Article
Multidisciplinary Sciences
Yakubu Egigogo Raji, Ooi Peck Toung, Niazlin Mohd Taib, Zamberi Bin Sekawi
Summary: The World Health Organization aims to reduce viral hepatitis incidence and mortality by 90% and 65%, respectively, by 2030. Hepatitis E virus (HEV) is one of the factors contributing to the increased burden of viral hepatitis. HEV is an emerging pathogen that is prevalent worldwide, causing acute and chronic infections. A meta-analysis was conducted to assess the overall prevalence of hepatitis E in Southeast Asia (SEA), which lacks uniform HEV prevalence data. The study found that the overall HEV seroprevalence in SEA was 21%, with high heterogeneity.
SCIENTIFIC REPORTS
(2023)
Article
Gastroenterology & Hepatology
Gustav Buescher, Ann-Kathrin Ozga, Eva Lorenz, Sven Pischke, Jurgen May, Marylyn M. Addo, Thomas Horvatits
Summary: The study aimed to compare the anti-HEV seroprevalence and HEV RNA positivity rate between transplant recipients and HIV patients. Results showed no significant difference in anti-HEV seroprevalence between the two groups, but transplant recipients had a significantly higher rate of HEV-RNA positivity, indicating ongoing infection.
LIVER INTERNATIONAL
(2021)
Review
Health Care Sciences & Services
Barnaby Flower, Duc Du Hong, Hang Vu Thi Kim, Khue Pham Minh, Ronald B. Geskus, Jeremy Day, Graham S. Cooke
Summary: Vietnam has a significant burden of chronic viral hepatitis, with high prevalence of Hepatitis B in antenatal and general populations, and high prevalence of Hepatitis C among people who inject drugs. Improvement in HBV vaccination and targeted HCV screening and treatment are urgently needed. Large-scale studies on HDV prevalence are required.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2022)
Article
Virology
Cosme Alvarado-Esquivel, Veronica Dayali Gutierrez-Martinez, Eda Guadalupe Ramirez-Valles, Antonio Sifuentes-Alvarez
Summary: This study revealed waste pickers as a high-risk group for HEV infection, with factors associated with HEV exposure including illness status and reflex impairment.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Clinical Neurology
Miriam Fritz-Weltin, Lisa Niedermeier, Estelle Frommherz, Nora Isenmann, Benedikt Csernalabics, Tobias Boettler, Christoph Neumann-Haefelin, Dominique Endres, Marcus Panning, Benjamin Berger
Summary: This retrospective study systematically screened 104 patients with Bell's palsy for acute HEV infection, but found no association between acute HEV infection and Bell's palsy. However, a high prevalence of anti-HEV IgG in Bell's palsy patients was observed, which increased with age.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Medicine, General & Internal
Fadi S. Qashqari
Summary: This study systematically assessed the seroprevalence of anti-HEV antibodies in Middle Eastern countries. The findings revealed a wide spread of HEV in the Middle East, with variations in infection rates among different countries and populations.
MEDICINA-LITHUANIA
(2022)
Article
Virology
Kaouther Ayouni, Ghassen Kharroubi, Rym Mallekh, Walid Hammami, Ridha Marouani, Moncef Mhamdi, Afif Ben Salah, Henda Triki, Jihene Bettaieb
Summary: Hepatitis A infection remains a significant global health concern, and a transition in the epidemiology of the virus has been observed in Tunisia. A study in Central-West Tunisia found a high seroprevalence of hepatitis A virus infection, with higher rates in certain age groups and rural areas. The study highlights the need for continued monitoring and potential vaccination strategies in regions with lower socioeconomic levels.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Public, Environmental & Occupational Health
Nur Hasnah Maamor, Nor Asiah Muhamad, Nor Soleha Mohd Dali, Mohd Hatta Abdul Mutalip, Fatin Norhasny Leman, Tahir Aris, Nai Ming Lai, Muhammad Radzi Abu Hassan
Summary: This study systematically reviewed published evidence on the seroprevalence of HBV infection among healthcare workers and synthesized evidence on the association between knowledge and awareness with HBV infection. The results showed that Africa and Asia have the highest seroprevalence of HBV infection, with African studies demonstrating good knowledge despite higher infection rates.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Virology
Tatiana Kuznetsova, Diana Moor, Gulara Khanirzayeva, Julia Geller
Summary: Hepatitis E virus (HEV) is the most common cause of acute hepatitis worldwide. This study analyzed 1002 sera samples from blood donors in Estonia to determine the prevalence of anti-HEV antibodies and RNA. The study found that 4.8% of the donor sera had anti-HEV antibodies, with 4% harboring anti-HEV IgG and 1.5% containing anti-HEV IgM. None of the listed risk factors were found to be associated with the presence of anti-HEV antibodies. The study also observed an increasing prevalence of anti-HEV IgG with age. HEV RNA was not detected in any of the blood serum samples. Based on these findings, there is no urgent necessity for total screening of blood plasma for HEV RNA prevalence in Estonia.
Review
Gastroenterology & Hepatology
Muhammad Abdel-Gawad, Sherief Abd-Elsalam, Ibrahim Abdel-Gawad, Mohammed Tag-Adeen, Marwa El-Sayed, Dalia Abdel-Malek
Summary: The study demonstrates that the seroprevalence of HCV in children worldwide is generally low, but research in this area is limited.
LIVER INTERNATIONAL
(2022)
Article
Virology
Magdalena Baymakova, Krasimira Terzieva, Rumen Popov, Elisaveta Grancharova, Todor Kundurzhiev, Roman Pepovich, Ilia Tsachev
Summary: This study investigated the seroprevalence of HEV infection among blood donors in Bulgaria, revealing a high rate of HEV seropositivity in this population.
Article
Immunology
Herman M. Chambaro, Michihito Sasaki, Walter Muleya, Masahiro Kajihara, Misheck Shawa, Kabemba E. Mwape, Hayato Harima, Yongjin Qiu, William W. Hall, Paul Fandamu, David Squarre, Edgar Simulundu, Hirofumi Sawa, Yasuko Orba
Summary: The study revealed a seroprevalence rate of 47.7% for HEV antibodies in domestic pigs in Zambia, and 16.0% of slaughtered pigs were found to have zoonotic genotype 3 HEV RNA. This is the first report of HEV infection in domestic pigs in Zambia, highlighting a potential risk of contamination in the pork supply chain and zoonotic transmission to abattoir workers, pig farmers, and handlers.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Public, Environmental & Occupational Health
Rebecca Veronesi, Marina Morach, Ella Huebschke, Claudia Bachofen, Roger Stephan, Magdalena Nueesch-Inderbinen
Summary: In Swiss dogs, 38% tested positive for antibodies of Hepatitis E virus, indicating exposure to the virus. Some dogs born abroad, fed with raw meat, and involved in hunting were found to have specific antibodies. However, no viral RNA could be detected in any of the serum and plasma samples.
ZOONOSES AND PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Bacary Djilocalisse Sadio, Martin Faye, Marco Kaiser, Maryam Diarra, Fanny Balique, Cheikh Tidiane Diagne, Oumar Faye, Moussa Moise Diagne, Gamou Fall, Oumar Ndiaye, Cheikh Loucoubar, Abdourahmane Sow, Ousmane Faye, Adama Faye, Cheikh Saad Bouh Boye, Amadou Alpha Sall
Summary: The rapid proliferation of traditional gold mining sites in the Kedougou region has led to a Hepatitis E virus outbreak. The study found a high rate of HEV infection among suspected cases, with a case fatality rate in pregnant women. Further research is needed to identify the virus reservoir and environmental risk factors.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Alexander Nersesov, Arnur Gusmanov, Byron Crape, Gulnara Junusbekova, Salim Berkinbayev, Almagul Jumabayeva, Jamilya Kaibullayeva, Saltanat Madenova, Mariya Novitskaya, Margarita Nazarova, Abduzhappar Gaipov, Aiymkul Ashimkhanova, Kainar Kadyrzhanuly, Kuralay Atageldiyeva, Sandro Vento, Alpamys Issanov
Summary: High-intermediate endemicity for HBsAg and high endemicity for anti-HCV antibodies were found in three large regions of Kazakhstan. Blood transfusion was associated with anti-HCV seropositivity, but further epidemiological studies are needed to assess the effectiveness of preventive measures in healthcare settings.
Article
Multidisciplinary Sciences
Lisandru Capai, Geraldine Piorkowski, Oscar Maestrini, Francois Casabianca, Shirley Masse, Xavier de Lamballerie, Remi N. Charrel, Alessandra Falchi
Summary: This study investigated the presence of three common porcine enteric viruses in pig farms in Corsica, France. The results showed that these viruses are frequently encountered in pigs born and bred in Corsica, with detection rates varying according to age and breeding methods.
Article
Environmental Sciences
Kathleen McColl, Marion Debin, Cecile Souty, Caroline Guerrisi, Clement Turbelin, Alessandra Falchi, Isabelle Bonmarin, Daniela Paolotti, Chinelo Obi, Jim Duggan, Yamir Moreno, Ania Wisniak, Antoine Flahault, Thierry Blanchon, Vittoria Colizza, Jocelyn Raude
Summary: This study investigates unrealistic optimism during the first wave of the COVID-19 pandemic in Europe, its changes over time, and its association with protective measures. The findings show the prevalence of unrealistic optimism influenced by the epidemic context. While absolute unrealistic optimism decreased over time, comparative unrealistic optimism increased, indicating accurate personal risk assessment but overestimation of others' risk. Comparative unrealistic optimism was negatively associated with the adoption of protective behaviors.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biology
Camille Bonnet, Shirley Masse, Hayat Benamar, Ana-Maria Vilcu, Morgane Swital, Thomas Hanslik, Sylvie van der Werf, Xavier Duval, Fabrice Carrat, Alessandra Falchi, Thierry Blanchon
Summary: The study compared the evolution of viral load between patients infected with the Alpha variant and those infected with historical SARS-CoV-2 strains, finding no significant difference in viral load evolution in saliva samples when controlling for the time interval between symptom onset and sampling.
Article
Infectious Diseases
Maria Ortuno, Clara Munoz, Tatiana Spitzova, Petra Sumova, Maria Asuncion Iborra, Pedro Perez-Cutillas, Nazli Ayhan, Remi N. Charrel, Petr Volf, Eduardo Berriatua
Summary: In a study conducted in Murcia Region, southeast Spain, the prevalence of antibodies against Phlebotomus perniciosus sandfly salivary gland homogenate (SGH) and recombinant protein rSP03B was found to be 69% and 88%, respectively. The prevalence of Toscana virus (TOSV), Sandfly Fever Sicilian virus (SFSV), and Leishmania infections were 26%, 0%, and 1%, respectively. The study also questioned the diagnostic value of rSP03B as a marker for these infections in humans.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Virology
Nazli Ayhan, Aissam Hachid, Laurence Thirion, Kamel Eddine Benallal, Laura Pezzi, Fayez Ahmed Khardine, Chahrazed Benbetka, Sihem Benbetka, Zoubir Harrat, Remi Charrel
Summary: Sindbis virus (SINV), a zoonotic alphavirus, has been identified as a cause of human diseases in Africa, Europe, Asia, and Australia. In this study, SINV was detected and isolated from mosquitoes in Algeria, and genetic analysis revealed its similarity to a strain found in Kenya.
Article
Virology
Dorine Decarreaux, Marie Pouquet, Cecile Souty, Ana-Maria Vilcu, Pol Prevot-Monsacre, Toscane Fourie, Paola Mariela Saba Villarroel, Stephane Priet, Helene Blanche, Jean-Marc Sebaoun, Jean-Francois Deleuze, Clement Turbelin, Andreas Werner, Fabienne Kochert, Brigitte Grosgogeat, Pascaline Rabiega, Julien Laupie, Nathalie Abraham, Caroline Guerrisi, Harold Noel, Sylvie van der Werf, Fabrice Carrat, Thomas Hanslik, Remi Charrel, Xavier de Lamballerie, Thierry Blanchon, Alessandra Falchi
Summary: This study aimed to investigate the immune response and neutralizing activity against SARS-CoV-2 among primary health care workers (PHCW) in France and assess the association between neutralizing activity and various factors, including the COVID-19 vaccination scheme. The study found that individuals with previous SARS-CoV-2 infection were more likely to have neutralizing antibodies, regardless of vaccination status. Among those vaccinated with two doses, the time since vaccination was associated with the detection of neutralizing antibodies.
Article
Virology
Khalil Dachraoui, Ifhem Chelbi, Mourad Ben Said, Raja Ben Osman, Saifedine Cherni, Remi Charrel, Elyes Zhioua
Summary: The study investigated the transmission dynamics of Punique virus (PUNV) in Tunisia and found that Phlebotomus perniciosus is the main vector of PUNV. The research provided evidence of intensive circulation of PUNV in sandflies and hosts, reaching a peak during the autumn season.
Article
Environmental Sciences
Dorine Decarreaux, Julie Sevila, Shirley Masse, Lisandru Capai, Toscane Fourie, Paola Mariela Saba Villarroel, Abdennour Amroun, Elif Nurtop, Matthieu Vareille, Marie Pouquet, Thierry Blanchon, Xavier de Lamballerie, Remi Charrel, Alessandra Falchi
Summary: This study estimated the seroprevalence of SARS-CoV-2 infection among the staff and students of the University of Corsica during the second wave of the epidemic. The overall seroprevalence was found to be 12.8%, and factors such as residence, public transportation usage, and contact with infected individuals were associated with seropositivity. The main symptoms associated with seropositivity were acute respiratory infection and loss of smell.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Infectious Diseases
Marie Pellerin, Bastien Trabucco, Lisandru Capai, Morgane Laval, Oscar Maestrini, Ferran Jori, Alessandra Falchi, Virginie Doceul, Francois Charrier, Francois Casabianca, Nicole Pavio
Summary: Hepatitis E virus (HEV) infection can range from acute and benign to chronic hepatitis with severe consequences. In areas with high HEV contamination in pig populations, foodborne transmission through consumption of raw or undercooked pork products is common. Early slaughter appears to be a major factor in the presence of HEV in pig livers. A study conducted in Corsica found that the prevalence of HEV in pig livers over 12 months was low, even in farms with high HEV circulation. This observation suggests the preferential use of livers from animals older than 12 months in raw pork liver products.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Environmental Sciences
Dorine Decarreaux, Julie Sevila, Shirley Masse, Lisandru Capai, Toscane Fourie, Paola Mariela Saba Villarroel, Abdennour Amroun, Elif Nurtop, Matthieu Vareille, Thierry Blanchon, Xavier de Lamballerie, Remi Charrel, Alessandra Falchi
Summary: This study investigated the humoral immune response to SARS-CoV-2 in a French adult population. The results showed that single infection does not provide effective protection, and vaccination significantly affects antibody levels and neutralizing activity.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Virology
Khalil Dachraoui, Ifhem Chelbi, Imen Labidi, Raja Ben Osman, Aida Sayadi, Mourad Ben Said, Saifedine Cherni, Mohammed Abdo Saghir Abbas, Remi Charrel, Elyes Zhioua
Summary: This study investigated the role of dogs as reservoir hosts for Toscana virus (TOSV) and Leishmania infantum infections. Dogs exposed to sandfly bites were examined for TOSV and L. infantum infections, and the sandflies were screened for the presence of these pathogens. The results showed that dogs with zoonotic visceral leishmaniasis (ZVL) can serve as reservoirs for both TOSV and L. infantum, and can transmit TOSV to sandfly vectors in natural settings.
Editorial Material
Microbiology
Sarah I. Bonnet, Stephane Bertagnoli, Alessandra Falchi, Julie Figoni, Johanna Fite, Thierry Hoch, Elsa Quillery, Sara Moutailler, Alice Raffetin, Magalie Rene-Martellet, Gwenael Vourc'h, Laurence Vial
Summary: Current and future changes in the distribution of Hyalomma ticks, which are vectors of pathogens, are of concern. However, there is limited evidence to validate the transmission of specific pathogens by specific Hyalomma species. A bibliographical study found very few validated cases of pathogen transmission by Hyalomma ticks.
