Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 50, Issue -, Pages 71-77Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2018.09.031
Keywords
Atherosclerosis; Foam cell formation; Gypenoside LVI; Gynostemma pentaphyllum; Macrophages
Categories
Funding
- Science and Technology Project of Guangzhou City [201604020150]
- Scientific Research Projects of the State Administration of traditional Chinese medicine [JDZX2015205]
- Guangdong Provincial Science and Technology Department Project [2016A040403105]
- Guangdong Provincial Hospital of Chinese Medicine Science and Technology Research Program [YN2016MJ01]
Ask authors/readers for more resources
Gynostemma pentaphyllum was widely consumed in China because of its various pharmacological activities. Numerous studies have confirmed the beneficial effects of G. pentaphyllum. However, the ultimate compounds responsible for its inhibitory effects on foam cell formation were still unknown. Gypenoside LVI (GPLVI), a dammarane-type gynosaponin was isolated and identified from G. pentaphyllum. Treatment of GPLVI successfully attenuated foam cell formation, as evidenced by Oil Red O staining, TG and cholesterol contents, and Dil-ox-LDL uptake analyses. GPLVI displayed significant inhibitory effects on secretion of IL-6 and IL-1 beta. In contrast, production of TNF-alpha was not markedly reduced. GPLVI also markedly induced ABCG1, SRB1 and LXR alpha expression. Additionally, GPLVI significantly blocked phosphorylation of ERK and JNK. Taken together, our results suggested that GPLVI might be responsible for the inhibitory effect of G. pentaphyllum on ox-LDL-induced foam cell formation mainly by promoting cholesterol efflux and inhibiting inflammatory response.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available