Understanding the Thalidomide Chirality in Biological Processes by the Self-disproportionation of Enantiomers

The self-disproportionation of enantiomers (SDE): a menace or an opportunity?

(2018) Jianlin Han et al.   Chemical Science

Biological evaluation of both enantiomers of fluoro-thalidomide using human myeloma cell line H929 and others

(2017) Etsuko Tokunaga et al.   PLoS One

Cereblon and its downstream substrates as molecular targets of immunomodulatory drugs

(2016) Takumi Ito et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Another action of a thalidomide derivative

(2015) Takumi Ito et al.   NATURE

Self-disproportionation of enantiomers of thalidomide and its fluorinated analogue via gravity-driven achiral chromatography: mechanistic rationale and implications

(2015) Mayaka Maeno et al.   Chemical Science

Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs

(2014) Philip P Chamberlain et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Optical Purifications via Self-Disproportionation of Enantiomers by Achiral Chromatography: Case Study of a Series of α-CF3-containing Secondary Alcohols

(2013) Alexander E. Sorochinsky et al.   CHIRALITY

Self-disproportionation of enantiomers via achiral chromatography: a warning and an extra dimension in optical purifications

(2012) Vadim A. Soloshonok et al.   CHEMICAL SOCIETY REVIEWS

Shedding light on an old mystery: Thalidomide suppresses survival pathways to induce limb defects

(2011) Jürgen Knobloch et al.   CELL CYCLE

Teratogenic effects of thalidomide: molecular mechanisms

(2011) Takumi Ito et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Fluorothalidomide: A Characterization of Maternal and Developmental Toxicity in Rabbits and Mice

(2011) Crystal J. J. Lee et al.   TOXICOLOGICAL SCIENCES

Synthesis and Configurational Stability of (S)- and (R)-Deuteriothalidomides

(2010) Takeshi Yamamoto et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Asymmetric Synthesis of Both Mirror Images of 3′-Fluorothalidomide by Enantiodivergent Fluorination Using a Single, Cinchona Alkaloid

(2010) Takeshi Yamamoto et al.   ORGANIC LETTERS

Evaluation of stability difference between asymmetric homochiral dimer in (S)-thalidomide crystal and symmetric heterochiral dimer in (RS)-thalidomide crystal

(2010) Toshiya Suzuki et al.   PHASE TRANSITIONS

Identification of a Primary Target of Thalidomide Teratogenicity

(2010) T. Ito et al.   SCIENCE

Rational application of self-disproportionation of enantiomers via sublimation—a novel methodological dimension for enantiomeric purifications

(2010) Hisanori Ueki et al.   TETRAHEDRON-ASYMMETRY

Synthesis, configurational stability and stereochemical biological evaluations of (S)- and (R)-5-hydroxythalidomides

(2009) Takeshi Yamamoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and Synthesis of Thalidomide–Deoxyribonucleoside Chimeras

(2009) Shigeru Suzuki et al.   CHEMISTRY LETTERS

Thalidomide as a Multi-Template for Development of Biologically Active Compounds

(2008) Yuichi Hashimoto   ARCHIV DER PHARMAZIE

Enzymatic resolution and evaluation of enantiomers of cis-5′-hydroxythalidomide

(2008) Takeshi Yamamoto et al.   ORGANIC & BIOMOLECULAR CHEMISTRY