Article
Multidisciplinary Sciences
Carol M. Sheppard, Daniel H. Goldhill, Olivia C. Swann, Ecco Staller, Rebecca Penn, Olivia K. Platt, Ksenia Sukhova, Laury Baillon, Rebecca Frise, Thomas P. Peacock, Ervin Fodor, Wendy S. Barclay
Summary: This study reveals that human ANP32A and ANP32B are redundant host factors for influenza virus genome replication. By investigating the evolution of influenza virus in cells lacking ANP32A and ANP32B, the researchers discovered mutations that enable the virus to utilize ANP32E, a novel host factor, and observed increased virulence in mice.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Chengjun Li, Hualan Chen
Summary: In early 2013, human infections caused by a novel H7N9 avian influenza virus were first reported in China, which later evolved into highly pathogenic strains. Since 2017, nationwide vaccination of chickens has successfully controlled H7N9 avian influenza infections in poultry and prevented human infections.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Zhiyuan Liu, Yanna Guo, Lingcai Zhao, Qingzheng Liu, Miao Tian, Nan Huang, Menglu Fan, Mengqi Yu, Huizhi Xia, Jihui Ping
Summary: This study identified circRNAs expressed in mouse lungs during infection with H7N9 influenza virus and its mutant viruses, and found that these circRNAs may have important immune-regulating functions during viral infection. The altered circRNA expression profiles following H7N9 influenza A virus infection suggest their potential role in the viral infection process.
Article
Microbiology
Guoqing Wang, Dong Liu, Jiao Hu, Min Gu, Xiaoquan Wang, Dongchang He, Lei Zhang, Jun Li, Xinxin Zheng, Zixiong Zeng, Huimou Liu, Shunlin Hu, Daxin Peng, Xinan Jiao, Xiufan Liu
Summary: The first avian H7N9 influenza outbreak in spring of 2013 posed a dual challenge to public health and poultry industry by unprecedented transmission from infected poultry to humans. Through generating a mouse-adapted H7N9 variant virus, the study found that the adapted virus showed higher replication efficiency and pathogenicity in mice.
VETERINARY MICROBIOLOGY
(2021)
Article
Microbiology
Jun Li, Rumeng Li, Qi Zhang, Peipei Peng, Xiaoquan Wang, Min Gu, Zenglei Hu, Xinan Jiao, Daxin Peng, Jiao Hu, Xiufan Liu
Summary: This study demonstrates that the H7N9 VLP vaccine provides complete clinical protection against HP H7N9 virus, significantly inhibits virus shedding, and abolishes viral replication in chickens. The VLP vaccine represents a promising alternative strategy for the development of novel H7N9 avian influenza vaccines for chickens.
VETERINARY MICROBIOLOGY
(2021)
Article
Microbiology
Xin Yin, Guohua Deng, Xianying Zeng, Pengfei Cui, Yujie Hou, Yanjing Liu, Jingzhen Fang, Shuxin Pan, Dongxue Wang, Xiaohan Chen, Yaping Zhang, Xiurong Wang, Guobin Tian, Yanbing Li, Yan Chen, Liling Liu, Yasuo Suzuki, Yuntao Guan, Chengjun Li, Jianzhong Shi, Hualan Chen
Summary: The H7N9 avian influenza virus has caused five waves of human infection in China, but further cases have been prevented since September 2017 through the use of a vaccine in poultry. However, the virus has not been eradicated from poultry, with genetic analysis revealing new genotypes and the potential for escape from vaccine-induced immunity. The antigenic differences identified between the 2019 H7N9 viruses and the vaccine strain used for control in poultry highlight ongoing challenges in evolution and control of the virus.
Article
Biochemistry & Molecular Biology
Chang Shu, Qinglan Sun, Guomei Fan, Kesheng Peng, Zhengfei Yu, Yingfeng Luo, Shenghan Gao, Juncai Ma, Tao Deng, Songnian Hu, Linhuan Wu
Summary: The VarEPS-Influ database is a risk assessment system for influenza virus variations that comprehensively evaluates various aspects of mutations, including physical and chemical properties, structural features, receptor affinity, antibody binding capacity, etc., and considers factors such as time and spatial distribution and host species distribution. It accurately evaluates and predicts the risk of influenza virus variations.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Medicine, Research & Experimental
Iuliia M. Gilchuk, Sandhya Bangaru, Nurgun Kose, Robin G. Bombardi, Andrew Trivette, Sheng Li, Hannah L. Turner, Robert H. Carnahan, Andrew B. Ward, James E. Crowe Jr
Summary: This study examined the B cell response to H7 HA in individuals who had recovered from natural H7N9 virus infection. Circulating H7-reactive B cells were found to recognize a diverse antigenic landscape on the HA molecule and exhibit broad recognition of unrelated H7 strains. Functional testing of the antibodies revealed diverse patterns of inhibition, including neutralizing and HA trimer-disrupting activities.
Article
Virology
Baodi Li, Guofeng Xiang, Jun He, Hongyu Li, Congshan Xu, Aihong Yu, Zhe Zhao, Xueying Wang, Lihua Zhang, Hui Zhang, Huimin Zhang, Mingjun Xie, Peng Wang, Deshan Yu
Summary: The fifth wave of Avian H7N9 influenza virus outbreak was reported in Gansu Province, China during 2016-2017, with 5 human cases detected. Environmental samples tested positive for H7N9, indicating potential threat to human health. Phylogenetic analysis suggested two distinct trade routes as potential sources of the virus introduction into Gansu.
Article
Microbiology
Zhibin Shi, Lili Wei, Pengfei Wang, Shida Wang, Zaisi Liu, Yongping Jiang, Jingfei Wang
Summary: This study conducted a spatial and temporal Bayesian evolutionary analysis to understand the spread and evolution process of the H7N9 influenza A virus. The findings showed that the virus likely emerged in August 2012 in a border area of Anhui Province, 6 months earlier than the first reported human case. By the end of 2013, two major epicenters had formed in the Yangtze River Delta and Pearl River Delta regions, and the virus spread to other regions at an average speed of 6.57 km/day. The study also developed a model based on the random forest algorithm to predict the occurrence risk of the H7N9 virus.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Virology
Swan Tan, Muhammad Farhan Sjaugi, Siew Chinn Fong, Li Chuin Chong, Hadia Syahirah Abd Raman, Nik Elena Nik Mohamed, Joseph Thomas August, Asif M. Khan
Summary: Avian influenza virus H7N9, which has been circulating in avian hosts for decades, was identified as a human pathogen in 2013. Through comparing sequences from avian and human H7N9 datasets, it was found that the virus has undergone significant amino acid substitutions possibly essential for human adaptation. The rapid evolution of the avian H7N9 virus has resulted in almost identical protein sequences in avian and human viruses, leading to increased risk of human infection and potential human-to-human transmission.
Article
Genetics & Heredity
Neli Korsun, Ivelina Trifonova, Silvia Voleva, Iliyana Grigorova, Svetla Angelova
Summary: This study analyzed the circulation of influenza viruses in Bulgaria during the 2019/2020 season, performed phylogenetic and molecular analyses of different virus strains, and identified amino acid substitutions compared to vaccine strains. The results confirm the rapid evolution of influenza viruses and the importance of continuous antigenic and genetic surveillance to track these changes.
Article
Microbiology
Yuncong Yin, Yuan Liu, Juan Fen, Kaituo Liu, Tao Qin, Sujuan Chen, Daxin Peng, Xiufan Liu
Summary: This study identifies the first evidence of the low-pathogenicity H7N9 avian influenza virus infecting camels, posing a high risk to public health.
MICROBIOLOGY SPECTRUM
(2023)
Article
Virology
Jun He, Sai Hou, Chenglong Xiong, Linjie Hu, Lei Gong, Junling Yu, Xiaoyu Zhou, Qingqing Chen, Yuan Yuan, Lan He, Meng Zhu, Weiwei Li, Yonglin Shi, Yong Sun, Haifeng Pan, Bin Su, Yihan Lu, Jiabing Wu
Summary: This study discusses the possible impact of H7N9 influenza A viruses (IAVs) on future influenza epidemics through gene reassortment events. A total of 61 human H7N9 isolates were obtained from Anhui province in China from 2013 to 2019, and bioinformatics analyses revealed the introduction of novel avian influenza A virus (AIV) subtypes through gene reassortment. The study also showed that H7N9, H9N2, and H5N1 can serve as persistent gene pools for AIVs in specific regions of China.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Veterinary Sciences
Jiao Hu, Peipei Peng, Jun Li, Qi Zhang, Rumeng Li, Xiaoquan Wang, Min Gu, Zenglei Hu, Shunlin Hu, Xiaowen Liu, Xinan Jiao, Daxin Peng, Xiufan Liu
Summary: The bivalent H5+H7 VLP vaccine candidate shows promising results in protecting poultry against highly pathogenic H5N1 and H7N9 avian influenza viruses, and may serve as a critical alternative to traditional egg-based inactivated vaccines.
FRONTIERS IN VETERINARY SCIENCE
(2021)