Review
Pharmacology & Pharmacy
Zeqing Wang, Zhikai Jiang, Ruijie Lu, Longfa Kou, Ying-Zheng Zhao, Qing Yao
Summary: Islet transplantation is a minimally invasive surgery that involves the transfusion of healthy islet cells into diabetic recipients to achieve insulin independence. However, poor oxygenation post-transplantation can lead to islet loss and dysfunction. This study reviews potential formulation strategies for providing oxygen-release to transplanted islets.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Materials Science, Multidisciplinary
Amir Erfani, Antonio E. Diaz, Patrick S. Doyle
Summary: Over the past decade, immunotherapy interventions have revolutionized oncology and autoimmune disease fields. Researchers are developing new platforms for immunotherapy that go beyond intravenous delivery strategies. Recent advances include using chemokines to direct immune cells, alternative therapies, and oncolytic viruses. Hydrogel-based materials show promise for diverse biomedical applications, including large molecule drug delivery. Local hydrogel delivery is a promising approach to increase the efficacy and decrease toxicities of immunotherapies. Challenges remain in the translation of hydrogels to the clinic and manufacturing.
Review
Chemistry, Multidisciplinary
Xiaojun Yu, Haitao Ma, Guiying Xu, Zhuang Liu
Summary: Radiotherapy is an important therapeutic approach for tumors, but it often causes organ toxicity and has limited ability to control tumor metastases. The combination of biomaterials and nanomedicine with radiotherapy has received increasing attention to enhance its efficacy, sensitizing tumors and boosting antitumor immune responses.
CHINESE CHEMICAL LETTERS
(2022)
Article
Oncology
Julien Balzeau, Anindita Ravindran, Xin Wang, Jinal Maisuria, Anna Lucchesi, Hui Yao, Satoko Matsueda
Summary: Tumor infiltrating lymphocytes (TIL) have shown efficacy in treating various solid cancers. However, most clinical trials exclude patients who have received systemic therapy before tumor tissue resection. In this study, we investigated whether patients who underwent chemotherapy prior to surgery can still benefit from TIL therapy. We found that TILs from tumor tissues can be successfully expanded ex vivo regardless of prior chemotherapy, suggesting that patients with recent chemotherapy history can be recruited for TIL therapy trials.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Review
Chemistry, Multidisciplinary
Christina M. Tringides, David J. Mooney
Summary: Surface electrode arrays are mainly made of rigid or elastic materials and ductile metal films, offering limited stretchability. They are often repurposed for different tissues without optimizing the materials and mechanical properties for the specific application. To improve tissue interfaces and reduce damage, it is important to characterize the biological environment and design technology accordingly for each specific organ.
ADVANCED MATERIALS
(2022)
Article
Multidisciplinary Sciences
Chun-Yang Lee, Gar-Yang Chau, Cheng-Yi Wei, Yee Chao, Yi-Hsiang Huang, Teh-Ia Huo, Ming-Chih Hou, Yu-Hui Su, Jaw-Ching Wu, Chien-Wei Su
Summary: The study found that surgical resection leads to better prognoses than non-surgical treatments for hepatocellular carcinoma patients with tumor rupture at diagnosis. Additionally, a sequential combination of transarterial chemoembolization (TACE) and surgical resection had similar clinical outcomes to surgical resection alone.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Physical
Ana Carolina Batista Brochado, Victor Hugo de Souza, Joice Correa, Suzana Azevedo dos Anjos, Carlos Fernando de Almeida Barros Mourao, Angelo Cardarelli, Pietro Montemezzi, Vinicius Schott Gameiro, Mariana Rodrigues Pereira, Elena Mavropoulos, Gutemberg Gomes Alves
Summary: This study compared the effects of three different titanium surface treatments on bone cell proliferation and migration, with sandblasting and acid etching surfaces showing higher cell density and migratory capability. The Hydroxyapatite coating surface performed the worst in all analyses.
Article
Medicine, General & Internal
Toshitaka Sugawara, Salvador Rodriguez Franco, Michael J. Kirsch, Kathryn L. Colborn, Jun Ishida, Samuele Grandi, Mohammed H. Al-Musawi, Ana Gleisner, Marco Del Chiaro, Richard D. Schulick
Summary: The study aimed to evaluate the association between surgical resection for small NF-PanNETs measuring 2 cm or smaller and survival. Data from the National Cancer Database were used, and patients diagnosed with NF-pancreatic neuroendocrine neoplasms between January 1, 2004, and December 31, 2017 were included. Surgical resection was associated with longer survival in select patients with NF-PanNETs measuring 1.1 to 2.0 cm who were younger than 65 years, had no comorbidities, received treatment at academic institutions, and had tumors of the distal pancreas.
Review
Biotechnology & Applied Microbiology
Qingrong Dong, Tingyu Xue, Haili Yan, Fang Liu, Ruixue Liu, Kun Zhang, Yu Chong, Jiangfeng Du, Hui Zhang
Summary: This review highlights recent advances in the applications of nano-biomaterials for radiotherapy-activated immunotherapy. It discusses the combination of nano-biomaterials with immune checkpoint inhibitors to enhance tumor immune response, as well as various nano-biomaterials-enabled tumor oxygenation strategies. The review also summarizes the rapid development of immune modulatable nano-biomaterials and discusses the key challenge in their development for tumor radio-immunotherapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Meghan J. O'Melia, Adriana Mulero-Russe, Jihoon Kim, Alyssa Pybus, Deborah DeRyckere, Levi Wood, Douglas K. Graham, Edward Botchwey, Andres J. Garcia, Susan N. Thomas
Summary: Immunotherapy is a powerful anti-cancer therapy, but current preclinical models have limitations. To overcome this, the authors used engineered biomaterials as scaffolds to alter the immune cells within tumors, resulting in improved tumor formation rate, decreased disease latency, and reduced variability of immune infiltrates. These findings highlight the significant role of the local immune microenvironment in immunotherapeutic response.
ADVANCED MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Subhasis Roy, Prasenjit Mukherjee, Pradip Kumar Das, Prabal Ranjan Ghosh, Pradyot Datta, Biswanath Kundu, Samit Kumar Nandi
Summary: Musculoskeletal disorders and bone deficiencies are important human health conditions today, with conventional therapy often being ineffective. Local drug delivery systems offer potential advantages in the management of bone disorders.
MATERIALS TODAY COMMUNICATIONS
(2021)
Review
Polymer Science
Huining Wan, Chenwei Sun, Jieyu Zhang, Xuefeng Hu, Yunbing Wang
Summary: Heart failure is an irreversible disease with a lack of effective treatment options. Functional hydrogels in cardiac tissue engineering show promise in preserving cardiac function and slowing down the progression of heart failure. However, research on this treatment method is limited.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Oncology
Alan R. Tang, Silky Chotai, Candace J. Grisham, Bradley S. Guidry, Jake R. McDermott, Chi H. Le, Peter J. Morone, Reid C. Thompson, Lola B. Chambless
Summary: Cystic meningiomas, a rare type of intracranial meningiomas, have similar characteristics and outcomes compared to solid meningiomas. They are predominantly WHO grade I and have a low proliferation index. Cysts in meningiomas may not be indicative of aggressive behavior.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Oncology
Aobo Zhuang, Weiqi Lu, Yuan Fang, Lijie Ma, Jing Xu, Jiongyuan Wang, Hanxing Tong, Yong Zhang
Summary: This study identified prognostic factors for FLR-RPS patients and developed predictive models in the Asian population, providing significant aid in treatment and prediction of survival and disease recurrence.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
M. S. Bhandare, A. Mondal, V Chaudhari, M. Bal, S. Yadav, A. Ramaswamy, V Ostwal, N. Shetty, S. Shrikhande
Summary: This study revealed that recurrence of periampullary cancer after pancreatoduodenectomy is common, with different patterns and survival rates between local recurrence and distant metastasis. Factors influencing recurrence mainly include tumor subtype, lymph node positivity, and presence of perineural invasion.
BRITISH JOURNAL OF SURGERY
(2021)
