Article
Behavioral Sciences
Sara de la Salle, Dhrasti Shah, Joelle Choueiry, Hayley Bowers, Judy McIntosh, Brooke Carroll, Vadim Ilivitsky, Verner Knott
Summary: This study demonstrated that ketamine administration affected P300 in healthy volunteers, with reductions in novelty processing P300 and negative correlations with dissociation symptoms. These findings suggest a potential role of NMDAR dysfunction in disrupted auditory attention in schizophrenia.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Clinical Neurology
Antonio Arjona-Valladares, Sabela Fondevila-Estevez, Ines Fernandez-Linsenbarth, Alvaro Diez, Francisco Javier Ruiz-Sanz, Alberto Rodriguez-Lorenzana, Vicente Molina
Summary: Mapping Event-Related Potentials (ERP) associated with auditory and visual odd-ball paradigms has shown consistent differences between healthy controls and schizophrenia patients. Higher attentional/cognitive load in tasks may lead to larger differences in these paradigms, helping understand cognitive deficits in schizophrenia. A study comparing the effects of increasing attentional/cognitive load on ERP in schizophrenia patients and healthy controls revealed significant differences in N100 and Late Slow Wave amplitudes.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Jennifer R. Lepock, Marcos Sanches, Sarah Ahmed, Cory J. Gerritsen, Michele Korostil, Romina Mizrahi, Michael Kiang
Summary: The N400 event-related brain potential (ERP) semantic priming effect is associated with long-term semantic memory and deficits in this measure have been found in individuals with schizophrenia and those at clinical high risk (CHR) for this disorder. In this study, it was tested whether these deficits in CHR patients predicted greater symptom severity and functional impairment over a period of two years. The results showed that CHR patients' N400 semantic priming effects did not predict clinical outcomes over 2 years, suggesting that this ERP measure may have greater value as a state or short-term prognostic neurophysiological biomarker.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Review
Neurosciences
Alexey A. Murashko, Konstantin A. Pavlov, Olga V. Pavlova, Olga I. Gurina, Alexander Shmukler
Summary: The study found that different detection methods led to variations in the prevalence of NMDAR antibodies, with live cell-based assays potentially being more sensitive but with poorer specificity. Additionally, there may be links between AB-positive status and acute symptoms, and immunotherapy could be effective in AB-positive patients but further research is needed.
NEUROPSYCHOBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Megan Roussy, Rogelio Luna, Lyndon Duong, Benjamin Corrigan, Roberto A. Gulli, Ramon Nogueira, Ruben Moreno-Bote, Adam J. Sachs, Lena Palaniyappan, Julio C. Martinez-Trujillo
Summary: Research has shown that administration of ketamine to rhesus monkeys results in transient working memory deficits while sparing perceptual and motor skills. Ketamine affects different neuronal types in the lateral prefrontal cortex, disrupting the balance between excitation and inhibition, ultimately leading to selective working memory deficits.
MOLECULAR PSYCHIATRY
(2021)
Article
Psychiatry
Sha-yu Jin, Jia-zhao Zhang, Ru-hong Sun, Chen-guang Jiang, Jun Wang, Zhen-he Zhou
Summary: Interference control function is impaired in patients with major depressive disorder (MDD) and contributes to working memory impairment. This study used event-related potentials (ERPs) to explore the neural processing of interference control in MDD. The results showed that MDD patients had lower hit rates and longer reaction times compared to healthy controls (HCs) in a Brown-Peterson task (BPT). Additionally, the amplitude of a centroparietal late positive potential (LPP) decreased with increasing difficulty in both MDD and HC groups, but was smaller in the MDD group. These findings suggest that interference control dysfunction may play a critical role in the impairment of working memory in MDD.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Health Care Sciences & Services
Yuko Higuchi, Tomiki Sumiyoshi, Takahiro Tateno, Suguru Nakajima, Daiki Sasabayashi, Shimako Nishiyama, Yuko Mizukami, Tsutomu Takahashi, Michio Suzuki
Summary: The study found that patients with schizophrenia showed smaller P300 amplitudes compared to healthy controls and subjects with at-risk mental states (ARMS), while subjects with ARMS had prolonged P300 latency. During follow-up, 8 out of 33 ARMS subjects developed overt psychosis while 25 did not. ARMS-P exhibited worse cognitive functions at baseline compared to ARMS-NP.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Mattia Marchi, Giacomo Galli, Federica Maria Magarini, Giorgio Mattei, Gian Maria Galeazzi
Summary: The meta-analysis found that sarcosine as an add-on treatment for schizophrenia may show certain effectiveness in patients with chronic and non-refractory schizophrenia, especially after a 6-week treatment period.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Article
Neurosciences
Robert A. Chesters, Fiona Pepper, Celia Morgan, Jonathan D. Cooper, Oliver D. Howes, Anthony C. Vernon, James M. Stone
Summary: Chronic ketamine use may lead to lower grey matter volumes and increased sub-threshold psychotic symptoms, suggesting distinct mechanisms in the development of schizophrenia-like symptoms.
PSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Lina Guerrero, Badiaa Bouazzaoui, Michel Isingrini, Lucie Angel
Summary: Working memory-related neural activity is influenced by task load and working memory capacity. This study investigated the relationship between parietal over frontal P300 amplitude and working memory capacity, as well as how this relationship is affected by task load. The results showed a classic parietal over frontal P300 predominance. Furthermore, the parietal over frontal predominance decreased with increasing task load, primarily due to an increase in frontal P300 amplitude. Interestingly, individuals with greater working memory capacity exhibited a stronger parietal over frontal predominance. This relationship did not vary across different task loads. Individuals with lower working memory capacity had a reduced parietal over frontal predominance and relied more on frontal neural resources, possibly due to the recruitment of supplementary attentional executive operations.
BRAIN AND COGNITION
(2023)
Article
Neurosciences
Farooq Kamal, Melanie Segado, Vincent Gagnon Shaigetz, Maxime Perron, Brian Lau, Claude Alain, Nusrat Choudhury
Summary: In this study, a visual working memory task was conducted in a virtual reality environment, with irrelevant auditory stimuli presented simultaneously. The results showed that even a simple task could have an immersive effect on participants, causing them to ignore irrelevant stimuli.
Article
Psychiatry
Juan R. Bustillo, Elizabeth G. Mayer, Joel Upston, Thomas Jones, Crystal Garcia, Sulaiman Sheriff, Andrew Maudsley, Mauricio Tohen, Charles Gasparovic, Rhoshel Lenroot
Summary: Research has shown that patients with schizophrenia have higher Glx levels in the right cingulate gyrus compared to patients with bipolar-I disorder. Additionally, patients with schizophrenia also showed higher levels of various metabolites compared to bipolar-I patients.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Edmund Wascher, Fariba Sharifian, Marie Gutberlet, Daniel Schneider, Stephan Getzmann, Stefan Arnau
Summary: In this study, two different approaches to latency estimation in EEG were systematically evaluated. It was found that using fractional area latency in pruned and jackknifed data can dramatically amplify within-subjects effect sizes.
Article
Clinical Neurology
Stevan Nikolin, Yi Yin Tan, Donel Martin, Adriano Moffa, Colleen K. Loo, Tjeerd W. Boonstra
Summary: This study investigated the working memory deficits in individuals with major depressive disorder (MDD) compared to healthy controls. The results showed that MDD participants had prolonged response times and increased activity in certain brain waves, suggesting they may require increased cognitive resources for working memory tasks.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Biological
Eva-Maria Hartmann, Miriam Gade, Marco Steinhauser
Summary: This study investigates whether conflict and adaptive control in working memory (WM) are reflected by the same neural markers as in selective attention tasks. The results suggest that conflict and adaptive control in WM show similarities to those observed in selective attention tasks, as indicated by event-related potentials (ERPs).
Article
Psychiatry
Matthias Kirschner, Andre Schmidt, Benazir Hodzic-Santor, Achim Burrer, Andrei Manoliu, Yashar Zeighami, Yvonne Yau, Nooshin Abbasi, Anke Maatz, Benedikt Habermeyer, Aslan Abivardi, Mihai Avram, Felix Brandl, Christian Sorg, Philipp Homan, Anita Riecher-Rossler, Stefan Borgwardt, Erich Seifritz, Alain Dagher, Stefan Kaiser
Summary: Negative symptoms and apathy in schizophrenia are related to morphometric abnormalities in the orbitofrontal cortex and striatum, with these abnormalities potentially appearing at different stages of the illness.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Psychiatry
Nikolaos Koutsouleris, Dominic B. Dwyer, Franziska Degenhardt, Carlo Maj, Maria Fernanda Urquijo-Castro, Rachele Sanfelici, David Popovic, Oemer Oeztuerk, Shalaila S. Haas, Johanna Weiske, Anne Ruef, Lana Kambeitz-Ilankovic, Linda A. Antonucci, Susanne Neufang, Christian Schmidt-Kraepelin, Stephan Ruhrmann, Nora Penzel, Joseph Kambeitz, Theresa K. Haidl, Marlene Rosen, Katharine Chisholm, Anita Riecher-Rossler, Laura Egloff, Andre Schmidt, Christina Andreou, Jarmo Hietala, Timo Schirmer, Georg Romer, Petra Walger, Maurizia Franscini, Nina Traber-Walker, Benno G. Schimmelmann, Rahel Fluckiger, Chantal Michel, Wulf Rossler, Oleg Borisov, Peter M. Krawitz, Karsten Heekeren, Roman Buechler, Christos Pantelis, Peter Falkai, Raimo K. R. Salokangas, Rebekka Lencer, Alessandro Bertolino, Stefan Borgwardt, Markus Noethen, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Frauke Schultze-Lutter, Anastasia Theodoridou, Eva Meisenzahl
Summary: This study successfully predicted psychosis transitions in patients with CHR or ROD using multimodal machine learning, achieving high accuracy. By combining human and algorithmic risk estimates in a sequential prognostic model, personalized prevention of psychosis can be enhanced.
Article
Audiology & Speech-Language Pathology
Timm Rosburg, Ralph Mager
Summary: The amplitude of the auditory evoked N1 component depends on the interstimulus interval, increasing with longer intervals until saturating around 10 seconds. The conflicting accounts of N1 recovery and habituation predict different outcomes for passive oddball experiments, with evidence suggesting that N1 refractoriness may play a more significant role in explaining stimulus repetition effects.
Article
Psychiatry
Mathilde Antoniades, Shalaila S. Haas, Amirhossein Modabbernia, Oleg Bykowsky, Sophia Frangou, Stefan Borgwardt, Andre Schmidt
Summary: The study revealed variability in brain structures in early psychosis, with significant differences in brain structural variability between CHR and FEP individuals compared to healthy controls. Normative modeling identified individuals with significantly deviant PBSI scores who showed lower IQ and higher psychopathology.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Psychiatry
Paris Alexandros Lalousis, Stephen J. Wood, Lianne Schmaal, Katharine Chisholm, Sian Lowri Griffiths, Renate L. E. P. Reniers, Alessandro Bertolino, Stefan Borgwardt, Paolo Brambilla, Joseph Kambeitz, Rebekka Lencer, Christos Pantelis, Stephan Ruhrmann, Raimo K. R. Salokangas, Frauke Schultze-Lutter, Carolina Bonivento, Dominic Dwyer, Adele Ferro, Theresa Haidl, Marlene Rosen, Andre Schmidt, Eva Meisenzahl, Nikolaos Koutsouleris, Rachel Upthegrove
Summary: This study aimed to identify prototypes of depression and psychosis by analyzing clinical data and brain structure data, finding that patients with affective comorbidity were more likely positioned closer to the depression prototype rather than the psychotic prototype.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Psychiatry
Maria Jalbrzikowski, Rebecca A. Hayes, Stephen J. Wood, Dorte Nordholm, Juan H. Zhou, Paolo Fusar-Poli, Peter J. Uhlhaas, Tsutomu Takahashi, Gisela Sugranyes, Yoo Bin Kwak, Daniel H. Mathalon, Naoyuki Katagiri, Christine I. Hooker, Lukasz Smigielski, Tiziano Colibazzi, Esther Via, Jinsong Tang, Shinsuke Koike, Paul E. Rasser, Chantal Michel, Irina Lebedeva, Wenche ten Velden Hegelstad, Camilo de la Fuente-Sandoval, James A. Waltz, Romina Mizrahi, Cheryl M. Corcoran, Franz Resch, Christian K. Tamnes, Shalaila S. Haas, Imke L. J. Lemmers-Jansen, Ingrid Agartz, Paul Allen, G. Paul Amminger, Ole A. Andreassen, Kimberley Atkinson, Peter Bachman, Inmaculada Baeza, Helen Baldwin, Cali F. Bartholomeusz, Stefan Borgwardt, Sabrina Catalano, Michael W. L. Chee, Xiaogang Chen, Kang Ik K. Cho, Rebecca E. Cooper, Vanessa L. Cropley, Montserrat Dolz, Bjorn H. Ebdrup, Adriana Fortea, Louise Birkedal Glenthoj, Birte Y. Glenthoj, Lieuwe de Haan, Holly K. Hamilton, Mathew A. Harris, Kristen M. Haut, Ying He, Karsten Heekeren, Andreas Heinz, Daniela Hubl, Wu Jeong Hwang, Michael Kaess, Kiyoto Kasai, Minah Kim, Jochen Kindler, Mallory J. Klaunig, Alex Koppel, Tina D. Kristensen, Jun Soo Kwon, Stephen M. Lawrie, Jimmy Lee, Pablo Leon-Ortiz, Ashleigh Lin, Rachel L. Loewy, Xiaoqian Ma, Patrick McGorry, Philip McGuire, Masafumi Mizuno, Paul Moller, Tomas Moncada-Habib, Daniel Munoz-Samons, Barnaby Nelson, Takahiro Nemoto, Merete Nordentoft, Maria A. Omelchenko, Ketil Oppedal, Lijun Ouyang, Christos Pantelis, Jose C. Pariente, Jayachandra M. Raghava, Francisco Reyes-Madrigal, Brian J. Roach, Jan I. Rossberg, Wulf Rossler, Dean F. Salisbury, Daiki Sasabayashi, Ulrich Schall, Jason Schiffman, Florian Schlagenhauf, Andre Schmidt, Mikkel E. Sorensen, Michio Suzuki, Anastasia Theodoridou, Alexander S. Tomyshev, Jordina Tor, Tor G. Vaernes, Dennis Velakoulis, Gloria D. Venegoni, Sophia Vinogradov, Christina Wenneberg, Lars T. Westlye, Hidenori Yamasue, Liu Yuan, Alison R. Yung, Therese A. M. J. van Amelsvoort, Jessica A. Turner, Theo G. M. van Erp, Paul M. Thompson, Dennis Hernaus
Summary: This study investigates baseline structural neuroimaging differences between individuals at clinical high risk and healthy controls, as well as differences between those who later developed a psychotic disorder and those who did not. The findings suggest that lower cortical thickness in individuals at CHR is associated with later psychosis conversion, and certain regions with lower cortical thickness also show abnormal associations with age.
Article
Psychiatry
Timm Rosburg, Regina Kunz, Bruno Trezzini, Urban Schwegler, Joerg Jeger
Summary: This study evaluated the role of Mini-ICF-APP ratings in psychiatric work disability evaluations, finding that ratings varied with primary psychiatric diagnoses and were strongly correlated with RWC estimates. The study showed differences in ratings between claimants with different psychiatric diagnoses, with a strong negative correlation between Mini-ICF-APP ratings and estimated RWC.
Article
Psychiatry
Jessica P. K. Doll, Jorge F. Vazquez-Castellanos, Anna-Chiara Schaub, Nina Schweinfurth, Cedric Kettelhack, Else Schneider, Gulnara Yamanbaeva, Laura Mahlmann, Serge Brand, Christoph Beglinger, Stefan Borgwardt, Jeroen Raes, Andre Schmidt, Undine E. Lang
Summary: This study reports the improvement of depressive symptoms in two patients with major depressive disorder after receiving fecal microbiota transplantation. The effects lasted up to 8 weeks in one patient. The findings suggest that further research on fecal microbiota transplantation in depression treatment is worth pursuing.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Paris Alexandros Lalousis, Lianne Schmaal, Stephen J. Wood, Renate L. E. P. Reniers, Nicholas M. Barnes, Katharine Chisholm, Sian Lowri Griffiths, Alexandra Stainton, Junhao Wen, Gyujoon Hwang, Christos Davatzikos, Julian Wenzel, Lana Kambeitz-Ilankovic, Christina Andreou, Carolina Bonivento, Udo Dannlowski, Adele Ferro, Theresa Lichtenstein, Anita Riecher-Rossler, Georg Romer, Rachel Upthegrove, Rebekka Lencer, Christos Pantelis, Stephan Ruhrmann, Raimo K. R. Salokangas, Frauke Schultze-Lutter, Andre Schmidt, Eva Meisenzahl, Nikolaos Koutsouleris, Dominic Dwyer, Marlene Rosen, Alessandro Bertolino, Stefan Borgwardt, Paolo Brambilla, Joseph Kambeitz
Summary: By analyzing structural neuroimaging data, researchers have identified two transdiagnostic neuroanatomically informed clusters among patients with recent-onset depression and psychosis. These clusters are clinically and biologically distinct, challenging current diagnostic boundaries and improving predictive accuracy for symptomatic remission.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Psychology, Biological
Timm Rosburg, Michael Weigl, Ralph Mager
Summary: This study investigated whether the presentation of non-repeating distractor stimuli ('novels') would lead to habituation disruption of the auditory evoked potential (AEP) component N1 after repeated standard stimuli. The results showed no increase in N1 amplitude for standards after novels, indicating a lack of habituation disruption.
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2022)
Article
Health Care Sciences & Services
Patrick Manser, Lars Michels, Andre Schmidt, Filip Barinka, Eling D. de Bruin
Summary: This study aims to explore the effectiveness of a newly developed exergame-based motor-cognitive training concept called Brain-IT in improving cognitive functioning in older adults with mild neurocognitive disorder. A randomized controlled trial will be conducted with 34 to 40 participants, and various outcomes such as global cognitive functioning, brain structure and function, and psychosocial factors will be assessed. Data collection is expected to be completed by December 2023, and the results will be submitted for publication in 2024.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Psychiatry
Julia Schulz, Felix Brandl, Michel J. Grothe, Matthias Kirschner, Stefan Kaiser, Andre Schmidt, Stefan Borgwardt, Josef Priller, Christian Sorg, Mihai Avram
Summary: This study used VBM technology and different stages of schizophrenia patients to find that the volumes of basal-forebrain cholinergic nuclei were smaller in patients with schizophrenia and were correlated with attentional deficits. However, it is unclear if and how these changes and their link to cognitive symptoms extend across the schizophrenia spectrum.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Clinical Neurology
Anna-Chiara Schaub, Marc Vogel, Sophie Baumgartner, Undine E. Lang, Stefan Borgwardt, Andre Schmidt, Marc Walter
Summary: This study reports functional brain changes in patients receiving long-term diacetylmorphine treatment. The study found that fronto-striatal resting-state functional connectivity increased in patients compared to healthy controls, and this effect was partly related to the treatment duration.
BRAIN COMMUNICATIONS
(2022)
Article
Neuroimaging
Anna-Chiara Schaub, Matthias Kirschner, Nina Schweinfurth, Laura Mahlmann, Cedric Kettelhack, Etna E. Engeli, Jessica P. K. Doll, Stefan Borgwardt, Undine E. Lang, Stefan Kaiser, Marc Walter, Marcus Herdener, Johannes Wrege, Andre Schmidt
Summary: Anhedonia is associated with abnormal striatal dopamine functioning in patients with various psychiatric disorders. Research showed negative relationships between anhedonia expression and putamen volume across different psychiatric diagnoses, as well as negative associations between anhedonia severity and volume of the bilateral cerebellum. These findings suggest volumetric abnormalities in the putamen and cerebellum as a common neural substrate for the severity of anhedonia across psychiatric entities.
NEUROIMAGE-CLINICAL
(2021)
Article
Psychology, Clinical
Timm Rosburg, Marlon O. Pflueger, Andreas Mokros, Coralie Boillat, Gunnar Deuring, Thorsten Spielmann, Marc Graf
Summary: The present study successfully differentiated pedophilic child sex offenders from nonoffending controls, as well as contact from noncontact offenders, using neuropsychological test measures and indirect test measures. The findings indicated that contact and noncontact offenders had similar profiles, but differed in terms of risk-taking behavior and susceptibility to perceptual interference.
SEXUAL ABUSE-A JOURNAL OF RESEARCH AND TREATMENT
(2021)