Article
Chemistry, Physical
Hadjer Belahlou, Sihem Abed, Mehdi Bouchouit, Said Taboukhat, Lyamine Messaadia, El-Eulmi Bendeif, Abdelmalek Bouraiou, Bouchta Sahraoui, Karim Bouchouit
Summary: A new conjugated chalcone compound has been synthesized and its crystal structure has been analyzed. The quadratic and cubic susceptibilities of this compound have been evaluated through second and third harmonic generation experiments. Density functional theory calculations have provided information about the electric dipole moment and dipole polarizability of the compound. The synthesized crystals have shown greater crystal transparency, polarizability, and pi-conjugation compared to previously published chalcone NLO crystals.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Optics
Xueting Mu, Fei You, Jinkang Ma, Rui Chen, Kai Xu, Tianhua Wang, Degao Zhong, Lifeng Cao, Bing Teng
Summary: A new NLO chalcone crystal FTMS was successfully designed and grown using slow evaporation solution growth technique. The crystal's cell data and structure refinement were determined through single crystal X-ray diffraction. FTMS exhibited SHG efficiency intensity 18 times higher than KDP. It had a thermal decomposition temperature of 235 degrees Celsius. The crystal demonstrated high transmittance (95%) in the range of 500-2000 nm with a cutoff wavelength of 405 nm.
Article
Chemistry, Physical
Harjinder Singh, Vaneet Saini
Summary: Pd(II)-catalyzed arylfluorination of disubstituted alkenes was achieved for the synthesis of challenging quaternary fluoro-and hydroxyl sulfonamide substrates. The study investigated the geometrical and electronic properties of the products and demonstrated their potential applications in material science and antibacterial research.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Arman Abdalla Ali, Shakhawan Ahmad Mhamad, Aso Hameed Hasan, Iqrar Ahmad, Siti Awanis Abdullah, Shajarahtunnur Jamil, Harun Patel, Sankaranarayanan Murugesan, Joazaizulfazli Jamalis
Summary: Acetylcholinesterase inhibitors (AChEIs) have been investigated for the treatment of Alzheimer's disease. This study focused on synthesizing chalcone derivatives with anti-cholinesterase potential. The compounds exhibited potent inhibitory activity against AChE, with compound 11i showing the most potent activity compared to the positive compound, Galantamine. Docking studies and molecular dynamics simulation confirmed the significant binding affinity and stability of compound 11i in the acetylcholinesterase enzyme.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Multidisciplinary
Haotian Qiu, Fuming Li, Congcong Jin, Zhihua Yang, Junjie Li, Shilie Pan, Miriding Mutailipu
Summary: Borate crystals can be modified using the fluorination strategy to produce fluorooxoborates with unique structures and characteristics. We successfully synthesized fluorooxoborates containing rarely tri-fluorinated [BF3X] (X=O and CH3) tetrahedra using bifluoride salts as a source of fluorine. Our study identified the optical properties and potential applications of organofluorinated groups for nonlinear optics, and discovered two non-centrosymmetric compounds that can potentially produce coherent light for nonlinear optics.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Organic
Mohamed Bensebaa, Mebarek Boukelkoul, Omer Tamer, Yusuf Atalay, Davut Avci
Summary: The present study investigates the nonlinear optical properties of a chalcone derivative and finds that it may be a candidate for first and second-order nonlinear optical materials.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Physical
Bastian Gonzalez-Barramuno, Esteban Cea-Klapp, Ilya Polishuk, Roberto Canales, Hector Quinteros-Lama, Jose Matias Garrido
Summary: In this study, molecular dynamic simulations and density gradient theory combined with statistical associating fluid theory were used to model and understand the interfacial behavior of azeotropic refrigerant mixtures. The results show that despite the non-ideal behavior in these mixtures, the models are able to accurately reproduce the changes in interfacial behavior.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Polymer Science
Jian-Jun He, Hai-Xia Yang, Feng Zheng, Shi-Yong Yang
Summary: Fluorinated aromatic polyimide (FAPI) films with rigid polymer backbones were prepared by chemical imidization approach. These films exhibited excellent mechanical properties, thermal stability, and transparency, as well as stable electrical properties in high frequency range.
Article
Chemistry, Multidisciplinary
Cem Yamali, Sedat Sevin, Merve Nenni, Mehtap Tugrak Sakarya, Recep Uyar, Abdurrahman Aygul, Mahmut Ulger, Recep Ilhan, Serkan Levent, Halise Inci Gul
Summary: Infections, metabolic diseases, and cancer are the leading causes of death globally. This study focuses on finding new drug candidates due to the lack of efficacy, low selectivity, and emergence of resistance in clinically used medications. Various compounds were designed, synthesized, and tested for their antibacterial, antituberculosis, antioxidant, and cytotoxic effects. Several compounds showed potential for innovative chemotherapeutic agents.
Article
Chemistry, Applied
Alexey A. Kalinin, Liliya N. Islamova, Artemiy G. Shmelev, Guzel M. Fazleeva, Olga D. Fominykh, Yulia B. Dudkina, Tatyana A. Vakhonina, Alina Levitskaya, Anastasiya Sharipova, Anvar S. Mukhtarov, Ayrat R. Khamatgalimov, Irek R. Nizameev, Yulia H. Budnikova, Marina Yu Balakina
Summary: Novel D-pi-A chromophores with quinoxaline/quinoxalinone core and bulky groups in the acceptor moiety were synthesized and systematically investigated at molecular and materials levels. These chromophores exhibit good optical properties and thermal stability, with certain substituents effectively preventing aggregation. Composite materials doped with these chromophores show promising optical response and thermal stability.
Article
Chemistry, Physical
Edgard Fabian Blanco-Acuna, Luis Antonio Vazquez-Lopez, Laura Gasque, Hector Garcia-Ortega
Summary: This study synthesized three coumarin-triphenylamine chalcone derivatives with push-pull structures by varying the substituent. The compounds showed strong solvatochromism and aggregation-induced emission, indicating potential nonlinear optical properties.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Materials Science, Multidisciplinary
Saleh K. Alsaee, Mohamad Aizat Abu Bakar, Dian Alwani Zainuri, Ainizatul Husna Anizaim, Muhamad Fikri Zaini, Mohd Mustaqim Rosli, Mundzir Abdullah, Suhana Arshad, Ibrahim Abdul Razak
Summary: Single crystal analysis shows the presence of C-H...O and pi...pi stacking in the crystal. The molecule's structure and electrical properties contribute to its high ICT characteristic, making it suitable for nonlinear optical devices. The theoretical results using density functional theory are consistent with the experimental findings.
Article
Optics
Saleh K. Alsaee, Elham Mzwd, Mohamad Aizat Abu Bakar, S. A. M. Samsuri, Naser M. Ahmed, Mundzir Abdullah, Ibrahim Abdul Razak, Suhana Arshad
Summary: A novel pyrene-based chalcone compound (BDP) was synthesized and its molecular and optical properties were investigated. It was found that the optical properties of the BDP compound are highly dependent on solvent polarity.
Article
Chemistry, Physical
M. Lawrence, P. Rajesh, Ahmad Irfan, S. Muthu
Summary: The molecule 2-Bromo-1H-imidazole-4,5-dicarbonitrile (2B1HID) was investigated using quantum mechanical and vibrational spectroscopic methods. The study employed the Atoms In Molecules (AIM) approach to determine the topology and bonding type. NBO studies were used to determine the solidity, while HOMO and LUMO analysis provided information on chemical parameters and band gaps. The TD-DFT approach, combined with simulated UV-Vis and various solvents, was used to study electronic transitions.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
Aniekan E. Owen, Hitler Louis, Ernest C. Agwamba, Akaninyene D. Udoikono, Amanda-Lee Ezra Manicum
Summary: In this study, the effect of dielectric constant on non-linear optics, structural benchmarking, and population analysis of p-synephrine was investigated using density functional theory, molecular docking, spectroscopy, and X-ray crystallography. The results suggest that p-synephrine has potential as an antihypotensive agent and exhibits higher binding affinity compared to the standard drug dobutamine.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Review
Chemistry, Organic
Jaqueline E. Queiroz, Lucas D. Dias, Giuliana M. Vila Verde, Gilberto L. B. Aquino, Ademir J. Camargo
Summary: This review presented and discussed the synthesis and pharmacological properties of pyrazoles obtained from Chalcone in the last 5 years (2016-2020). The cyclization and acetylation method of alpha,beta-unsaturated chalcones and substituted hydrazine were selected and analyzed as synthetic approaches for pyrazoles. A total of 105 pyrazole derivatives were evaluated for their pharmacological activities, including antineoplastic, anti-inflammatory, antioxidant, antibacterial, antifungal, and other properties. It is important to research the synthetic methods and therapeutic properties of different pyrazole derivatives.
CURRENT ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Jean M. F. Custodio, Fernanda S. Fernandes, Wesley F. Vaz, Allen G. Oliver, Clodoaldo Valverde, Francisco A. P. Osorio, Guilherme R. Oliveira, Tertius L. Fonseca
Summary: The theoretical analysis of electronic properties of a synthesized nitro chalcone with a neolignan moiety revealed the relationship between crystal structure and nonlinear application potential. The impact of environment polarization on absorption spectrum and linear polarizability was found to be moderate, while it was significant for the second hyperpolarizability of the molecule. The results indicate that the NOPP crystal exhibits promising nonlinear optical properties.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Applied
Caua A. Moreira, Eduardo C. M. Faria, Jaqueline E. Queiroz, Vitor S. Duarte, Marcelo do N. Gomes, Aline M. da Silva, Renata Layse G. de Paula, Chris H. J. Franco, Eduardo H. de S. Cavalcanti, Gilberto L. B. de Aquino, Hamilton B. Napolitano
Summary: This study examines chalcones as a potential antioxidant additive to diesel-biodiesel blends, aiming to improve energy efficiency and emission levels.
FUEL PROCESSING TECHNOLOGY
(2022)
Article
Chemistry, Physical
Renato Medeiros, Clodoaldo Valverde, Md. Serajul Haque Faizi, Asif Jamal, Francisco A. P. Osorio
Summary: A quinoline derivative, 4-(quinolin-2-ylmethylene)aminophenol, was synthesized and characterized. The compound showed a good nonlinear optical response. The crystal structure and optical properties were examined through X-ray diffraction and theoretical calculations.
INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY
(2023)
Article
Optics
Antonio S. N. Aguiar, Pablo G. M. Dias, Jaqueline E. Queiroz, Pollyana P. Firmino, Jean M. F. Custodio, Lucas D. Dias, Gilberto L. B. Aquino, Ademir J. Camargo, Hamilton B. Napolitano
Summary: The synthesis and characterization of a butylchalcone derivative (BMP) was carried out to obtain natural-based compounds with potential photoprotective activity. Comparative analysis using density functional theory (DFT) showed differences in electronic structures and supramolecular arrangement between BMP and BBP. Theoretical calculations verified the antioxidant property of BMP and highlighted its potential use as an organic photoprotective agent based on electronic transitions and UV-vis absorption spectra.
Article
Biochemistry & Molecular Biology
Milene Aparecida Andrade, Melina Mottin, Bruna K. de P. Sousa, Joao Alexandre Ribeiro Goncalves Barbosa, Clenia dos Santos Azevedo, Camila Lasse Silva, Marina Goncalves de Andrade, Flavia Nader Motta, Christine Maulay-Bailly, Severine Amand, Jaime Martins de Santana, Carolina Horta Andrade, Philippe Grellier, Izabela M. D. Bastos
Summary: This study screened 2,320 compounds from the chemical library of the Museum National d'Histoire Naturelle of Paris, and identified five compounds with high inhibitory activity against ZIKV NS2B-NS3 protease, including 2-(3-methoxyphenoxy) benzoic acid.
Article
Chemistry, Medicinal
Amanda Alves de Oliveira, Livia do Carmo Silva, Bruno Junior Neves, Vinicius Alexandre Fiaia Costa, Eugene N. Muratov, Carolina Horta Andrade, Celia Maria de Almeida Soares, Vinicius M. Alves, Maristela Pereira
Summary: This study aims to discover new anti-Paracoccidioides compounds through computational strategies. The researchers collected and curated a library of compounds tested against Paracoccidioides spp., conducted experimental evaluations, and used computational tools to identify potential targets for the most active compounds. Seven compounds showed activity against Paracoccidioides spp., making them potential candidates for developing new compounds.
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Jade Milhomem Lemos, Meryck Felipe Brito da Silva, Alexandra Maria dos Santos Carvalho, Henric Pietro Vicente Gil, Vinicius Alexandre Fiaia Costa, Carolina Horta Andrade, Rodolpho Campos Braga, Philippe Grellier, Eugene N. Muratov, Sebastien Charneau, Jose Teofilo Moreira-Filho, Izabela Marques Dourado Bastos, Bruno Junior Neves
Summary: This study created an explainable multitask pipeline to profile the activity of compounds against three trypanosomes, successfully discovering four new experimental hits, among which LC-6 showed promising results. The results demonstrate that the multitask protocol offers predictivity and interpretability in virtual screening, potentially improving hit rates in Chagas and human African trypanosomiasis projects.
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Microbiology
A. B. C. Marcos Junior, Livia C. Silva, Olivia B. Rocha, Amanda A. Oliveira, Igor G. Portis, Antonio Alonso, Lais Alonso, Kleber S. F. Silva, Marcelo N. Gomes, Carolina H. Andrade, Celia M. A. Soares, Maristela Pereira
Summary: A proteomic approach was used to investigate the metabolic changes caused by a chalcone derivative (LabMol-75) in Paracoccidioides brasiliensis yeast cells. The compound downregulated proteins associated with glycolysis, & beta;-oxidation, the citrate cycle, and the electron transport chain, resulting in an energetic imbalance and oxidative stress.
FUTURE MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Amanda de Oliveira Matos, Pedro Henrique dos Santos Dantas, Mike Telemaco Contreras Colmenares, Geraldo Rodrigues Sartori, Marcelle Silva-Sales, Joao Herminio Martins Da Silva, Bruno Junior Neves, Carolina Horta Andrade, Helioswilton Sales-Campos
Summary: Researchers used computational simulations to investigate the potential binding domains between TREM-1 and its five known ligands. They found that the complementarity-determining regions, especially the CDR3 loop, were the main mediators of antigen recognition. This study provides a structural basis for understanding the recognition process of TREM-1 and may be valuable for future computational and biological investigations.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Marianna C. Silva, Vitor S. Duarte, Loide O. Sallum, Gracielle O. S. Cunha, Jean M. F. Custodio, Allen G. Oliver, Josana C. Peixoto, Antonio C. S. Menezes, Hamilton B. Napolitano
Summary: The Brazilian Cerrado biome is a hotspot of bioactive compounds due to its biodiversity, but the reduction of its native area may have compromised its knowledge. This study describes an isolated compound from the Cerrado plant and analyzes its molecular architecture. The results contribute to the understanding of pharmacological compounds in the Cerrado.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Medicinal
Jose Teofilo Moreira-Filho, Bruno Junior Neves, Rayssa Araujo Cajas, Josue de Moraes, Carolina Horta Andrade
Summary: Machine learning models were used to predict the schistosomicidal activity of untested compounds. Four compounds demonstrated significant activity against schistosomula without toxicity in animal and human cell lines.
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Igor D. D. Borges, Eduardo C. M. Faria, Jean F. M. Custodio, Vitor S. S. Duarte, Fernanda S. S. Fernandes, Christian G. G. Alonso, Flavio O. Sanches-Neto, Valter H. H. Carvalho-Silva, Guilherme R. R. Oliveira, Hamilton B. B. Napolitano
Summary: Biodiesel production is a promising strategy to reduce diesel consumption and contribute to climate change, but its stability remains a challenging issue. Organic additives are being investigated to improve stability and reduce harmful emissions, with this study focusing on the stability of B15 and the potential of antioxidants as additives for diesel-biodiesel blends. Using a machine learning computational platform, a systematic description of oxidation stability was conducted.
Article
Chemistry, Multidisciplinary
Wafa A. Bawazir, Maymoona A. Al-Mahmood, Rawan S. Almalki, Ghadi F. Alofi, Raghad S. Alharbi, Zoya Zaheer
Summary: This study investigates the interaction between sulfathiazole and three types of surfactants using UV-visible spectroscopy and conductivity measurements. The results show that the critical micelle concentration of cationic and anionic surfactants decreases with increasing sulfathiazole concentration, while the interaction with non-ionic surfactant is weak.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Musaad K. Aleid, Khalid N. Alharbi, Mona A. Aljufareen, Areej S. Aloliwi, Alhanouf K. Almutairi, Rahaf S. Alsaif, Nada K. Alshayeb, Mohammed S. Almoiqli
Summary: This study assessed the levels of trihalomethane compounds in the water network of Riyadh city and identified the factors influencing their formation. The concentrations of trihalomethane compounds were within the permissible limits, indicating the water's safety for human consumption. The presence of bromide ions, organic carbon, free chlorine, and pH values were found to affect trihalomethane formation.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Said Arhzaf, Jamal Houssaini, Mohammed Naciri Bennani, Marwa Alaqarbeh, Mohammed Bouachrine
Summary: The study shows that Mg-Al hydrotalcite catalysts intercalated with acetate and carbonate anions exhibit superior catalytic activity in the aldol condensation reaction between furfural and acetone. The optimal reaction conditions are at 90 degrees C for 2 hours, achieving conversion rates of over 98% with high selectivity towards F2A for the acetate catalyst.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Uyen-Chi Nguyen Le, Ngoc Xuan Dat Mai, Kieu-Minh Le, Hoang Anh Vu, Huynh-Nhu Thi Tran, Tan Le Hoang Doan
Summary: This study aimed to enhance the bioavailability of rosmarinic acid, a bioactive compound with high anticancer activity, by encapsulating it in tetrasulfide-based porous organosilica nanoparticles. The synthesized nanoparticles were small in size and had a high surface area and an average pore diameter. The nanoparticles showed effective accumulation in cancer cells without toxicity to normal cells. Treatment with rosmarinic acid-containing nanoparticles resulted in significant cell death in cancer cells. Overall, these findings suggest that the synthesized nanoparticles can enhance the pharmacological effects of rosmarinic acid.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Jiamin Qi, Hengxi Zhu, Tianyu Yang, Xingyuan Wang, Zixuan Wang, Xiaoli Lei, Bin Li, Wenmin Qian
Summary: This study synthesized a novel iron-biochar adsorbent using the iron content in red mud to remove heavy metals from wastewater. The adsorbent showed excellent removal efficiency and sustainability. This method addresses both industrial waste recovery and heavy metal adsorption issues.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Bo Yi, Li Zhang, Haiyang Zhou
Summary: Plasma protein binding plays a crucial role in the pharmacokinetics and pharmacodynamics of therapeutic bioactive materials. In this study, the interaction of nordentatin, a member of coumarins, with human alpha-1 acid glycoprotein (AGP) was investigated, and the anticancer potency of nordentatin against human colorectal cancer cells was evaluated. The results showed that nordentatin binds to AGP through a static quenching mechanism and exhibits inhibitory effects on the growth of HCT-116 cells by increasing intracellular ROS and [Ca2+] levels and triggering apoptosis-related gene overexpression. Therefore, nordentatin could be a promising plant-based therapy for colorectal cancer.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Qiming Pang, Cui Wang, Bangtao Li, Suli Zhang, Jiaoyang Li, Shuo Gu, Xueyu Shi
Summary: This study evaluated the effects of resveratrol loaded in copolymer nanoparticles on cerebral ischemia/reperfusion (I/R) injury in rats. The results showed that RES.CP.NPs could have neuroprotective effects through their antioxidant and anti-inflammatory activities, leading to improved neurological disability scores and decreased oxidative stress levels.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Maryam Rachmawati Sumitra, Lung-Ching Chen, Wei-Chen Tsai, Muhamad Ansar, Bashir Lawal, Ntlotlang Mokgautsi, Jih-Hwa Guh, Alexander T. H. Wu, Hsu-Shan Huang
Summary: Tetraheterocyclic compounds derived from natural sources and contemporary pharmaceuticals have shown promise as multitarget therapeutic agents. In this study, a series of synthesized compounds were evaluated for their potential in breast cancer treatment. Compounds 18 and 20 demonstrated significant antiproliferative activity against breast cancer cell lines and their mode of action was revealed through molecular docking simulations.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Mohammad Khosravani, Mohsen Dehghani Ghanatghestani, Farid Moeinpour, Hossein Parvaresh
Summary: The aim of removing Pb(II) from water is to minimize the potential harm posed by toxic metals to both human health and the environment. A covalent organic framework adsorbent called TFPOTDB-SO3H was developed with excellent properties such as high repeatability, selectivity, and easy solid-liquid separation. The adsorbent showed impressive capability of adsorbing Pb(II) and effective removal of it from a solution with various ions, suggesting its potential for effectively adsorbing and removing Pb(II) heavy metal ions from wastewater.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Ashraf H. Farha, Mohamed S. Shams, Hasna A. Alali, Zakia H. Alhashem, Shehab A. Mansour, Shrouq H. Aleithan, Ragab A. Elsad
Summary: The current study examines the dielectric and thermal properties of transformer oil incorporated with Mn0.5 Zn0.5 Fe2O4 nanoparticles. The results show that the addition of Mn-Zn ferrite NPs improves the dielectric constant, dissipation factor, AC breakdown voltage, and convective heat transfer of the nanofluid.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Limin Hou, Zongpei Jiang, Minqi Ye, Xueyan Sun, Kexin Liu, Yifan Zhu, Xiaoyu Wang, Liangzhu Chen, Ruiheng Gu, Binghu Fang
Summary: The excessive accumulation of antibiotic residue in animal-derived foods poses a threat to health. Therefore, it is necessary to establish a rapid, simple, effective, safe, and highly sensitive method for detecting lincomycin residues. By using a pre-column derivatization method on high-performance liquid chromatography equipped with ultraviolet, the UV absorption of lincomycin is improved, allowing for detection and quantification.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Kun Tang, Xin-Xin Wang, Jin-Jin Zhao, Ning Ren, Jian-Jun Zhang
Summary: This study reports the synthesis, crystal structures, and thermal degradation properties of three new rare earth coordination compounds. Compounds 1-3 exhibit binuclear structures which can form chain-like structures via hydrogen bonding. Compound 2 shows potential application value in the orange-red luminescence region.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Seoyoun Yang, Eunbi Yu, See-Hyoung Park, Sae Woong Oh, Kitae Kwon, Su Bin Han, Soo Hyun Kang, Jung Hyun Lee, Heejun Ha, Minkyung Song, Jae Youl Cho, Jongsung Lee
Summary: This study investigated the effects of blue light on the hypodermis and found that it has antiadipogenic properties by reducing lipid accumulation and downregulating the expression of adipogenic genes. Blue light also increased the phosphorylation of PPAR gamma and TRPV1, suggesting its anti-adipogenic effect through these signaling pathways.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Abdul Nasir, Abdul Waheed Khan, Hamid Rafiq Khattak, Abdus Samad, Sami Ullah, Haroon Khan, Muhammad Faheem, Qian Bai
Summary: This study evaluated the effects of isoxazolone derivatives on cisplatin-induced neuropathy in a rat model. The results showed that isoxazolone derivatives effectively reversed mechanical allodynia, similar to the known therapeutic agent pregabalin. Molecular docking analysis indicated that isoxazolone derivatives have strong binding affinity for relevant receptors and potential inhibitory activity against relevant signaling pathways. This study has innovative implications for the treatment of cisplatin-induced neuropathic pain.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Shahid Wahab, Haroon Muhammad Ali, Maham Khan, Tariq Khan, Chandran Krishnaraj, Soon-Il Yun
Summary: In this study, we synthesized chitosan nanoparticles, silver nanoparticles, and chitosan/silver nanocomposites using aqueous ginger extract as a green approach. These nanomaterials showed significant antibacterial properties and low toxicity. Furthermore, the nanomaterials conjugated with tobramycin demonstrated enhanced antibacterial efficacy and exhibited interactions with Pseudomonas aeruginosa.
ARABIAN JOURNAL OF CHEMISTRY
(2024)