Decoding the role of TET family dioxygenases in lineage specification

Decoding the dynamic DNA methylation and hydroxymethylation landscapes in endodermal lineage intermediates during pancreatic differentiation of hESC

(2018) Jia Li et al.   NUCLEIC ACIDS RESEARCH

Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter

(2018) Ruili Yang et al.   Nature Communications

Cytosine modifications modulate the chromatin architecture of transcriptional enhancers

(2017) Elise A. Mahé et al.   GENOME RESEARCH

The Loss of TET2 Promotes CD8+T Cell Memory Differentiation

(2017) Shannon A. Carty et al.   JOURNAL OF IMMUNOLOGY

TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells

(2017) Nipun Verma et al.   NATURE GENETICS

A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer

(2017) Charly R. Good et al.   NUCLEIC ACIDS RESEARCH

Tet-mediated DNA hydroxymethylation regulates retinal neurogenesis by modulating cell-extrinsic signaling pathways

(2017) Pawat Seritrakul et al.   PLoS Genetics

TET-Catalyzed 5-Hydroxymethylation Precedes HNF4A Promoter Choice during Differentiation of Bipotent Liver Progenitors

(2017) Pierre-Benoit Ancey et al.   Stem Cell Reports

Ten-Eleven Translocation-2 (Tet2) Is Involved in Myogenic Differentiation of Skeletal Myoblast Cells in Vitro

(2017) Xia Zhong et al.   Scientific Reports

TET1 contributes to neurogenesis onset time during fetal brain development in mice

(2016) Hyerim Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ten-Eleven Translocation 1 and 2 Confer Overlapping Transcriptional Programs for the Proliferation of Cultured Adult Neural Stem Cells

(2016) Koji Shimozaki   CELLULAR AND MOLECULAR NEUROBIOLOGY

A mutation in thetuftmouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure

(2016) Keith S. K. Fong et al.   Disease Models & Mechanisms

Epigenetic regulation of intestinal stem cells by Tet1-mediated DNA hydroxymethylation

(2016) Rinho Kim et al.   GENES & DEVELOPMENT

Control of Foxp3 stability through modulation of TET activity

(2016) Xiaojing Yue et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations

(2016) Dali Han et al.   MOLECULAR CELL

Isoform Switch of TET1 Regulates DNA Demethylation and Mouse Development

(2016) Wenhao Zhang et al.   MOLECULAR CELL

TET-mediated DNA demethylation controls gastrulation by regulating Lefty–Nodal signalling

(2016) Hai-Qiang Dai et al.   NATURE

Active DNA demethylation at enhancers during the vertebrate phylotypic period

(2016) Ozren Bogdanović et al.   NATURE GENETICS

Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment

(2016) Yohko Kitagawa et al.   NATURE IMMUNOLOGY

TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells

(2016) Ageliki Tsagaratou et al.   NATURE IMMUNOLOGY

Role of Tet1/3 Genes and Chromatin Remodeling Genes in Cerebellar Circuit Formation

(2016) Xiaodong Zhu et al.   NEURON

FOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function

(2016) Yeqing A. Yang et al.   NUCLEIC ACIDS RESEARCH

A primary role of TET proteins in establishment and maintenance ofDe Novobivalency at CpG islands

(2016) Lingchun Kong et al.   NUCLEIC ACIDS RESEARCH

Tissue-specific DNA demethylation is required for proper B-cell differentiation and function

(2016) Shari Orlanski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tet proteins influence the balance between neuroectodermal and mesodermal fate choice by inhibiting Wnt signaling

(2016) Xiang Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA hydroxymethylation controls cardiomyocyte gene expression in development and hypertrophy

(2016) Carolina M. Greco et al.   Nature Communications

5-Hydroxymethylcytosine Marks Sites of DNA Damage and Promotes Genome Stability

(2016) Georgia Rose Kafer et al.   Cell Reports

5-Hydroxymethylcytosine Remodeling Precedes Lineage Specification during Differentiation of Human CD4 + T Cells

(2016) Colm E. Nestor et al.   Cell Reports

Tet3-Mediated DNA Demethylation Contributes to the Direct Conversion of Fibroblast to Functional Neuron

(2016) Juan Zhang et al.   Cell Reports

TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities

(2016) Sara Montagner et al.   Cell Reports

Tet3 Reads 5-Carboxylcytosine through Its CXXC Domain and Is a Potential Guardian against Neurodegeneration

(2016) Seung-Gi Jin et al.   Cell Reports

Tet2 and Tet3 cooperate with B-lineage transcription factors to regulate DNA modification and chromatin accessibility

(2016) Chan-Wang Lio et al.   eLife

Metabolism and epigenetics in the nervous system: Creating cellular fitness and resistance to neuronal death in neurological conditions via modulation of oxygen-, iron-, and 2-oxoglutarate-dependent dioxygenases

(2015) Saravanan S. Karuppagounder et al.   BRAIN RESEARCH

TET-catalyzed oxidation of intragenic 5-methylcytosine regulates CTCF-dependent alternative splicing

(2015) R. J. Marina et al.   EMBO JOURNAL

The Methylcytosine Dioxygenase Tet2 Promotes DNA Demethylation and Activation of Cytokine Gene Expression in T Cells

(2015) Kenji Ichiyama et al.   IMMUNITY

Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis

(2015) Ruili Yang et al.   IMMUNITY

A Novel Function of TET2 in CNS: Sustaining Neuronal Survival

(2015) Yajing Mi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Stable 5-Hydroxymethylcytosine (5hmC) Acquisition Marks Gene Activation During Chondrogenic Differentiation

(2015) Sarah EB Taylor et al.   JOURNAL OF BONE AND MINERAL RESEARCH

TET1 is controlled by pluripotency-associated factors in ESCs and downmodulated by PRC2 in differentiated cells and tissues

(2015) Francesco Neri et al.   NUCLEIC ACIDS RESEARCH

TET-catalyzed 5-hydroxymethylcytosine regulates gene expression in differentiating colonocytes and colon cancer

(2015) Christopher G. Chapman et al.   Scientific Reports

Overlapping Requirements for Tet2 and Tet3 in Normal Development and Hematopoietic Stem Cell Emergence

(2015) Cheng Li et al.   Cell Reports

Loss of Tet Enzymes Compromises Proper Differentiation of Embryonic Stem Cells

(2014) Meelad M. Dawlaty et al.   DEVELOPMENTAL CELL

Role of Tet proteins in enhancer activity and telomere elongation

(2014) Falong Lu et al.   GENES & DEVELOPMENT

Nucleosome repositioning links DNA (de)methylation and differential CTCF binding during stem cell development

(2014) Vladimir B. Teif et al.   GENOME RESEARCH

Dynamics of ten-eleven translocation hydroxylase family proteins and 5-hydroxymethylcytosine in oligodendrocyte differentiation

(2014) Xianghui Zhao et al.   GLIA

TET2 Plays an Essential Role in Erythropoiesis by Regulating Lineage-Specific Genes via DNA Oxidative Demethylation in a Zebrafish Model

(2014) L. Ge et al.   MOLECULAR AND CELLULAR BIOLOGY

5mC Oxidation by Tet2 Modulates Enhancer Activity and Timing of Transcriptome Reprogramming during Differentiation

(2014) Gary C. Hon et al.   MOLECULAR CELL

Critical Role of Tet3 in Neural Progenitor Cell Maintenance and Terminal Differentiation

(2014) Ting Li et al.   MOLECULAR NEUROBIOLOGY

Dissecting the dynamic changes of 5-hydroxymethylcytosine in T-cell development and differentiation

(2014) A. Tsagaratou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TET2 Deficiency Inhibits Mesoderm and Hematopoietic Differentiation in Human Embryonic Stem Cells

(2014) Thierry Langlois et al.   STEM CELLS

Hydroxymethylation at Gene Regulatory Regions Directs Stem/Early Progenitor Cell Commitment during Erythropoiesis

(2014) Jozef Madzo et al.   Cell Reports

Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells

(2013) Wei Xie et al.   CELL

Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition

(2013) Run-Rui Zhang et al.   Cell Stem Cell

Ten-Eleven Translocation-2 (TET2) Is a Master Regulator of Smooth Muscle Cell Plasticity

(2013) Renjing Liu et al.   CIRCULATION

TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS

(2013) Rachel Deplus et al.   EMBO JOURNAL

Dynamic changes in DNA methylation and hydroxymethylation when hES cells undergo differentiation toward a neuronal lineage

(2013) Mirang Kim et al.   HUMAN MOLECULAR GENETICS

The MLL3/MLL4 Branches of the COMPASS Family Function as Major Histone H3K4 Monomethylases at Enhancers

(2013) D. Hu et al.   MOLECULAR AND CELLULAR BIOLOGY

Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX

(2013) Myunggon Ko et al.   NATURE

TETonic shift: biological roles of TET proteins in DNA demethylation and transcription

(2013) William A. Pastor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tet1 Is Critical for Neuronal Activity-Regulated Gene Expression and Memory Extinction

(2013) Andrii Rudenko et al.   NEURON

Genome-wide comparison of DNA hydroxymethylation in mouse embryonic stem cells and neural progenitor cells by a new comparative hMeDIP-seq method

(2013) Li Tan et al.   NUCLEIC ACIDS RESEARCH

Alteration of genic 5-hydroxymethylcytosine patterning in olfactory neurons correlates with changes in gene expression and cell identity

(2013) Bradley M. Colquitt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamics of 5-Hydroxymethylcytosine and Chromatin Marks in Mammalian Neurogenesis

(2013) Maria A. Hahn et al.   Cell Reports

DNA methylation presents distinct binding sites for human transcription factors

(2013) Shaohui Hu et al.   eLife

Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells

(2013) Francesco Neri et al.   GENOME BIOLOGY

MeCP2 Binds to 5hmC Enriched within Active Genes and Accessible Chromatin in the Nervous System

(2012) Marian Mellén et al.   CELL

Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome

(2012) Miao Yu et al.   CELL

Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development

(2012) Yufei Xu et al.   CELL

Promoter DNA methylation couples genome-defence mechanisms to epigenetic reprogramming in the mouse germline

(2012) J. A. Hackett et al.   DEVELOPMENT

Inhibition of  -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

(2012) M. Xiao et al.   GENES & DEVELOPMENT

Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA

(2012) Liang Zhang et al.   Nature Chemical Biology

Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers

(2012) Aurélien A. Sérandour et al.   NUCLEIC ACIDS RESEARCH

Quantitative Sequencing of 5-Methylcytosine and 5-Hydroxymethylcytosine at Single-Base Resolution

(2012) M. J. Booth et al.   SCIENCE

Tet2 disruption leads to enhanced self-renewal and altered differentiation of fetal liver hematopoietic stem cells

(2012) Hiroyoshi Kunimoto et al.   Scientific Reports

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

(2011) Z. Li et al.   BLOOD

Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation

(2011) Kelly Moran-Crusio et al.   CANCER CELL

Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids

(2011) Lakshminarayan M. Iyer et al.   CELL CYCLE

Tet1 and Tet2 Regulate 5-Hydroxymethylcytosine Production and Cell Lineage Specification in Mouse Embryonic Stem Cells

(2011) Kian Peng Koh et al.   Cell Stem Cell

Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells

(2011) H. Wu et al.   GENES & DEVELOPMENT

Thymine DNA Glycosylase Can Rapidly Excise 5-Formylcytosine and 5-Carboxylcytosine

(2011) Atanu Maiti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide Regulation of 5hmC, 5mC, and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells

(2011) Yufei Xu et al.   MOLECULAR CELL

CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing

(2011) Sanjeev Shukla et al.   NATURE

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

(2011) Kristine Williams et al.   NATURE

Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells

(2011) William A. Pastor et al.   NATURE

Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells

(2011) Hao Wu et al.   NATURE

Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine

(2011) Khursheed Iqbal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

(2011) Y.-F. He et al.   SCIENCE

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

(2010) Shinsuke Ito et al.   NATURE

Human DNA methylomes at base resolution show widespread epigenomic differences

(2009) Ryan Lister et al.   NATURE

Mutation inTET2in Myeloid Cancers

(2009) François Delhommeau et al.   NEW ENGLAND JOURNAL OF MEDICINE

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2

(2008) C Bach et al.   ONCOGENE