Article
Biochemistry & Molecular Biology
Celine Abueva, Hyun Seok Ryu, Jun Won Min, Phil Sang Chung, Hyeon Sook You, Myung Suk Yang, Seung Hoon Woo
Summary: The study synthesized a quaternary ammonium chitosan derivative, which when complexed with povidone-iodine showed increased effectiveness against multidrug-resistant bacteria and fungi, with no cytotoxic effects and promoting wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Physical
Gozde Bayer, Silvia Grasselli, Annalisa Malchiodi, Ilker S. Bayer
Summary: An alternative approach of fabricating soy lecithin/alginate gels without solvents was demonstrated, successfully encapsulating the antiseptic drug PVPI. The composite gels exhibited minimal drug loss and slow drug release, showing potential in disinfecting aqueous media.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Pharmacology & Pharmacy
Daniela Vergara, Noelia Loza-Rodriguez, Francisca Acevedo, Mariela Bustamante, Olga Lopez
Summary: In this study, bigels loaded with PVP-I were prepared and their properties and antibacterial effectiveness were evaluated. The results indicate that the bigels can be promising alternatives to hand antiseptic products.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Medicine, General & Internal
Veronica Romano, Donato Di Gennaro, Anna Maria Sacco, Enrico Festa, Emanuela Roscetto, Morena Anna Basso, Tiziana Ascione, Giovanni Balato
Summary: This study evaluated the cytotoxicity of solutions containing povidone-iodine (PI) and hydrogen peroxide (H2O2), alone or in combination. The results showed that the toxicity of all tested solutions increased as exposure time increased, except for 0.3% PI solution, which exhibited the lowest toxicity. The combined solutions had lower cellular killing at 3 and 5 min compared to equal concentrations of H2O2, similar to PI solutions.
Review
Ophthalmology
Jen-Yu Liu, Hsiao-Sang Chu, Yi-Hsuan Wei, Chia-Yi Cheng, Mei-Chi Tsui, Jo-Hsuan Wu, Wei-Lun Huang, Hsin-Yu Liu, Yu-Chih Hou, I-Jong Wang, Fung-Rong Hu, Wei-Li Chen
Summary: Preoperative skin antiseptic preparation is crucial for preventing surgical infection, but improper use can cause serious ocular damage. Common antiseptics include chlorhexidine, iodine/iodophors, and alcohol-based disinfectants. Proper selection of antiseptics is important, especially in ocular surgeries.
Article
Nanoscience & Nanotechnology
Dong-Ho Kang, Chunqing Ma, Nam-Gyu Park
Summary: In this study, the unique characteristic of povidone-iodine (PVP-I) was utilized to improve the photovoltaic performance of perovskite solar cells (PSCs). The addition of PVP-I in the perovskite precursor solution resulted in increased power conversion efficiency and improved fill factor and current density. Electron microscopy confirmed that PVP-I can protect the grain boundaries. Conductive atomic force microscopy revealed that the addition of PVP-I reduces the defect density and enhances the film conductivity of the perovskite film. PVP-I treated PSCs showed better stability compared to the control devices.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Medicine, General & Internal
Rosario Musumeci, Pasquale Troiano, Marianna Martinelli, Matteo Piovella, Claudio Carbonara, Scipione Rossi, Giovanni Alessio, Luisa Molteni, Claudio Giuseppe Molteni, Laura Saderi, Giovanni Sotgiu, Clementina Elvezia Cocuzza
Summary: The study showed that using 0.66% povidone-iodine eye drops before cataract surgery effectively reduced the conjunctival bacterial load and facilitated the smooth progress of the operation. Analysis of 120 patients revealed that all subjects showed a reduction or no regrowth of bacterial load. The study indicates that povidone-iodine eye drops can be an effective perioperative prophylactic treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
S. J. Monstrey, D. Lepelletier, A. Simon, G. Touati, S. Vogt, F. Favalli
Summary: This study investigated the impact of different application techniques on the antiseptic activity of alcoholic povidone-iodine solution. The results showed significant antiseptic activity with all modes of application, and greater efficacy was achieved with back-and-forth friction method compared to concentric circle method. These findings suggest that application technique may influence antiseptic activity, and comparable application techniques should be considered when comparing the efficacy of different antiseptic substances.
JOURNAL OF HOSPITAL INFECTION
(2022)
Article
Biochemistry & Molecular Biology
Sneha Singh, Onkar B. Sawant, Shahzad Mian, Ashok Kumar
Summary: PVP-I demonstrates potent antiviral effects against ZIKV and CHIKV infection of ocular cells in vitro, primarily by direct viral inactivation to attenuate the virus' ability to infect host cells, without causing cellular toxicity.
Article
Chemistry, Medicinal
Zuzanna Lucja Babalska, Marzena Korbecka-Paczkowska, Tomasz M. Karpinski
Summary: Issues in wound healing are common, with chronic wound infections affecting 1.5% of the population. Antiseptics are commonly used in wound treatment, but older ones like boric acid and iodine are not recommended. Only newer antiseptics like OCT, PHMB, PVP-I, NaOCl and nanosilver are advised for wound treatment.
Article
Public, Environmental & Occupational Health
Phat Tran, Jonathan Kopel, Keaton Luth, Huy Dong, Ameesh Dev, Dilip Mehta, Kelly Mitchell, Keith W. Moeller, Cameron D. Moeller, Ted Reid
Summary: This study aimed to determine if the combination of 5% betadine solution and silver colloidal gel is more effective than either substance alone in inhibiting the growth of gram-negative and gram-positive bacteria. The results showed that silver gel had complete inhibition on all the bacteria species examined except for the Klebsiella pneumoniae clinical isolate strain, while 5% betadine solution did not completely kill any of the tested bacteria. However, when 5% betadine solution and silver gel were used together, they were able to completely eliminate K. pneumoniae. The study concluded that the combination of 5% betadine solution and silver gel was superior at eliminating all tested bacteria.
AMERICAN JOURNAL OF INFECTION CONTROL
(2023)
Article
Cardiac & Cardiovascular Systems
Takahiro Matsumoto, Eiji Tamiya, Haruyo Yamashita, Tomosato Takabe, Akihito Nakajima, Shouichi Yamamoto, Shuko Nojiri, Tatsuji Kanoh, Hiroyuki Daida
Summary: The study found that Olanedine (R) is a safe and effective antiseptic for cardiovascular catheterization, with efficacy and safety comparable to povidone-iodine (PI), making it a promising new option for disinfecting cardiovascular catheterization procedures.
INTERNATIONAL HEART JOURNAL
(2021)
Article
Anatomy & Morphology
Zumrut Ceren Ozduman, Burcu Oglakci, Mirac Dogan, Ceren Deger, Evrim Eliguzeloglu Dalkilic
Summary: This study compared the effect of different mouthwashes during the COVID-19 pandemic on the bond strength of universal adhesive to enamel. The results showed that in the self-etch mode, the group without mouthwash had significantly higher bond strength than other mouthwash groups; in the etch-and-rinse mode, teeth without mouthwash had significantly higher bond strength than the chlorhexidine and povidone-iodine groups.
MICROSCOPY RESEARCH AND TECHNIQUE
(2022)
Review
Nursing
Li Li, Yu Wang, Shouyan Wang
Summary: This study conducted a systematic review and meta-analysis to evaluate the efficacy of chlorhexidine and povidone-iodine in preventing postoperative surgical site infections (SSI) and relevant bacterial data. The results indicated that chlorhexidine was more effective than povidone-iodine in preventing SSI, and the two disinfectants had different effects on bacterial colonization depending on the type of incision.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2022)
Article
Ophthalmology
Smriti Nair, Aretha Zhu, Mustafa Jaffry, Hassaam Choudhry, Mohammad H. H. Dastjerdi
Summary: This paper aims to compile information on the use, safety profile, adverse effects, and possible alternatives of Povidone-iodine (PVI). While the allergic potential to PVI is disputed, there are nonallergic adverse effects of PVI that should not be overlooked. Alternatives to PVI including chlorhexidine, polyhexamethylene biguanide, and octenidine have been identified.
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
(2023)
Article
Ophthalmology
Carla Lanca, Mohammad Hassan Emamian, Yee Ling Wong, Hassan Hashemi, Mehdi Khabazkhoob, Andrzej Grzybowski, Seang Mei Saw, Akbar Fotouhi
Summary: This study aimed to determine the spherical equivalent (SE) progression among children in the Shahroud School Children Eye Cohort Study in Iran. The results showed that older age, female sex, near work, parental myopia, and greater myopic baseline SE were associated with myopic shift.
Editorial Material
Ophthalmology
Oliver Zeitz, Sobha Sivaprasad, Antonia M. Joussen, Andrzej Grzybowski
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Andrzej Grzybowski, Charles Claoue, Stephen G. Schwartz
Summary: The first successful planned extracapsular cataract extraction was performed by Jacques Daviel in 1752. Prior to this, other doctors made important contributions to the development of cataract surgery, with a key insight being the recognition that cataract is the opacified crystalline lens itself, not a membrane or opacity located in front of the lens.
ACTA OPHTHALMOLOGICA
(2023)
Editorial Material
Ophthalmology
Andrzej Grzybowski, Jan-Willem Beenakker
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Review
Health Care Sciences & Services
Huimin Li, Jing Cao, Andrzej Grzybowski, Kai Jin, Lixia Lou, Juan Ye
Summary: The emergence of artificial intelligence, especially advanced deep learning frameworks, has caused a revolution in all medical fields, including ophthalmology. Ocular image-based AI technology, due to the unique microvascular and neural structures of the eyes, may serve as a valuable tool for predicting systemic diseases, especially in resource-limited settings. This review summarizes the current applications of AI in predicting systemic diseases using multimodal ocular images, including cardiovascular diseases, dementia, chronic kidney diseases, and anemia. The review also discusses the current challenges and future directions of these applications.
Review
Ophthalmology
Andrzej Grzybowski, Panisa Singhanetr, Onnisa Nanegrungsunk, Paisan Ruamviboonsuk
Summary: Diabetic retinopathy (DR), a leading cause of preventable blindness, is expected to continue to be a growing health burden worldwide. Artificial intelligence (AI) has been shown to be an effective tool for screening DR and reducing the burden of vision loss. However, there are challenges in the deployment of AI for DR screening, including workflow issues, technical issues, ethical issues, and health-economic issues. The governance model for AI in healthcare should be followed to ensure fairness, transparency, trustworthiness, and accountability in the deployment of AI for DR screening.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Ophthalmology
Maciej Gawecki, Andrzej Grzybowski, Anna Swiech
Summary: Central serous chorioretinopathy (CSCR) is a common disease that can cause visual impairment. This study aimed to identify characteristic biometric parameters for CSCR. The results showed that CSCR patients had increased choroidal thickness, and longer disease duration was associated with decreased retinal thickness.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Dermatology
Andrzej Grzybowski, Katarzyna Pawlikowska-Lagod, Andreas Altenburg, Christos C. Zouboulis
Summary: Adamantiades-Behcet disease is an inflammatory, vascular disease of unknown etiology. It is most common in the region of the Silk Road and has the highest incidence rate in Turkey. The disease is characterized by various symptoms, including recurrent aphthous ulcers and organ involvement.
CLINICS IN DERMATOLOGY
(2023)
Editorial Material
Dermatology
Andrzej Grzybowski, Jane M. Grant-Kels
CLINICS IN DERMATOLOGY
(2023)
Article
Dermatology
Marta Kurzeja, Malgorzata Olszewska, Andrzej Grzybowski, Lidia Rudnicka
Summary: Autoimmune bullous diseases are a group of disorders caused by autoantibodies against adhesion molecules. The severity of ocular involvement varies, ranging from mild symptoms to severe impairment of vision, and even blindness. The prevalence of ocular involvement differs among different diseases, with the highest being up to 70%.
CLINICS IN DERMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Edyta Sienkiewicz-Szlapka, Ewa Fiedorowicz, Angelika Krol-Grzymala, Natalia Kordulewska, Dominika Rozmus, Anna Cieslinska, Andrzej Grzybowski
Summary: This article examines the etiology of diabetic retinopathy by screening chromosomes and genes, identifying specific genes and their polymorphisms that are closely related to the development of the disease. The collected data contribute to a comprehensive understanding of the disease and the selection of candidate genes as markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Malgorzata Nita, Andrzej Grzybowski
Summary: Age-related macular degeneration (AMD) is an oxidative stress-linked neurodegenerative disease that leads to irreversible damage of the central retina and severe visual impairment. The roles of heterophagy, autophagy, and mitophagy in maintaining homeostasis in the retina are emphasized. Modifying the activity of these molecular mechanisms represents a new therapeutic strategy in AMD.
Article
Medicine, General & Internal
Ziying Zhou, Xuan Zhang, Xiajing Tang, Andrzej Grzybowski, Juan Ye, Lixia Lou
Summary: This study analyzed the global publications on artificial intelligence in strabismus using a bibliometric approach, finding an increasing trend in the number of publications and citations. The top productive country was the USA, with research domains in Ophthalmology, Engineering Biomedical, and Optics. Keywords analysis pointed towards deep learning and machine learning as future hotspots in this field, indicating a trend towards optimized technology and algorithms. The findings provide valuable insights for future research directions in the application of AI in strabismus.
FRONTIERS IN MEDICINE
(2023)
Editorial Material
Public, Environmental & Occupational Health
Carla Lanca, Chi Pui Pang, Andrzej Grzybowski
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Clinical Neurology
Pareena Chaitanuwong, Panisa Singhanetr, Methaphon Chainakul, Niracha Arjkongharn, Paisan Ruamviboonsuk, Andrzej Grzybowski
Summary: Alzheimer's disease is the leading cause of dementia worldwide, and early detection is crucial for disease management. Eye biomarkers, especially eye movement tracking, have the potential to detect early Alzheimer's disease. However, there is currently no definitive eye biomarker for early Alzheimer's disease. Studies using artificial intelligence with eye biomarkers have shown promising results in improving the accuracy of identifying Alzheimer's disease patients, which may serve as a screening tool for early detection in older patients.
NEUROLOGY AND THERAPY
(2023)
