Article
Pharmacology & Pharmacy
Soumyarwit Manna, Anna M. Donnell, Rafaela Q. Caixeta Faraj, Blanca I. Riemann, Christopher D. Riemann, James J. Augsburger, Zelia M. Correa, Rupak K. Banerjee
Summary: The research demonstrates that chitosan and poly(lactic-co-glycolic) acid-based methotrexate intravitreal micro-implants show promising pharmacokinetics and low toxicity in normal rabbit eyes, maintaining therapeutic concentrations for 56 days. Histopathologic evaluation reveals no signs of toxicity, and the micro-implants remain stationary at their implantation site.
Article
Polymer Science
Amaraporn Wongrakpanich, Nichakan Khunkitchai, Yanisa Achayawat, Jiraphong Suksiriworapong
Summary: This study developed ketorolac microparticles using hyaluronic acid stabilized poly(lactide-co-glycolide) (PLGA), poly(lactide) (PLA), and their blend for osteoarthritis treatment. Different emulsification techniques and polymer compositions influenced the microparticle characteristics, with probe sonication resulting in smaller size and broader size distribution than high-speed stirring. The microparticles showed biphasic drug release over 35 days and demonstrated potential for treating osteoarthritis.
Article
Chemistry, Medicinal
Yusuke Oe, Shinichi Ogino, Masanori Kobayashi, Hiroyuki Kojima, Takayuki Terukina, Takanori Kanazawa, Hiromu Kondo
Summary: This study developed a sustained release testosterone formulation for the treatment of fecal incontinence. The formulation effectively affected both the internal and external anal sphincters with a sufficient safety profile.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Shuaikai Ren, Chunxin Wang, Liang Guo, Congcong Xu, Yan Wang, Changjiao Sun, Haixin Cui, Xiang Zhao
Summary: Microcapsules with uniform size and tailored dimensions were prepared using emulsification and solvent evaporation methods in this study for the construction of controlled-release drug carriers. Morphology and structure of the microcapsules could be tailored by regulating the preparation conditions, and the release rate of protein could be controlled by adjusting the pore size. This controlled-release novel microcapsule carrier system shows great potential for biomedical applications.
Article
Pharmacology & Pharmacy
Majd Alrashdan, Ziad A. Shraideh, Samer R. Abulateefeh
Summary: This study developed a novel injectable long-acting carvedilol-ISFD, which exhibited tunable extended-release behavior by choosing the appropriate grade of polymer. The PLGA-based ISFD formulations demonstrated excellent release behaviors and were able to extend the release of carvedilol over 30 days.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Alessia Romeo, Teresa Musumeci, Claudia Carbone, Angela Bonaccorso, Simona Corvo, Gabriella Lupo, Carmelina Daniela Anfuso, Giovanni Puglisi, Rosario Pignatello
Summary: The study proposes a novel method to improve the bioavailability of ferulic acid through nanoformulations, specifically polymeric nanoparticles. Various tests and analyses demonstrated the potential application of these nanoformulations in ocular drug delivery.
Article
Pharmacology & Pharmacy
Wenting Lin, Tao Xu, Zhongzhi Wang, Jianghan Chen
Summary: The study synthesized AMB-loaded thermogel for the treatment of cryptococcal meningitis, demonstrating its sustained release, reduced neurotoxicity, and improved therapeutic effect compared to traditional AMB solution, indicating the potential of the PLGA-PEG-PLGA thermogel as a biocompatible carrier for intrathecal drug delivery.
Article
Materials Science, Biomaterials
Xin Li, Tristan T. Y. Tan, Qianyu Lin, Chen Chuan Lim, Rubayn Goh, Ken-ichi Otake, Susumu Kitagawa, Xian Jun Loh, Jason Y. C. Lim
Summary: In recent years, there has been increasing interest in multidrug therapy due to its potential for synergistic drug action and sequential drug delivery. However, the combination of metal-organic frameworks (MOFs) with temperature-responsive hydrogels (or thermogels) in composite materials for simultaneous multidrug delivery has received limited attention. In this study, we conducted a systematic investigation of different MOFs embedded within PEG-containing thermogel matrices, and identified that UiO-66 can achieve temporally differentiated yet sustained simultaneous drug release.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Marcin K. Heljak, Wojciech Swieszkowski
Summary: This paper presents a computational model of bevacizumab release from PLGA microspheres administered intravitreally, validated against experimental data, to evaluate anti-VEGF therapies in ocular transport.
Article
Pharmacology & Pharmacy
Raghad M. Abuhamdan, Bayan H. Al-Anati, Yazan Al Thaher, Ziad A. Shraideh, Mahmoud Y. Alkawareek, Samer R. Abulateefeh
Summary: By optimizing the internal phase separation process, aqueous core microcapsules with polymeric shells composed of PLGA or PLA can serve as controlled release platforms for hydrophilic drugs. Varying polymer properties and formulation compositions can dramatically impact the characteristics and release durations of the produced microcapsules. These microcapsules can be tailored for long-acting encapsulation of a variety of hydrophilic drugs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Medicinal
Stijn H. S. Koshari, Xutao Shi, Linda Jiang, Debby Chang, Karthikan Rajagopal, Abraham M. Lenhoff, Norman J. Wagner
Summary: An extensive data set was used to advance the development of a model-informed design of controlled drug release. An improved drug-release model incorporating mechanistic modeling of hydrolytic polymer degradation was used and validated against in vitro experiments. The study demonstrates the potential for achieving a priori design of controlled drug release by combining parameter estimates from the literature with model fits to the data set. The results highlight the importance of careful selection of the polymer grade and the need for better understanding of phenomena like pore formation in designing drug release systems.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Marcin K. Heljak, Wojciech Swieszkowski
Summary: A computational model for the sustained release of bevacizumab from intravitreal poly(lactic-co-glycolic acid) (PLGA) microspheres and its concentration in ocular tissues has been developed. The model showed high accuracy in predicting the release of bevacizumab from different sizes of PLGA microspheres and its concentration in the retina when given in solution.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Materials Science, Multidisciplinary
Gregory Callahan, Austin Veith, Alberto Madariaga, Manuel K. Rausch, Daniel Stromberg, Aaron B. Baker
Summary: In this study, a drug eluting chest tube was developed to reduce the use of systemic opioids in patients after chest tube implantation. The tube was made from a porous polymer loaded with bupivacaine, which was protected during tube insertion and following implantation. The optimized solid casting strategy released high amounts of the drug for at least 14 days.
APPLIED MATERIALS TODAY
(2023)
Article
Polymer Science
Pierluigi Stipa, Stefania Marano, Roberta Galeazzi, Cristina Minnelli, Giovanna Mobbili, Emiliano Laudadio
Summary: Biodegradable polymeric nanoparticles are promising non-toxic vehicles for drug delivery, but lack of regulatory guidance in assessment and characterization delays their clinical success. Understanding drug-polymer interactions is crucial for optimizing drug delivery systems.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Fangfei Hu, Jianping Qi, Yi Lu, Haisheng He, Wei Wu
Summary: To overcome the short half-life and low stability of peptide and protein drugs, long-acting drug delivery systems using PLGA implants have been developed. Various technologies have been developed for lab-scale fabrication or industrial manufacture to meet the demand for delivering peptides and proteins. This review introduces recent advances in PLGA implants, including their fundamental properties, fabrication technologies, drug release processes, and future perspectives.
CHINESE CHEMICAL LETTERS
(2023)
