Journal
ACS CATALYSIS
Volume 8, Issue 11, Pages 10316-10320Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.8b03170
Keywords
Iridium; P,N-ligands; asymmetric hydrogenation; unfunctionalized olefins; cyclic beta-enamides
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Funding
- Spanish Ministry of Economy and Competitiveness [CTQ2016-74878-P]
- European Regional Development Fund (AEI/FEDER, UE)
- Catalan Government [2017SGR1472]
- ICREA Foundation (ICREA Academia)
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We have developed a family of Ir-P,oxazoline catalysts for asymmetric hydrogenation. These catalysts, with a simple modular architecture, have shown a high tolerance to the olefin geometry and substitution pattern, and to the presence of several neighboring polar groups. Thus, they were able to successfully hydrogenate disubstituted, trisubstituted, and tetrasubstituted minimally functionalized olefins (with enantiomeric excess values up to 99%). The excellent catalytic performance was also extended to the hydrogenation of cyclic beta-enamides.
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