert Spaczynski, Miroslaw Wielgos, Jaroslaw Pinkas, Teresa Jackowska, Ewa Helwich, Artur Mazur, Marek Ruchala, Arkadiusz Zygmunt, Mieczyslaw Szalecki, Artur Bossowski, Justyna Czech-Kowalska, Marek Wojcik, Beata Pyrzak, Michal A. Zmijewski, Pawel Abramowicz, Jerzy Konstantynowicz, Ewa Marcinowska-Suchowierska, Andrius Bleizgys, Spirydon N. Karras, William B. Grant, Carsten Carlberg, Stefan Pilz, Michael F. Holick, Waldemar Misiorowski
Summary: It is found that vitamin D deficiency is prevalent among the Polish population based on epidemiological studies. To address this concern, a Polish multidisciplinary group reviewed the evidence and formulated recommendations for prevention and treatment of vitamin D deficiency. The final Polish recommendations included a range of serum vitamin D levels indicating deficiency, guidelines for prophylaxis and treatment, and the importance of improving the overall population's vitamin D status and treating at-risk patient groups.
Review
Nutrition & Dietetics
Armin Zittermann, Christian Trummer, Verena Theiler-Schwetz, Stefan Pilz
Summary: This study summarized the harmful effects of a daily vitamin D supplement of 3200-4000 IU, showing that this dosage increases the risk of hypercalcemia and other adverse events in some individuals.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Engineering, Biomedical
Armin Zittermann, Pilz Stefan, Morshuis Michiel, Gummert F. Jan, Milting Hendrik
Summary: This study investigated the association between vitamin D deficiency and driveline infection in patients with continuous flow LVAD implants. The results showed that patients with circulating 25-hydroxyvitamin D concentrations < 25 nmol/L had a higher risk of driveline infection. Although endocrine regulators of calcium and phosphorus metabolism were not significantly associated with the risk of infection, these data suggest that deficient vitamin D status in LVAD recipients may predict the occurrence of driveline infection.
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
(2023)
Review
Endocrinology & Metabolism
Armin Zittermann, Annemarie Schmidt, Julia Haardt, Nicole Kalotai, Andreas Lehmann, Sarah Egert, Sabine Ellinger, Anja Kroke, Stefan Lorkowski, Sandrine B. Louis, Matthias Schulze, Lukas Schwingshackl, Roswitha I. Siener, Gabriele Stangl, Dorothee Volkert, Bernhard A. Watzl, Heike Bischoff-Ferrari
Summary: This umbrella review aimed to assess the impact of protein intake exceeding the current recommendations for different age groups on bone health. The review analyzed systematic reviews of studies published between 2008 and 2021, evaluating the effect of both animal and plant protein. The overall certainty of evidence was found to be insufficient, except for a possible link between high protein intake and reduced hip fracture risk.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
Julia Gotte, Armin Zittermann, Rene Schramm, Sabine Bleiziffer, Markus Andre Deutsch, Andre Renner, Jan F. Gummert
Summary: By analyzing the data from 369 patients undergoing isolated tricuspid valve surgery, the study found that the surgical approaches and pre- and postoperative valve function were associated with the expected mortality rates. The majority of patients showed improved tricuspid valve function postoperatively. Randomized controlled trials are needed to compare the long-term outcomes of surgical and interventional procedures.
THORACIC AND CARDIOVASCULAR SURGEON
(2023)
Editorial Material
Nutrition & Dietetics
Pawel Pludowski
Article
Biology
Darko Radakovic, Armin Zittermann, Sebastian V. Rojas, Dragan Opacic, Artyom Razumov, Emir Prashovikj, Henrik Fox, Rene Schramm, Michiel Morshuis, Volker Rudolph, Jan Gummert, Christian Flottmann, Marcus-Andre Deutsch
Summary: This study aimed to evaluate the effect of prophylactic left ventricular (LV) unloading with Impella pump during VA-ECMO therapy for refractory cardiogenic shock. The results showed that compared with the bail-out unloading strategy, prophylactic unloading was associated with lower 30-day mortality risk and higher probability of myocardial recovery.
Article
Nutrition & Dietetics
Marek Wojcik, Maciej Jaworski, Pawel Pludowski
Summary: This study aimed to assess the concentration of 25(OH)D and its potential changes during the growth and maturation period in children. The study found that 18.9% of the subjects had vitamin D deficiency from 2014 to 2019. Effective prevention of vitamin D deficiency was observed in children aged 3 years and younger. There was no relationship between the concentrations of 25(OH)D and calcium.