A Ketogenic Diet Improves Cognition and Has Biochemical Effects in Prefrontal Cortex That Are Dissociable From Hippocampus

Dissociable effects of advanced age on prefrontal cortical and medial temporal lobe ensemble activity

(2018) Abbi R. Hernandez et al.   NEUROBIOLOGY OF AGING

Anxiolytic Effect of Exogenous Ketone Supplementation Is Abolished by Adenosine A1 Receptor Inhibition in Wistar Albino Glaxo/Rijswijk Rats

(2018) Zsolt Kovács et al.   Frontiers in Behavioral Neuroscience

Rodent age-related impairments in discriminating perceptually similar objects parallel those observed in humans

(2017) Sarah A. Johnson et al.   HIPPOCAMPUS

Acetoacetate is a more efficient energy-yielding substrate for human mesenchymal stem cells than glucose and generates fewer reactive oxygen species

(2017) Mary Board et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Antiepileptic Ketogenic Diet Alters Hippocampal Transporter Levels and Reduces Adiposity in Aged Rats

(2017) Abbi R Hernandez et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Decline of prefrontal cortical-mediated executive functions but attenuated delay discounting in aged Fischer 344 × brown Norway hybrid rats

(2017) Caesar M. Hernandez et al.   NEUROBIOLOGY OF AGING

Medial prefrontal-perirhinal cortical communication is necessary for flexible response selection

(2017) Abbi R. Hernandez et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Prefrontal cortical GABAergic signaling and impaired behavioral flexibility in aged F344 rats

(2017) B.S. Beas et al.   NEUROSCIENCE

Anxiety is associated with cognitive impairment in newly-diagnosed Parkinson's disease

(2017) Nadeeka N.W. Dissanayaka et al.   PARKINSONISM & RELATED DISORDERS

Involvement of insulin resistance in D-galactose-induced age-related dementia in rats: Protective role of metformin and saxagliptin

(2017) Sara Kenawy et al.   PLoS One

Metformin Impairs Spatial Memory and Visual Acuity in Old Male Mice

(2017) Nopporn Thangthaeng et al.   Aging and Disease

Nutritional Ketosis Affects Metabolism and Behavior in Sprague-Dawley Rats in Both Control and Chronic Stress Environments

(2017) Milene L. Brownlow et al.   Frontiers in Molecular Neuroscience

The Current Status of the Ketogenic Diet in Psychiatry

(2017) Emmanuelle C. S. Bostock et al.   Frontiers in Psychiatry

Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

(2017) Mark A. Reger et al.   JOURNAL OF ALZHEIMERS DISEASE

Fueling Performance: Ketones Enter the Mix

(2016) Brendan Egan et al.   Cell Metabolism

Impact of Single or Repeated Dose Intranasal Zinc-free Insulin in Young and Aged F344 Rats on Cognition, Signaling, and Brain Metabolism

(2016) Katie L. Anderson et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy

(2016) Erica Barini et al.   Molecular Neurodegeneration

Age-related changes in tonic activation of presynaptic versus extrasynaptic γ-amniobutyric acid type B receptors in rat medial prefrontal cortex

(2016) Haley E. Carpenter et al.   NEUROBIOLOGY OF AGING

Effects of acute administration of the GABA(B) receptor agonist baclofen on behavioral flexibility in rats

(2016) B. Sofia Beas et al.   PSYCHOPHARMACOLOGY

Exogenous Ketone Supplements Reduce Anxiety-Related Behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk Rats

(2016) Csilla Ari et al.   Frontiers in Molecular Neuroscience

Age-related impairments in object-place associations are not due to hippocampal dysfunction.

(2015) Abigail R. Hernandez et al.   BEHAVIORAL NEUROSCIENCE

Seizure control by decanoic acid through direct AMPA receptor inhibition

(2015) Pishan Chang et al.   BRAIN

Acetoacetate Accelerates Muscle Regeneration and Ameliorates Muscular Dystrophy in Mice

(2015) Xiaoting Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Memory impairment in aged primates is associated with region-specific network dysfunction

(2015) A Thomé et al.   MOLECULAR PSYCHIATRY

Obesity diminishes synaptic markers, alters microglial morphology, and impairs cognitive function

(2015) Miriam E. Bocarsly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular aspects of age-related cognitive decline: the role of GABA signaling

(2015) Joseph A. McQuail et al.   TRENDS IN MOLECULAR MEDICINE

Prefrontal Cortical GABAergic Dysfunction Contributes to Age-Related Working Memory Impairment

(2014) C. Banuelos et al.   JOURNAL OF NEUROSCIENCE

Ketogenic Diet in Neuromuscular and Neurodegenerative Diseases

(2014) Antonio Paoli et al.   Biomed Research International

Normal Cognitive Aging

(2013) Caroline N. Harada et al.   CLINICS IN GERIATRIC MEDICINE

Towards new approaches to disorders of fear and anxiety

(2013) Brian G Dias et al.   CURRENT OPINION IN NEUROBIOLOGY

Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin

(2013) E. M. Moore et al.   DIABETES CARE

The hippocampal–prefrontal pathway: The weak link in psychiatric disorders?

(2013) Bill P. Godsil et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Ketogenic Diet Improves Motor Performance but Not Cognition in Two Mouse Models of Alzheimer’s Pathology

(2013) Milene L. Brownlow et al.   PLoS One

Early Decline in Glucose Transport and Metabolism Precedes Shift to Ketogenic System in Female Aging and Alzheimer's Mouse Brain: Implication for Bioenergetic Intervention

(2013) Fan Ding et al.   PLoS One

Ketone bodies as signaling metabolites

(2013) John C. Newman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

‘Metabolic syndrome’ in the brain: deficiency in omega-3 fatty acid exacerbates dysfunctions in insulin receptor signalling and cognition

(2012) Rahul Agrawal et al.   JOURNAL OF PHYSIOLOGY-LONDON

A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease

(2012) Yoshihiro Kashiwaya et al.   NEUROBIOLOGY OF AGING

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

Characterizing cognitive aging of working memory and executive function in animal models

(2012) Jennifer L. Bizon et al.   Frontiers in Aging Neuroscience

Age-associated deficits in pattern separation functions of the perirhinal cortex: A cross-species consensus.

(2011) Sarah N. Burke et al.   BEHAVIORAL NEUROSCIENCE

A ketogenic diet suppresses seizures in mice through adenosine A1 receptors

(2011) Susan A. Masino et al.   JOURNAL OF CLINICAL INVESTIGATION

Single KATP Channel Opening in Response to Action Potential Firing in Mouse Dentate Granule Neurons

(2011) G. R. Tanner et al.   JOURNAL OF NEUROSCIENCE

Neural Correlates of Object-in-Place Learning in Hippocampus and Prefrontal Cortex

(2011) J. Kim et al.   JOURNAL OF NEUROSCIENCE

GABAB receptor GTP-binding is decreased in the prefrontal cortex but not the hippocampus of aged rats

(2011) Joseph A. McQuail et al.   NEUROBIOLOGY OF AGING

How the Neurocircuitry and Genetics of Fear Inhibition May Inform Our Understanding of PTSD

(2010) Tanja Jovanovic et al.   AMERICAN JOURNAL OF PSYCHIATRY

A ketogenic diet does not impair rat behavior or long-term potentiation

(2010) Liu Lin Thio et al.   EPILEPSIA

Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adults

(2010) Michael A. Yassa et al.   HIPPOCAMPUS

Ketones prevent synaptic dysfunction induced by mitochondrial respiratory complex inhibitors

(2010) Do Young Kim et al.   JOURNAL OF NEUROCHEMISTRY

Disconnection of the Hippocampal-Perirhinal Cortical Circuits Severely Disrupts Object-Place Paired Associative Memory

(2010) Y. S. Jo et al.   JOURNAL OF NEUROSCIENCE

Acute oxidative stress and systemic Nrf2 activation by the ketogenic diet

(2010) Julie B. Milder et al.   NEUROBIOLOGY OF DISEASE

High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic Mild Cognitive Impairment

(2010) Michael A. Yassa et al.   NEUROIMAGE

Synchronized Activity between the Ventral Hippocampus and the Medial Prefrontal Cortex during Anxiety

(2010) Avishek Adhikari et al.   NEURON

Age differences in prefontal recruitment during verbal working memory maintenance depend on memory load

(2009) Katherine A. Cappell et al.   CORTEX

Long-term efficacy of pregabalin in generalized anxiety disorder

(2009) Douglas Feltner et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

Changing Fear: The Neurocircuitry of Emotion Regulation

(2009) Catherine A Hartley et al.   NEUROPSYCHOPHARMACOLOGY

Performance level modulates adult age differences in brain activation during spatial working memory

(2009) Irene E. Nagel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ketogenic diet: Uses in epilepsy and other neurologic illnesses

(2008) Kristin W. Barañano et al.   Current Treatment Options in Neurology

The prevalence of anxiety in older adults: Methodological issues and a review of the literature

(2008) Christina Bryant et al.   JOURNAL OF AFFECTIVE DISORDERS

The roles of the medial prefrontal cortex and hippocampus in a spatial paired-association task

(2008) I. Lee et al.   LEARNING & MEMORY