Enhanced anti-metastatic bioactivity of an IGF-TRAP re-engineered to improve physicochemical properties

Loss of neutrophil polarization in colon carcinoma liver metastases of mice with an inducible, liver-specific IGF-I deficiency

(2018) Roni F. Rayes et al.   Oncotarget

Rapid protein production from stable CHO cell pools using plasmid vector and the cumate gene-switch

(2017) Adeline Poulain et al.   JOURNAL OF BIOTECHNOLOGY

Insulin-Like Growth Factor Bioactivity, Stanniocalcin-2, Pregnancy-Associated Plasma Protein-A, and IGF-Binding Protein-4 in Pleural Fluid and Serum From Patients With Pulmonary Disease

(2017) Ulrick Skipper Espelund et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Toward in vitro-to-in vivo translation of monoclonal antibody pharmacokinetics: Application of a neonatal Fc receptor-mediated transcytosis assay to understand the interplaying clearance mechanisms

(2017) Claudia A. Castro Jaramillo et al.   mAbs

Aberrant bispecific antibody pharmacokinetics linked to liver sinusoidal endothelium clearance mechanism in cynomolgus monkeys

(2016) Amita Datta-Mannan et al.   mAbs

Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain

(2016) Tristan I. Croll et al.   STRUCTURE

The type I insulin-like growth factor regulates the liver stromal response to metastatic colon carcinoma cells

(2016) Maria Celia Fernandez et al.   Oncotarget

Crosstalk between the TNF and IGF pathways enhances NF-κB activation and signaling in cancer cells

(2015) Shun Li et al.   GROWTH HORMONE & IGF RESEARCH

Effect of linker flexibility and length on the functionality of a cytotoxic engineered antibody fragment

(2015) Maximilian Klement et al.   JOURNAL OF BIOTECHNOLOGY

Pharmacokinetic properties of IgG and various Fc fusion proteins in mice

(2015) Felix Unverdorben et al.   mAbs

A novel in vitro assay to predict neonatal Fc receptor-mediated human IgG half-life

(2015) Colby A Souders et al.   mAbs

The IGF-Trap: Novel Inhibitor of Carcinoma Growth and Metastasis

(2015) N. Wang et al.   MOLECULAR CANCER THERAPEUTICS

The dog prostate cancer (DPC-1) model: a reliable tool for molecular imaging of prostate tumors and metastases

(2015) Simone Chevalier et al.   EJNMMI Research

Understanding the Key to Targeting the IGF Axis in Cancer: A Biomarker Assessment

(2015) Kunal Amratlal Lodhia et al.   Frontiers in Oncology

SNP array profiling of mouse cell lines identifies their strains of origin and reveals cross-contamination and widespread aneuploidy

(2014) John P Didion et al.   BMC GENOMICS

Quantification of Binding of IGF-1 to BI 836845, a Candidate Therapeutic Antibody Against IGF-1 and IGF-2, and Effects of This Antibody on IGF-1:IGFBP-3 Complexes In Vitro and in Male C57BL/6 Mice

(2014) Matei Mireuta et al.   ENDOCRINOLOGY

Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms

(2014) Vaheh Oganesyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization and screening of IgG binding to the neonatal Fc receptor

(2014) Tobias Neuber et al.   mAbs

NOTCH Decoys That Selectively Block DLL/NOTCH or JAG/NOTCH Disrupt Angiogenesis by Unique Mechanisms to Inhibit Tumor Growth

(2014) Thaned Kangsamaksin et al.   Cancer Discovery

Targeting the Insulin-like Growth Factor Axis for the Development of Novel Therapeutics in Oncology

(2012) J. Gao et al.   CANCER RESEARCH

The role of the insulin-like growth factor-I receptor in malignancy: An update

(2012) Erica Seccareccia et al.   GROWTH HORMONE & IGF RESEARCH

Characterization of Fc-Fusion Protein Aggregates Derived from Extracellular Domain Disulfide Bond Rearrangements

(2012) James Strand et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Dual IGF-I/II-Neutralizing Antibody MEDI-573 Potently Inhibits IGF Signaling and Tumor Growth

(2011) J. Gao et al.   CANCER RESEARCH

Quantification of the GH/IGF-axis components: Lessons from human studies

(2011) J. Frystyk   DOMESTIC ANIMAL ENDOCRINOLOGY

Monoclonal Antibodies with Identical Fc Sequences Can Bind to FcRn Differentially with Pharmacokinetic Consequences

(2011) W. Wang et al.   DRUG METABOLISM AND DISPOSITION

Potential Relevance of Bell-Shaped and U-Shaped Dose-Responses for the Therapeutic Targeting of Angiogenesis in Cancer

(2010) Andrew R. Reynolds   Dose-Response

Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists

(2010) B. J. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Receptor-Fc fusion therapeutics, traps, and MIMETIBODY™ technology

(2009) Chichi Huang   CURRENT OPINION IN BIOTECHNOLOGY

Autologous Bone Marrow Stromal Cells Genetically Engineered to Secrete an IGF-I Receptor Decoy Prevent the Growth of Liver Metastases

(2009) Ni Wang et al.   MOLECULAR THERAPY

Pharmacology of the Novel Antiangiogenic Peptide ATN-161 (Ac-PHSCN-NH2): Observation of a U-Shaped Dose-Response Curve in Several Preclinical Models of Angiogenesis and Tumor Growth

(2008) F. Donate et al.   CLINICAL CANCER RESEARCH