Article
Biotechnology & Applied Microbiology
Pengfei Li, Huina Lv, Yongkai Wu, Ke Xu, Min Xu, Yegang Ma
Summary: The study revealed that E2F1 inhibits miR-375 expression and promotes SESN3 expression to activate the PI3K/AKT pathway in ESCC, ultimately promoting cell growth and development.
Article
Oncology
Kunpeng Wu, Feng Liu, Tingting Zhang, Zhiliang Zhou, Shouqiang Yu, Yonghui Quan, Shaojin Zhu
Summary: This study found that miR-375 is downregulated in patients with esophageal squamous cell carcinoma and is associated with a poor prognosis. Further investigation revealed that miR-375 suppresses the growth and infiltration of esophageal squamous cell carcinoma cells by targeting PRDX1, and has anti-tumor effects both in vitro and in vivo.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Yen-Chiang Tseng, Chih-Wen Shu, Hui-Min Chang, Yi-Hsuan Lin, Yen-Han Tseng, Han-Shui Hsu, Yih-Gang Goan, Ching-Jiunn Tseng
Summary: EGR-1 plays a key role in esophageal squamous cell carcinoma, suppressing tumor growth and reflecting the efficacy of chemotherapy. Analysis of experiments and clinical samples found that patients with high expression of EGR-1 have a lower risk of cancer-related death.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Sora Kim, Gwang Ha Kim, Su Jin Park, Chae Hwa Kwon, I Hoseok, Moon Won Lee, Bong Eun Lee
Summary: Exosomal miRNAs have the potential to serve as biomarkers for esophageal squamous cell carcinoma (ESCC). This study identified specific exosomal miRNAs that were differentially expressed in ESCC, and validated their expression levels in the plasma of healthy controls and ESCC patients. The results showed that plasma exosomal miR-205-5p, miR-429, and miR-375-3p could be potential biomarkers for the diagnosis of ESCC.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Sheyne Sta Ana Choi, Josephine Mun-Yee Ko, Valen Zhuoyou Yu, Lvwen Ning, Maria Li Lung
Summary: This study investigated the role of ZNF750 in inducing cell differentiation and suppressing tumor growth in esophageal squamous cell carcinoma (ESCC). The results revealed a functional link between ZNF750's ability to induce cell differentiation through to terminal differentiation and its function as a growth suppressor in ESCC.
Article
Biochemistry & Molecular Biology
Yen-Chiang Tseng, Chih-Wen Shu, Hui-Min Chang, Yi-Hsuan Lin, Yen-Han Tseng, Han-Shui Hsu, Yih-Gang Goan, Ching-Jiunn Tseng
Summary: This study investigates the effects of Egr-1 gene silencing on ESCC cells using RNA interference, Next Generation Sequencing, and bioinformatics analysis. The study identifies several mRNA and microRNA that show significant expression changes after Egr-1 knockdown in ESCC cells. The findings suggest that the interactions between Egr-1 and these genes and microRNAs may be important in tumor progression.
Article
Oncology
Hong Wu, Xuefeng Leng, Qianshi Liu, Tianqin Mao, Tao Jiang, Yiqiang Liu, Feifei Li, Chenhui Cao, Jun Fan, Liang Chen, Yaqi Chen, Quan Yao, Shun Lu, Renchuan Liang, Lanlin Hu, Mingxin Liu, Yejian Wan, Zhaoshen Li, Jun Peng, Qiyu Luo, Hang Zhou, Jun Yin, Ke Xu, Mei Lan, Xinhao Peng, Haitao Lan, Gang Li, Yongtao Han, Xia Zhang, Zhi-Xiong Jim Xiao, Jinyi Lang, Guihua Wang, Chuan Xu
Summary: Analysis of intratumoral microbiota in patients with esophageal cancer reveals a microbiota signature that is associated with chemoimmunotherapy response, showing that Streptococcus stimulates CD8+ T-cell infiltration and induces a favorable response. These findings suggest the potential clinical utility of intratumoral microbiota for cancer immunotherapy.
Article
Biochemistry & Molecular Biology
Jianliang Zhang, Irwin H. Gelman, Jun Qu, Steven N. Hochwald
Summary: Current clinical therapies targeting receptor tyrosine kinases have limited efficacy in treating esophageal squamous cell carcinoma (ESCC). However, recent research has shown that glucose-induced growth factor-independent proliferation in ESCC requires the phosphorylation of focal adhesion kinase (FAK) at His58. Furthermore, NME1, a histidine kinase, has been found to play a role in glucose-induced FAK(poHis58) and ESCC cell proliferation. Additionally, glucose-induced binding of retinoblastoma transcriptional corepressor 1 (RB1) to FAK in the cytoplasm has been shown to correlate with increased ESCC G1 → S phase transition.
Article
Biochemistry & Molecular Biology
Shintaro Fujihara, Hideki Kobara, Noriko Nishiyama, Kayo Hirose, Hisakazu Iwama, Tsutomu Masaki
Summary: Esophageal squamous cell carcinoma (ESCC) requires early detection and treatment for improved survival, but diagnosis can be challenging due to observer variation. Studies have shown significant dysregulation of miRNA expression in superficial ESCC, particularly with miR-21-5p, miR-146b-5p, and miR-210-3p. These miRNAs are associated with ESCC invasion depth and lymphovascular invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Sureshkumar Muthupalani, Damodaran Annamalai, Yan Feng, Suresh M. Ganesan, Zhongming Ge, Mark T. Whary, Hiroshi Nakagawa, Anil K. Rustgi, Timothy C. Wang, James G. Fox
Summary: Chronic inflammation is closely associated with the development of esophageal adenocarcinoma and esophageal squamous cell carcinoma. A new transgenic mouse model expressing human IL-1 beta has been used to investigate the consequences of chronic inflammation in the oral and esophageal squamous epithelia. This model has expanded the understanding of the key pathways involved in inflammation-driven esophageal diseases.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Xuejiao Liu, Simin Zhao, Keke Wang, Liting Zhou, Ming Jiang, Yunfeng Gao, Ran Yang, Shiwen Yan, Wen Zhang, Bingbing Lu, Feifei Liu, Ran Zhao, Wenting Liu, Zihan Zhang, Kangdong Liu, Xiang Li, Zigang Dong
Summary: Spatial transcriptomics analysis revealed expression changes in TAGLN2 and CRNN during the progression from esophageal squamous precancerous lesions (ESPL) to esophageal squamous cell carcinoma (ESCC). TAGLN2 expression significantly increased, while CRNN expression decreased along with ESCC progression. These findings suggest that TAGLN2 and CRNN can serve as candidate indicators for predicting the risk of ESCC at the ESPL stage.
NATURE COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Pai Pang, Hui Fang, Hong Wu, Song Wang, Minda Liu, Shan Jin, Zhongzheng Qi, Zhenning Li, Fayu Liu, Changfu Sun
Summary: This study identified a SP1/miR-92b feedback loop that regulates the migration and invasion of head and neck squamous cell carcinoma (HNSCC). Elevated expression of miR-92b was associated with higher clinical stage and worse prognosis in HNSCC patients. Both miR-92b and SP1 promoted each other's expression and cooperatively facilitated the migration, invasion, and proliferation of HNSCC cells. Decreased levels of SP1/miR-92b resulted in inhibition of in vivo tumor growth. This feedback loop presents a potential therapeutic target for the treatment of HNSCC patients.
Review
Oncology
Suliman Khan, De-Yu Zhang, Ji-Yu Zhang, Mian Khizar Hayat, Jingli Ren, Safyan Nasir, Muhammad Fawad, Qian Bai
Summary: The expression and function of miRNAs play a crucial role in the development of HCC, affecting the biological behavior and clinical pathological features of liver cancer. Despite the unclear regulatory mechanisms, the potential of miRNA-based therapy for HCC warrants further exploration.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Xing Wang, Xinwei Chen, Yuanyuan Liu, Shan Huang, Jian Ding, Baoxin Wang, Pin Dong, Zhenfeng Sun, Lixiao Chen
Summary: CSMD1 plays a role in inhibiting tumor progression and promoting CD8(+) T cell immune response in esophageal squamous cell carcinoma, indicating it as a potential target for ESCC treatment.
EXPERIMENTAL CELL RESEARCH
(2022)
Review
Medicine, Research & Experimental
Jiale Zhang, Yanxin Dong, Shouyin Di, Shun Xie, Boshi Fan, Taiqian Gong
Summary: Tumor-associated macrophages (TAMs) play a crucial role in esophageal squamous carcinoma (ESCC), influencing tumor growth, invasion, and treatment outcomes. Understanding the function of TAMs is essential for the development of innovative therapeutic strategies for ESCC.
BIOMEDICINE & PHARMACOTHERAPY
(2023)