Article
Chemistry, Multidisciplinary
Xing-mei Liang, Qiong Qin, Bo-ning Liu, Xiao-qing Li, Li-li Zeng, Jing Wang, Ling-ping Kong, Dian-sheng Zhong, Lin-lin Sun
Summary: The study reveals that DNA damage repair capacity is compromised in osimertinib-resistant cells, and inhibiting DNA-PK can increase sensitivity to osimertinib. Combination of osimertinib with DNA-PK inhibitors synergistically suppresses proliferation of resistant cells.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Oncology
Zichun Li, Xuanye Zhang, Yuhong Wang, Zhixin Yu, Chunlong Yang, Yixin Zhou, Shaodong Hong
Summary: A comparative analysis suggests that osimertinib is a more suitable adjuvant therapy than immunotherapy for completely resected EGFR-mutant NSCLC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Shiqi Ma, Lu Zhang, Yuan Ren, Wei Dai, Tingqing Chen, Liping Luo, Juan Zeng, Kun Mi, Jinyi Lang, Bangrong Cao
Summary: This study revealed the impact of EREG on EGFR-TKI sensitivity and its mechanisms in NSCLC, suggesting macrophage-produced EREG as a potential novel regulator and biomarker for EGFR-TKI therapy in NSCLC.
Article
Medicine, Research & Experimental
Suntae Kim, Jang Su Jeon, Yong June Choi, Ga Hee Baek, Sang Kyum Kim, Keon Wook Kang
Summary: The heterogeneity of glutamine metabolism in EGFR-TKI-resistant lung cancer cells was evaluated in this study. It was found that CB-839, a specific GLS inhibitor, can effectively inhibit glutamine metabolism and exert enhanced anti-proliferating effects on acquired EGFR-TKI-resistant lung cancer cells.
Article
Chemistry, Multidisciplinary
Peijun Cao, Yongwen Li, Ruifeng Shi, Yin Yuan, Hao Gong, Guangsheng Zhu, Zihe Zhang, Chen Chen, Hongbing Zhang, Minghui Liu, Zhenhua Pan, Hongyu Liu, Jun Chen
Summary: Lung cancer has the highest mortality rate globally, and EGFR-TKIs have improved the survival of NSCLC patients by inducing autophagy. However, acquired resistance is common. Drug-resistant cells exhibit higher autophagy activity, and autophagy inhibitors can enhance the toxicity of EGFR-TKIs. Moreover, increased autophagy is associated with decreased EZH2 expression.
FRONTIERS IN CHEMISTRY
(2022)
Review
Oncology
Jingwei Li, Peiyi Li, Jun Shao, Shufan Liang, Yuntian Wan, Qiran Zhang, Changshu Li, Yalun Li, Chengdi Wang
Summary: This review summarizes the potential mechanisms of noncoding RNAs in EGFR TKI-resistant lung cancer and their clinical applications, and highlights the barriers that need to be addressed.
Article
Biotechnology & Applied Microbiology
Cheng-Yu Chang, Yi-Chun Lai, Yu-Feng Wei, Chung-Yu Chen, Shih-Chieh Chang
Summary: Epidermal growth factor receptor (EGFR) mutations are most common in Eastern Asia and EGFR-tyrosine kinase inhibitors (TKIs) are recommended as first-line therapeutic options for non-small cell lung cancer (NSCLC) with sensitizing EGFR mutations. The expression of programmed cell death-ligand 1 (PD-L1) in patients with metastatic NSCLC and EGFR mutations is not uncommon, but its influence on clinical outcomes with standard initial treatment seems to be insignificant.
ONCOTARGETS AND THERAPY
(2021)
Article
Oncology
Kentaro Tanaka, Hajime Asahina, Junji Kishimoto, Yoshihiro Miyata, Takahiro Uchida, Kana Watanabe, Kosuke Hamai, Taishi Harada, Yukari Tsubata, Shunichi Sugawara, Kunihiko Kobayashi, Kenji Sugio, Satoshi Oizumi, Isamu Okamoto
Summary: The study investigated the combination of osimertinib with cytotoxic chemotherapy for EGFR-mutated NSCLC patients, finding that adding chemotherapy as a second-line treatment did not prolong survival but was generally well-tolerated.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Kyoichi Kaira, Kunihiko Kobayashi, Ayako Shiono, Ou Yamaguchi, Kosuke Hashimoto, Atsuto Mouri, Shun Shinomiya, Yu Miura, Hisao Imai, Hiroshi Kagamu
Summary: For NSCLC patients with resistance to EGFR-TKIs, EGFR-TKI rechallenge immediately after PD-1 blockade treatment was identified as an effective therapy.
Article
Immunology
Yujing Li, Haohua Jiang, Fangfei Qian, Ya Chen, Wensheng Zhou, Yanwei Zhang, Jun Lu, Yuqing Lou, Baohui Han, Wei Zhang
Summary: This study retrospectively investigated the outcomes of immune checkpoint inhibitor (ICI)-based treatments for EGFR-mutated NSCLC patients with PD-L1 TPS ≥ 50% after EGFR-TKI resistance. Results showed that ICI-based treatment, especially in combination with chemotherapy, provided better survival outcomes compared to classical chemotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Minehiko Inomata, Yosuke Kawashima, Ryota Saito, Daisuke Morinaga, Hitomi Nogawa, Masamichi Sato, Yohei Suzuki, Satoru Yanagisawa, Takashi Kikuchi, Daisuke Jingu, Naruo Yoshimura, Toshiyuki Harada, Eisaku Miyauchi
Summary: This study compared the efficacy of EGFR-TKI monotherapy with combined EGFR-TKI plus VEGF inhibitor/cytotoxic therapy in PD-L1-positive EGFR-mutant NSCLC patients. The results showed that combined therapy significantly reduced the risk of progression compared to first- and second-generation EGFR-TKI monotherapy, suggesting it may be a promising treatment option for NSCLC patients.
Review
Oncology
Binhua Pan, Xuyong Wei, Xiao Xu
Summary: Animal models are essential for evaluating human cancers and investigating anticancer drugs and prevention. In hepatopancreatobiliary cancer research, mouse models are widely used. While current CDX models have limitations, the emerging PDX model shows promise for precision cancer medicine in hepatopancreatobiliary cancer research.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Mingchen Shi, Yu Wang, Dong Lin, Yuzhuo Wang
Summary: Patient-derived xenografts (PDXs) have gained significant attention in cancer research as relevant models due to their retention of histopathological and molecular heterogeneity from donor tumors. Neuroendocrine prostate cancer (NEPC) PDX models are increasingly being generated and have shown utility in various research applications. This review provides a comprehensive overview of NEPC PDX collections, highlighting their potential for identifying therapeutic targets and evaluating drug responses.
Review
Cell Biology
Dylan A. Farnsworth, Yankuan T. Chen, Georgia de Rappard Yuswack, William W. Lockwood
Summary: Mutant EGFR is a molecular driver of non-small cell lung cancer, and tumors with these mutations often rely on sustained oncogene signaling. While inhibiting EGFR with tyrosine kinase inhibitors has shown clinical benefits, resistance remains a challenge. The genetic mechanisms underlying EGFR dependency and factors allowing tumor cells to escape this dependency are still not fully understood.
Review
Cell Biology
Xingyu Chen, Yongyun Li, Tengteng Yao, Renbing Jia
Summary: Zebrafish are widely used in cancer research due to their low cost, quick establishment, and small sample size required. The zebrafish patient-derived xenograft (zPDX) models show promising evidence for short-term clinical treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Letter
Pharmacology & Pharmacy
Ricardo Pena-Silva, Stephen B. Duffull, Andrew C. Steer, Sandra X. Jaramillo-Rincon, Amanda Gwee, Xiao Zhu
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Letter
Pharmacology & Pharmacy
Isabelle H. S. Kuan, Daniel F. B. Wright, Stephen B. Duffull, Xiao Zhu
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Zi-ran Li, Chen-yu Wang, Xiao Zhu, Zheng Jiao
Summary: Levetiracetam pharmacokinetics are influenced by body weight, renal function, and concomitant use of other antiepileptic drugs. Children have a higher apparent clearance rate than adults, and enzyme-inducing drugs can increase drug clearance while valproate acid can decrease it.
CLINICAL PHARMACOKINETICS
(2021)
Letter
Infectious Diseases
Courtney Brusamarello, Andrew J. Daley, Xiao Zhu, Cornelia Landersdorfer, Amanda Gwee
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Liang Yang, Xiao Zhu, David B. Finlay, Michelle Glass, Stephen B. Duffull
Summary: Classical pharmacological bioassays typically construct concentration-effect curves using observed effects from a concentration series at a single equilibrium time point. However, more precise parameter estimates can be achieved by using a full kinetic method that evaluates the full kinetic profile of the effect data for each concentration simultaneously. The full kinetic approach provides more precise estimates than the reference method with equal or smaller group sizes, making it potentially more useful for researchers.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiao-Qin Liu, Yi-Wei Yin, Chen-Yu Wang, Zi-Ran Li, Xiao Zhu, Zheng Jiao
Summary: This study aimed to explore appropriate remedial dosing regimens for non-adherent rivaroxaban-treated patients using a Monte Carlo simulation based on a population pharmacokinetic/pharmacodynamic model. The proposed regimens resulted in shorter deviation time than that of the EHRA guide, providing valid evidence to minimize the risk of bleeding and thromboembolism.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2021)
Article
Geochemistry & Geophysics
Weifan Lu, Yijian Zhou, Zeyan Zhao, Han Yue, Shiyong Zhou
Summary: In this study, a seismic network was deployed near the source region of the 2017 Jiuzhaigou earthquake to monitor aftershock activity and investigate the fault structure. The results show that the main shock possibly ruptured both the Huya fault and the Minjiang fault, and a "weak strength" fault portion was identified near the main shock hypocentre. This study provides valuable insights into the fault geometry and behavior of the Jiuzhaigou earthquake.
GEOPHYSICAL JOURNAL INTERNATIONAL
(2022)
Article
Infectious Diseases
Amanda Gwee, Stephen B. Duffull, Andrew J. Daley, Michelle Lim, Susie Germano, Hajira Bilal, Samantha Hall, Nigel Curtis, Xiao Zhu
Summary: The study aimed to determine the therapeutic target of vancomycin in young infants with staphylococcal infections. The results showed that an AUC(0-24) >= 300 mg/L center dot h or AUC(24-48) >= 424 mg/L center dot h was associated with an increase in bacteriological cure in young infants with staphylococcal bloodstream infections.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Chemistry, Medicinal
Min Li, Qingfeng He, Li Yao, Xiaofeng Wang, Zhijia Tang, Xiao Zhu, Hai-Shu Lin, Xiaoqiang Xiang
Summary: A reliable HPLC-MS/MS method for the simultaneous quantification of PTU and its N-beta-D glucuronide was developed and validated in this study. UGT1A9 was identified as an important enzyme responsible for the glucuronidation of PTU. The information obtained from this study will aid in the future mechanistic investigation of PTU hepatotoxicity and may optimize its clinical application.
Article
Biochemistry & Molecular Biology
Qingfeng He, Fengjiao Bu, Qizhen Wang, Min Li, Jiaying Lin, Zhijia Tang, Wen Yao Mak, Xiaomei Zhuang, Xiao Zhu, Hai-Shu Lin, Xiaoqiang Xiang
Summary: Schizandrol A and schizandrol B, two active ingredients of Wuzhi capsule, have been found to potentially interact with tacrolimus. A pharmacokinetic model was used to predict the impact of these herbal ingredients on tacrolimus metabolism. This finding highlights the importance of considering the combined use of Wuzhi capsule and tacrolimus in clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Han Yue, Zheng-Kang Shen, Zeyan Zhao, Teng Wang, Bonan Cao, Zhen Li, Xuewei Bao, Li Zhao, Xiaodong Song, Zengxi Ge, Chunmei Ren, Weifan Lu, Yong Zhang, Jing Liu-Zeng, Min Wang, Qinghua Huang, Shiyong Zhou, Lian Xue
Summary: This study investigates the deformation mode of the SongpanGanzi terrane (SGT) in central-east Tibet through the analysis of the 2021 Mw 7.4 Maduo earthquake. The research reveals that the SGT upper crust exhibits distributed shear deformation and distinct transverse anisotropy, which are associated with folded structures. The earthquake occurred on a slow-moving fault and its occurrence is influenced by the unique tectonic setting of the SGT.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Xiwei Ji, Xiangrui Meng, Qingfeng He, Xiaoqiang Xiang, Yufei Shi, Xiao Zhu
Summary: This study investigated the antitumor effects of foretinib on triple-negative breast cancer cells and its pharmacokinetic characteristics. The results showed that foretinib inhibited tumor growth in a dose-dependent manner and suppressed the expression of p-MET and HGF in both cells and tumors, suggesting that the decrease of p-MET and HGF may play a crucial role in the anti-breast cancer properties of foretinib.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Qiuyu Jia, Qingfeng He, Li Yao, Min Li, Jiaying Lin, Zhijia Tang, Xiao Zhu, Xiaoqiang Xiang
Summary: This paper summarizes the current situation and shortcomings of pharmacokinetic research on natural medicine and introduces the concept and advantages of PBPK modeling in the study of natural medicine pharmacokinetics.
Review
Environmental Sciences
Jiaying Lin, Min Li, Wenyao Mak, Yufei Shi, Xiao Zhu, Zhijia Tang, Qingfeng He, Xiaoqiang Xiang
Summary: Drug-induced liver injury is a major cause of drug withdrawal, and early prediction of hepatotoxicity using modeling methods is important.
Article
Pharmacology & Pharmacy
Wenyu Yang, Wenyao Mak, Amanda Gwee, Meng Gu, Yue Wu, Yufei Shi, Qingfeng He, Xiaoqiang Xiang, Bing Han, Xiao Zhu
Summary: This study aimed to establish a parametric model repository of ganciclovir and valganciclovir by summarizing existing population pharmacokinetic information and analyzing the sources of variability. The results showed that dosing regimens should be adjusted according to body size and renal function.