Alpha-tubulin acetyltransferase/MEC-17 regulates cancer cell migration and invasion through epithelial–mesenchymal transition suppression and cell polarity disruption

Loss of α-Tubulin Acetylation Is Associated with TGF-β-induced Epithelial-Mesenchymal Transition

(2016) Shuchen Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Tubulin Acetylation Elevated in Metastatic and Basal-like Breast Cancer Cells Promotes Microtentacle Formation, Adhesion, and Invasive Migration

(2014) A. E. Boggs et al.   CANCER RESEARCH

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Spatial control of Cdc42 signalling by a GM130–RasGRF complex regulates polarity and tumorigenesis

(2014) Francesco Baschieri et al.   Nature Communications

Loss of MEC-17 Leads to Microtubule Instability and Axonal Degeneration

(2014) Brent Neumann et al.   Cell Reports

Mice Lacking α-Tubulin Acetyltransferase 1 Are Viable but Display α-Tubulin Acetylation Deficiency and Dentate Gyrus Distortion

(2013) Go-Woon Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development and therapeutic impact of HDAC6-selective inhibitors

(2012) Sabrina Dallavalle et al.   BIOCHEMICAL PHARMACOLOGY

Cdc42 Activity Regulates Hematopoietic Stem Cell Aging and Rejuvenation

(2012) Maria Carolina Florian et al.   Cell Stem Cell

Genetically Separable Functions of the MEC-17 Tubulin Acetyltransferase Affect Microtubule Organization

(2012) Irini Topalidou et al.   CURRENT BIOLOGY

ATAT1/MEC-17 acetyltransferase and HDAC6 deacetylase control a balance of acetylation of alpha-tubulin and cortactin and regulate MT1-MMP trafficking and breast tumor cell invasion

(2012) Antonio Castro-Castro et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

ARHGAP21 Protein, a New Partner of α-Tubulin Involved in Cell-Cell Adhesion Formation and Essential for Epithelial-Mesenchymal Transition

(2012) Karin S. A. Barcellos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MEC-17 Deficiency Leads to Reduced  -Tubulin Acetylation and Impaired Migration of Cortical Neurons

(2012) L. Li et al.   JOURNAL OF NEUROSCIENCE

RAC1 activation mediates Twist1-induced cancer cell migration

(2012) Wen-Hao Yang et al.   NATURE CELL BIOLOGY

Cdc42 negatively regulates intrinsic migration of highly aggressive breast cancer cells

(2011) Yufeng Zuo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pseudopodial Actin Dynamics Control Epithelial-Mesenchymal Transition in Metastatic Cancer Cells

(2010) Jay Shankar et al.   CANCER RESEARCH

Nonhistone protein acetylation as cancer therapy targets

(2010) Brahma N Singh et al.   Expert Review of Anticancer Therapy

Post-translational modifications of microtubules

(2010) D. Wloga et al.   JOURNAL OF CELL SCIENCE

MEC-17 is an α-tubulin acetyltransferase

(2010) Jyothi S. Akella et al.   NATURE

Tubulin acetyltransferase discovered: Ciliary role in the ancestral eukaryote expanded to neurons in metazoans

(2010) M. R. Leroux   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The major  -tubulin K40 acetyltransferase  TAT1 promotes rapid ciliogenesis and efficient mechanosensation

(2010) T. Shida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cdc42 Regulates Microtubule-Dependent Golgi Positioning

(2010) Heidi Hehnly et al.   TRAFFIC

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Histone modifying enzymes: Structures, mechanisms, and specificities

(2008) Ronen Marmorstein et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The Cytoplasmic Deacetylase HDAC6 Is Required for Efficient Oncogenic Tumorigenesis

(2008) Y.-S. Lee et al.   CANCER RESEARCH

Requirement of HDAC6 for Transforming Growth Factor-β1-induced Epithelial-Mesenchymal Transition

(2008) Bin Shan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polarity proteins in migration and invasion

(2008) S Etienne-Manneville   ONCOGENE

Transcriptional regulation of cell polarity in EMT and cancer

(2008) G Moreno-Bueno et al.   ONCOGENE

Regulation of Actin Assembly Associated With Protrusion and Adhesion in Cell Migration

(2008) Christophe Le Clainche et al.   PHYSIOLOGICAL REVIEWS