AMPK-dependent autophagy upregulation serves as a survival mechanism in response to Tumor Treating Fields (TTFields)

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

(2018) Mario Mauthe et al.   Autophagy

Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma

(2017) Roger Stupp et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Tumor treating fields (TTFields) delay DNA damage repair following radiation treatment of glioma cells

(2017) Moshe Giladi et al.   Radiation Oncology

Tumor-treating fields elicit a conditional vulnerability to ionizing radiation via the downregulation of BRCA1 signaling and reduced DNA double-strand break repair capacity in non-small cell lung cancer cell lines

(2017) Narasimha Kumar Karanam et al.   Cell Death & Disease

Biological activity of tumor-treating fields in preclinical glioma models

(2017) Manuela Silginer et al.   Cell Death & Disease

Determining the Optimal Inhibitory Frequency for Cancerous Cells Using Tumor Treating Fields (TTFields)

(2017) Yaara Porat et al.   Jove-Journal of Visualized Experiments

Alternating electric fields (TTFields) in combination with paclitaxel are therapeutically effective against ovarian cancer cellsin vitroandin vivo

(2016) Tali Voloshin et al.   INTERNATIONAL JOURNAL OF CANCER

Tumor treating fields: a novel treatment modality and its use in brain tumors

(2016) Andreas F. Hottinger et al.   NEURO-ONCOLOGY

Glioblastoma, hypoxia and autophagy: a survival-prone ‘ménage-à-trois’

(2016) Soha Jawhari et al.   Cell Death & Disease

Autophagy in dental tissues: a double-edged sword

(2016) H Zhuang et al.   Cell Death & Disease

Therapeutic Targeting of Autophagy

(2016) Christina G. Towers et al.   EBioMedicine

Targeting autophagy to overcome drug resistance in cancer therapy

(2015) Ankit Kumar et al.   Future Medicinal Chemistry

Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma

(2015) Roger Stupp et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The role for autophagy in cancer

(2015) Eileen White   JOURNAL OF CLINICAL INVESTIGATION

Tumor Treating Fields Perturb the Localization of Septins and Cause Aberrant Mitotic Exit

(2015) Nidhi Gera et al.   PLoS One

Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells

(2015) Akihiro Ohashi et al.   Nature Communications

Alternating Electric Fields (Tumor-Treating Fields Therapy) Can Improve Chemotherapy Treatment Efficacy in Non-Small Cell Lung Cancer Both In Vitro and In Vivo

(2014) Moshe Giladi et al.   SEMINARS IN ONCOLOGY

Mitotic disruption and reduced clonogenicity of pancreatic cancer cells in vitro and in vivo by tumor treating fields

(2013) Moshe Giladi et al.   PANCREATOLOGY

ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy

(2012) José Manuel Rodríguez-Vargas et al.   CELL RESEARCH

NovoTTF-100A versus physician’s choice chemotherapy in recurrent glioblastoma: A randomised phase III trial of a novel treatment modality

(2012) Roger Stupp et al.   EUROPEAN JOURNAL OF CANCER

Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells

(2012) Silvia Stingele et al.   Molecular Systems Biology

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The chemotherapeutic agent paclitaxel inhibits autophagy through two distinct mechanisms that regulate apoptosis

(2012) R A Veldhoen et al.   ONCOGENE

Autophagy Inhibitor Chloroquine Enhanced the Cell Death Inducing Effect of the Flavonoid Luteolin in Metastatic Squamous Cell Carcinoma Cells

(2012) Lien Verschooten et al.   PLoS One

Correlating light scattering with internal cellular structures

(2012) Oana C. Marina et al.   Biomedical Optics Express

Targeting Aneuploidy for Cancer Therapy

(2011) Eusebio Manchado et al.   CELL

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Identification of Aneuploidy-Selective Antiproliferation Compounds

(2011) Yun-Chi Tang et al.   CELL

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Autophagy contributes to resistance of tumor cells to ionizing radiation

(2011) Hassan Chaachouay et al.   RADIOTHERAPY AND ONCOLOGY

ATM engages the TSC2/mTORC1 signaling node to regulate autophagy

(2010) Angela Alexander et al.   Autophagy

Autophagy: cancer therapy’s friend or foe?

(2010) Dan Grandér et al.   Future Medicinal Chemistry

Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase

(2010) You-Tong Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

(2010) A. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Senescent Keratinocytes Die by Autophagic Programmed Cell Death

(2009) Karo Gosselin et al.   AMERICAN JOURNAL OF PATHOLOGY

Autophagy-A double-edged sword in oncology

(2009) Anja Apel et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells

(2008) Takashi Shingu et al.   INTERNATIONAL JOURNAL OF CANCER