Editorial Material
Oncology
Sean Harrop, Neha Mehta-Shah, Criselle Dsouza, Ella Thompson, Anand Deva, Henry Miles Prince
Summary: BIA-ALCL is a rare subtype of anaplastic large-cell lymphoma associated with breast prostheses. Most patients present with a localised periprosthetic effusion and are managed with removal of the implant and surrounding capsule. Recent research has provided insights into the genomic landscape of BIA-ALCL, highlighting constitutive JAK/STAT pathway activation as a key component.
Review
Oncology
Yichen Wang, Qi Zhang, Yufang Tan, Wenchang Lv, Chongru Zhao, Mingchen Xiong, Kai Hou, Min Wu, Yuping Ren, Ning Zeng, Yiping Wu
Summary: This article provides a review on the etiology, pathogenesis, diagnosis, and therapy of breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL). It also reviews the physical characteristics of breast implants and their potential pathogenic effect, aiming to provide a foundation for the optimal choice of implants with minimal morbidity.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
I. Garces de los Fayos Alonso, L. Zujo, I Wiest, P. Kodajova, G. Timelthaler, S. Edtmayer, M. Zrimsek, S. Kollmann, C. Giordano, M. Kothmayer, H. A. Neubauer, S. Dey, M. Schlederer, B. S. Schmalzbauer, T. Limberger, C. Probst, O. Pusch, S. Hogler, S. Tangermann, O. Merkel, A. Schiefer, C. Kornauth, N. Prutsch, M. Zimmerman, B. Abraham, J. Anagnostopoulos, L. Quintanilla-Martinez, S. Mathas, P. Wolf, D. Stoiber, P. B. Staber, G. Egger, W. Klapper, W. Woessmann, T. A. Look, P. Gunning, S. D. Turner, R. Moriggl, S. Lagger, L. Kenner
Summary: This study reveals the important role of PDGFRβ in aggressive ALCL and its activation of STAT5 in inducing cell growth and survival-related gene expression. Simultaneous deletion of STAT5 gene products significantly impairs cell viability. Additionally, blockade of PDGFRβ and STAT3/5 activity effectively obstructs tumor development. Thus, PDGFRβ and PDGFRβ-STAT3/5 signaling may serve as novel targets for the treatment of aggressive ALCL.
Review
Surgery
Ryan C. DeCoster, Evan B. Lynch, Alisha R. Bonaroti, John Matthew Webster, Timothy A. Butterfield, Bernard Mark Evers, Henry C. Vasconez, Mark W. Clemens
Summary: This evidence-based systematic review critically evaluates current clinical recommendations and advances in diagnosis and treatment of BIA-ALCL, aiming to raise awareness among physicians from various specialties.
Article
Surgery
Ryan C. DeCoster, Mark W. Clemens, Arianna Di Napoli, Evan B. Lynch, Alisha R. Bonaroti, Brian D. Rinker, Timothy A. Butterfield, Henry C. Vasconez
Summary: BIA-ALCL is an emerging and highly treatable cancer associated with textured-surface breast implants. The underlying cause is not fully understood, but mechanisms such as chronic inflammation and genetic susceptibility have been proposed. The JAK-STAT3 pathway is believed to play a key role in BIA-ALCL tumorigenesis and progression, offering potential avenues for prognostic indicators and therapeutic targets in advanced disease.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Surgery
Sarah E. Tevis, Kelly K. Hunt, Roberto N. Miranda, Caitlin Lange, Chelsea C. Pinnix, Swaminathan Iyer, Charles E. Butler, Mark W. Clemens
Summary: This study evaluated breast implant ALCL patients in a prospective manner and reported their presentation, clinical course, treatment, and outcomes. The majority of patients presented with delayed seroma and most had Stage IA disease. Patient outcomes were excellent with a low recurrence rate and high complete remission rate.
Article
Surgery
Anne K. Groth, Mark W. Clemens, Ruth Graf, Ana P. Sebastiao, Ana P. Azambuja, Maria H. Louveira, Linei A. B. D. Urban, Bernardo N. Batista
Summary: This study found that awareness of breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) remains low in Brazil compared to other regions, and there may be many cases that go undiagnosed. Lack of preoperative diagnostic testing compromises disease treatment and oncologic outcomes.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Review
Oncology
Shaikha Alotaibi, Mehdi Hamadani, Mubarak Al-Mansour, Mahmoud Aljurf
Summary: BIA-ALCL is a rare lymphoproliferative disorder associated with textured implants, with unclear pathogenesis requiring further research. Proper evaluation for diagnosis confirmation is necessary, and treatment approaches vary depending on the disease severity.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2021)
Review
Oncology
Martina Vittorietti, Sergio Mazzola, Claudio Costantino, Daniele Domenico De Bella, Santo Fruscione, Nicole Bonaccorso, Martina Sciortino, Davide Costanza, Miriam Belluzzo, Alessandra Savatteri, Fabio Tramuto, Paolo Contiero, Giovanna Tagliabue, Palmira Immordino, Francesco Vitale, Arianna Di Napoli, Walter Mazzucco
Summary: This study investigated the main characteristics of breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) and the factors predicting BIA-ALCL onset in patients with and without an implant replacement. The findings suggest that implant substitution and/or capsulectomy may delay the onset of the disease, but there is a risk of earlier reoccurrence in these patients. Additionally, the time to BIA-ALCL onset slightly increases with age.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Milena Rondon-Lagos, Nelson Rangel, Gloria Camargo-Villalba, Maribel Forero-Castro
Summary: Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare form of cancer that can develop around breast implants, with its cellular and molecular causes not being fully understood. There has been an increase in the number of women diagnosed with anaplastic large cell lymphoma with breast implants in recent years.
Article
Oncology
Rachel L. O'Connell, Bhupinder Sharma, Dima El-Sharkawi, Andrew Wotherspoon, Ayoma D. Attygalle, Fiona MacNeill, Aadil A. Khan, Marios-Konstantinos Tasoulis
Summary: This study aimed to assess the longer-term oncological outcomes of patients receiving multidisciplinary treatment for breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). The study found that surgical management is sufficient in early-stage disease and is associated with excellent oncological outcomes. This provides reassuring information for patients when discussing the risk of recurrence.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Anna Rotili, Federica Ferrari, Luca Nicosia, Filippo Pesapane, Valentina Tabanelli, Stefano Fiori, Anna Vanazzi, Lorenza Meneghetti, Francesca Abbate, Antuono Latronico, Enrico Cassano
Summary: BIA-ALCL is a rare subtype of T cell Non-Hodgkin Lymphoma associated with breast implants, generally localized and effectively treated with capsulectomy. Some patients may present with aggressive mass-forming subtype requiring systemic therapy.
BRITISH JOURNAL OF RADIOLOGY
(2021)
Article
Oncology
Sonia Cappelli, Francesco Marchesi, Marco Clementi, Letizia Perracchio, Francesca Palombi, Fabio Pelle, Claudio Botti, Maurizio Costantini
Summary: Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare T-cell lymphoma associated with textured breast implants. It can present as periprosthetic seroma or locally advanced mass-formed disease with lymph node involvement. A multidisciplinary approach is required for worse prognosis cases, including chemotherapy, radiation therapy, and surgery. This case report demonstrates the effectiveness of neoadjuvant chemotherapy as part of a reverse strategy in selected cases of advanced-stage BIA-ALCL, allowing for less demolitive surgery and good outcomes.
FRONTIERS IN ONCOLOGY
(2023)
Article
Surgery
Aishu Ramamurthi, Harsh Patel, Dhivya R. Srinivasa
Summary: The study examines the sources and credibility of online health information using Google Trends analysis. The results indicate that news platforms have higher visibility among the public compared to official announcements from regulatory agencies. This highlights limitations in the public's access to credible information. The study suggests that tools like Google Trends can be used to strategically disseminate important medical announcements to the public.
AESTHETIC PLASTIC SURGERY
(2022)
Review
Oncology
Neha Mehta-Shah, Paola Ghione
Summary: Breast implant-associated anaplastic large cell lymphoma is a rare subtype of T-cell non-Hodgkin lymphoma that usually occurs around breast implants. Most patients can be cured with surgery alone, but treatment for more advanced cases remains challenging due to its rarity and limited data.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2022)