Exchange Protein Directly Activated by cAMP Modulates Ebola Virus Uptake into Vascular Endothelial Cells

Post-exposure treatments for Ebola and Marburg virus infections

(2018) Robert W. Cross et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of Ellagic Acid from Plant Rhodiola rosea L. as an Anti-Ebola Virus Entry Inhibitor

(2018) Qinghua Cui et al.   Viruses-Basel

Histology, immunohistochemistry, and in situ hybridization reveal overlooked Ebola virus target tissues in the Ebola virus disease guinea pig model

(2018) Timothy K. Cooper et al.   Scientific Reports

Ebola: new outbreak appears in Congo a week after epidemic was declared over

(2018) Owen Dyer   BMJ-British Medical Journal

From bench to almost bedside: the long road to a licensed Ebola virus vaccine

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The ongoing evolution of antibody-based treatments for Ebola virus infection

(2017) Emelissa J Mendoza et al.   Immunotherapy

Analyses of PDE-regulated phosphoproteomes reveal unique and specific cAMP-signaling modules in T cells

(2017) Michael-Claude G. Beltejar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ebola and Marburg virus vaccines

(2017) Pierce Reynolds et al.   VIRUS GENES

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Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1

(2017) Euan Parnell et al.   Scientific Reports

Increased microvascular permeability in mice lacking Epac1 (Rapgef3)

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Ebola virus vaccines – reality or fiction?

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Different cAMP sources are critically involved in G protein–coupled receptor CRHR1 signaling

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Feverish Quest for Ebola Immunotherapy: Straight or Cocktail?

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The cAMP sensors, EPAC1 and EPAC2, display distinct subcellular distributions despite sharing a common nuclear pore localisation signal

(2015) Euan Parnell et al.   CELLULAR SIGNALLING

Analysis of Ebola Virus Entry Into Macrophages

(2015) Franziska Dahlmann et al.   JOURNAL OF INFECTIOUS DISEASES

Structure–Activity Relationship Studies of Substituted 2-(Isoxazol-3-yl)-2-oxo-N′-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists

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Role of EXT1 and Glycosaminoglycans in the Early Stage of Filovirus Entry

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Structure-Guided Design of Selective Epac1 and Epac2 Agonists

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Ebola Virus Entry: A Curious and Complex Series of Events

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Lipid interactions during virus entry and infection

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Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses

(2014) Roosecelis Brasil Martines et al.   JOURNAL OF PATHOLOGY

Blocking of Exchange Proteins Directly Activated by cAMP Leads to Reduced Replication of Middle East Respiratory Syndrome Coronavirus

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Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A

(2014) Robert Fledrich et al.   NATURE MEDICINE

Post-exposure therapy of filovirus infections

(2014) Gary Wong et al.   TRENDS IN MICROBIOLOGY

Recent Advances in the Discovery of Small Molecules Targeting Exchange Proteins Directly Activated by cAMP (EPAC)

(2013) Haijun Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of transferrin receptor 1 as a hepatitis C virus entry factor

(2013) D. N. Martin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses

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Efficient synthesis of ESI-09, a novel non-cyclic nucleotide EPAC antagonist

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Vaccines for viral hemorrhagic fevers—progress and shortcomings

(2013) Darryl Falzarano et al.   Current Opinion in Virology

Vesicular Stomatitis Virus-Based Vaccines Protect Nonhuman Primates against Bundibugyo ebolavirus

(2013) Chad E. Mire et al.   PLoS Neglected Tropical Diseases

Enhanced Leptin Sensitivity, Reduced Adiposity, and Improved Glucose Homeostasis in Mice Lacking Exchange Protein Directly Activated by Cyclic AMP Isoform 1

(2012) J. Yan et al.   MOLECULAR AND CELLULAR BIOLOGY

Bacterial effector binds host cell adenylyl cyclase to potentiate G s-dependent cAMP production

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cAMP During HIV Infection: Friend or Foe?

(2011) Maria E. Moreno-Fernandez et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Bacterial toxins can inhibit host cell autophagy through cAMP generation

(2011) Shahab Shahnazari et al.   Autophagy

Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

(2011) Marceline Côté et al.   NATURE

The myriad roles of cyclic AMP in microbial pathogens: from signal to sword

(2011) Kathleen A. McDonough et al.   NATURE REVIEWS MICROBIOLOGY

T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus

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The Ebola virus glycoprotein mediates entry via a non-classical dynamin-dependent macropinocytic pathway

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Intracellular Events and Cell Fate in Filovirus Infection

(2011) Judith Olejnik et al.   Viruses-Basel

Phosphoinositide-3 Kinase-Akt Pathway Controls Cellular Entry of Ebola Virus

(2011) Mohammad F. Saeed et al.   PLoS Pathogens

Epac: Defining a New Mechanism for cAMP Action

(2010) Martijn Gloerich et al.   Annual Review of Pharmacology and Toxicology

Ebola and Marburg Hemorrhagic Fever

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Crosstalk Between PKA and Epac Regulates the Phenotypic Maturation and Function of Human Dendritic Cells

(2010) J. Garay et al.   JOURNAL OF IMMUNOLOGY

The Tyro3 Receptor Kinase Axl Enhances Macropinocytosis of Zaire Ebolavirus

(2010) C. L. Hunt et al.   JOURNAL OF VIROLOGY

Ebola haemorrhagic fever

(2010) Heinz Feldmann et al.   LANCET

Filovirus emergence and vaccine development: A perspective for health care practitioners in travel medicine

(2010) Uzma N. Sarwar et al.   Travel Medicine and Infectious Disease

Cellular Entry of Ebola Virus Involves Uptake by a Macropinocytosis-Like Mechanism and Subsequent Trafficking through Early and Late Endosomes

(2010) Mohammad F. Saeed et al.   PLoS Pathogens

Ebolavirus Is Internalized into Host Cells via Macropinocytosis in a Viral Glycoprotein-Dependent Manner

(2010) Asuka Nanbo et al.   PLoS Pathogens

Sustained cyclic AMP production by parathyroid hormone receptor endocytosis

(2009) Sébastien Ferrandon et al.   Nature Chemical Biology

Protein Kinase A-Dependent Step(s) in Hepatitis C Virus Entry and Infectivity

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Cyclic nucleotide analogs as probes of signaling pathways

(2008) Heiko Poppe et al.   NATURE METHODS