Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 52, Issue -, Pages 587-595Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2018.11.044
Keywords
Stevia; Chlorogenic acids; Hydroxycinnamate derivatives; D-galactose; Aging; Oxidative stress
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Funding
- Project of High-level Teachers in Beijing Municipal Universities [CITTCD201704042, IDHT20180506]
- National Key Research and Development Program [2016YFD0400802, 2016YFD0400502-02]
- National Natural Science Foundation of China [31571801, 31701575]
- construct of innovation service ability Science and technology achievement transformation Upgrade project [PXM2016-014213-000034]
- Beijing Municipal Science and Technology Project [Z171100002217019]
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The present study investigated the effect of Stevia residue extract (SRE) against oxidative stress in D-galactose (Dgal) induced aging mice. LC-MS/MS analysis revealed that SRE is a good source of chlorogenic acids. Biochemical results showed that SRE significantly increased the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and total antioxidant capacity (T-AOC), and decreased acetylcholinesterase (AChE) activity and malondialdehyde (MDA) level in serum, liver or brain of D-gal induced aging mice. At 200 mg/kg, SRE up-regulated the mRNA expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream target genes including GPx1, CAT, SOD1, quinone oxidoreductase-1 (NQO1) and heme oxygenase-1 (HO-1) in D-gal treated mice liver. SRE also up-regulated the protein expression of Nrf2, HO-1 and the ratio of phosphorylated Akt to Akt (pAkt/Akt) in D-gal treated mice liver. These findings suggest that SRE is able to protect against oxidative stress in D-gal induced aging model via activation of Akt/Nrf2/HO-1 pathway. In conclusion, SRE may provide a promising dietary approach for the prevention or alleviation of oxidative stress and age-related conditions.
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