Article
Medicine, Research & Experimental
Jelena Matovic, Katayun Bahrami, Philipp Stockmann, Iris K. . Sokka, You Cheng Khng, Mirkka Sarparanta, Evamarie Hey-Hawkins, Jarkko Rautio, Filip S. Ekholm
Summary: Boron neutron capture therapy (BNCT) is a cancer treatment that uses boron delivery agents to selectively eradicate tumor cells. In this study, we focus on a GLUT1-targeting strategy to BNCT and synthesize carborane-bearing D-galactose, D-mannose, and D-allose as potential delivery agents. We find that these agents exhibit significantly improved boron delivery capacity compared to clinically approved agents in vitro, laying the groundwork for future preclinical assessment studies.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Applied
Valentina A. Ol'shevskaya, Andrei V. Zaitsev, Albina S. Petrova, Anastasia Yu Arkhipova, Mikhail M. Moisenovich, Alexey A. Kostyukov, Anton E. Egorov, Olga A. Koroleva, Galina V. Golovina, Yulia L. Volodina, Elena V. Kalinina, Vladimir A. Kuzmin, Yoshinori Sakurai, Hiroki Tanaka, Norio Miyoshi, Alexander A. Shtil
Summary: Tetrapyrrolic macrocycles can be chemically modified for use in new agents for binary antitumor treatment and diagnosis. These modified compounds accumulate preferentially in drug-resistant cells and show potent effects in photodynamic and boron neutron capture therapies.
Review
Chemistry, Medicinal
Paolo Coghi, Jinxin Li, Narayan S. Hosmane, Yinghuai Zhu
Summary: Boron neutron capture therapy (BNCT) is a promising treatment method in cancer therapy. The currently used boron compounds, l-boronophenylalanine (BPA) and sodium borocaptate (BSH), have their limitations and there is a need for next generation BNCT agents. Various boron compounds, including small molecules and macro/nano-vehicles, have been explored and have shown better success. This review summarizes the current knowledge of different boron compounds for BNCT application and provides a perspective for the future of BNCT in cancer treatment.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Cell Biology
Giorgia Ailuno, Alice Balboni, Gabriele Caviglioli, Francesco Lai, Federica Barbieri, Irene Dellacasagrande, Tullio Florio, Sara Baldassari
Summary: Boron neutron capture therapy is a promising low-invasive cancer therapy, but its success is hindered by the lack of appropriate drug delivery systems. Nanoparticle systems are being explored to selectively deliver boron atoms to cancer cells and avoid damage to healthy tissues.
Review
Medicine, Research & Experimental
Qi Dai, QiYao Yang, Xiaoyan Bao, Jiejian Chen, Min Han, Qichun Wei
Summary: Boron neutron capture therapy (BNCT) is a promising biological targeted technique for cancer therapy, with good targeting and high effectiveness. It causes less damage to surrounding healthy tissue compared to other methods. Measuring boron concentration is crucial but current technology falls short. This review discusses the development of methods and imaging to improve measurement accuracy.
MOLECULAR PHARMACEUTICS
(2022)
Review
Medicine, Research & Experimental
Qi Dai, QiYao Yang, Xiaoyan Bao, Jiejian Chen, Min Han, Qichun Wei
Summary: Boron neutron capture therapy (BNCT) is a promising cancer treatment method with good targeting and high efficacy. Measuring B-10 concentrations is vital for treatment effectiveness, but current technology needs improvement.
MOLECULAR PHARMACEUTICS
(2022)
Review
Oncology
Dmitry O. Zharkov, Anna Yudkina, Tim Riesebeck, Polina S. Loshchenova, Evgeny A. Mostovich, Grigory L. Dianov
Summary: Despite progress in cancer therapy, the delivery and accumulation of boron in cancer cells remain major obstacles for the clinical use of BNCT. Incorporating boron-containing nucleotides into the DNA of cancer cells may significantly increase the efficacy of BNCT.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Oncology
Timothy D. Malouff, Danushka S. Seneviratne, Daniel K. Ebner, William C. Stross, Mark R. Waddle, Daniel M. Trifiletti, Sunil Krishnan
Summary: Boron neutron capture therapy (BNCT) is an emerging treatment modality that utilizes boron-10 to target tumors and has shown promising results in various cancer types in clinical studies.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Pierre Loap, Ludovic De Marzi, Carlos Eduardo Almeida, Amelia Barcellini, Julie Bradley, Maria Carmen de Santis, Remi Dendale, Rachel Jimenez, Ester Orlandi, Youlia Kirova
Summary: Radiotherapy plays a crucial role in breast cancer treatment, and Hadrontherapy techniques have potential for improving therapeutic outcomes by limiting side effects and enhancing tumor control.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Medicine, Research & Experimental
Jun Arima, Kohei Taniguchi, Masashi Yamamoto, Tsubasa Watanabe, Yusuke Suzuki, Hiroki Hamamoto, Yosuke Inomata, Hideki Kashiwagi, Shinji Kawabata, Keitaro Tanaka, Kazuhisa Uchiyama, Minoru Suzuki, Sang-Woong Lee
Summary: This study found that boro neutron capture therapy (BNCT) mediated by bomnophenylalanine (BPA) has anti-cancer effects in pelvic recurrence of colorectal cancer (CRC), with no obvious side effects.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Maria K. Fedotova, Maksim N. Usachev, Ekaterina V. Bogdanova, Ekaterina Diachkova, Yuriy Vasil'ev, Vladimir I. Bregadze, Andrey F. Mironov, Mikhail A. Grin
Summary: In this study, a conjugate of chlorin e6 methyl ester with cyclen and dioxane, as well as nitrile derivatives of cobalt bis(dicarbollide), were synthesized to combine the neutron-capturing properties of boron nanoclusters and the photodynamic properties of natural chlorins. The purification conditions for compounds by HPLC were selected due to the presence of closely related impurities in natural compounds.
BIOENGINEERING-BASEL
(2022)
Article
Chemistry, Multidisciplinary
Yuquan Wang, Giacomo Reina, Heon Gyu Kang, Xiaoxiao Chen, Yajuan Zou, Yoshie Ishikawa, Minoru Suzuki, Naoki Komatsu
Summary: Boron neutron capture therapy (BNCT) is a non-invasive cancer treatment that utilizes nuclear fission of B-10 upon neutron irradiation. In this study, B-10 enriched boron carbide nanoparticle is functionalized with polyglycerol to improve its dispersibility in a physiological environment. Pharmacokinetic experiments show that this modified nanoparticle fulfills the requirements for BNCT and in vivo study reveals its significant effect in suppressing cancer growth and eradicating cancer with the help of near-infrared light irradiation.
Article
Oncology
Song Wang, Zhengchao Zhang, Lele Miao, Jiaxing Zhang, Futian Tang, Muzhou Teng, Yumin Li
Summary: Boron Neutron Capture Therapy (BNCT) is a new binary radiation therapy that uses neutron capture reaction to kill tumor cells. It has been included in the clinical backup program for the treatment of glioma, melanoma, and other diseases. However, the key challenge of BNCT lies in developing more efficient boron delivery agents to improve targeting and selectivity.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Makoto Shirakawa, Alexander Zaboronok, Kei Nakai, Yuhki Sato, Sho Kayaki, Tomonori Sakai, Takao Tsurubuchi, Fumiyo Yoshida, Takashi Nishiyama, Minoru Suzuki, Hisao Tomida, Akira Matsumura
Summary: The study focuses on improving the accumulation and retention of boron in tumor tissues by designing novel PBL liposomes, providing promising candidates for BNCT treatment.
Review
Chemistry, Inorganic & Nuclear
Bing-De Zheng, Jing Ye, Xue-Qin Zhang, Na Zhang, Mei-Tian Xiao
Summary: Phthalocyanines are widely used in photodynamic therapy but lack selectivity. Introducing activatable photosensitizers significantly improves their selectivity and effectiveness. Various phthalocyanine-based activatable photosensitizers have been developed to reduce damage to normal cells and enhance their potential in anti-cancer therapy.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea Ciardiello, Saverio Altieri, Francesca Ballarini, Valerio Bocci, Silva Bortolussi, Laura Cansolino, Daniele Carlotti, Mario Ciocca, Riccardo Faccini, Angelica Facoetti, Cinzia Ferrari, Luca Ficcadenti, Emiliano Furfaro, Stefano Giagu, Francesco Iacoangeli, Giampiero Macioce, Carlo Mancini-Terracciano, Andrea Messina, Luisa Milazzo, Severina Pacifico, Simona Piccolella, Ian Postuma, Dante Rotili, Valerio Vercesi, Cecilia Voena, Francesca Vulcano, Silvia Capuani
Summary: The aim of this study was to evaluate the in vitro internalization of F-19-labelled p-boronophenylalanine (F-19-BPA) in pancreatic cancer cells and assess its potential application in BNCT and PBFT. Results indicated that F-19-BPA was internalized by the cells, and the three independent techniques used provided consistent results. F-19 NMR spectroscopy was validated as an effective method to study F-19-BPA internalization and suggested its potential as a promising carrier for the treatment of pancreatic cancer.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2022)
Article
Engineering, Biomedical
Francesca Lizzi, Abramo Agosti, Francesca Brero, Raffaella Fiamma Cabini, Maria Evelina Fantacci, Silvia Figini, Alessandro Lascialfari, Francesco Laruina, Piernicola Oliva, Stefano Piffer, Ian Postuma, Lisa Rinaldi, Cinzia Talamonti, Alessandra Retico
Summary: This study focuses on using artificial intelligence to identify, segment, and quantify COVID-19 pulmonary lesions. The quality of annotation has an impact on the accuracy of segmentation. The LungQuant system achieved satisfactory generalization ability in predicting CT-SS.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2022)
Article
Nuclear Science & Technology
Gabriele Parisi, Andrea Pola, Davide Bortot, Davide Mazzucconi, Giovanni D'Angelo, Chiara Magni, Ian Postuma, Silva Bortolussi, Nicoletta Protti, Saverio Altieri, Umberto Anselmi Tamburini, Valerio Vercesi, Stefano Agosteo
Summary: This paper presents a novel neutron spectrometer called ACSpect, which consists of a two-stages monolithic silicon telescope detector and an organic scintillator. It is capable of high-resolution measurements in the energy range of 250keV-4MeV.
RADIATION MEASUREMENTS
(2022)
Article
Biology
Giuliano Franco Perotti Bernardini, Silva Bortolussi, Hanna Koivunoro, Lucas Provenzano, Cinzia Ferrari, Laura Cansolino, Ian Postuma, Daniel German Carando, Leena Kankaanranta, Heikki Joensuu, Sara Josefina Gonzalez
Summary: This study investigates the effect of using in vitro or in vivo radiobiological studies on the consistency of the photon isoeffective dose model for SCC head and neck cancer treated with BNCT. The results show that the photon isoeffective dose model based on in vitro data generally has higher doses than the model based on in vivo data, but both models have good predictive performance. The traditional model yields substantially larger doses and is statistically rejected, emphasizing the importance of using experimental data closely linked to the tumor type.
RADIATION RESEARCH
(2022)
Article
Chemistry, Applied
Geping Qu, Danish Khan, Feini Yan, Armagan Atsay, Hui Xiao, Qian Chen, Hu Xu, Ilgin Nar, Zong-Xiang Xu
Summary: The combination of thiophene and phthalocyanine as isomers can improve the photovoltaic performance and structural stability of perovskite solar cells, achieving a highest power conversion efficiency of 18%.
JOURNAL OF ENERGY CHEMISTRY
(2022)
Article
Oncology
Federica Tonon, Maja Cemazar, Urska Kamensek, Cristina Zennaro, Gabriele Pozzato, Sergio Caserta, Flora Ascione, Mario Grassi, Stefano Guido, Cinzia Ferrari, Laura Cansolino, Francesco Trotta, Biljana Grcar Kuzmanov, Giancarlo Forte, Fabiana Martino, Francesca Perrone, Riccardo Bomben, Valter Gattei, Nicola Elvassore, Erminio Murano, Nhung Hai Truong, Michael Olson, Rossella Farra, Gabriele Grassi, Barbara Dapas
Summary: The study demonstrates that 5-Aza can impair the development of HCC by upregulating miR-139-5p, which then affects the proliferative and migratory pathways of HCC.
Article
Chemistry, Multidisciplinary
Ozge Erguder, Sultan Sahin Keskin, Ilgin Nar, Levent Trabzon, Caner Unlu
Summary: This study enhanced the quantum yield of yellow emissive CDs using two different methods and found that aflatoxin B1 can act as an emission booster for CDs. The highly luminescent yellow emissive CDs have potential applications in sensing aflatoxin B1.
Article
Biology
Agostina Vitali, Maria Paola Demichelis, Greta Di Martino, Ian Postuma, Silva Bortolussi, Andrea Falqui, Chiara Milanese, Chiara Ferrara, Patrizia Sommi, Umberto Anselmi-Tamburini
Summary: In this study, multifunctional boron carbide nanoparticles stabilized with polyacrylic acid (PAA) and a gadolinium (Gd)-rich solid phase were synthesized and their biological activity was evaluated. The incorporation of a fluorophore (DiI) allowed for confocal microscopy imaging of the nanoparticles. Novel correlative microscopy techniques were employed to analyze the interaction and activity of these fluorescent Gd-containing B4C nanoparticles (FGdBNPs) with cultured cells. The results indicate that these nanoparticles have the potential to achieve high boron concentration in tumor cells.
Article
Chemistry, Multidisciplinary
Stefano Scaramuzza, Clara M. G. de Faria, Vito Coviello, Daniel Forrer, Luca Artiglia, Denis Badocco, Paolo Pastore, Paolo Ghigna, Ian Postuma, Laura Cansolino, Cinzia Ferrari, Silva Bortolussi, Riccardo Vago, Antonello E. Spinelli, Marina Bekic, Miodrag Colic, Vincenzo Amendola
Summary: New multifunctional theranostic vectors combining boron neutron capture therapy and X-ray radiotherapy show promise for treating normal and XRT-resistant hypoxic tumor regions. Polymer-coated Au-B nanoparticles with biocompatible and stable properties allow for cell targeting and internalization. The laser-assisted synthetic pathway enables reproducibility, environmental sustainability, and cost affordability.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Physical
Gil Goncalves, Stefania Sandoval, Marina Llenas, Belen Ballesteros, Tatiana Da Ros, Silva Bortolussi, Laura Cansolino, Cinzia Ferrari, Ian Postuma, Nicoletta Protti, Manuel Melle-Franco, Saverio Altieri, Gerard Tobias-Rossell
Summary: Neutron capture therapy (NCT) is a form of radiotherapy that utilizes specific isotopes to capture neutrons and release high linear energy transfer particles for cancer treatment. This study introduces a novel approach of using carbon nanomaterials to encapsulate active NCT nuclides, enhancing selectivity and biocompatibility.
Article
Engineering, Biomedical
Elena Delgrosso, Franca Scocozza, Laura Cansolino, Federica Riva, Michele Conti, Giada Loi, Ferdinando Auricchio, Ian Postuma, Silva Bortolussi, Lorenzo Cobianchi, Cinzia Ferrari
Summary: Osteosarcoma, the most frequent primary malignant bone tumor, requires new therapeutic options due to limited treatment choices. Boron neutron capture therapy (BNCT) is an experimental alternative radiotherapy that can selectively kill infiltrative tumor cells while sparing healthy tissues. This study aims to develop a 3D in vitro osteosarcoma model as a platform for BNCT studies, providing an alternative or parallel approach to 2D in vitro culture and in vivo animal models.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Article
Polymer Science
Giada Loi, Gaia Stucchi, Franca Scocozza, Laura Cansolino, Francesca Cadamuro, Elena Delgrosso, Federica Riva, Cinzia Ferrari, Laura Russo, Michele Conti
Summary: A standardized experimental protocol for characterizing a new bioink has been proposed in this study to achieve printability and biocompatibility in 3D bioprinting. The protocol consists of pre-printing, 3D bioprinting, and post-printing steps to evaluate the performance of the bioink. A functionalized hydrogel based on gelatin and chitosan was used. The results show that the hydrogel is suitable for printing grids with good resolution and is biocompatible for UMR-106 cell growth.
Article
Chemistry, Inorganic & Nuclear
Sacide Melek Kestir, Sultan Sahin Keskin, Ozge Erguder, Nida Uk, Yurdanur Turker, Ilgin Nar, Levent Trabzon, Caner Unlu
Summary: In this study, researchers modified a traditional two-phase synthesis method to successfully synthesize CdTeS quantum dots with precise control over size and photophysical properties. They also demonstrated the interaction between CdTeS quantum dots and other fluorophores, resulting in enhanced fluorescence intensity.
DALTON TRANSACTIONS
(2023)
