Article
Pharmacology & Pharmacy
Xiaolu Yu, Junnan Zhou, Fuli Zhao, Xuan Liu, Yuhang Mao, Li Diao, Chuanjun Wen, Mei Liu
Summary: Tomatidine (Td) shows inhibitory effects on inflammatory responses in arthritis and therapeutic effects on synovial inflammation and joint destruction in rats. Td can significantly suppress the production of pro-inflammatory cytokines and may act by reducing the activation of MAPKs and NF-κB.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Shih-Yao Chen, Jeng-Long Hsieh, Po-Ting Wu, Ai-Li Shiau, Chao-Liang Wu
Summary: This study found that decreased expression of miR-133 is associated with aberrant proliferation and migration of RA FLS. Overexpression of miR-133 reduced cell viability and migration of RA FLS, with decreased levels of FSCN1, EGFR, and MET.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Immunology
Mingcheng Huang, Keping Wu, Shan Zeng, Wenfen Liu, Tianjiao Cui, Zhiqing Chen, Lian Lin, Dongying Chen, Hui Ouyang
Summary: The study demonstrated that punicalagin has anti-inflammatory and anti-bone destruction effects in rheumatoid arthritis by inhibiting the proliferation and migration of FLSs and modulating NF-kappa B pathways.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Immunology
Zewen Wu, Dan Ma, Helin Yang, Jinfang Gao, Gailian Zhang, Ke Xu, Liyun Zhang
Summary: Fibroblast-like synoviocytes (FLS) play a crucial role in the pathophysiology of rheumatoid arthritis (RA) and have become the main focus of research. Advances in technology, such as high-throughput sequencing, have made it possible to identify different FLS subsets, allowing for a detailed study of RA pathogenesis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Xiao-feng Li, Shu-qin Yin, Hao Li, Ying-li Yang, Xin Chen, Biao Song, Sha Wu, Yuan-yuan Wu, Hua Wang, Jun Li
Summary: This study found that reduced expression of PPAR-gamma and increased expression of TNF-alpha are important factors in the inflammatory response of synoviocytes in rheumatoid arthritis. By binding with p53, PPAR-gamma can alleviate the activation and inflammation of synoviocytes induced by TNF-alpha.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Pharmacology & Pharmacy
Ana Teresa Rufino, Mariana Lucas, Artur M. S. Silva, Daniela Ribeiro, Eduarda Fernandes
Summary: The study found that 2-SC can reduce oxidative stress and inflammation in rheumatoid arthritis by inhibiting the NF-kappa B pathway. However, one of the 2-SC also has the ability to suppress the NF-kappa B pathway, further reducing the expression of inflammatory factors. These results suggest that 2-SC may be potential drugs for new therapeutic strategies for rheumatoid arthritis.
Article
Immunology
Yong Chen, Baojiang Wang, Yanjuan Chen, Qunyan Wu, Wing-Fu Lai, Laiyou Wei, Kutty Selva Nandakumar, Dongzhou Liu
Summary: HAPLN1 plays a role in promoting cell proliferation and pro-inflammatory phenotype in rheumatoid arthritis, contributing to the pathogenesis of the disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Integrative & Complementary Medicine
Lianhua He, Huijie Luan, Juan He, Miaomiao Zhang, Qingxia Qin, Yiping Hu, Yueming Cai, Desheng Sun, Yu Shi, Qingwen Wang
Summary: Shikonin has anti-inflammatory and immunomodulatory activities and has been shown to reduce arthritis incidence and inflammation in collagen-induced arthritis mice. It also inhibits the invasion, adhesion, and migration of fibroblast-like synoviocytes, as well as the expression of inflammatory cytokines. Shikonin targets suppressor of cytokine signaling 1 and blocks the Janus kinase/signal transducer and activator of transcription signaling pathway, making it a promising candidate for the treatment of rheumatoid arthritis.
Article
Integrative & Complementary Medicine
Wei-Jen Cheng, Hsuan-Tzu Yang, Chih-Chao Chiang, Kuei-Hung Lai, Yu-Li Chen, Huei-Lin Shih, Jong-Jen Kuo, Tsong-Long Hwang, Chi-Chien Lin
Summary: This study investigates the anti-arthritic and anti-inflammatory effects of deer velvet antler (DA) on rheumatoid arthritis (RA). The results show that DA can reduce inflammation and alleviate arthritis symptoms and tissue damage in experimental models. Additionally, several components potentially related to the anti-inflammatory effects of DA were identified.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Min Wang, Tianming Dai, Siming Li, Wen Wang
Summary: This study found that eugenol can inhibit the proliferation, migration, invasion, angiogenesis, and inflammatory response of fibroblast-like synovial cells from rheumatoid arthritis (RA), and promote apoptosis. The molecular mechanisms of eugenol may be associated with vascular endothelial growth factor (VEGF) and NF-kappaB (NF-kB) signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Immunology
Ji Hyeon Ryu, Jisu Park, Bo-Young Kim, Yeonye Kim, Nam Gyun Kim, Yong-Il Shin
Summary: This study investigates the effects and mechanisms of photobiomodulation (PBM) on fibroblast-like synoviocytes (FLSs) from rheumatoid arthritis (RA) patients and a mouse model of collagen-induced arthritis (CIA). PBM significantly reduced proliferation, migration, and invasion of RA-FLSs, and inhibited synovial inflammation and cartilage degradation in the CIA model. PBM therapy also showed a synergistic effect when combined with methotrexate (MTX), a disease-modifying anti-rheumatic drug (DMARD).
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Tao Wu, Xue-Pei Zhang, Qian Zhang, Yao-Yao Zou, Jian-Da Ma, Le-Feng Chen, Yao-Wei Zou, Ji-Meng Xue, Ruo-Fan Ma, Zhong Chen, Lie Dai
Summary: This study demonstrates the presence of GSDME-mediated pyroptosis in RA synovial tissues and its association with cell migration, invasion, and release of inflammatory cytokines.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Junnan Zhou, Yuhang Mao, Xiaotian Shi, Yudie Zhang, Xiaolu Yu, Xuan Liu, Li Diao, Xue Yang, Changze Liu, Dan Liu, Xin Tan, Mei Liu
Summary: This study demonstrates the potential therapeutic effect of peimine on rheumatoid arthritis (RA), including the inhibition of destructive behaviors and over-expression of pro-inflammatory cytokines. It also provides insights into the molecular mechanism of action of peimine on RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yuan Liu, Peishi Rao, Hongyan Qian, Yesi Shi, Shiju Chen, Jingying Lan, Dan Mu, Rongjuan Chen, Xinwei Zhang, Chaoqiong Deng, Gang Liu, Guixiu Shi
Summary: Fibroblast-like synoviocytes (FLS) are the main cell component in inflamed joints of patients with rheumatoid arthritis (RA) and interact with infiltrating T cells. Under normal conditions, FLS have inhibitory effects on T cells, but in RA, FLS exhibit a proinflammatory phenotype. The signals that control FLS heterogeneity are still unclear.
Article
Cell Biology
Qoyama Noel Baito, Halmat M. Jaafar, Talar Ahmad Merza Mohammad
Summary: In this study, piperine was found to induce apoptosis and reduce proliferation of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) through inhibition of the NF-kappa B pathway. It also decreased the expression of genes related to RA-FLS proliferation, apoptosis inhibition, and inflammation, while increasing the expression of apoptosis-related genes. Moreover, piperine reduced the secretion of cytokines and chemokines by FLSs as a result of NF-kappa B inhibition.
CELLULAR IMMUNOLOGY
(2023)
Letter
Dentistry, Oral Surgery & Medicine
Xiaolan Gao, Yiwen Deng, Hanming Wang, Wei Liu
Article
Engineering, Electrical & Electronic
Hanming Wang, Jinghong Zhao, Jie Xue, Hansi Chen, Guoqiang Guo, Yiyong Xiong, Sinian Yan
Summary: This paper proposes an ensemble multi-objective optimal design method for a short primary double-sided linear induction motor (SP-DLIM). By using a simplified Quasi-3D equivalent circuit model (ECM) and an improved differential evolutionary (IDE) algorithm, the efficiency, power factor, and tooth weight of the motor can be optimized.
IET ELECTRIC POWER APPLICATIONS
(2022)
Article
Engineering, Electrical & Electronic
Hanming Wang, Jinghong Zhao, Guoqiang Guo, Hansi Chen, Yiyong Xiong, Sinian Yan
Summary: This paper investigates the optimization design issues of linear induction motors and proposes an analytical model, an iterative design method, and a multi-objective optimal design method. The results indicate that the proposed methods have competitive performance.
JOURNAL OF ELECTRICAL ENGINEERING & TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Guohua Zhou, Yufen Wang, Kena Wu, Hanming Wang
Summary: This paper proposes a localization method for underwater sensors based on the optimization of magnetic field gradients. By optimizing the positions of the magnetic source and the sensors, accurate localization can be achieved.
Article
Engineering, Chemical
Jie Xue, Jinghong Zhao, Sinian Yan, Hanming Wang, Changduo Zhou, Dongao Yan, Hansi Chen
Summary: In this study, an analytical model of an unequal-pitch linear phase-shifting transformer was established using the distributed magnetic circuit method and Schwartz-Christopher transformation. By considering variables such as magnetic field strength, an accurate magnetic field analysis model was developed, taking into account saturation, cogging, and edge effects. The model's accuracy and feasibility were verified through finite element method simulations and experiments. This research method can also be applied to establish magnetic field models for other similar structures in new energy power systems, particularly those with cogging structures.
Article
Biotechnology & Applied Microbiology
Zhu Chen, Kaixuan Zhao, Boyu Tan, Zengrui Tong, Ziyu He, Xiaofang Luo, Lei Cai, Hanming Wang, Polly H. M. Leung, Franklin Wang-Ngai Chow, Hui Chen, Yan Deng
Summary: This paper reports a method for HSV type testing, which includes selection, design, and synthesis of specific primers, validation of amplification products by sequencing and analysis, and optimization of reaction system and PCR reaction program by orthogonal design and sensitivity testing. Results showed that this method has great potentials for HSV type testing, with a lowest detection limit of approximately 6.67 x 10(6) copies/ml, and high specificity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Energy & Fuels
Hansi Chen, Jinghong Zhao, Hanming Wang, Qingfei Zhang, Xiangyu Luo, Hao Xu, Yiyong Xiong
Summary: This paper presents an analytical design optimization method for the five-phase squirrel cage induction motor (FSCIM) based on the coupling of electromagnetic equivalent circuit (EEC) and differential evolution algorithm (DEA). The effects of design parameters on motor performance are evaluated using an analytical model, and various factors are considered in the comprehensive objective function calculation. Transient finite element analysis and experimental testing confirm the accuracy of the proposed model.
Article
Computer Science, Artificial Intelligence
Hanming Wang, Jinghong Zhao
Summary: The high-level target navigation Pigeon-inspired optimization (HTNPIO) is an improvement over the canonical Pigeon-inspired optimization (PIO). It enhances the global exploration capability by introducing selective mutation strategy, levy-based map-compass strategy, and enhanced landmark strategy to balance exploration and exploitation. Experimental results demonstrate that HTNPIO performs well on benchmark problems and real-world problems, providing promising solutions.
APPLIED INTELLIGENCE
(2023)
Article
Engineering, Mechanical
Xuhui Pei, Yin Du, Hanming Wang, Mingchuan Hu, Haifeng Wang, Weimin Liu
Summary: The effect of Si addition on the high temperature tribological properties of TiZrV0.5Nb0.5 refractory high entropy alloy was systematically studied. The results show that Si-microalloying can modulate the evolution of tribo-layer, thus affecting the tribological properties. Si-microalloying increases the sintering rate of wear debris at low temperatures, resulting in a local tribo-layer with strong wear resistance. However, at high temperatures, Si-microalloying leads to stress concentration and accelerated fracture of the tribo-layer, reducing the wear resistance.
TRIBOLOGY INTERNATIONAL
(2022)
Article
Cell Biology
Liqing Chi, Lin Huan, Chunyan Zhang, Hanming Wang, Jian Lu
Summary: Ovarian cancer is highly lethal with limited therapeutic options. PARP inhibitor (PARPi) has shown efficacy as a maintenance therapy, but resistance to PARPi is a major challenge. In this study, we identified increased expression of adenosine receptor A2b (Adora2b/A(2B)) and activation of the inflammatory pathway in Olaparib-resistant ovarian cancer cells. A(2B) was also highly expressed in recurrent ovarian tumors and associated with poor clinical outcomes. Blocking the A(2B)-IL-6-STAT3 axis overcame Olaparib resistance and inhibited tumor cell growth. These findings highlight the critical role of A(2B) signaling in PARPi resistance and provide potential targets for novel therapies in ovarian cancer.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Engineering, Mechanical
Wenting Ye, Mingda Xie, Zhuobin Huang, Hanming Wang, Qing Zhou, Long Wang, Biao Chen, Haifeng Wang, Weimin Liu
Summary: In-situ carbide/CoCrFeNiMn composites were fabricated with graphene oxide, leading to improved wear resistance due to the formation of hard carbide phase and strong interfacial bonding.
TRIBOLOGY INTERNATIONAL
(2023)
Article
Engineering, Electrical & Electronic
Changduo Zhou, Jinghong Zhao, Hanming Wang, Sinian Yan, Dongao Yan
Summary: This paper proposes an inverter system based on a linear phase-shifting transformer to improve its electrical performance and make the output waveform close to a sinusoidal waveform by eliminating low harmonics with opposite phase through phase shift and superposition effect. The components and working process of the multiple superposition inverter system are introduced, and the working principle and winding structure of the linear phase-shifting transformer are analyzed. Fourier decomposition of the inverter output voltage is conducted to obtain harmonic currents at the same frequency, and it is demonstrated that the inverter can eliminate most of the harmonics below the 23rd order. The effectiveness of the inverter device and winding structure on harmonic suppression is proved through spectral analysis of voltage waveforms with different load types and power factors, and experiments verify the reasonableness and accuracy of the proposed method.
IEEJ TRANSACTIONS ON ELECTRICAL AND ELECTRONIC ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Xuhui Pei, Yin Du, Tao Li, Hanming Wang, Mingchuan Hu, Haifeng Wang
Summary: TiZrV0.5Nb0.5Six (x = 0.1, 0.2, 0.3) refractory high entropy alloys were used to evaluate the relationship between microstructure, mechanical properties, and elevated temperature service performance. Increasing Si addition resulted in a transition from single-phase BCC to dual-phase BCC and silicide, accompanied by increased micro-hardness/strength and improved wear and oxidation resistance. The formation of a strong silicide phase inhibited oxide layer cracking and volatilization, leading to excellent oxidation resistance. Improved wear resistance was attributed to enhanced micro-hardness and formation of a dense glaze layer at elevated temperatures. These findings provide insights into designing refractory high entropy alloys for harsh environments.
MATERIALS CHARACTERIZATION
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Li Yan, Hanming Wang, Jiefu Chen
Summary: This paper investigates the formation prediction and look-ahead capability of ultra-deep electromagnetic logging tool in low-angle drilling operations. By incorporating a reference model into the cost function, the look-ahead capability can be significantly improved.
2022 PHOTONICS & ELECTROMAGNETICS RESEARCH SYMPOSIUM (PIERS 2022)
(2022)
Article
Engineering, Electrical & Electronic
Hanming Wang, Jinghong Zhao, Yiyong Xiong, Hao Xu, Sinian Yan
Summary: In this paper, a new optimization method is proposed to improve the efficiency and power factor of linear induction motors (LIMs) used in urban rail transit. The method is based on a steady state equivalent circuit model and the differential evolutionary algorithm. The optimized motor design is validated using a 2D transient finite element method.
WORLD ELECTRIC VEHICLE JOURNAL
(2022)