Article
Oncology
Yi-Jun Hua, Yan-Feng Ou-Yang, Xiong Zou, Le Xia, Dong-Hua Luo, Ming-Yuan Chen
Summary: Radiotherapy is crucial for nasopharyngeal carcinoma patients, with a typical treatment duration of six to six and a half weeks. Prolonged radiotherapy duration is associated with higher risk of distant metastasis and death, highlighting the importance of avoiding prolonged treatment to improve outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Health Care Sciences & Services
Ko-Chun Fang, Tai-Lin Huang, Kuan-Cho Liao, Tsair-Fwu Lee, Yang-Wei Hsieh, Wen-Ling Tsai, Fu-Min Fang
Summary: A study investigated dosimetric parameters related to acute radiation dermatitis (ARD) in NPC patients treated with IMPT, finding smoking habit, N2-N3 status, and V58CGE to skin 5 mm as significant predictors for developing grade 2 and 3 ARD. The study suggested that V58CGE to skin 5 mm < 5.0 cm(3) could be used as a constraint in treatment planning for these patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Jing-Lin Mi, Meng Xu, Chang Liu, Ren-Sheng Wang
Summary: This study identified four independent prognostic factors for distant metastasis in nasopharyngeal carcinoma patients and developed a nomogram with a high predictive accuracy of DMFS. The nomogram is useful for oncologists to predict DMFS accurately and individualize treatment for NPC patients.
Article
Oncology
Zhaodong Fei, Ting Xu, Xiufang Qiu, Mengying Li, Taojun Chen, Li Li, Chaoxiong Huang, Chuanben Chen
Summary: In patients with T4 nasopharyngeal carcinoma, an additional boost dose of radiation therapy can significantly improve overall survival and local recurrence-free survival. Boost dose was shown to be the only protective prognostic factor in multivariate analysis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Jiang Hu, Boji Liu, Weihao Xie, Jinhan Zhu, Xiaoli Yu, Huikuan Gu, Mingli Wang, Yixuan Wang, ZhenYu Qi
Summary: The automatic KBP method using the DVH prediction model provides a possible way to generate clinically acceptable plans in a short time for NPC patients, achieving significant dose reduction in critical organs but showing limitations in spinal cord protection.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Shan Lu, Huiqi Fan, Xueyuan Hu, Xin Li, Yingying Kuang, Deyang Yu, Shanshan Yang
Summary: This study compared different radiotherapy plans for locally advanced nasopharyngeal carcinoma (NPC) and found that helical tomotherapy (HT) and volume-modulated arc therapy (VMAT) had better target homogeneity and conformity. HT also showed the best reduction in doses delivered to organs at risk. VMAT, on the other hand, had the shortest treatment time and improved radiation delivery efficiency.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Kaixuan Yang, Wenji Xie, Xiangbin Zhang, Yu Wang, Arthur Shou, Qiang Wang, Jiangfang Tian, Jiangping Yang, Guangjun Li
Summary: This study aimed to predict late radiation xerostomia and successfully developed a predictive model, which can effectively improve patients' quality of life.
Article
Radiology, Nuclear Medicine & Medical Imaging
Dan Bao, Yanfeng Zhao, Wenli Wu, Hongxia Zhong, Meng Yuan, Lin Li, Meng Lin, Xinming Zhao, Dehong Luo
Summary: This study evaluated the predictive potential of histogram analysis derived from ADC maps in radiation-induced temporal lobe injury (RTLI) in nasopharyngeal carcinoma (NPC) patients after intensity-modulated radiotherapy (IMRT). The results showed that the combination of ADC histogram parameters and T stage had a satisfactory ability to predict RTLI in NPC after IMRT.
INSIGHTS INTO IMAGING
(2022)
Article
Oncology
De-Huan Xie, Zheng Wu, Wang-Zhong Li, Wan-Qin Cheng, Ya-Lan Tao, Lei Wang, Shao-Wen Lv, Fei-Fei Lin, Nian-Ji Cui, Chong Zhao, Jun Ma, Shao-Min Huang, Tai-Xiang Lu, Ya-Qian Han, Yong Su
Summary: Individualized CTV delineation in unilateral NPC leads to excellent long-term local control with limited out-of-field recurrences, reduced dose to tumor-contralateral organs, and mild late toxicities.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Oncology
Yi Xu, Yang Liu, Zekun Wang, Jingbo Wang, Jianghu Zhang, Xuesong Chen, Runye Wu, Qingfeng Liu, Yuan Qu, Kai Wang, Xiaodong Huang, Jingwei Luo, Li Gao, Guozhen Xu, Ye Zhang, Junlin Yi
Summary: In the era of IMRT, the severity of INN in primary NPC patients is reduced. This study showed that treatment strategies contribute little to the development of INN, while the accumulated dose of radiation may be related to its occurrence.
RADIATION ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Danfang Yan, Xin Yin, Lihong Wang, Liming Huang, Qiuying Tang, Kejia Cheng, Senxiang Yan
Summary: This study aimed to investigate whether induction chemotherapy (IC) reduces target volume drift during intensity-modulated radiation therapy (IMRT), potentially reducing the replanning workload. The results showed that IC significantly decreased the degree of target volume shrinkage and anatomical and target dose drift during IMRT, potentially reducing locoregional recurrence and improving survival in patients with locoregionally advanced nasopharyngeal carcinoma (NPC).
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Oncology
Pei-Wen Wu, Chien-Chia Huang, Yun-Shien Lee, Yung-Chih Chou, Kang-Hsing Fan, Chien-Yu Lin, Bing-Shen Huang, Shih-Wei Yang, Chi-Che Huang, Po-Hung Chang, Ta-Jen Lee, Joseph Tung-Chieh Chang
Summary: This study compared the incidence and severity of chronic rhinosinusitis (CRS) in patients with nasopharyngeal carcinoma (NPC) after radiotherapy using intensity-modulated proton therapy (IMPT) and volume-modulated arc therapy (VMAT). The results showed that patients in the IMPT group had a significantly lower incidence and decreased severity of CRS compared to the VMAT group, and also showed better and faster recovery of sinonasal function after radiotherapy.
Article
Otorhinolaryngology
Yanyan Chen, Quxia Zhang, Tianzhu Lu, Cairong Hu, Jingfeng Zong, Yun Xu, Wei Zheng, Lisha Chen, Senan Lin, Sufang Qiu, Luying Xu, Jianji Pan, Qiaojuan Guo, Shaojun Lin
Summary: A retrospective review on T4 NPC patients found that it is feasible to achieve ideal local control by maximizing gross tumor volume dose coverage, even when exceeding the constraint standards for the central nervous system, without significantly increasing craniocerebral toxicity.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Otorhinolaryngology
Xixi Liu, Bian Wu, Jing Huang, You Qin, Zhanjie Zhang, Liangliang Shi, Xiaohua Hong, Qian Ding, Gang Peng, Kunyu Yang
Summary: This study aims to identify tumor factors associated with in-field failure in patients with nasopharyngeal carcinoma (NPC) receiving intensity-modulated radiotherapy (IMRT). The results showed that in-field failure was the major pattern of recurrence in NPC patients. Large tumor volume, nonkeratinizing differentiated carcinoma, and cervical nodal necrosis were independent tumor factors associated with in-field failure.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)