Article
Biochemistry & Molecular Biology
Marc Labetoulle, Jose Manuel Benitez-del-Castillo, Stefano Barabino, Rocio Herrero Vanrell, Philippe Daull, Jean-Sebastien Garrigue, Maurizio Rolando
Summary: This review describes the main categories of ingredients in tear substitutes and their effects on the ocular surface. It also provides insights into how to select the appropriate tear substitute formulations based on the predominant causes of dry eye disease (DED).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Zhenyu Wei, Yuandong Su, Guanyu Su, Christophe Baudouin, Antoine Labbe, Qingfeng Liang
Summary: This study aimed to investigate the change in dynamic optical quality in dry eye patients after the use of artificial tears. The study found that optical quality indices were significantly higher in dry eye patients compared to the control group, but decreased significantly after 5 minutes of artificial tear instillation in severe dry eye patients. There were no significant differences in optical quality parameters among the three groups after 30 minutes.
Article
Ophthalmology
Marta Blanco-Vazquez, Amanda Vazquez, Itziar Fernandez, Andrea Novo-Diez, Elena Martinez-Plaza, Carmen Garcia-Vazquez, Maria J. Gonzalez-Garcia, Eva M. Sobas, Margarita Calonge, Amalia Enriquez-de-Salamanca
Summary: The purpose of this study was to analyze inflammation-and pain-related molecules in tears of patients suffering from chronic ocular pain associated with dry eye and/or a previous corneal refractive surgery. The study found that IL-10 and SP levels in tears were increased in patients with a history of corneal refractive surgery. IL-9 levels were associated with chronic ocular pain. These findings suggest that tear cytokines and neuromodulators could serve as biomarkers for chronic ocular pain, leading to improved therapeutic and disease management decisions.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Ophthalmology
Marta Blanco-Vazquez, Amanda Vazquez, Itziar Fernandez, Andrea Novo-Diez, Elena Martinez-Plaza, Carmen Garcia-Vazquez, Maria J. Gonzalez-Garcia, Eva M. Sobas, Margarita Calonge, Amalia Enriquez-de-Salamanca
Summary: The purpose of this study was to analyze inflammation- and pain-related molecules in tears of patients suffering from chronic ocular pain associated with dry eye and/or a previous corneal refractive surgery. The results showed that IL-9 tear levels were increased in patients with chronic ocular pain, IL-10, SP, MIP-1 alpha/CCL3, IL-2, and IFN-gamma were associated with previous surgery, and IL-8/CXCL8, MIP-1 alpha/CCL3, IL-2, and IFN-gamma were associated with DE-related inflammation. Higher NGF levels were related to chronic ocular pain and DE in patients with previous surgery. These findings are important for understanding biomarkers of chronic ocular pain and making better therapeutic and disease management decisions.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Ophthalmology
Paramdeep Bilkhu, James Wolffsohn, Christine Purslow
Summary: The study found that concentration task and treatment had different effects on tear film evaporation rate, tear meniscus height, symptomology, etc. Tear film lipid layer thickness, non-invasive tear film break-up time and tear meniscus height may be key clinical metrics that drive ocular comfort.
CONTACT LENS & ANTERIOR EYE
(2021)
Article
Ophthalmology
Tai-Yuan Su, Shu-Wen Chang
Summary: By constructing normalized ocular surface temperature (NOST) models for different tear film characteristics, it is possible to differentiate tear film types and potentially use them for dry-eye screening. The study found that in dry-eye screening, the NOST order was normal > short-BUT > short BUT with SPK.
Article
Chemistry, Multidisciplinary
Deborah Lee, Seoyoon Song, Geonho Cho, Lucia C. Dalle Ore, Noah Malmstadt, Ahmed Fuwad, Sun Min Kim, Tae-Joon Jeon
Summary: This study reveals the important role of lysozyme in tear film lipid layer functionality, improving ocular health through increased tear evaporation and resistance to bacterial invasion.
Article
Ophthalmology
Arantxa Acera, Beatriz Abad, Xandra Pereiro, Francisco David Rodriguez, Noelia Ruzafa, Juan Antonio Duran, Elena Vecino
Summary: The tear film lipid layer (TFLL) plays a crucial role in maintaining high-quality vision, protecting the cornea, and promoting wound healing. Plasma rich in growth factor (PRGF) eye drops have emerged as a new treatment for aqueous deficient dry eye. This study compared the lipid profiles of PRGF eye drops with tears and found that the lipids in PRGF eye drops could be used as a supplement for altered tear lipid composition.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Juan Torrent-Burgues, Javier Hoyo, Tzanko Tzanov
Summary: The study found that there were no significant differences in the behavior of lipid tear products at the air/liquid interface, despite differences in applications. Sodium chloride, glucose, albumin, and lysozyme were observed to have a notable influence on the surface properties of the lipid Langmuir films.
CHEMISTRY AND PHYSICS OF LIPIDS
(2021)
Review
Ophthalmology
Shizuka Koh, Srinivas Rao, Sanjeev Srinivas, Louis Tong, Alvin Young
Summary: With the increasing prevalence of dry eye disease, there is a growing focus on diagnostic methods. Numerous technologies have been developed to measure tear function and ocular surface health, but finding a cost-effective and efficient method remains challenging. In the Indian context, a quick and easy clinical approach for accurate diagnosis is needed as most patients consult general ophthalmologists.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Ophthalmology
Cem Simsek, Murat Dogru
Summary: Sjogren syndrome is a chronic inflammatory autoimmune disease affecting the lacrimal and salivary glands. Tears may contain biomarkers for diagnosis and treatment assessment. The aim of the review is to identify reliable, sensitive, and specific biomarkers for guiding treatment decisions.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2021)
Article
Biochemistry & Molecular Biology
Saki Sakakura, Emi Inagaki, Yuichiro Ochiai, Masatoshi Yamamoto, Naofumi Takai, Taeko Nagata, Kazunari Higa, Yasunori Sato, Hiroshi Toshida, Dogru Murat, Masatoshi Hirayama, Yoko Ogawa, Kazuno Negishi, Shigeto Shimmura
Summary: The tear film stability of a rabbit dry eye model induced by dacryoadenectomy was assessed in this study. The results showed that this model partially captured the phenotypes of human short TBUT-type dry eye, making it a potentially useful animal model for investigating potential drug candidates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Jiraporn Leanpolchareanchai, Patamaporn Tangteerakoon, Patcharin Supapsophon, Somsiri Sukavatcharin, Pornchai Simaroj, Jiraphong Suksiriworapong
Summary: This study aimed to prepare extemporaneous 20 mg/mL ganciclovir in artificial tears and compare its stability with that of ganciclovir in sterile water for ophthalmic administration. The results showed that ganciclovir/0.1% HYA eyedrops had good stability at different temperatures and could be used as home medications for the treatment of ophthalmic viral infections.
Article
Medicine, General & Internal
Zhengyu Gu, Qinyi Lu, Ao Zhang, Zong Wen Shuai, Rongfeng Liao
Summary: The study showed that Systemic Lupus Erythematosus (SLE) patients without secondary Sjogren's syndrome are at a higher risk for dry eye disease (DED) compared to healthy populations, with poorer ocular surface characteristics and tear film quality. A combination of SLE disease activity index (SLEDAI), age, and non-invasive tear film breakup time (NIKBUT) demonstrated high efficiency in diagnosing DED in SLE patients, suggesting practical clinical applications.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Maria Carmen Sanchez-Gonzalez, Raul Capote-Puente, Marta-C Garcia-Romera, Concepcion De-Hita-Cantalejo, Maria-Jose Bautista-Llamas, Carmen Silva-Viguera, Jose-Maria Sanchez-Gonzalez
Summary: This study describes the role of OSA as a new non-invasive diagnostic device for dry eye disease. OSA provides accurate and non-invasive parameters to interpret distinct functions of the tear film. A complete examination protocol for OSA and OSA Plus devices is presented. These devices represent a renewal in dry eye disease diagnosis and have the potential to replace invasive techniques.
FRONTIERS IN MEDICINE
(2022)
Review
Ophthalmology
Raquel Gil-Cazorla, Sunil Shah, Shehzad A. Naroo
BRITISH JOURNAL OF OPHTHALMOLOGY
(2016)
Article
Ophthalmology
Phillip J. Buckhurst, Shehzad A. Naroo, Leon N. Davies, Sunil Shah, Hetal Buckhurst, Alec Kingsnorth, Tom Drew, James S. Wolffsohn
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2015)
Article
Ophthalmology
Sunil Shah, Cristina Peris-Martinez, Thomas Reinhard, Paolo Vinciguerra
JOURNAL OF REFRACTIVE SURGERY
(2015)
Article
Ophthalmology
M. Rana, A. Lau, A. Aralikatti, S. Shah
CONTACT LENS & ANTERIOR EYE
(2015)
Article
Ophthalmology
Antonio Leccisotti, Stefania V. Fields, Johnny Moore, Sunil Shah, Tara C. B. Moore
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2016)
Article
Ophthalmology
Hasnain Ramji, Johnny Moore, C. B. Tara Moore, Sunil Shah
CONTACT LENS & ANTERIOR EYE
(2016)
Review
Ophthalmology
Margarita Calonge, Marc Labetoulle, Elisabeth M. Messmer, Sunil Shah, Yonca A. Akova, Kostas G. Boboridis, Jesus Merayo-Lloves, Pasquale Aragona, Jose Benitez-Del-Castillo, Gerd Geerling, Maurizio Rolando, Christophe Baudouin
CURRENT EYE RESEARCH
(2018)
Article
Ophthalmology
Harvey S. Uy, Pik Sha Chan, Raquel Gil-Cazorla, Sunil Shah
INTERNATIONAL OPHTHALMOLOGY
(2019)
Article
Ophthalmology
Gerd Uwe Auffarth, Elfriede Friedmann, Detlef Breyer, Hakan Kaymak, Detlef Holland, Burkhard Dick, Alexander Petzold, Sunil Shah, Luis Salva Ladaria, Scott Anderson Garcia, Ramin Khoramnia
Summary: Implantation of FEMTIS IOL resulted in excellent visual and stable refractive outcomes, with low IOL decentration and exceptional in-the-bag stability over a 12-month period.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Mark A. Bullimore, Eric R. Ritchey, Sunil Shah, Nicolas Leveziel, Rupert R. A. Bourne, D. Ian Flitcroft
Summary: The article examines the potential benefits of slowing myopia progression and whether they outweigh the associated risks, such as contact lens wear. It concludes that myopia control can help prevent visual impairment, and the benefits outweigh the risks with a number needed to treat to prevent 5 years of visual impairment between 4.1 and 6.8.
Article
Infectious Diseases
Srikanth Dumpati, Shehzad A. Naroo, Sunil Shah, Debarun Dutta
Summary: This study assessed the antimicrobial activity of a UVC device against microorganisms related to contact lens adverse events. The results showed that UVC exposure had a high antimicrobial efficacy and could be used for lens disinfection.
Article
Ophthalmology
Sunil Shah, Debarun Dutta, Ankur Barua, Ludger Hanneken, Shehzad A. Naroo
Summary: The study aimed to determine the effects of Tixel (R) treatment on dry eye disease. The results showed that Tixel treatment significantly improved dry eye symptoms and had no adverse events.
CONTACT LENS & ANTERIOR EYE
(2023)
Article
Ophthalmology
Phillip J. Buckhurst, Shehzad A. Naroo, Leon N. Davies, Sunil Shah, Tom Drew, James S. Wolffsohn
BMJ OPEN OPHTHALMOLOGY
(2016)
Meeting Abstract
Ophthalmology
Raymond A. Applegate, Sandeep K. Dhallu, Amy Louise Sheppard, Toshifumi Mihashi, Tom Drew, Sunil Shah, James Stuart Wolffsohn
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2015)