Article
Biochemistry & Molecular Biology
Lukasz Chrobok, Jagoda Stanislawa Jeczmien-Lazur, Monika Bubka, Kamil Pradel, Aleksandra Klekocinska, Jasmin Daniela Klich, Amalia Ridla Rahim, Jihwan Myung, Mariusz Kepczynski, Marian Henryk Lewandowski
Summary: The study reveals a coordination between the orexin system and the rodent superior colliculus across the day-night cycle, with orexin input predominantly occurring nocturnally and the SC neurons responding to orexin A and exhibiting circadian expression of clock genes.
Letter
Clinical Neurology
Thomas Nyffeler, Brigitte C. Kaufmann, Dario Cazzoli
Summary: This case report details a young, healthy woman with a small abscess in the right superior colliculus.
Article
Neurosciences
Hui Chen, Elise L. Savier, Victor J. DePiero, Jianhua Cang
Summary: Through studying the mouse superior colliculus, it was found that direction-selective neurons are not organized into stereotypical columns, but rather exist in clusters. This phenomenon is not affected by factors such as animal state, SC depth, research technique, and stimulus type, challenging recent reports on region-specific organizations in the mouse SC.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Qingpeng Yu, Hang Fu, Gang Wang, Jiayi Zhang, Biao Yan
Summary: The study found that visual experience can potentiate spontaneous activity in mouse superior colliculus neurons, with feature selectivity for direction and orientation. By stimulating retinal ganglion cells or optogenetically activating parvalbumin neurons, this potentiation can be attenuated or blocked.
NEUROSCIENCE BULLETIN
(2021)
Article
Anatomy & Morphology
Shuang Jiang, Suraj Honnuraiah, Greg J. Stuart
Summary: This study determines the types of cells in the superficial superior colliculus that receive visual input from the primary visual cortex in mice. The results show that all four cell types in the superficial layers of the superior colliculus receive direct input from the primary visual cortex, with wide-field neurons being the most likely to receive this input.
FRONTIERS IN NEUROANATOMY
(2023)
Article
Biology
Ya-tang Li, Markus Meister
Summary: The superior colliculus in the brain is a crucial visual processing station that receives input from various types of retinal ganglion cells. Through recording mouse superficial SC neurons, we identified 24 functional types using an unsupervised clustering algorithm. These types can be grouped into two categories: one that responds similarly to retinal ganglion cells and another with more diverse and specialized stimulus selectivity. Cells of the same functional type tend to cluster together in anatomical space, and the visual representation in the SC has lower dimensionality compared to the retina, suggesting a sifting process along the visual pathway.
Review
Neurosciences
Bonnie Cooper, Robert M. McPeek
Summary: The superior colliculus has long been associated with the control of eye movements, but recent studies suggest it may also be involved in more complex movements such as skeletomotor muscle group coordination and whole-body movement sequences.
ANNUAL REVIEW OF VISION SCIENCE, VOL 7, 2021
(2021)
Review
Neurosciences
Meredith N. Schmehl, Jennifer M. Groh
Summary: Coordination between different sensory systems is crucial for sensory processing, and recent studies have shown that visual-auditory interactions occur in areas of the mammalian brain traditionally considered to be auditory. Visual signals can modulate auditory-evoked activity in the auditory cortex and inferior colliculus, suggesting a role in modifying auditory perception. These findings indicate the presence of undiscovered visual signals in other stages of the auditory pathway as well.
ANNUAL REVIEW OF VISION SCIENCE, VOL 7, 2021
(2021)
Article
Neurosciences
Alessio Fracasso, Antimo Buonocore, Ziad M. Hafed
Summary: Visual neural processing is distributed among various brain areas, exhibiting different functional specializations and spatial representational anisotropies. This study found that humans and monkeys perform better in identifying the orientation of visual stimuli in the upper visual field during peri-saccadic periods, contrary to the expected superiority of the lower visual field. These findings suggest that the peri-saccadic orientation identification performance is influenced by oculomotor rather than visual map spatial anisotropies.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Anna M. Lavezzi, Riffat Mehboob, Francesco Piscioli, Teresa Pusiol
Summary: The aim of this study was to investigate the involvement of the mesencephalic superior colliculus (SC) in the pathogenetic mechanism of SIDS. In-depth neuropathological investigations showed alterations in the laminar arrangement of the SC deep layers in 69% of SIDS cases, but never in the controls. These SC anomalies represent a new step in understanding the pathogenetic process of SIDS.
Article
Biology
Sebastian H. Zahler, David E. Taylor, Joey Y. Wong, Julia M. Adams, Evan H. Feinberg
Summary: The study shows that mice can make sensory-guided gaze shifts involving both eye movements and attempted head movements. The flexibility of mouse gaze shifts is revealed under head-fixed conditions, offering insights into the characteristics of mouse gaze shifts and laying the foundation for studying the coupling between head and eye movements.
Article
Cell Biology
Wen Wen, Yue Wang, Jiawei Zhou, Sheng He, Xinghuai Sun, Hong Liu, Chen Zhao, Peng Zhang
Summary: Abnormal visual experiences early in life, particularly amblyopia, have been found to impact the subcortical visual pathways of the adult human brain. This leads to selective alterations in the parvocellular layers of the lateral geniculate nucleus and corticotectal pathways, providing a neural basis for deficits in visual acuity, ocular motor control, and attention associated with amblyopia.
Article
Engineering, Multidisciplinary
Peikun Qiu, Jianwen Le, Yuanfei Han, Yue Chen, Guangfa Huang, Jianwei Mao, Liming Lei, Weijie Lu
Summary: Superplastic forming is a promising technique for producing complex-shaped components of hard-to-deform titanium matrix composites. The effects of matrix microstructural characteristics and whisker orientation on superplastic deformation behavior were investigated. The results showed that these factors have a significant impact on the deformation behavior.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Neurosciences
Robert A. Marino, Ron Levy, Douglas P. Munoz
Summary: The removal of a fixation point before the appearance of a saccade target affects pre-motor circuits and reduces saccadic reaction time. Neurons in different parts of the SCi exhibit varied activity patterns in response to changes in FP luminance during the warning period, reflecting both goal-driven saccade preparation signals and FP sensory properties.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Computer Science, Artificial Intelligence
Simon Forest, Jean-Charles Quinton, Mathieu Lefort
Summary: The research explores multimodal merging based on imprecise information, introducing a computational model based on dynamic neural fields. It simulates decision dynamics and localization decisions, compared with the traditional Bayesian model, and analyzes the free parameters within the model.
NEURAL COMPUTATION
(2022)
Article
Neurosciences
Mansoureh Sabzalizadeh, Mohammad Reza Afarinesh, Saeed Esmaeili-Mahani, Alireza Farsinejad, Ali Derakhshani, Ehsan Arabzadeh, Vahid Sheibani
Summary: The study investigated the effects of stem cell transplantation in the damaged somatosensory barrel cortex of rats and found that the therapy significantly improved sensory discrimination ability. The expression of neuronal markers was higher in the DPSCs group compared to the control group, while GFAP level was lower in the DPSCs group.
BRAIN RESEARCH BULLETIN
(2021)
Article
Neurosciences
Noorya Yasmin Ahmed, Yadollah Ranjbar-Slamloo, Alice Shaam Al Abed, Lingxiao Gao, Yovina Sontani, Alexandre RCom-H'Cheo-Gauthier, Ehsan Arabzadeh, Nathalie Dehorter
Summary: This study reveals that Er81 is expressed in CINs and its specific ablation leads to prominent changes in their molecular, morphologic, and electrophysiological features, particularly amplifying intrinsic delayed-rectifier and hyperpolarization-activated currents. The expression of Er81 is crucial for normal CIN pause and time-locked responses to sensorimotor inputs in awake mice.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Physiology
Sepideh Ghazvineh, Morteza Salimi, Milad Nazari, Mani Garousi, Farhad Tabasi, Kolsoum Dehdar, Alireza Salimi, Hamidreza Jamaati, Javad Mirnajafi-Zadeh, Ehsan Arabzadeh, Mohammad Reza Raoufy
Summary: The study suggests that reintroducing nasal airflow during mechanical ventilation can significantly improve working memory performance in rats. Air-puffs induced enhanced oscillatory activity in specific brain regions, leading to better cognitive outcomes. This non-invasive brain stimulation approach shows promise in alleviating neurological complications caused by prolonged mechanical ventilation.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2021)
Article
Biology
Goncalo Lopes, Karolina Farrell, Edward A. B. Horrocks, Chi-Yu Lee, Mai M. Morimoto, Tomaso Muzzu, Amalia Papanikolaou, Fabio R. Rodrigues, Thomas Wheatcroft, Stefano Zucca, Samuel G. Solomon, Aman B. Saleem
Summary: BonVision is an easy-to-use open-source software for real-time rendering of closed-loop visual environments, which has been tested on humans and mice and is capable of supporting new experimental designs in other animal models of vision. It benefits from native integration with experimental hardware and enables easy implementation of closed-loop experiments.
Article
Biology
Yuxi Liu, Xian Long, Paul R. Martin, Samuel G. Solomon, Pulin Gong
Summary: Levy walks describe patterns of intermittent motion with variable step sizes, different from global synchronization or regular propagating waves. Levy walk dynamics in the primate cerebral cortex result in localized burst patterns of gamma activity, representing a previously undiscovered mode of brain activity.
COMMUNICATIONS BIOLOGY
(2021)
Article
Neurosciences
Cong Wang, Teri M. Furlong, Peter G. Stratton, Conrad C. Y. Lee, Li Xu, Sam Merlin, Chris Nolan, Ehsan Arabzadeh, Roger Marek, Pankaj Sah
Summary: During recognition memory, coupled theta activity between the hippocampus and medial prefrontal cortex plays a key role in novelty discrimination, with monosynaptic connections identified as crucial for guiding behavior based on recognition memory.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Matthias Fritsche, Samuel G. Solomon, Floris P. de Lange
Summary: Visual processing is influenced by recent stimulus history, and the visual system optimizes encoding by exploiting the temporal statistics of the world. Neurons in the early visual cortex maintain long-term memory traces of individual stimuli, leading to long-term and stimulus-specific adaptation.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biology
Amalia Papanikolaou, Fabio R. Rodrigues, Joanna Holeniewska, Keith G. Phillips, Aman B. Saleem, Samuel G. Solomon
Summary: Alzheimer's disease and other dementias impair neural plasticity. This study investigates the impact of tauopathy on visual cortical plasticity and visually evoked behaviors using a transgenic mouse model. The results reveal that both short- and long-term visual plasticity are disrupted in early stages of tauopathy and further reduced in older animals, and visually evoked behaviors are also affected.
COMMUNICATIONS BIOLOGY
(2022)
Review
Neurosciences
Thomas Wheatcroft, Aman B. Saleem, Samuel G. Solomon
Summary: The superior colliculus (SC) is a highly conserved area in the mammalian midbrain that is involved in the organization and control of behavior. Recent studies in mice have provided anatomical data and experimental evidence to understand the roles of different cells within SC in simple behaviors. The functional organization of SC can be explained by three distinct circuits supporting three classes of simple behaviors- arrest, turning towards, and the triggering of escape or capture.
FRONTIERS IN NEURAL CIRCUITS
(2022)
Article
Neurosciences
Jenny M. Bosten, Ruben Coen-Cagli, Anna Franklin, Samuel G. Solomon, Michael A. Webster
Summary: This article reviews various aspects and issues surrounding the general concept of calibration in visual processing, with a focus on the plasticity within the encoding and representational stages. It suggests unresolved questions and emphasizes the importance of ongoing calibrations in vision.
Article
Multidisciplinary Sciences
Fabio R. Rodrigues, Amalia Papanikolaou, Joanna Holeniewska, Keith G. Phillips, Aman B. Saleem, Samuel G. Solomon
Summary: Neurodegenerative disorders disrupt brain activity and rhythms, and dysfunction of Tau protein is associated with some disorders. This study found that slower brain rhythms are impaired earlier than gamma rhythms in a tauopathy mouse model, suggesting that electrophysiological measurements can track the progression of tauopathic neurodegeneration.
Editorial Material
Neurosciences
Jenny M. Bosten, Ruben Coen-Cagli, Anna Franklin, Samuel G. Solomon, Michael A. Webster
Article
Multidisciplinary Sciences
Matthew F. Tang, Ehsan Kheradpezhouh, Conrad C. Y. Lee, J. Edwin Dickinson, Jason B. Mattingley, Ehsan Arabzadeh
Summary: The response of cortical neurons to sensory stimuli is influenced by past events and expectation of future events. In this study, researchers investigated how expectation affects orientation selectivity in the primary visual cortex of male mice. They found that neurons enhanced their response to unexpected stimuli, both in awake and anaesthetized mice. A computational model was used to show that trial-to-trial variability in neuronal responses was best characterized when adaptation and expectation effects were combined.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Samuel G. Solomon, Hadrien Janbon, Adam Bimson, Thomas Wheatcroft
Summary: Visual stimuli can trigger instinctive approach and avoidance behaviors in mice. Different visual features and locations have different effects on mouse behavior, such as a black disc inducing escape behavior, while a small moving disc eliciting approach and exploration behaviors.
ROYAL SOCIETY OPEN SCIENCE
(2023)
Article
Biochemical Research Methods
Ehsan Kheradpezhouh, Wricha Mishra, Ehsan Arabzadeh
Summary: This protocol allows for simultaneous recording and labeling of single cortical neurons in vivo under local application of a chemical, providing a useful tool to investigate the impact of chemicals on sensory information processing by cortical neurons. Juxtacellular labeling helps identify the cell type and morphology of recorded neurons, demonstrating pharmacological modulations in encoding of sensory stimuli. For full details, refer to Kheradpezhouh et al. (2020).