Article
Nutrition & Dietetics
Christopher Morrissey, Marie-Josephe Amiot, Aurelie Goncalves, Cecile Raverdy, Delphine Masson, Catherine Tardivel, Sandrine Gayrard, Myriam Carrere, Jean-Francois Landrier, Agnes Vinet, Antonia Perez-Martin
Summary: This study assessed the effects of vitamin D supplementation on arterial stiffness in obese adolescents. The researchers found that a high proportion of obese adolescents had vitamin D deficiency and supplementation improved carotid intima-media thickness (IMT) and reduced the risk of arterial stiffness.
Article
Cardiac & Cardiovascular Systems
Karsten Konigstein, Julia Charlotte Buschges, Giselle Sarganas, Susanne Krug, Hannelore Neuhauser, Arno Schmidt-Trucksass
Summary: This study found that exercise can reduce cardiovascular risk in young individuals, but has little effect on carotid structure and function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Acoustics
Karsten Koenigstein, Ursula von Schenck, Julia Charlotte Bueschges, Dieter Schweizer, Felicitas Vogelgesang, Stefan Damerow, Giselle Sarganas, Julia Dratva, Arno Schmidt-Trucksaess, Hannelore Neuhauser
Summary: The study evaluated the applicability of a novel third-generation method for assessing atherosclerotic risk in young individuals, demonstrating high completeness in measurements in a nationally representative sample and identifying obesity as a predictor of unsuccessful measurements.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Review
Pediatrics
Jennifer J. Y. Lee, Ethan Lin, Jessica Widdifield, Quenby Mahood, Brian W. McCrindle, Rae S. M. Yeung, Brian M. Feldman
Summary: The aim of this study was to determine the long-term mortality and prognosis of children after KD. The study found that the survival rate of KD children was over 90% during a 30-year follow-up. MACE was observed in children with CAA, but there were fewer studies on children without CAA.
Article
Cardiac & Cardiovascular Systems
Lisa Baumgartner, Heidi Weberruss, Tobias Engl, Thorsten Schulz, Renate Oberhoffer-Fritz
Summary: The study revealed that training duration and intensity were associated with vascular structure and function in children and adolescents, with higher intensity training contributing to thicker cIMT but also increased vascular elasticity.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Maria M. Pereira, Juan Torrado, Claudio Sosa, Yanina Zocalo, Daniel Bia
Summary: Preeclampsia is a serious pregnancy complication with potential origins in maternal cardiovascular maladaptation rather than just placental dysfunction. While a majority of cases may be related to abnormal placentation, not all affected women fit the placental hypothesis. Recent research suggests that arterial biomechanics play a significant role in preeclampsia pathophysiology, impacting maternal heart function and fetal-placental circulation.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ge Meng, Jiping Yao, Jiaoyang Li, Yeqing Gu, Hongmei Wu, Qing Zhang, Li Liu, Xuena Wang, Juanjuan Zhang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Kaijun Niu
Summary: This study investigated the relationship between whole-grain consumption and carotid atherosclerosis in adult Chinese population. The results showed no significant association between whole-grain consumption and the risk of carotid atherosclerosis.
Article
Pediatrics
Doaa M. Mahrous, Asmaa N. Moustafa, Mahmoud M. Higazi, Aliaa M. Higazi, Reem A. AbdelAziz
Summary: The prolonged use of antiseizure medications has been found to increase plasma homocysteine levels, leading to an increased risk of cardiovascular disease. Children with epilepsy on old generation and polytherapy antiseizure medications are at a higher risk and require early intervention.
Article
Clinical Neurology
Christy Taylor, Christopher E. Kline, Thomas B. Rice, Chunzhe Duan, Anne B. Newman, Emma Barinas-Mitchell
Summary: The study found that snoring is associated with vascular remodeling in overweight/obese young to middle-aged adults, even in the absence of obstructive sleep apnea (OSA). This suggests that snoring may contribute to cardiovascular disease risk and warrants further investigation in larger prospective cohorts.
Article
Pediatrics
Luisa Semmler, Heidi Weberruss, Lisa Baumgartner, Raphael Pirzer, Renate Oberhoffer-Fritz
Summary: Arterial alterations in children, including intima-media thickness and vascular diameter enlargement, are important hemodynamic parameters that correlate with higher cardiovascular risk in adults. This study provides values for vascular diameter, intima-media thickness/diameter ratio, and tensile stress in children, with differences observed between sexes and body mass index influencing these parameters. Systolic and diastolic blood pressure also significantly impact these vascular parameters.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Multidisciplinary Sciences
Kevin S. Heffernan, Lee Stoner, Andrew S. London, Jacqueline A. Augustine, Wesley K. Lefferts
Summary: This study examines the construct validity of a measure of PWV estimated from age and blood pressure (ePWV), and finds that ePWV is strongly associated with established measures of vascular aging, such as carotid thickness, carotid stiffness, and carotid augmentation index. The sensitivity and specificity of elevated ePWV (>= 10 m/s) for identifying high cfPWV (>= 10 m/s) were 85.4% and 73.0%, respectively.
Article
Biology
Guang-Quan Zhou, Hao Wei, Xiaoyi Wang, Kai-Ni Wang, Yuzhao Chen, Fei Xiong, Guanqing Ren, Chunying Liu, Le Li, Qinghua Huang
Summary: In this work, we propose an end-to-end boundary-salience multi-branch network, BSMNet, to identify the carotid intima-media from ultrasound images. Our method exploits prior shape knowledge and anatomical dependence to improve the accuracy of boundary identification and incorporates a strip attention model for segmenting thin strip regions. Experimental results demonstrate the promising performance of our method, achieving about 0.02 improvement in Dice and HD95 compared to other state-of-the-art methods. Our method is expected to advance the analysis of systemic arterial disease with ultrasound imaging.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Michaela Kozakova, Carmela Morizzo, Giuli Jamagidze, Daniele Della Latta, Sara Chiappino, Dante Chiappino, Carlo Palombo
Summary: This study aimed to test the association between plasma LDL-cholesterol and several vascular biomarkers to identify suitable biomarkers for early prevention in intermediate-risk individuals. The results showed an independent association of plasma LDL-cholesterol with coronary artery calcification and femoral intima-media thickness, suggesting their utility in guiding lipid-lowering treatment decisions.
Review
Medicine, General & Internal
Hao Wu, Meihua Xu, Hong Hao, Michael A. Hill, Canxia Xu, Zhenguo Liu
Summary: Patients with inflammatory bowel disease (IBD) exhibit significant endothelial dysfunction, increased arterial stiffness, and carotid intima-media thickness (cIMT). Thus, patients with IBD may benefit from aggressive risk stratification for cardiovascular diseases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Mustafa Can, Muhammet Kocabas, Melia Karakose, Fatma Humeyra Yerlikaya, Yakup Alsancak, Kultigin Turkmen, Mustafa Kulaksizoglu, Feridun Karakurt
Summary: In this study, the researchers investigated arterial stiffness, carotid intima-media thickness, endocan level, and A disintegrin and metalloproteinase with thrombospondin type I motif 9 level in patients with acromegaly and their relationship with disease activity and cardiovascular risk factors. The results showed that arterial stiffness increased in patients with acromegaly with cardiovascular risk factors and was associated with hemodynamic and metabolic parameters.
ENDOCRINE PRACTICE
(2022)
Article
Endocrinology & Metabolism
Jing Wang, Mengjiao Liu, Valerie Sung, Anneke Grobler, Richard Saffery, Katherine Lange, David Burgner, Melissa Wake
Summary: This study found that inflammation may play a significant mediating role in the association between obesity and hearing loss, especially in children.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Endocrinology & Metabolism
Katherine Lange, Jessica A. Kerr, Toby Mansell, Justin M. O'Sullivan, David P. Burgner, Susan A. Clifford, Tim Olds, Terence Dwyer, Melissa Wake, Richard Saffery
Summary: This study compared the utility of existing large-scale adult-derived PGSs to predict common anthropometric traits in children and adults, and found that adult PGSs can predict childhood BMI with a certain degree of accuracy.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Immunology
Alastair Weng, Nigel Curtis, Seilesh Kadambari, Kaya Gardiner, David Burgner, Amanda Gwee
Summary: This case report discusses a 20-month-old girl with Mycobacterium avium complex infection of the retropharyngeal space, and summarizes the literature on the pathogenesis and management of nontuberculous mycobacterial infections in the retropharynx.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Multidisciplinary Sciences
Julie Hibbert, Tobias Strunk, Elizabeth Nathan, Amy Prosser, Dorota Doherty, Karen Simmer, Peter Richmond, David Burgner, Andrew Currie
Summary: This study aimed to characterize and compare leukocyte populations in preterm infants with and without late-onset sepsis (LOS) during the first month of life. The results showed that compared to infants without LOS, infants who developed LOS had lower counts and frequencies of neutrophils, basophils, and non-cytotoxic T lymphocytes, as well as higher counts of immature granulocytes over the first month of life. Furthermore, changes in non-cytotoxic T lymphocytes occurred following LOS, suggesting sepsis-induced immune suppression.
Article
Obstetrics & Gynecology
Karin Hammarberg, Jane Halliday, Joanne Kennedy, David P. Burgner, David J. Amor, Lex W. Doyle, Markus Juonala, Sarath Ranganathan, Liam Welsh, Michael Cheung, Robert McLachlan, John McBain, Sharon Lewis
Summary: The study explores the impact of assisted reproductive technology (ART) conception and psychosocial factors on the quality of life of adults. It finds that being ART-conceived can confer advantages in quality of life in adulthood.
Editorial Material
Public, Environmental & Occupational Health
Jessica E. Miller, David P. Burgner
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Nutrition & Dietetics
Christoph Saner, Alistair M. Senior, Hanyue Zhang, Aino-Maija Eloranta, Costan G. Magnussen, Matthew A. Sabin, Markus Juonala, Marco Janner, David P. Burgner, Ursula Schwab, Eero A. Haapala, Berit L. Heitmann, Stephen J. Simpson, David Raubenheimer, Timo A. Lakka
Summary: This study tested for protein leverage and the protein leverage hypothesis in children and adolescents. The results showed that proportional energy intake of proteins was inversely associated with energy intake, and increased energy intake on diets with lower protein content was counterbalanced by increased energy expenditure and did not lead to increased adiposity.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Miaobing Zheng, Kylie D. Hesketh, Peter Vuillermin, Jodie Dodd, Li Ming Wen, Louise A. Baur, Rachael Taylor, Rebecca Byrne, Seema Mihrshahi, David Burgner, Mimi L. K. Tang, Karen J. Campbell
Summary: This study investigated the pathways linking maternal pre-pregnancy BMI, infant birth weight, breastfeeding duration, and rapid weight gain during infancy to overweight outcomes in early childhood. The results showed that maternal pre-pregnancy BMI was directly associated with infant birth weight, child BMI z-score, and overweight status. Rapid weight gain in infancy exhibited the strongest direct association with child overweight outcomes.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Immunology
Nigel Curtis, ChatGPT
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Pediatrics
Paul Gee, David Burgner, Waverley Gee, Angela Forbes, Christopher M. A. Frampton, Andrew McCombie
Summary: This study aims to describe the recent epidemiology of Kawasaki disease (KD) in New Zealand (NZ), including incidence, seasonal variation, long-term outcomes, and mortality. Over the study period, there were 1008 children hospitalized for KD, with an increasing annual incidence rate. Asian and Pacific Island ethnicities had the highest incidence, while Maori had a higher mortality rate.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Review
Immunology
Christie C. A. Noble, Nicole L. Messina, Laure F. Pittet, Nigel Curtis
Summary: BCG vaccination has potential off-target effects on nonmycobacterial infections. Trials investigating the off-target protection of BCG against COVID-19 have shown conflicting results, likely due to differences in participant characteristics, BCG vaccination variables, outcome measures, and follow-up durations. Controlling these factors will be crucial in designing future trials and intervention strategies to fully exploit the off-target effects of BCG.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Pediatrics
Cassandra Cardenas-Brown, Ryan D. Lucas, Jim Buttery, Philip N. Britton, Nicholas Wood, Davinder Singh-Grewal, David Burgner
Summary: Australian and New Zealand guidelines recommend postponing live vaccines for 11 months after treatment of Kawasaki disease (KD) with intravenous immunoglobulin (IVIG). This study aimed to assess the adherence to guidelines regarding live-vaccine administration after KD treatment and found that the majority of Australian children treated for KD with IVIG may not be optimally protected by MMRV vaccination.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Cindy Pham, Sarah Thomson, Sung-Tong Chin, Peter Vuillermin, Martin O'Hely, David Burgner, Samuel Tanner, Richard Saffery, Toby Mansell, Sze Bong, Elaine Holmes, Peter D. Sly, Nicola Gray, Anne-Louise Ponsonby, Barwon Infant Study Invest Grp
Summary: Childhood mental disorders are becoming increasingly common, and higher maternal oxidative stress during pregnancy is linked to these disorders. Social and prenatal environmental factors contribute to maternal oxidative stress and childhood mental disorders. Future studies are needed to further understand the role of early-life oxidant damage in childhood mental disorders.
MOLECULAR PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Angela Yu, Maria A. C. Jansen, Geertje W. Dalmeijer, Patricia Bruijning-Verhagen, Cornelis K. van der Ent, Diederick E. Grobbee, David P. Burgner, Cuno S. P. M. Uiterwaal
Summary: Recent use of antibiotics is associated with adverse vascular phenotypes in early childhood, while non-hospitalized infections are not related to vascular phenotypes.
Article
Immunology
Nicole L. Messina, Susie Germano, Rebecca McElroy, Rajeev Rudraraju, Rhian Bonnici, Laure F. Pittet, Melanie R. Neeland, Suellen Nicholson, Kanta Subbarao, Nigel Curtis
Summary: BCG vaccination has immunomodulatory effects on SARS-CoV-2 and reduces the secretion of cytokines associated with severe COVID-19. In addition, BCG vaccination promotes specific T cell immune responses and activates eosinophils.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2022)
