The ALS-inducing factors, TDP43A315T and SOD1G93A, directly affect and sensitize sensory neurons to stress

Cytoskeleton dynamics in axon regeneration

(2018) Oriane Blanquie et al.   CURRENT OPINION IN NEUROBIOLOGY

ALS Genes in the Genomic Era and their Implications for FTD

(2018) Hung Phuoc Nguyen et al.   TRENDS IN GENETICS

Changes in the Excitability of Neocortical Neurons in a Mouse Model of Amyotrophic Lateral Sclerosis Are Not Specific to Corticospinal Neurons and Are Modulated by Advancing Disease

(2017) Juhyun Kim et al.   JOURNAL OF NEUROSCIENCE

TDP-43 and Cytoskeletal Proteins in ALS

(2017) Moritz Oberstadt et al.   MOLECULAR NEUROBIOLOGY

Sensory neuropathy in progressive motor neuronopathy (pmn) mice is associated with defects in microtubule polymerization and axonal transport

(2016) Michael K. Schäfer et al.   BRAIN PATHOLOGY

Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis

(2016) Akshata A. Almad et al.   GLIA

ALS mouse model SOD1G93Adisplays early pathology of sensory small fibers associated to accumulation of a neurotoxic splice variant of peripherin

(2016) Jenny Sassone et al.   HUMAN MOLECULAR GENETICS

Reduced stress granule formation and cell death in fibroblasts with the A382T mutation of TARDBP gene: evidence for loss of TDP-43 nuclear function

(2016) Sandro Orrù et al.   HUMAN MOLECULAR GENETICS

Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease

(2016) Daniel Fil et al.   HUMAN MOLECULAR GENETICS

Familial Amyotrophic Lateral Sclerosis-linked Mutations inProfilin 1Exacerbate TDP-43-induced Degeneration in the Retina ofDrosophila melanogasterthrough an Increase in the Cytoplasmic Localization of TDP-43

(2016) Koji Matsukawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Profilin 1 mutants form aggregates that induce accumulation of prion-like TDP-43

(2016) Yoshinori Tanaka et al.   Prion

Mutant PFN1 causes ALS phenotypes and progressive motor neuron degeneration in mice by a gain of toxicity

(2016) Chunxing Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Dynamics Decrease Prior to Axon Degeneration Induced by Vincristine and are Partially Rescued by Overexpressed cytNmnat1

(2016) Gregory W. Berbusse et al.   Frontiers in Cellular Neuroscience

Overexpression of ATF3 or the combination of ATF3, c-Jun, STAT3 and Smad1 promotes regeneration of the central axon branch of sensory neurons but without synergistic effects

(2015) Nitish D. Fagoe et al.   HUMAN MOLECULAR GENETICS

TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets

(2015) Emma L. Scotter et al.   Neurotherapeutics

Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS

(2015) Shuying Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frontotemporal dementia: a bridge between dementia and neuromuscular disease

(2014) Adeline S.L. Ng et al.   Annals of the New York Academy of Sciences

Glial cells in amyotrophic lateral sclerosis

(2014) T. Philips et al.   EXPERIMENTAL NEUROLOGY

Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice

(2014) Sarah Herdewyn et al.   Molecular Neurodegeneration

Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations

(2014) Nael H. Alami et al.   NEURON

ATF3 expression improves motor function in the ALS mouse model by promoting motor neuron survival and retaining muscle innervation

(2014) R. Seijffers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accumulation of Misfolded SOD1 in Dorsal Root Ganglion Degenerating Proprioceptive Sensory Neurons of Transgenic Mice with Amyotrophic Lateral Sclerosis

(2014) Javier Sábado et al.   Biomed Research International

Etv1 Inactivation Reveals Proprioceptor Subclasses that Reflect the Level of NT3 Expression in Muscle Targets

(2013) Joriene C. de Nooij et al.   NEURON

TDP-43 aggregation in neurodegeneration: Are stress granules the key?

(2012) Colleen M. Dewey et al.   BRAIN RESEARCH

SMN Is Required for Sensory-Motor Circuit Function in Drosophila

(2012) Wendy L. Imlach et al.   CELL

Alterations in the motor neuron-renshaw cell circuit in theSod1G93Amouse model

(2012) Hanna Wootz et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Motor Circuits in Action: Specification, Connectivity, and Function

(2012) Silvia Arber   NEURON

Axonal transport deficits and degeneration can evolve independently in mouse models of amyotrophic lateral sclerosis

(2012) P. Marinkovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

(2011) Amanda M Haidet-Phillips et al.   NATURE BIOTECHNOLOGY

Clinical diagnosis and management of amyotrophic lateral sclerosis

(2011) Orla Hardiman et al.   Nature Reviews Neurology

Early Functional Impairment of Sensory-Motor Connectivity in a Mouse Model of Spinal Muscular Atrophy

(2011) George Z. Mentis et al.   NEURON

Proportional neuronal loss between the primary motor and sensory cortex in amyotrophic lateral sclerosis

(2011) Yoko Mochizuki et al.   NEUROSCIENCE LETTERS

Current hypotheses for the underlying biology of amyotrophic lateral sclerosis

(2010) Jeffrey D. Rothstein   ANNALS OF NEUROLOGY

Effects of ALS-related SOD1 mutants on dynein- and KIF5-mediated retrograde and anterograde axonal transport

(2010) Ping Shi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The unfolded protein response in familial amyotrophic lateral sclerosis

(2010) L. Wang et al.   HUMAN MOLECULAR GENETICS

The “Dying-Back” Phenomenon of Motor Neurons in ALS

(2010) Michal Dadon-Nachum et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Mechanisms of Axonal Spheroid Formation in Central Nervous System Wallerian Degeneration

(2010) Bogdan Beirowski et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Deficits in axonal transport precede ALS symptoms in vivo

(2010) L. G. Bilsland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensory involvement in the SOD1-G93A mouse model of amyotrophic lateral sclerosis

(2009) Yan-Su Guo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

(2009) I. Wegorzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-Cell-Autonomous Effect of Human SOD1G37R Astrocytes on Motor Neurons Derived from Human Embryonic Stem Cells

(2008) Maria C.N. Marchetto et al.   Cell Stem Cell

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

(2008) Edor Kabashi et al.   NATURE GENETICS