The thiosemicarbazone Me2NNMe2 induces paraptosis by disrupting the ER thiol redox homeostasis based on protein disulfide isomerase inhibition

Anticancer Thiosemicarbazones: Chemical Properties, Interaction with Iron Metabolism, and Resistance Development

(2018) Petra Heffeter et al.   ANTIOXIDANTS & REDOX SIGNALING

Morusin induces paraptosis-like cell death through mitochondrial calcium overload and dysfunction in epithelial ovarian cancer

(2018) Jing Xue et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Cyclometalated iridium(iii) complexes induce mitochondria-derived paraptotic cell death and inhibit tumor growth in vivo

(2018) Liang He et al.   DALTON TRANSACTIONS

6-Shogaol induces caspase-independent paraptosis in cancer cells via proteasomal inhibition

(2018) Divya Nedungadi et al.   EXPERIMENTAL CELL RESEARCH

Novel anti-cancer drug COTI-2 synergizes with therapeutic agents and does not induce resistance or exhibit cross-resistance in human cancer cell lines

(2018) Saman Maleki Vareki et al.   PLoS One

Paraptosis in human glioblastoma cell line induced by curcumin

(2018) Monika Garrido-Armas et al.   TOXICOLOGY IN VITRO

Hinokitiol copper complex inhibits proteasomal deubiquitination and induces paraptosis-like cell death in human cancer cells

(2017) Xin Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR)

(2017) Philip Kranz et al.   Cell Death & Disease

Therapeutic potential of the phosphino Cu(I) complex (HydroCuP) in the treatment of solid tumors

(2017) Valentina Gandin et al.   Scientific Reports

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics

(2016) Danuta S. Kalinowski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention

(2016) Christian R. Kowol et al.   JOURNAL OF MEDICINAL CHEMISTRY

Paraptosis in the anti-cancer arsenal of natural products

(2016) Dongjoo Lee et al.   PHARMACOLOGY & THERAPEUTICS

A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC

(2016) Nicole A Seebacher et al.   Cell Death & Disease

Epigenetic down-regulation of integrin α7 increases migratory potential and confers poor prognosis in malignant pleural mesothelioma

(2015) Viktoria Laszlo et al.   JOURNAL OF PATHOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

New insights into the roles of CHOP-induced apoptosis in ER stress

(2014) Yiming Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes

(2014) Kimiko Ishiguro et al.   BIOCHEMICAL PHARMACOLOGY

The role of MAPK signalling pathways in the response to endoplasmic reticulum stress

(2014) Nicola J. Darling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The ER mitochondria calcium cycle and ER stress response as therapeutic targets in amyotrophic lateral sclerosis

(2014) Vedrana Tadic et al.   Frontiers in Cellular Neuroscience

Drug Resistance in Cancer: An Overview

(2014) Genevieve Housman et al.   Cancers

Pathview: an R/Bioconductor package for pathway-based data integration and visualization

(2013) Weijun Luo et al.   BIOINFORMATICS

A phase II trial of sequential ribonucleotide reductase inhibition in aggressive myeloproliferative neoplasms

(2013) J. F. Zeidner et al.   HAEMATOLOGICA

Manumycin A inhibits triple-negative breast cancer growth through LC3-mediated cytoplasmic vacuolation death

(2013) P K Singha et al.   Cell Death & Disease

Ophiobolin A induces paraptosis-like cell death in human glioblastoma cells by decreasing BKCa channel activity

(2013) M Bury et al.   Cell Death & Disease

Protein disulfide isomerase in redox cell signaling and homeostasis

(2012) Francisco R.M. Laurindo et al.   FREE RADICAL BIOLOGY AND MEDICINE

An Involvement of Oxidative Stress in Endoplasmic Reticulum Stress and Its Associated Diseases

(2012) Bidur Bhandary et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bcl2 at the endoplasmic reticulum protects against a Bax/Bak-independent paraptosis-like cell death pathway initiated via p20Bap31

(2011) Hannah M. Heath-Engel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Antitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in Lysosomes

(2011) D. B. Lovejoy et al.   CANCER RESEARCH

Novel Thiosemicarbazones of the ApT and DpT Series and Their Copper Complexes: Identification of Pronounced Redox Activity and Characterization of Their Antitumor Activity

(2010) Patric J. Jansson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins

(2010) Benjamin G Hoffstrom et al.   Nature Chemical Biology

Thiosemicarbazones: the new wave in cancer treatment

(2009) Danuta S Kalinowski et al.   Future Medicinal Chemistry

The Thioxotriazole Copper(II) Complex A0 Induces Endoplasmic Reticulum Stress and Paraptotic Death in Human Cancer Cells

(2009) Saverio Tardito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis

(2009) Gang Li et al.   JOURNAL OF CELL BIOLOGY

Impact of Metal Coordination on Cytotoxicity of 3-Aminopyridine-2-carboxaldehyde Thiosemicarbazone (Triapine) and Novel Insights into Terminal Dimethylation

(2009) Christian R. Kowol et al.   JOURNAL OF MEDICINAL CHEMISTRY

A phase 2 consortium (P2C) trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) for advanced adenocarcinoma of the pancreas

(2008) Steven Attia et al.   INVESTIGATIONAL NEW DRUGS

Mitochondrial Calcium Buffering Contributes to the Maintenance of Basal Calcium Levels in Mouse Taste Cells

(2008) Kyle Hacker et al.   JOURNAL OF NEUROPHYSIOLOGY

A Phase I study of the novel ribonucleotide reductase inhibitor 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine®) in combination with the nucleoside analog fludarabine for patients with refractory acute leukemias and aggressive myeloproliferative disorders

(2007) Judith E. Karp et al.   LEUKEMIA RESEARCH