Article
Multidisciplinary Sciences
Wolfgang J. Mayer, Andreas Ohlmann, Anna Schuh, Siegfried Priglinger, Thomas Kohnen, Mehdi Shajari
Summary: This study compared anterior lens capsule cutting edge profiles in cataract patients using femtosecond laser-assisted surgery. Results showed that performing femtosecond laser capsulotomy before lens fragmentation resulted in smoother cutting edges, while performing the procedures in the opposite sequence resulted in more tags and bridges.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Soo Jeong Yoon, Soo Hyun Kim, Hyun Jung Bahk, Yeong Seo Ahn, Ji Joo Lee, Hye Jin Kim, Ha Jin Lim, Min Ji Choi, Jong Hee Shin, Yeon-Kyeng Lee
Summary: In November 2020, an unusual increase in fungal endophthalmitis cases after cataract surgery was reported in South Korea. Investigation revealed that the outbreak was caused by a contaminated lot of ocular viscoelastic devices (OVDs) from a specific manufacturer. It was recommended to discontinue the use of these products and emphasize the importance of early recognition and joint responses from government agencies in reducing the risk of fungal endophthalmitis.
EMERGING INFECTIOUS DISEASES
(2022)
Review
Medicine, General & Internal
Caroline Tresch, Marine Lallemant, Rajeev Ramanah
Summary: This study aimed to review the influence of enhanced rehabilitation on outcomes of pelvic organ prolapse surgery. The findings showed no significant difference in operating time, complications, blood loss, and pain scores before and after the adoption of the enhanced recovery after surgery (ERAS) program. However, there was a noticeable decrease in intravenous intakes, opioid administration, length of stay, and overall hospital costs with the adoption of ERAS. Patients were also able to mobilize more rapidly and reported higher satisfaction levels.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Kuldeep Dole, Neha Baheti, Rahul Deshpande, Sucheta Kulkarni, Rakesh Shetty, Madan Deshpande
Summary: This study compared the improvement in visual function parameters after manual small-incision cataract surgery (MSICS) and phacoemulsification cataract surgery. The results showed that both surgeries are safe and effective for visual rehabilitation, but phacoemulsification surgery has better outcomes. This is important in determining the choice of surgical method for cataract patients.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Malgorzata Mrugacz, Mateusz Olszewski, Magdalena Pony-Uram, Jacek Brymerski, Anna Bryl
Summary: This study analyzed the changes in refraction caused by the length of the eyeball in cataract surgery patients who underwent phacoemulsification, and assessed the stability of refraction. The results showed that stable refraction was achieved in a high percentage of emmetropic, myopic, and hypermetropic patients after three weeks postoperatively, using optical biometry and lens power calculation formula.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Joshua G. Kovoor, Brandon Stretton, Jonathan Henry W. Jacobsen, Aashray K. Gupta, Christopher D. Ovenden, Joseph N. Hewitt, John M. Glynatsis, Suzanne Edwards, Kaitryn Campbell, Gayatri P. Asokan, David R. Tivey, Wendy J. Babidge, Christopher K. Rayner, Adrian A. Anthony, Markus Trochsler, Michael Horowitz, Peter J. Hewett, Karen L. Jones, Guy J. Maddern
Summary: This study aims to characterize the duration of postoperative gastrointestinal recovery across all surgical procedures and determine the associations between factors that may affect this. The outcomes will be disseminated through publication in scientific journals and presentations at conferences.
Article
Medicine, General & Internal
Chaeyeon Lee, Eunhae Shin, Mina Kim, Yoonjong Bae, Tae-Young Chung, Sang Won Seo, Hyemin Jang, Dong Hui Lim
Summary: This study investigated the effect of cataract surgery on the incidence of dementia in a Korean population aged >= 45 years with a previous diagnosis of cataract. The results showed that cataract surgery significantly reduced the incidence of dementia in male patients and patients under 65 years of age with good visual acuity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Antti Viljanen, Kimmo Koskela, Harri Koskela, Raimo Tuuminen, Hannu Uusitalo
Summary: CLE and MIOL implantation can improve HRQoL and VRQoL of presbyopia patients before cataracts develop, with the increase of HRQoL being correlated with the increase of VRQoL.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Medicine, General & Internal
Jung Hye Shin, Seok Hwan Kim, Sohee Oh, Kyoung Min Lee
Summary: This study compared refractive prediction errors between phacotrabeculectomy and phacoemulsification and found that phacotrabeculectomy had larger prediction errors. Larger prediction errors were associated with higher intraocular pressure difference and shallower anterior chamber depth.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Anders L. Ebbehoj, Peter Sparre, Kristian K. Jensen
Summary: This study described the postoperative course after laparoscopic parastomal hernia repair, revealing inadequate pain management postoperatively and a high risk of complications.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Editorial Material
Ophthalmology
Christopher D. Conrady, Benjamin K. Young, Cagri Besirli
Summary: The woman in her 40s presenting with nausea and headache after a dilated eye examination may have choroidal detachment syndrome, requiring further evaluation and treatment.
JAMA OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Edyta Chlasta-Twardzik, Anna Nowinska, Edward Wylegala
Summary: The study described a potential complication of unintended corneal incision during FLACS procedure using femtosecond laser, however, this complication did not affect the patient's visual function during the 2-year follow-up period.
Review
Oncology
Giorgio Bogani, Giuseppe Sarpietro, Gabriella Ferrandina, Valerio Gallotta, Violante Di Donato, Antonino Ditto, Ciro Pinelli, Jvan Casarin, Fabio Ghezzi, Giovanni Scambia, Francesco Raspagliesi
Summary: ERAS is a pathway designed to promote early recovery for patients undergoing major surgery, with three important components: preoperative, intraoperative, postoperative program. Adoption of ERAS can lead to lower complication rates, shorter hospital stays, improved patient outcomes, and reduced overall cost of care.
Article
Ophthalmology
Xiaoling Fang, Shenyu Ben, Yiping Dong, Xia Chen, Wenwen Xue, Yulan Wang
Summary: The study compared the accuracy of five IOL power calculation formulas in extremely long axial length eyes after LASIK surgery, with the results showing that the Haigis-L formula was less accurate for eyes with extremely flat corneas. SRK/T-corrected K and Shammas-PL performed better in this type of eyes.
Article
Oncology
Xin Li
Summary: Evidence-based nursing significantly improves visual acuity recovery in patients after cataract surgery, reduces the incidence of postoperative complications and recurrence rate. It also has a positive impact on patients' adverse psychological status and postoperative quality of life.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Maria Szatmari-Toth, Tanja Ilmarinen, Alexandra Mikhailova, Heli Skottman, Anu Kauppinen, Kai Kaarniranta, Endre Kristof, Lyubomyr Lytvynchuk, Zoltan Vereb, Laszlo Fesus, Goran Petrovski
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Editorial Material
Pharmacology & Pharmacy
Susanna Porela-Tiihonen, Hannu Kokki, Merja Kokki
EXPERT OPINION ON PHARMACOTHERAPY
(2020)
Review
Biochemistry & Molecular Biology
Janusz Blasiak, Elzbieta Pawlowska, Jan Chojnacki, Joanna Szczepanska, Cezary Chojnacki, Kai Kaarniranta
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Janusz Blasiak, Elzbieta Pawlowska, Anna Sobczuk, Joanna Szczepanska, Kai Kaarniranta
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Sofia Ranta-aho, Niina Piippo, Eveliina Korhonen, Kai Kaarniranta, Maria Hytti, Anu Kauppinen
Summary: The study found that TAS-116 could prevent the activation of caspase-1, subsequently reducing the release of mature IL-1 beta. TAS-116 has a better in vitro therapeutic index than geldanamycin. In summary, TAS-116 appears to be a well-tolerated Hsp90 inhibitor, with the capability to prevent the activation of the NLRP3 inflammasome in human RPE cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Janusz Blasiak, Juha M. T. Hyttinen, Joanna Szczepanska, Elzbieta Pawlowska, Kai Kaarniranta
Summary: AMD is the leading cause of visual impairment in the aging population, with age and family history as the strongest risk factors. Long non-coding RNAs play a significant role in the pathogenesis of AMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Vanessa Derenji de Mello, Tuomas Selander, Jaana Lindstroem, Jaakko Tuomilehto, Matti Uusitupa, Kai Kaarniranta
Summary: Elevated serum plasmalogen dm16:0, saturated odd-chain FA 15.0, and omega-3 very long-chain FAs were found to be associated with a decreased occurrence of retinal microaneurysms (MA). The correlation of high serum triglycerides with MA occurrence was attenuated when considering these MA-associated serum lipid markers.
Review
Pharmacology & Pharmacy
Charis Rousou, Carl C. L. Schuurmans, Arto Urtti, Enrico Mastrobattista, Gert Storm, Chrit Moonen, Kai Kaarniranta, Roel Deckers
Summary: This review discusses the use of ultrasound and microbubbles for ocular drug delivery, focusing on enhancing efficacy by disrupting the blood-retina barrier, inducing cellular uptake, and achieving targeted delivery of genes. Safety and tolerability aspects of USMB are also highlighted as crucial for clinical translation.
Article
Cell Biology
Mooud Amirkavei, Flavia Plastino, Anders Kvanta, Kai Kaarniranta, Helder Andre, Ari Koskelainen
Summary: Cells have stress-response pathways to cope with stress factors for homeostasis maintenance; low doses of stress may be beneficial; HHS was found to enhance autophagy gene expression and activation through HSF1.
Article
Biochemistry & Molecular Biology
Ali Koskela, Federico Manai, Filippo Basagni, Mikko Liukkonen, Michela Rosini, Stefano Govoni, Massimo Dal Monte, Adrian Smedowski, Kai Kaarniranta, Marialaura Amadio
Summary: Antioxidant systems play key roles in elderly diseases, including age-related macular degeneration (AMD). This study investigated the protective effects of nature-inspired hybrids on retinal pigment epithelial (RPE) cells. The hybrids increased the expression of Nrf2-target genes and improved intracellular redox balance without affecting autophagy flux. Furthermore, the hybrids enhanced cell survival and reduced inflammation when exposed to proteasome and autophagy inhibitors. The study suggests that Nrf2 is a valuable target for treating AMD.
Review
Nutrition & Dietetics
Susanne Csader, Sonja Korhonen, Kai Kaarniranta, Ursula Schwab
Summary: The purpose of this study was to evaluate the effect of dietary supplementation on the progression of age-related macular degeneration (AMD). The systematic review and meta-analysis showed that the combination of lutein, zeaxanthin, and n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) supplementation may be beneficial in preventing AMD progression and deterioration of visual function. These results encourage further research on the combination of lutein, zeaxanthin, and n-3 LC-PUFA in early AMD patients.
Review
Cell Biology
Hanna Helotera, Kai Kaarniranta
Summary: Age-related macular degeneration (AMD) is the leading cause of visual impairment in the aging population. It is classified into dry and neovascular forms, with neovascular AMD being associated with angiogenesis and inflammatory regulators.
Review
Biochemistry & Molecular Biology
Juha M. T. Hyttinen, Janusz Blasiak, Kai Kaarniranta
Summary: Age-related macular degeneration (AMD) is a complex disease characterized by damage to the retina and is a major cause of vision loss in elderly people. This review explores the role of non-coding RNAs in regulating mitochondrial function and antioxidant stress response in AMD. These molecules have the potential to be used as diagnostic markers and therapeutic targets for AMD and other oxidative stress-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Maeve Boyce, Ying Xin, Olivia Chowdhury, Peng Shang, Haitao Liu, Victoria Koontz, Anastasia Strizhakova, Mihir Nemani, Stacey Hose, J. Samuel Zigler, Matthew Campbell, Debasish Sinha, James T. Handa, Kai Kaarniranta, Jiang Qian, Sayan Ghosh
Summary: This study reveals the interaction between microglia and neutrophils in the pathogenesis of AMD, demonstrating that microglia trigger early RPE changes by regulating neutrophil function and inducing their activation. The study also identifies the Akt2 pathway in microglia as a potential therapeutic target for early AMD.
Article
Biochemistry & Molecular Biology
Maija Toppila, Maria Hytti, Eveliina Korhonen, Sofia Ranta-aho, Niina Harju, Markus M. Forsberg, Kai Kaarniranta, Aaro Jalkanen, Anu Kauppinen
Summary: Increased oxidative stress, dysfunctional cellular clearance, and chronic inflammation are associated with age-related macular degeneration (AMD). Inhibition of PROLY-OLIGOPEPTIDASE (PREP) by KYP-2047 has been shown to reduce oxidative stress and inflammation, and clear cellular protein aggregates.