Article
Biotechnology & Applied Microbiology
Sven Holcombe, Yuan Huang
Summary: Human body models (HBMs) play a crucial role in improving vehicle safety systems, but their geometry may not fully represent the target demographic due to being derived from single individuals. This study provides reference values for assessing the cross-sectional geometry of human ribs and offers clear guidelines for improving rib geometry in current HBMs.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Unni Syversen, Mats Peder Mosti, Ida Maria Mynarek, Trude Seselie Jahr Vedal, Kristin Aasarod, Trude Basso, Janne E. Reseland, Per Medboe Thorsby, Bjorn O. Asvold, Erik Fink Eriksen, Astrid Kamilla Stunes
Summary: This study found compromised bone material strength and microarchitecture in men with T1D. Additionally, the data confirmed a modest decrease in BMD and low bone turnover in T1D patients, indicating that bone should be recognized as a target of diabetic complications.
ENDOCRINE CONNECTIONS
(2021)
Article
Public, Environmental & Occupational Health
Yichen Liu, Yue Zeng, Jun Lu, Xiaoya Zhang, Zikai Zhang, Huijuan Li, Peipei Liu, Bin Ma, Yiqun Gu, Lige Song
Summary: This study aimed to evaluate the correlation between hemoglobin (Hb) and osteoporosis (OP) in the Chinese elderly population. The results showed that Hb level was positively correlated with bone mineral density (BMD) at the lumbar spine, femur neck, and total hip. After adjusting for confounding variables, the relationship remained significant. Additionally, lower Hb levels were associated with a higher risk of OP.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Stefan Lars Reckelkamm, Anke Hannemann, Thomas Kocher, Matthias Nauck, Henry Voelzke, Benjamin Ehmke, Martina Rauner, Zoheir Alayash, Sebastian-Edgar Baumeister, Michael Nolde, Birte Holtfreter
Summary: This study reveals positive associations of N-procollagen type 1 amino-terminal propeptide, bone-specific alkaline phosphatase, and sclerostin with periodontitis, while wingless-type mouse mammary tumor virus integration site family member 5a showed an inverse association. However, the results are contradictory in the overall context and previous associations reported in other studies could not be confirmed.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Orthopedics
Gao-Xiang Wang, Jun-Tong Li, Fang-ying Cai, Bao-Li Huang, Ze-Bin Fang, Heng-Xia Zhao, Shu-Fang Chu, De-Liang Liu, Hui-Lin Li
Summary: This study explored the correlation between bone turnover markers (BTMs) and lumbar bone mineral density (BMD) in middle-aged populations. Data from NHANES were analyzed in a cross-sectional analysis. Serum bone alkaline phosphatase (sBAP) and urinary N-telopeptide (uNTx) levels were used as representatives of bone turnover. Multivariable linear regression models were used to detect the correlation of sBAP and uNTx with lumbar BMD.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Medicine, General & Internal
Sophia X. Sui, Kara L. Holloway-Kew, Natalie K. Hyde, Lana J. Williams, Monica C. Tembo, Sarah Leach, Julie A. Pasco
Summary: This study demonstrates the variability in sarcopenia prevalence estimates when different criteria are used. While population-specific criteria may be relevant for some populations, consensus is needed to determine the key deficits in skeletal muscle health for establishing an operational definition of sarcopenia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Manuela Schoeb, Elizabeth M. Winter, Maria A. Sleddering, Mirjam A. Lips, Abbey Schepers, Marieke Snel, Natasha M. Appelman-Dijkstra
Summary: The study showed that bone material properties are altered in patients with primary hyperparathyroidism (PHPT), especially in those with prevalent fractures. Impact microindentation (IMI) may be a valuable additional tool for assessing bone fragility in PHPT patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Dentistry, Oral Surgery & Medicine
Mai Hussein, Youssef M. K. Farag, Stephen Sonis
Summary: This study aimed to investigate the association between psoriasis and periodontal and dentition status. Analysis of a large number of adults in the United States revealed no significant association between psoriasis and periodontal disease, but a significant association was found with non-functional dentition.
Article
Endocrinology & Metabolism
Yang Xu, Li Shen, Lianyong Liu, Zhenlin Zhang, Weiwei Hu
Summary: This study investigated the profile of serum undercarboxylated osteocalcin (ucOC) levels and their associations with bone mineral density (BMD), bone turnover markers (BTMs), and prevalence of osteopenia and osteoporosis in the Chinese population. The results showed that ucOC levels were higher in men than women and decreased with age until the age of 50, after which they increased. Higher ucOC levels were correlated with lower BMD values and higher levels of BTMs in both men and women. Furthermore, an increase in ucOC levels was associated with an increased risk of osteopenia and osteoporosis in both genders.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Health Care Sciences & Services
Xolani Ntinga, Franco Musiello, Alfred Kipyegon Keter, Ruanne Barnabas, Alastair van Heerden
Summary: This study aimed to assess the feasibility and acceptability of a chatbot-supported HIV self-testing program in South Africa. The results showed that most participants preferred the chatbot over human counselors for HIV testing, as they felt the chatbot's responses were similar to daily conversations. This study highlights the potential of digital technology interventions to improve HIV self-testing in low- and middle-income countries.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Orthopedics
Yasuyuki Omichi, Noriaki Mima, Ryo Okada, Keizo Wada, Masatoshi Morimoto, Koichi Sairyo
Summary: This study investigated the risk factors for vertebral fracture in the Japanese population and evaluated the usefulness of TBS. The results showed that TBS was a significant indicator of vertebral fractures and could help identify patients who need pharmacologic therapy.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Multidisciplinary Sciences
Briohny Kennedy, Lyndal Bugeja, Jake Olivier, Sjaan Koppel, Jeremy Dwyer, Joseph Ibrahim
Summary: This study aims to examine the characteristics and factors associated with older adult homicide in the Australian state of Victoria. Using data from the Victorian Homicide Register, this study will analyze consecutive cases of homicide among community-dwelling older adults. The findings will help practitioners, policymakers, and other stakeholders strengthen prevention strategies to reduce the risk of future homicides among older Victorians.
Article
Multidisciplinary Sciences
Felicity Aiano, Samuel E. Jones, Zahin Amin-Chowdhury, Jessica Flood, Ifeanyichukwu Okike, Andrew Brent, Bernadette Brent, Joanne Beckmann, Joanna Garstang, Shazaad Ahmad, Frances Baawuah, Mary E. Ramsay, Shamez N. Ladhani
Summary: The reopening of schools during the COVID-19 pandemic has prompted concerns about the spread of SARS-CoV-2, leading to a national surveillance project in primary schools in England. The study found that primary school staff and parents were supportive of regular SARS-CoV-2 testing, with a preference for weekly testing. Children preferred nasal swabs and oral fluid samples over throat swabs or blood tests.
Article
Public, Environmental & Occupational Health
Yin Liu, Juan Su, Xiaoyang Wang, Huifang Xu, Hong Wang, Ruihua Kang, Liyang Zheng, Yixian Wang, Chunya Liu, Yiping Jing, Shaokai Zhang
Summary: This study examined HCV knowledge, self-reported testing behavior, and willingness to undergo screening in the general Chinese population. The findings revealed low HCV knowledge and testing rates among the general population in China. Individuals who are less educated, reside in less-developed areas, currently drink alcohol, and are female should be prioritized for health education and interventions.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Endocrinology & Metabolism
Ingrid Bretherton, Ali Ghasem-Zadeh, Shalem Y. Leemaqz, Ego Seeman, Xiaofang Wang, Thomas McFarlane, Cassandra Spanos, Mathis Grossmann, Jeffrey D. Zajac, Ada S. Cheung
Summary: This study compared bone microarchitecture between transgender individuals receiving gender-affirming hormone therapy and control groups. The results showed that trans men had higher bone density and thickness, while trans women had lower bone density, thickness, and trabecular volume.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Sophia X. Sui, Lana J. Williams, Kara L. Holloway-Kew, Natalie K. Hyde, Kara B. Anderson, Monica C. Tembo, Alex B. Addinsall, Sarah Leach, Julie A. Pasco
Summary: The study investigated the association between muscle density and cognition, finding a positive correlation in certain domains, with little to no influence from factors such as inflammation or body fat mass.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Sophia X. Sui, Lana J. Williams, Kara L. Holloway-Kew, Natalie K. Hyde, Julie A. Pasco
Summary: Sarcopenia and cognitive decline share common risk factors and underlying pathophysiological pathways. Ageing and lifestyle risk factors play significant roles in both disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Marlene Gojanovic, Kara L. Holloway-Kew, Natalie K. Hyde, Mohammadreza Mohebbi, Nitin Shivappa, James R. Hebert, Adrienne O'Neil, Julie A. Pasco
Summary: This study found that a pro-inflammatory diet is associated with lower muscle mass, poorer muscle function, and increased likelihood of the combination of low muscle mass and poor muscle function. Further research is needed to investigate whether anti-inflammatory dietary interventions could reduce the risk of sarcopenia.
Article
Endocrinology & Metabolism
Kara L. Holloway-Kew, Pamela Rufus-Membere, Kara B. Anderson, Monica C. Tembo, Sophia X. Sui, Natalie K. Hyde, Adolfo Diez-Perez, Mark A. Kotowicz, Julie A. Pasco
Summary: Weak associations were found between some pQCT-derived bone parameters and BMSi, which remained significant after adjusting for weight, height, and other potential confounders.
Article
Endocrinology & Metabolism
Julie A. Pasco, Sophia X. Sui, Emma C. West, Kara B. Anderson, Pamela Rufus-Membere, Monica C. Tembo, Natalie K. Hyde, Lana J. Williams, Zoe S. J. Liu, Mark A. Kotowicz
Summary: The study found a negative correlation between fatty liver index and muscle density, indicating that accumulation of fat in the liver is associated with fat infiltration into skeletal muscle. Participants in the highest FLI quartile were six times more likely to have sarcopenia, even after adjusting for age and sedentary lifestyle.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Kara L. Holloway-Kew, Kara B. Anderson, Monica C. Tembo, Sophia X. Sui, Jacob W. Harland, Natalie K. Hyde, Mark A. Kotowicz, Julie A. Pasco
Summary: Individuals with T2DM have higher risk of fracture, but do not have reduced bone mineral density. This study investigated the associations between pQCT and glycaemia status.
JOURNAL OF BONE AND MINERAL METABOLISM
(2023)
Article
Endocrinology & Metabolism
Jasmine R. Cleminson, Julie A. Pasco, Chiara C. Bortolasci, Kara L. Holloway-Kew, Jason M. Hodge, Kara B. Anderson, Mark A. Kotowicz, Rasika M. Samarasinghe, Lana J. Williams
Summary: This study aimed to investigate the association between serum lipopolysaccharide-binding protein (LBP) and potential effects on bone density, quality, and turnover in men. The results showed that LBP was associated with lower bone density at the mid-forearm and broadband ultrasound attenuation measure in heavier participants. However, the data did not support clear associations between serum LBP and bone health.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Emergency Medicine
Bianca E. Kavanagh, Kara L. Holloway-Kew, Timothy Baker, Mohammedreza Mohebbi, Julie A. Pasco, Kayla B. Corney, Mark A. Kotowicz, Shae E. Quirk, Lana J. Williams
Summary: This study aims to examine mental health emergency presentations in the Barwon South West region of Victoria, Australia, which includes urban and rural areas. A retrospective synthesis was conducted on mental health emergency presentations from February 1, 2017 to December 31, 2019. The results showed that neurotic, stress-related and somatoform disorders, as well as mental and behavioural disorders due to psychoactive substance use, were the most frequent types of presentations recorded.
EMERGENCY MEDICINE AUSTRALASIA
(2023)
Article
Endocrinology & Metabolism
Kara L. Holloway-Kew, Kara B. Anderson, Pamela Rufus-Membere, Monica C. Tembo, Sophia X. Sui, Natalie K. Hyde, Mark A. Kotowicz, Stella M. Gwini, Jun Yang, Adolfo Diez-Perez, Maciej Henneberg, Wan-Hui Liao, Julie A. Pasco
Summary: This study investigated the association between components of the RAAS and bone mineral density. The results showed that men with likely primary aldosteronism had lower bone area, suggesting that high levels of ARR may have a negative impact on bone health.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Pamela Rufus-Membere, Kara L. Holloway-Kew, Adolfo Diez-Perez, Natasha M. Appelman-Dijkstra, Mary L. Bouxsein, Erik F. Eriksen, Joshua N. Farr, Sundeep Khosla, Mark A. Kotowicz, Xavier Nogues, Mishaela Rubin, Julie A. Pasco
Summary: Impact microindentation (IMI) is a novel technique for assessing bone material strength index (BMSi) in vivo. The aim of this study was to define the reference intervals for men and women by evaluating healthy adults from multiple countries. BMSi values ranged from 48 to 101, with mean values of 84.4 +/- 6.9 for men and 79.0 +/- 9.1 for women.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Kara L. Holloway-Kew, Pamela G. Rufus-Membere, Kara B. Anderson, Jacob W. Harland, Adolfo Diez-Perez, Mark A. Kotowicz, Julie A. Pasco
Summary: This study compared the bone material strength index (BMSi) values of men and women from the same geographical location in Australia. The results showed that men had significantly higher BMSi values than women, indicating that male bones are more resistant to indentation. This difference persisted even after adjusting for weight and height. Therefore, BMSi may have predictive value for fractures.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Kara L. Holloway-Kew, Amelia G. Betson, Kara B. Anderson, Filip Sepetavc, James Gaston, Mark A. Kotowicz, Wan-Hui Liao, Maciej Henneberg, Julie A. Pasco
Summary: Medications used to treat hypertension, especially ACEI and low-dose ARB, are associated with increased fracture risk in men. ACEI use is also associated with higher fracture risk in women.
CALCIFIED TISSUE INTERNATIONAL
(2022)
