Article
Biochemistry & Molecular Biology
Haripriya Gupta, Byeong-Hyun Min, Raja Ganesan, Yoseph Asmelash Gebru, Satya Priya Sharma, Eunju Park, Sung-Min Won, Jin-Ju Jeong, Su-Been Lee, Min-Gi Cha, Goo-Hyun Kwon, Min-Kyo Jeong, Ji-Ye Hyun, Jung-A Eom, Hee-Jin Park, Sang-Jun Yoon, Mi-Ran Choi, Dong-Joon Kim, Ki-Tae Suk
Summary: Non-alcoholic fatty liver disease (NAFLD) is a significant health threat globally and has attracted attention in the field of liver diseases. It comprises various fatty degenerative disorders in the liver, with complex and multifactor-driven pathophysiology. In addition to viruses, metabolic syndrome, and alcohol, evidence suggests that the microbiome is also associated with the development and progression of NAFLD.
Article
Nutrition & Dietetics
Mattia Coronati, Francesco Baratta, Daniele Pastori, Domenico Ferro, Francesco Angelico, Maria Del Ben
Summary: Studies have found that fructose added to foods via high fructose corn syrup and sucrose could contribute to the onset and progression of NAFLD and MetS. Fructose affects liver function through multiple pathways, including inducing de novo lipogenesis, triggering endoplasmic reticulum stress and liver inflammation, reducing fatty acids oxidation, and increasing intestinal permeability. In addition, fructose intake is also associated with weight gain and hypertension.
Article
Nutrition & Dietetics
Karolina Drozdz, Katarzyna Nabrdalik, Weronika Hajzler, Hanna Kwiendacz, Janusz Gumprecht, Gregory Y. H. Lip
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common condition associated with type 2 diabetes (T2DM) and cardiovascular disease (CVD). The new term metabolic-associated fatty liver disease (MAFLD) highlights the bidirectional relationships between NAFLD, T2DM, and CVD. Lifestyle changes and targeting the gut microbiota may be important for NAFLD treatment.
Review
Nutrition & Dietetics
Qi Zhang, Wenmin Xing, Qiao Wang, Zhan Tang, Yazhen Wang, Wenyan Gao
Summary: The increasing prevalence of non-alcoholic fatty liver disease (NAFLD) has become a significant healthcare burden worldwide. Recent investigations have shown that the gut microbiota plays a crucial role in the progression of NAFLD through the gut-liver axis or gut-brain-liver axis. The composition of the microbiota can be influenced by various factors, including dietary style, nutritional supplements, or exercise. Additionally, microbiota metabolites can impact mitochondrial function and inflammatory response, which are important factors in NAFLD.
FRONTIERS IN NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Roberta Forlano, Benjamin H. Mullish, Lauren A. Roberts, Mark R. Thursz, Pinelopi Manousou
Summary: Non-alcoholic fatty liver disease (NAFLD) is an increasing cause of liver disease worldwide, mirroring the epidemics of obesity and metabolic syndrome. There is an increasing body of evidence showing a crucial role of the crosstalk between the gut and the liver in the development and progression of NAFLD. Gut permeability is an important factor associated with the development of NAFLD, type-2 diabetes, and obesity, and may be a potential therapeutic target for NAFLD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Wan-Li Cheng, Shao-Jung Li, Ting- Lee, Ting-Wei Lee, Cheng-Chih Chung, Yu-Hsun Kao, Yi-Jen Chen
Summary: Chronic intake of fructose may contribute to metabolic diseases and cardiac inflammation, with recent findings highlighting the significant role of the small intestine in fructose metabolism. Overconsumption of fructose leads to dysbiosis of the gut microbiota, increased intestinal permeability, and activation of host inflammation, affecting cardiac health.
Article
Food Science & Technology
Siyu Wei, Jiaojiao Wang, Cheng Wang, Yizhen Wang, Mingliang Jin
Summary: Inulin alleviates obesity and metabolic disorders induced by high fructose through modulating gut microbiota and serum metabolites.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Gastroenterology & Hepatology
Sonja Lang, Anna Martin, Xinlian Zhang, Fedja Farowski, Hilmar Wisplinghoff, Maria J. G. T. Vehreschild, Marcin Krawczyk, Angela Nowag, Anne Kretzschmar, Claus Scholz, Philipp Kasper, Christoph Roderburg, Raphael Mohr, Frank Lammert, Frank Tacke, Bernd Schnabl, Tobias Goeser, Hans-Michael Steffen, Muenevver Demir
Summary: The study found that BMI was most strongly associated with histological fibrosis in NAFLD patients, while PNPLA3 gene variants, gut bacterial features, and dietary factors were all associated with different histology features.
LIVER INTERNATIONAL
(2021)
Article
Cell Biology
Daixi Jiang, Jianbin Zhang, Shuangzhe Lin, Yuqin Wang, Yuanwen Chen, Jiangao Fan
Summary: The gut-liver axis plays a role in NAFLD, and PREP disruption can modulate gut microbiota composition and reduce inflammation in the liver. Additionally, PREP disruption may have a therapeutic potential in targeting hepatic mechanisms related to liver, gut, and microbiota during NAFLD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Microbiology
Yiming Ni, Mengna Lu, Yuan Xu, Qixue Wang, Xinyi Gu, Ying Li, Tongxi Zhuang, Chenyi Xia, Ting Zhang, Xiao-jun Gou, Mingmei Zhou
Summary: Non-alcoholic fatty liver disease (NAFLD) is a growing global health problem with suboptimal treatments. Bile acids and gut microbiota play crucial roles in the pathogenesis of NAFLD, and investigating these factors may aid in the development of novel drugs.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Lanfeng Xue, Zhiliang Deng, Wenhui Luo, Xingxiang He, Yu Chen
Summary: Fecal microbiota transplantation (FMT) can attenuate fat accumulation in patients with non-alcoholic fatty liver disease (NAFLD) by improving gut microbiota dysbiosis. Significant differences in clinical features and gut microbiota were observed between lean and obese NAFLD patients, with FMT showing better effects in lean NAFLD patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hsiu-Chen Huang, Chiung-Ju Chen, Yu-Heng Lai, Yu-Chun Lin, Wei-Chung Chiou, Hsu-Feng Lu, Ying-Fang Chen, Yu-Hsin Chen, Cheng Huang
Summary: Momordica cochinchinensis aril (MCA) has preventive effects on obesity, non-alcoholic fatty liver disease, and insulin resistance induced by high-fat diet. MCA inhibits adipose tissue expansion and hepatic fat accumulation, regulates gut microbiota composition, and activates the AMPK and PPAR-alpha signaling pathways. These mechanisms contribute to the prevention of fat-induced metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Microbiology
Zhonglin Li, Hang Yuan, Huikuan Chu, Ling Yang
Summary: In recent years, the role of gut microbiota in the pathogenesis of NAFLD has been increasingly recognized. Intestinal bacteria regulate bile acid metabolism through various reactions, affecting NAFLD development via bile acid receptors such as FXR, TGR5, and VDR. Conversely, the composition of gut microbiota is also influenced by bile acid levels. This review summarizes the mutual regulation between specific bacteria and bile acids in NAFLD, and the latest clinical research based on microbiota and bile acids, which may lead to novel treatment strategies in NAFLD.
Article
Biochemistry & Molecular Biology
Inaki Milton-Laskibar, Amanda Cuevas-Sierra, Maria P. Portillo, J. Alfredo Martinez
Summary: The study demonstrates that resveratrol administration can improve non-alcoholic fatty liver disease through modulating gut microbiota composition. Resveratrol effectively reduces liver weight and serum cholesterol levels while increasing HDL cholesterol levels. It also prevents obesogenic diet-induced liver damage by improving liver steatosis and inflammation. The results of gut microbiota sequencing show a complex relationship between certain bacteria from the Ruminococcaceae family and hepatic markers.
Review
Biochemistry & Molecular Biology
Charlotte Teunis, Max Nieuwdorp, Nordin Hanssen
Summary: The prevalence of non-alcoholic fatty liver disease (NAFLD) and its burden of disease are increasing. NAFLD is associated with cirrhosis and other metabolic conditions such as diabetes, obesity, and atherosclerosis. These cardiometabolic diseases are linked by a state of low-grade inflammation, characterized by elevated levels of cytokines and C-reactive protein. The metabolism of tryptophan, specifically its three main pathways, may be a therapeutic target for reducing the inflammation associated with NAFLD and its related conditions.
Article
Gastroenterology & Hepatology
Ming Song, Dale A. Schuschke, Zhanxiang Zhou, Wei Zhong, Jiayuan Zhang, Xiang Zhang, Yuhua Wang, Craig J. McClain
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2015)
Article
Biochemical Research Methods
Xiaoli Wei, Ming Song, Xinmin Yin, Dale A. Schuschke, Imhoi Koo, Craig J. McClain, Xiang Zhang
JOURNAL OF PROTEOME RESEARCH
(2015)
Article
Toxicology
Banrida Wahlang, Russell A. Prough, K. Cameron Falkner, Josiah E. Hardesty, Ming Song, Heather B. Clair, Barbara J. Clark, J. Christopher States, Gavin E. Arteel, Matthew C. Cave
TOXICOLOGICAL SCIENCES
(2016)
Article
Substance Abuse
Ming Song, Theresa Chen, Russell A. Prough, Matthew C. Cave, Craig J. McClain
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2016)
Article
Substance Abuse
Vatsalya Vatsalya, Ming Song, Melanie L. Schwandt, Matthew C. Cave, Shirish S. Barve, David T. George, Vijay A. Ramchandani, Craig J. McClain
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2016)
Article
Biochemical Research Methods
Imhoi Koo, Seongho Kim, Biyun Shi, Pawel Lorkiewicz, Ming Song, Craig McClain, Xiang Zhang
JOURNAL OF CHROMATOGRAPHY A
(2016)
Article
Gastroenterology & Hepatology
Michael Mendoza, Shelley Caltharp, Ming Song, Lindsay Collin, Juna V. Konomi, Craig J. McClain, Miriam B. Vos
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2017)
Article
Gastroenterology & Hepatology
Ming Song, Xiaohong Li, Xiang Zhang, Hongxue Shi, Miriam B. Vos, Xiaoli Wei, Yuhua Wang, Hong Gao, Eric C. Rouchka, Xinmin Yin, Zhanxiang Zhou, Russell A. Prough, Matthew C. Cave, Craig J. McClain
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2018)
Article
Biochemical Research Methods
Liqing He, Xiaoli Wei, Xipeng Ma, Xinmin Yin, Ming Song, Howard Donninger, Kavitha Yaddanapud, Craig J. McClain, Xiang Zhang
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2019)
Review
Surgery
Guangzhong Xu, Ming Song
Summary: Bariatric and metabolic surgery (BMS) is considered the most effective treatment for obesity, type 2 diabetes, and related complications, with physiological changes in the gastrointestinal tract leading to improvements in overall health outcomes for patients.
SURGERY FOR OBESITY AND RELATED DISEASES
(2021)
Article
Endocrinology & Metabolism
Ming Song, Fang Yuan, Xiaohong Li, Xipeng Ma, Xinmin Yin, Eric C. Rouchka, Xiang Zhang, Zhongbin Deng, Russell A. Prough, Craig J. McClain
Summary: Our study revealed sex differences in gut microbial abundance, activities, and hepatic steatosis in response to dietary copper-fructose interaction in weanling Sprague-Dawley rats. The correlation between sex differences in metabolic phenotypes and alterations of gut microbial activities remains unclear.
BIOLOGY OF SEX DIFFERENCES
(2021)
Editorial Material
Surgery
Ming Song
SURGERY FOR OBESITY AND RELATED DISEASES
(2021)
Letter
Surgery
Ming Song
SURGERY FOR OBESITY AND RELATED DISEASES
(2022)
Article
Chemistry, Analytical
Md Aminul Islam Prodhan, Biyun Shi, Ming Song, Liqing He, Fang Yuan, Xinmin Yin, Patrick Bohman, Craig J. McClain, Xiang Zhang