4.4 Article

Recovery after cataract surgery

Journal

ACTA OPHTHALMOLOGICA
Volume 94, Issue -, Pages 1-34

Publisher

WILEY
DOI: 10.1111/aos.13055

Keywords

-

Categories

Ask authors/readers for more resources

Cataract surgery is the most common ophthalmological surgical procedure, and it is predicted that the number of surgeries will increase significantly in the future. However, little is known about the recovery after surgery. The first aim of this study was to evaluate the prevalence, severity and duration of pain and other ocular discomfort symptoms experienced after cataract surgery. The other objectives were to identify the factors associated with lower postoperative patient satisfaction and to measure the effect of cataract surgery on patients' health-related quality of life (HRQoL) and visual function in everyday life. The study design was a prospective follow-up study. The course of the recovery and the presence of ocular symptoms were evaluated by interviewing the patients via a questionnaire at 1 day, 1 week, 6 weeks and one year after surgery The visual functioning in everyday life was measured with Visual Functioning Index VF-7 and Catquest-9SF-questionnaires and furthermore the HRQoL was measured with the 15D-instrument before surgery and at 12 months after surgery. The patients returned the questionnaires by mail and were interviewed in the hospital on the day of the surgery. The same patients filled-in all the questionnaires. The patient reports were used to collect the data on medical history. A total of 303 patients were approached at Kuopio University Hospital in 2010-2011 and of these 196 patients were eligible and willing to participate, with postoperative data being available from 186 (95%) patients. A systematic review article was included in the study procedure and it revealed the wide range in the reported incidence of postoperative ocular pain. Some of the identified randomized controlled studies reported no or only minor pain whereas in some studies significant pain or pain lasting for several weeks has been described in more than 50% of the study patients. In the present study setting, pain was reported by 34% during the first postoperative hours and by approximately 10% of patients during the first six weeks after surgery. During the early recovery in the hospital, only a minority of the patients reporting pain were provided with pain medication. The ocular discomfort symptoms such as itchiness, burning, foreign-body sensation and tearing were common both before (54%) and after surgery (38-52%). These symptoms can also be described as painful symptoms and are often difficult to distinguish from ocular pain. The symptoms are also typical of ocular surface disease, and some patients may benefit from the postoperative administration of tear substitutes. The patients reporting postoperative ocular symptoms were less satisfied with the treatment outcome at 12 months after surgery (p = 0.001) compared to the patients who experienced no symptoms. Those patients reporting less disability in visual functioning before surgery were more satisfied than patients with more reported disability. The HRQoL improved significantly after cataract surgery (p = 0.002). However, when compared to an age-and gender-standardized control population, in cataract subjects the HRQoL remained slightly worse both before and at 12 months after surgery.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.4
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Biochemistry & Molecular Biology

Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium-Role in Dead Cell Clearance and Inflammation

Maria Szatmari-Toth, Tanja Ilmarinen, Alexandra Mikhailova, Heli Skottman, Anu Kauppinen, Kai Kaarniranta, Endre Kristof, Lyubomyr Lytvynchuk, Zoltan Vereb, Laszlo Fesus, Goran Petrovski

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Editorial Material Pharmacology & Pharmacy

An up-to-date overview of sublingual sufentanil for the treatment of moderate to severe pain

Susanna Porela-Tiihonen, Hannu Kokki, Merja Kokki

EXPERT OPINION ON PHARMACOTHERAPY (2020)

Review Biochemistry & Molecular Biology

Zinc and Autophagy in Age-Related Macular Degeneration

Janusz Blasiak, Elzbieta Pawlowska, Jan Chojnacki, Joanna Szczepanska, Cezary Chojnacki, Kai Kaarniranta

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

The Aging Stress Response and Its Implication for AMD Pathogenesis

Janusz Blasiak, Elzbieta Pawlowska, Anna Sobczuk, Joanna Szczepanska, Kai Kaarniranta

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

TAS-116, a Well-Tolerated Hsp90 Inhibitor, Prevents the Activation of the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells

Sofia Ranta-aho, Niina Piippo, Eveliina Korhonen, Kai Kaarniranta, Maria Hytti, Anu Kauppinen

Summary: The study found that TAS-116 could prevent the activation of caspase-1, subsequently reducing the release of mature IL-1 beta. TAS-116 has a better in vitro therapeutic index than geldanamycin. In summary, TAS-116 appears to be a well-tolerated Hsp90 inhibitor, with the capability to prevent the activation of the NLRP3 inflammasome in human RPE cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Potential of Long Non-Coding RNAs in Age-Related Macular Degeneration

Janusz Blasiak, Juha M. T. Hyttinen, Joanna Szczepanska, Elzbieta Pawlowska, Kai Kaarniranta

Summary: AMD is the leading cause of visual impairment in the aging population, with age and family history as the strongest risk factors. Long non-coding RNAs play a significant role in the pathogenesis of AMD.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Nutrition & Dietetics

Serum Levels of Plasmalogens and Fatty Acid Metabolites Associate with Retinal Microangiopathy in Participants from the Finnish Diabetes Prevention Study

Vanessa Derenji de Mello, Tuomas Selander, Jaana Lindstroem, Jaakko Tuomilehto, Matti Uusitupa, Kai Kaarniranta

Summary: Elevated serum plasmalogen dm16:0, saturated odd-chain FA 15.0, and omega-3 very long-chain FAs were found to be associated with a decreased occurrence of retinal microaneurysms (MA). The correlation of high serum triglycerides with MA occurrence was attenuated when considering these MA-associated serum lipid markers.

NUTRIENTS (2021)

Review Pharmacology & Pharmacy

Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application

Charis Rousou, Carl C. L. Schuurmans, Arto Urtti, Enrico Mastrobattista, Gert Storm, Chrit Moonen, Kai Kaarniranta, Roel Deckers

Summary: This review discusses the use of ultrasound and microbubbles for ocular drug delivery, focusing on enhancing efficacy by disrupting the blood-retina barrier, inducing cellular uptake, and achieving targeted delivery of genes. Safety and tolerability aspects of USMB are also highlighted as crucial for clinical translation.

PHARMACEUTICS (2021)

Article Cell Biology

Hormetic Heat Shock Enhances Autophagy through HSF1 in Retinal Pigment Epithelium Cells

Mooud Amirkavei, Flavia Plastino, Anders Kvanta, Kai Kaarniranta, Helder Andre, Ari Koskelainen

Summary: Cells have stress-response pathways to cope with stress factors for homeostasis maintenance; low doses of stress may be beneficial; HHS was found to enhance autophagy gene expression and activation through HSF1.

CELLS (2022)

Article Biochemistry & Molecular Biology

Nature-Inspired Hybrids (NIH) Improve Proteostasis by Activating Nrf2-Mediated Protective Pathways in Retinal Pigment Epithelial Cells

Ali Koskela, Federico Manai, Filippo Basagni, Mikko Liukkonen, Michela Rosini, Stefano Govoni, Massimo Dal Monte, Adrian Smedowski, Kai Kaarniranta, Marialaura Amadio

Summary: Antioxidant systems play key roles in elderly diseases, including age-related macular degeneration (AMD). This study investigated the protective effects of nature-inspired hybrids on retinal pigment epithelial (RPE) cells. The hybrids increased the expression of Nrf2-target genes and improved intracellular redox balance without affecting autophagy flux. Furthermore, the hybrids enhanced cell survival and reduced inflammation when exposed to proteasome and autophagy inhibitors. The study suggests that Nrf2 is a valuable target for treating AMD.

ANTIOXIDANTS (2022)

Review Nutrition & Dietetics

The Effect of Dietary Supplementations on Delaying the Progression of Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis

Susanne Csader, Sonja Korhonen, Kai Kaarniranta, Ursula Schwab

Summary: The purpose of this study was to evaluate the effect of dietary supplementation on the progression of age-related macular degeneration (AMD). The systematic review and meta-analysis showed that the combination of lutein, zeaxanthin, and n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) supplementation may be beneficial in preventing AMD progression and deterioration of visual function. These results encourage further research on the combination of lutein, zeaxanthin, and n-3 LC-PUFA in early AMD patients.

NUTRIENTS (2022)

Review Cell Biology

A Linkage between Angiogenesis and Inflammation in Neovascular Age-Related Macular Degeneration

Hanna Helotera, Kai Kaarniranta

Summary: Age-related macular degeneration (AMD) is the leading cause of visual impairment in the aging population. It is classified into dry and neovascular forms, with neovascular AMD being associated with angiogenesis and inflammatory regulators.

CELLS (2022)

Review Biochemistry & Molecular Biology

Non-Coding RNAs Regulating Mitochondrial Functions and the Oxidative Stress Response as Putative Targets against Age-Related Macular Degeneration (AMD)

Juha M. T. Hyttinen, Janusz Blasiak, Kai Kaarniranta

Summary: Age-related macular degeneration (AMD) is a complex disease characterized by damage to the retina and is a major cause of vision loss in elderly people. This review explores the role of non-coding RNAs in regulating mitochondrial function and antioxidant stress response in AMD. These molecules have the potential to be used as diagnostic markers and therapeutic targets for AMD and other oxidative stress-related diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Article Cell Biology

Microglia-Neutrophil Interactions Drive Dry AMD-like Pathology in a Mouse Model

Maeve Boyce, Ying Xin, Olivia Chowdhury, Peng Shang, Haitao Liu, Victoria Koontz, Anastasia Strizhakova, Mihir Nemani, Stacey Hose, J. Samuel Zigler, Matthew Campbell, Debasish Sinha, James T. Handa, Kai Kaarniranta, Jiang Qian, Sayan Ghosh

Summary: This study reveals the interaction between microglia and neutrophils in the pathogenesis of AMD, demonstrating that microglia trigger early RPE changes by regulating neutrophil function and inducing their activation. The study also identifies the Akt2 pathway in microglia as a potential therapeutic target for early AMD.

CELLS (2022)

Article Biochemistry & Molecular Biology

The Prolyl Oligopeptidase Inhibitor KYP-2047 Is Cytoprotective and Anti-Inflammatory in Human Retinal Pigment Epithelial Cells with Defective Proteasomal Clearance

Maija Toppila, Maria Hytti, Eveliina Korhonen, Sofia Ranta-aho, Niina Harju, Markus M. Forsberg, Kai Kaarniranta, Aaro Jalkanen, Anu Kauppinen

Summary: Increased oxidative stress, dysfunctional cellular clearance, and chronic inflammation are associated with age-related macular degeneration (AMD). Inhibition of PROLY-OLIGOPEPTIDASE (PREP) by KYP-2047 has been shown to reduce oxidative stress and inflammation, and clear cellular protein aggregates.

ANTIOXIDANTS (2023)

No Data Available