Article
Clinical Neurology
Sandra J. Weiss, Heather Flynn, Lisa Christian, Liisa Hantsoo, Teresa Lanza di Scalea, Sara L. Kornfield, Maria Muzik, Diana Simeonova, Bruce A. Cooper, Anna Strahm, Kristina M. Deligiannidis
Summary: The study identified three distinct profiles of depressive symptoms among high-risk women, including generally asymptomatic, elevated symptoms of comorbid anxiety and depression, and somatic symptoms. Financial security and greater social support were protective factors, while menstrual irregularity and stronger expression of neurovegetative symptoms characterized the different classes.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Brittany Lapin, Sara Davin, Mary Stilphen, Joshua K. Johnson, Edward Benzel, Ghaith Habboub, Irene L. Katzan
Summary: The study aimed to identify clinical symptom classes among patients presenting to a spine clinic and evaluate the demographic and clinical differences across classes. The results showed that patients with low back pain could be categorized into three distinct symptom classes, which could be used to inform specific symptom-based treatments.
Article
Oncology
Julie Hallet, Jesse Zuckerman, Matthew P. Guttman, Tyler R. Chesney, Barbara Haas, Alyson Mahar, Antoine Eskander, Wing C. Chan, Amy Hsu, Victoria Barabash, Natalie Coburn
Summary: Patient-reported symptom burden remains stable for up to 1 year after cancer surgery among older adults, with neither surgery nor adjuvant therapy coinciding with a worsening in symptom burden. However, the persistence of symptoms at 1 year may suggest gaps in supportive care for older adults.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Jingbo Yu, Betty K. Hamilton, James Turnbull, Susan K. Stewart, Alla Vernaya, Valkal Bhatt, Oren Meyers, John Galvin
Summary: This study investigated the symptom burden and impact on activities of daily living (ADL) in patients with chronic GVHD. The results showed a high symptom burden and significant interference with physical function and ADL in patients with chronic GVHD.
Article
Multidisciplinary Sciences
Tito R. Mendoza, David S. Hong, Christine B. Peterson, Bettzy Stephen, Ecaterina Dumbrava, Shubbam Pant, Apostolia Maria Tsimberidou, Timothy Anthony Yap, Ajay Sheshadri, Mehmet Altan, Goldy George, Lilibeth Castillo, Enedelia Rodriguez, Jing Gong, Vivek Subbiah, Filip Janku, Siqing Fu, Sarina A. Piha-Paul, Jordi Rodon Ahnert, Daniel D. Karp, Charles Cleeland, Funda Meric-Bernstam, Aung Naing
Summary: This study aimed to investigate the symptom burden and trajectory of patients with rare solid tumors treated with immunotherapy. The results showed that fatigue, pain, disturbed sleep, lack of appetite, and drowsiness were the most severe symptoms reported by patients, while symptoms such as abdominal pain, rash, and diarrhea were less severe. Some rare malignancy patients experienced high symptom burden even at the beginning of the treatment, and the symptom burden remained stable over the 9-week treatment period.
SCIENTIFIC REPORTS
(2022)
Article
Health Care Sciences & Services
Josephine J. Koldenhof, Frederieke H. van der Baan, Elisabeth G. Verberne, Annemarleen M. Kamphuis, Rik J. Verheijden, Erwin H. Tonk, Anne S. van Lindert, Janneke van der Stap, Saskia C. Teunissen, Petronella O. Witteveen, Karjin P. Suijkerbuijk
Summary: This study examined the symptoms and impact of immune-related adverse events (irAEs) on health-related quality of life (HRQL) in patients with melanoma or non-small lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICI). The results showed that the prevalence of symptoms decreased during treatment, and patients generally reported a low influence of side effects on HRQL. However, a higher number of clinically relevant symptoms was associated with poorer wellbeing in patients.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2022)
Article
Oncology
Carolyn L. Qian, Emilia R. Kaslow-Zieve, Chinenye C. Azoba, Nora Horick, Irene Wang, Emily Van Seventer, Richard Newcomb, Barbara J. Cashavelly, Vicki A. Jackson, David P. Ryan, Joseph A. Greer, Areej El-Jawahri, Jennifer S. Temel, Ryan D. Nipp
Summary: Hospitalized patients with cancer report high care satisfaction, which is associated with older age and admission to a dedicated oncology service. Higher satisfaction is associated with lower symptom burden and shorter hospital length of stay, highlighting the importance of improving symptom management and care coordination in this population.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Health Care Sciences & Services
Sara Wallstrom, Jason M. Sutherland, Jacek A. Kopec, Aslam H. Anis, Richard Sawatzky
Summary: According to the research findings, there are significant differences in symptom patterns among patients during their initial oncology visit, which are closely associated with clinical diagnoses and socio-demographic differences. These results highlight the importance of considering the social situation of patients, rather than just their diagnosis, to better understand the differences in symptom patterns among people living with cancer.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2022)
Article
Psychology, Multidisciplinary
Yanran Li, Zonghao Zhang, Xuanxuan Ma, Xue Zhang, Shuwen Li
Summary: The purpose of this study was to identify the latent classes of resilience in patients with esophageal cancer after esophagectomy and explore the association between these classes and patient-reported symptoms. The results revealed significant differences in symptoms and symptom-related interference among different resilience classes. Accurate interventions should be developed based on each type of resilience to maximize intervention efficacy.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Pediatrics
Natasha A. Jawa, Adam Rapoport, Kimberley Widger, Michael Zappitelli, Sara N. Davison, Sarita Jha, Allison B. Dart, Mina Matsuda-Abedini
Summary: This study developed a patient-reported symptom assessment tool for children with CKD/kidney failure (PRO-Kid) and optimized the questionnaire design through cognitive interviews with 24 participants. The most common symptoms reported by children with CKD/kidney failure included feeling left out, feeling sad/depressed, inability to focus, tiredness, nausea, vomiting, not wanting to eat, and changes in the taste of food.
PEDIATRIC NEPHROLOGY
(2022)
Article
Multidisciplinary Sciences
Damien S. E. Broekharst, Sjaak Bloem, Edward A. G. Groenland, W. Fred van Raaij, Michel van Agthoven
Summary: Many people have attempted to develop burden of disease rankings for various purposes in healthcare. However, the rankings based on expert reports may differ from those based on patient reports. This study highlights the importance of developing and utilizing patient reported burden of disease rankings to establish a more comprehensive perspective on burden of disease.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Elena Parvez, Megan Chu, David Kirkwood, Aristithes Doumouras, Mark Levine, Jessica Bogach
Summary: This study compared the symptom burden between immigrant and long-term resident women undergoing breast cancer surgery in Ontario, Canada. The results showed that immigrant women had a higher burden of pain and other symptoms.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Nursing
Kristine L. Kwekkeboom, Ann Wieben, Loyda Braithwaite, Kaitlyn Hopfensperger, Kyung Soo Kim, Kathleen Montgomery, Margaret Reske, Jennifer Stevens
Summary: This study reveals significant variability in the characteristics of symptom clusters among cancer patients, with greater burden and interference of symptom clusters being associated with poorer health outcomes. The patient-centered view of symptom clusters has important implications for symptom management.
WESTERN JOURNAL OF NURSING RESEARCH
(2022)
Article
Urology & Nephrology
Amy S. You, Sara S. Kalantar, Keith C. Norris, Rene Amel Peralta, Yoko Narasaki, Ronald Fischman, Michael Fischman, Avedik Semerjian, Tracy Nakata, Zahra Azadbadi, Danh Nguyen, Kamyar Kalantar-Zadeh, Connie M. Rhee
Summary: This study aimed to investigate the prevalence and severity of unpleasant symptoms in hemodialysis patients. The study found that fatigue, dry skin, trouble falling asleep, muscle cramps, and itching were common symptoms in dialysis patients, with variations in severity among different racial groups. Lower hemoglobin, iron stores, and dialysis adequacy were associated with higher symptom severity.
JOURNAL OF NEPHROLOGY
(2022)
Article
Oncology
Kai-nan Zhou, Yan Wang, Yi Xie, Shu-han Yang, Su-ying Liu, Yu-hang Fang, Ying Zhang
Summary: The purpose of this study is to determine the incidence and severity of symptoms in patients with cervical cancer within 6 months after radiotherapy and chemotherapy. The study identified nine symptom clusters and highlighted the three most serious symptom clusters. This research provides important insights for improving symptom management in cervical cancer patients after radiotherapy and chemotherapy.
SUPPORTIVE CARE IN CANCER
(2023)
Review
Nursing
Hongjin Li, Tingting Liu, Lacey W. Heinsberg, Mark B. Lockwood, Derek A. Wainwright, Min Kyeong Jang, Ardith Z. Doorenbos
BIOLOGICAL RESEARCH FOR NURSING
(2020)
Article
Gastroenterology & Hepatology
Elena Ignatiev, Melanie K. Samardzija, Sonali Paul, Karen M. Vuckovic, Mark B. Lockwood
Summary: The study educated patients with ascites and their caregivers using a self-monitoring guide, resulting in improved clinician and patient satisfaction. Implementation of self-monitoring may lead to increased satisfaction among clinicians and patients, as well as improvements in clinic workflows.
GASTROENTEROLOGY NURSING
(2021)
Review
Oncology
Asha Mathew, Amit Jiwan Tirkey, Hongjin Li, Alana Steffen, Mark B. Lockwood, Crystal L. Patil, Ardith Z. Doorenbos
Summary: This systematic review examined the conceptual approaches and methodologies used in symptom-cluster research in patients with head and neck cancer. The study identified three prominent symptom clusters in these patients: general, head and neck cancer-specific, and gastrointestinal. Factors such as being female and quality of life were found to be significantly associated with high symptom group or cluster severity.
SEMINARS IN ONCOLOGY NURSING
(2021)
Review
Urology & Nephrology
Rebecca S. Ahdoot, Kamyar Kalantar-Zadeh, James O. Burton, Mark B. Lockwood
Summary: CKD-aP significantly impairs HRQoL in patients with ESKD undergoing dialysis and is associated with adverse clinical outcomes. Despite being underrecognized and undertreated, clinical studies have shown that reduction of itch intensity may alleviate other associated symptoms, such as poor sleep quality. CKD-aP and its associated symptoms are inadequately managed in clinical practice, highlighting the need for greater understanding and awareness to improve overall symptom management and HRQoL in dialysis patients.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2022)
Review
Urology & Nephrology
Daniel G. Tobin, Mark B. Lockwood, Paul L. Kimmel, Laura M. Dember, Nwamaka D. Eneanya, Manisha Jhamb, Thomas D. Nolin, William C. Becker, Michael J. Fischer
Summary: Chronic pain is prevalent among patients with haemodialysis-dependent kidney failure, but its management is often inadequate. Opioid analgesics are commonly prescribed in these patients, but are associated with increased morbidity, mortality and healthcare resource use. Evidence for the effectiveness of opioids in pain management in this population is lacking.
NATURE REVIEWS NEPHROLOGY
(2022)
Article
Urology & Nephrology
Kamyar Kalantar-Zadeh, Mark B. Lockwood, Connie M. Rhee, Ekamol Tantisattamo, Sharon Andreoli, Alessandro Balducci, Paul Laffin, Tess Harris, Richard Knight, Latha Kumaraswami, Vassilios Liakopoulos, Siu-Fai Lui, Sajay Kumar, Maggie Ng, Gamal Saadi, Ifeoma Ulasi, Allison Tong, Philip Kam-Tao Li
Summary: Patients with chronic kidney disease (CKD) often experience symptom burden caused by disease processes, comorbid conditions, therapeutics, and lifestyle regimens. These symptoms may involve various systems and are often worsened by factors such as uremic toxins, comorbid conditions, pharmacotherapies, and aging. A tailored palliative care approach can help identify and target these unpleasant symptoms, ultimately improving patient outcomes and quality of life.
NATURE REVIEWS NEPHROLOGY
(2022)
Review
Urology & Nephrology
Mark B. Lockwood, Jennifer L. Steel, Ardith Z. Doorenbos, Blanca N. Contreras, Michael J. Fischer
Summary: Patients with chronic kidney disease often experience moderate to severe pain, compounded by comorbid depression and anxiety. Nonpharmacologic treatments targeting pain, depression, and anxiety show promise, but their effects in this population are still largely unknown.
SEMINARS IN NEPHROLOGY
(2021)
Article
Nursing
Wiphawadee Potisopha, Karen M. Vuckovic, Holli A. DeVon, Chang G. Park, Nichapatr Phutthikhamin, Patricia E. Hershberger
Summary: Decision delay is a significant factor contributing to prehospital delay in stroke patients, and it can be influenced by various factors.
WESTERN JOURNAL OF NURSING RESEARCH
(2023)
Article
Urology & Nephrology
Connie M. Rhee, Dawn Edwards, Rebecca S. Ahdoot, James O. Burton, Paul T. Conway, Steven Fishbane, Daniel Gallego, Maurizio Gallieni, Nieltje Gedney, Glen Hayashida, Julie Ingelfinger, Merle Kataoka-Yahiro, Richard Knight, Joel D. Kopple, Latha Kumarsawami, Mark B. Lockwood, Mariana Murea, Victoria Page, J. Emilio Sanchez, Jacek C. Szepietowski, Siu-Fai Lui, Kamyar Kalantar-Zadeh
Summary: Chronic kidney disease (CKD) leads to a variety of uremic symptoms that may not be properly recognized, diagnosed, or treated. Optimizing symptom management is crucial for preventing or delaying the need for dialysis. Taking into account the individual needs and priorities of CKD patients, including effective symptom management, is essential for optimal treatment.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Nursing
Mark B. Lockwood, George E. Chlipala, Mark Maeinschein-Cline, Holli A. DeVon, Alicia B. Lichvar, Manpreet K. Samra, Chang G. Park, Maya Campara, Ardith Z. Doorenbos, Lisa M. Tussing-Humphreys, Mario Spaggiari, Ulf G. Bronas, Jennifer L. Steel, Stefan S. Green
Summary: This study aimed to explore the associations between gut microbiome features and pain interference before and after kidney transplantation. The researchers collected fecal specimens and pain interference data from 19 living donor kidney transplant recipients. The results showed that the gut microbiota community structure differed between groups with and without pain interference at 3 months after transplantation. Additionally, certain taxa associated with intestinal barrier integrity and chronic inflammation were found to be related to posttransplant pain.
PAIN MANAGEMENT NURSING
(2023)
Article
Nursing
Hongjin Li, Mark B. Lockwood, Judith M. Schlaeger, Tingting Liu, Oana C. Danciu, Ardith Z. Doorenbos
Summary: This study investigated the relationship between the metabolites involved in the tryptophan-kynurenine pathway and psychoneurological symptoms among breast cancer survivors, and found that the tryptophan-kynurenine pathway and impaired tryptophan availability may contribute to the development of psychoneurological symptoms.
PAIN MANAGEMENT NURSING
(2023)
Article
Nursing
Hye Jin Chong, Min Kyeong Jang, Mark B. Lockwood, Chang Park
Summary: This study analyzed the impact of the constructs of the health belief model on influenza vaccine uptake in kidney transplant recipients. The findings showed that previous influenza vaccination directly influenced the behavior of the recipients, while cues to action alone did not have a direct impact. Perceived benefits played a significant role as a mediator in improving vaccine uptake. The study underscores the importance of health professionals assessing perceived benefits at an individual level and providing patient-centered interventions based on theoretical mechanisms.
WESTERN JOURNAL OF NURSING RESEARCH
(2023)
Review
Nursing
Choa Sung, Patricia Ensweiler Hershberger, Mark B. Lockwood
Summary: Sickness symptoms, such as depressive symptoms, anxiety, and fatigue, are common among people with chronic illness, including KT recipients. While these symptoms are interrelated, they do not form a distinct cluster. Fatigue, anxiety, and depressive symptoms are the most prevalent among KT recipients. Various factors, including demographic, clinical, and psychosocial factors, can predict these symptoms.
WESTERN JOURNAL OF NURSING RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Holli A. DeVon, Nathan Tintle, Ulf G. Bronas, Sahereh Mirzaei, Eleanor Rivera, Melissa Gutierrez-Kapheim, Windy W. Alonso, Steven J. Keteyian, Madison Goodyke, Susan L. Dunn
Summary: In adults with ischemic heart disease, comorbidities and hopelessness are independently associated with increased risk of mortality. This study found an association between comorbidities and state hopelessness in individuals hospitalized for ischemic heart disease. Therefore, hospitalized individuals with ischemic heart disease who have higher number of comorbidities may benefit from targeted assessment and brief cognitive intervention to identify and ameliorate the state hopelessness associated with worse long-term outcomes.
Article
Medicine, Research & Experimental
Mark B. Lockwood, Michael J. Fischer, Kimberly Silva, Blanca N. Contreras, Guillermo Zamora, Amanda Goldstein, Monya Meinel, Christopher Holden, James Lash, Alana Steffens, Ardith Doorenbos
Summary: Pain has negative effects on hemodialysis treatment adherence, quality of life, and mortality. The lack of effective nonpharmacological strategies to treat pain has had detrimental effects on end-stage kidney disease patients on hemodialysis. The gut microbiome has been found to play a critical role in health and chronic pain. This pilot study aims to investigate the effects of a nonpharmacological pain intervention on the composition and function of the gut microbiome and circulating metabolites.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2022)
