Review
Chemistry, Multidisciplinary
Qing Dan, Xinpeng Jiang, Run Wang, Zhifei Dai, Desheng Sun
Summary: Biogenic imaging contrast agents (BICAs) have unique properties that make them valuable in various in vitro and in vivo studies, such as quantification of gene expression, observation of protein interactions, visualization of cellular proliferation, monitoring of metabolism, and detection of dysfunctions. BICAs are matched with different imaging techniques, including fluorescent proteins for fluorescence imaging, gas vesicles for ultrasound imaging, and ferritin for magnetic resonance imaging. Bimodal and multimodal imaging can be achieved by combining the functions of different BICAs, overcoming the limitations of monomodal imaging.
Article
Chemistry, Physical
Wen-Jie Shu, Zhe Ma, Xiaojie Tian, Fu Wang
Summary: In this study, a genetic switch system based on OATP1B3 is designed and optimized to achieve near-infrared fluorescent imaging of miRNA by the uptake of ICG dye. The system is shown to be sensitive for imaging miRNA in mammalian cells and functional for real-time imaging in living mice. This study establishes a novel genetic encoded reporter for near-infrared fluorescence imaging of miRNA.
Review
Biochemistry & Molecular Biology
Chien-Hsiu Li, Chiao-Chun Liao
Summary: Cancer is often the result of abnormal glucose uptake and imbalanced nutrient metabolism. Dysregulation of glucose metabolism and autophagy, as well as the involvement of miRNA Let-7, play crucial roles in tumor progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Genetics & Heredity
Jun Liu, Madeline A. Sauer, Shaza G. Hussein, Junyu Yang, Daniel G. Tenen, Li Chai
Summary: SALL4, a transcription factor important in embryonic stem cells, is re-expressed in various human cancers and its dysregulation contributes to cancer pathogenesis and drug resistance. Recent studies suggest that miRNAs play a crucial role in controlling SALL4 expression, making them promising therapeutic targets for cancer treatment.
Article
Oncology
Guangcheng Bao, Jun Sun, Helin Zheng, Jingxin Hou, Jie Huang, Jie Wei, Yuanqiao Fu, Jiawen Qiu, Xuefeng Zou, Bin Xiang, Jinhua Cai
Summary: The study developed a miR-21-responsive gene reporter system for MRI visualization of miR-21 dynamics in neuroblastoma by monitoring FTH1 expression, MRI contrast, and intracellular iron uptake, which provides a potential method for visualizing endogenous miR-21 activity and its response to gene therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Physiology
Ying Huang, Manshu Yu, Akihiro Kuma, Janet D. Klein, Yanhua Wang, Faten Hassounah, Hui Cai, Xiaonan H. Wang
Summary: This study found that Acu/LFES enhances protein synthesis in both hindlimb and forelimb muscles by reducing let-7-5p levels, which leads to upregulation of the Igf1 signaling pathway. This provides a new understanding of how electrical acupuncture treatment positively influences muscle health.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tomohiro Inui, Hideki Sezutsu, Takaaki Daimon
Summary: The let-7 microRNA controls the timing of developmental programs and triggers the juvenile-adult transition in various organisms. In Bombyx mori, let-7 is required for the coordination of ecdysone and juvenile hormone biosynthesis during metamorphosis.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Oncology
Anna Laura Di Pace, Andrea Pelosi, Piera Filomena Fiore, Nicola Tumino, Francesca Besi, Linda Quatrini, Silvia Santopolo, Paola Vacca, Lorenzo Moretta
Summary: Natural Killer (NK) cells release exosomes containing miRNAs that play a role in their anti-tumor function. In this study, the miRNA content of NK exosomes was explored and a small subset of highly expressed miRNAs was identified. NK exosomes were found to increase let-7b-5p expression in pancreatic cancer cells, inhibiting cell proliferation. However, co-culture with pancreatic cancer cells reduced the cytolytic activity and miRNA content of NK exosomes. This study provides new insights into the molecular mechanisms and potential applications of NK exosomes in cancer treatment.
Article
Pharmacology & Pharmacy
Niloufar Maghsoudnia, Reza Baradaran Eftekhari, Alireza Naderi Sohi, Farid Abedin Dorkoosh
Summary: The study aimed to investigate the anti-tumor effect of let-7b-loaded PAMAM dendrimers on NSCLC cells and employed chloroquine to enhance endosomal escape. Nanoparticles coated with hyaluronic acid were developed as carriers targeting CD44 receptors on NSCLC cells. The results demonstrated that this combination could be a promising therapeutic option for cancer cell inhibition.
CURRENT DRUG DELIVERY
(2021)
Article
Biochemistry & Molecular Biology
Calder W. Reinsborough, Helene Ipas, Nathan S. Abell, Ellen B. Gouws, J. Paige Williams, Marvin Mercado, Carla Van den Berg, Blerta Xhemalce
Summary: BCDIN3D plays a crucial role in regulating metabolic pathways in cancer, with a connection to increased glycolysis and reduced glucose metabolism capacity, while also regulating ALDOC expression. This connection may be relevant to breast cancer, obesity, and T2D.
Review
Biochemistry & Molecular Biology
Tianxin Gao, Pei Wang, Teng Gong, Ying Zhou, Ancong Wang, Xiaoying Tang, Xiaolei Song, Yingwei Fan
Summary: The use of molecular imaging technologies in brain imaging is not only important for disease diagnosis and treatment, but also for in-depth study of brain functions. Reporter gene technology based on optical imaging has made breakthroughs in molecular-level brain function studies. The applications of magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), and positron emission tomography (PET) reporter gene technologies in brain imaging are discussed, with a focus on cell therapies and gene therapies. These methods have shown potential for preclinical and clinical research, providing deeper imaging depths and wider imaging ranges.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Aranzazu Chamorro-Jorganes, Walid K. Sweaad, Rajesh Katare, Marie Besnier, Maryam Anwar, N. Beazley-Long, Graciela Sala-Newby, Inigo Ruiz-Polo, Dhananjie Chandrasekera, Alison A. Ritchie, Andrew Benest, Costanza Emanueli
Summary: The research revealed that METTL3 regulates m(6)A RNA methylation in endothelial cells and is essential for angiogenesis, potentially through influencing the processing of let-7e and miR-17-92 cluster.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Immunology
Wenjiao Wu, Chao Wang, Changliang Xia, Shuwen Liu, Qinghua Mei
Summary: The study reveals the regulatory effect of let-7 on influenza A infection, wherein let-7 can modulate interferon expression and inhibit viral replication. Additionally, let-7 may serve as a potential biomarker of influenza A infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Xinling Li, Xiaochun Yang, Zhijian Li, Xiaobin Zheng, Yong-Jian Peng, Wenjie Lin, Ling Zhou, Dehai Cao, Minyi Situ, Qingqiang Tu, Huiqiang Huang, Wei Fan, Guokai Feng, Xiaofei Zhang
Summary: Cell therapies have achieved cures for hematopoietic disorders, neurodegenerative diseases, and cancer, but not all patients can benefit from them. The clinical methods for monitoring the therapeutic functions of transferred cells over time are limited, resulting in uncertain prognosis. Positron emission tomography (PET) cell tracking provides comprehensive information on the proliferation status and distribution of therapeutic cells. This study developed the first SNAP-tagged PET radiotracer, which can selectively target SNAP-tagged cells for in vivo cell tracking, with promising results in vitro and in vivo.
Article
Endocrinology & Metabolism
Jiahui Song, Haining Lv, Beibei Liu, Mingjun Hao, Hugh S. Taylor, Xuchen Zhang, Da Li, Yingqun Huang
Summary: The study reveals the important role of let-7 in liver fibrosis progression. It inhibits the production of TGF-I31 and expression of FAS, thereby reducing hepatocyte apoptosis and liver fibrosis. The findings highlight the potential use of let-7 and its derivatives as therapeutic agents for liver fibrosis.
MOLECULAR METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Fang-Ju Cheng, Chia-Hung Chen, Wen-Chen Tsai, Bo-Wei Wang, Meng-Chieh Yu, Te-Chun Hsia, Ya-Ling Wei, Yu-Chun Hsiao, Dai-Wei Hu, Chien-Yi Ho, Tzong-Shiun Li, Chun-Yi Wu, Wen-Yu Chou, Yung-Luen Yu, Chih-Hsin Tang, Chih-Yi Chen, Chuan-Mu Chen, Jennifer L. Hsu, Hsiao-Fan Chen, Yeh Chen, Chih-Yen Tu, Mien-Chie Hung, Wei-Chien Huang
Summary: Smokers with non-small cell lung cancer have lower sensitivity to EGFR tyrosine kinase inhibitors, as exposure to cigarette smoke extract enhances glycolysis and weakens the inhibition of mTOR by AMPK, thus reducing the sensitivity of NSCLC cells to EGFR TKI by repressing LKB1 expression. Additionally, LKB1 expression is positively correlated with TKI sensitivity in NSCLC patients, and combined treatment with EGFR TKI and AMPK activators increases TKI sensitivity synergistically.
Article
Biochemistry & Molecular Biology
Yi-Hsuan Lo, Ting-Yu Chang, Chuan-Lin Chen, Ming-Hsien Lin, Hsin-Ell Wang, Chi-Wei Chang, Ren-Shyan Liu, Chun-Yi Wu
Summary: This study successfully prepared novel radiolabeled conjugates, F-18-FPABZA and F-18-FNABZA, demonstrating that F-18-FPABZA is a promising PET probe for melanotic melanoma targeting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Chun-Yi Wu, Hsin-Hua Hsieh, Ting-Yu Chang, Jia-Jia Lin, Chin-Ching Wu, Ming-Hua Hsu, Ming-Chia Lin, Shin-Lei Peng
Summary: This study aimed to develop novel AuNPs containing boron and gadolinium for BNCT. The in vitro MR images showed a positive correlation between signal intensity and Gd concentration, allowing clear visualization of tumors. The developed AuNPs show potential for theranostic applications in cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yi-Ping Yang, Andy Chi-Lung Lee, Liang-Ting Lin, Yi-Wei Chen, Pin- Huang, Hsin- Ma, Yi-Chen Chen, Wen-Liang Lo, Yuan-Tzu Lan, Wen-Liang Fang, Chien-Ying Wang, Yung-Yang Liu, Po-Kuei Hsu, Wen-Chang Lin, Chung-Pin Li, Ming-Teh Chen, Chian-Shiu Chien, Mong-Lien Wang
Summary: This study presents a new therapeutic strategy for GBM tumor by targeting the protein-protein interaction between MSI1 and AGO2 with synthetic peptides. The decoy peptides identified from the C-terminus of MSI1 showed promising therapeutic efficacy in suppressing tumor growth and prolonging survival rates. These findings provide a new rationale for developing targeted therapeutics for GBM.
Article
Pharmacology & Pharmacy
Min-Ying Lin, Hsin-Hua Hsieh, Jyh-Cheng Chen, Chuan-Lin Chen, Nin-Chu Sheu, Wen-Sheng Huang, Shinn-Ying Ho, Ting-Wen Chen, Yi-Jang Lee, Chun-Yi Wu
Summary: Lu-1(77)-DTPA-pAuNS can accumulate in head and neck squamous cell carcinoma tumors and provide therapeutic efficacy, with lower radiation absorbed dose to the tumor compared to Lu-177-DTPA. The combination of Lu-177-DTPA-pAuNS with photothermal therapy shows enhanced tumor-suppressive effects, indicating potential for use in brachytherapy for HNSCC.
Article
Biochemistry & Molecular Biology
Chun-Yi Wu, Yu-Hsin Lin, Hsin-Hua Hsieh, Jia-Jia Lin, Shin-Lei Peng
Summary: The study found that rats with diabetes had significantly decreased brain metabolism in all regions compared to healthy controls, and female diabetic rats showed a further reduction in cerebral metabolism relative to male diabetic rats. These results suggest a potential sexual dimorphism in diabetes-related brain alterations.
Article
Nanoscience & Nanotechnology
Shiying Li, Kwok-Ho Lui, Wing-Sum Lau, Juyu Chen, Wai-Sum Lo, Xin Li, Yan-Juan Gu, Liang-ting Lin, Wing-Tak Wong
Summary: A novel multifunctional nanotheranostic agent PAuE has been developed for multispectral optoacoustic tomography-guided photo-thermal therapy and chemotherapy, showing remarkable tumor growth inhibition in mouse models and providing a new insight into anti-cancer therapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sheng-Min Huang, Chun-Yi Wu, Yu-Hsin Lin, Hsin-Hua Hsieh, Hui-Chieh Yang, Shao-Chieh Chiu, Shin-Lei Peng
Summary: This study found that fALFF can differentiate healthy controls from diabetic animals, providing meaningful information about abnormal neural activity in diabetic rats.
BMC MEDICAL IMAGING
(2022)
Article
Chemistry, Multidisciplinary
Hsin-Hua Hsieh, Wei-Ying Kuo, Jia-Jia Lin, Hong -Sen Chen, Hung-Ju Hsu, Chun-Yi Wu
Summary: By constructing a synthetic antibody library and conducting various experiments, we successfully identified 11A antibody with optimal biological characteristics as an excellent PSMA-targeting component.
Article
Pharmacology & Pharmacy
Kuang-Chung Shih, Hui-Wen Chan, Chun-Yi Wu, Hui-Yen Chuang
Summary: Radiotherapy combined with curcumin enhances the abscopal effect by boosting immune activation, leading to significant tumor suppression and increased accumulation of activated T cells. The combination treatment also upregulates the expression of proapoptotic and proinflammatory proteins in primary and secondary tumors. These findings suggest that curcumin can effectively augment RT-induced anti-tumor and abscopal effects as an immune booster.
Article
Chemistry, Medicinal
Li-An Chen, Yueh-Hsiang Yu, Wei-Ting Tian, Wei-Chen Lin, Cedric Grauffel, Chun-Yi Wu, Chuan-Lin Chen, Carmay Lim, Hsing-Mao Chu, Tse-Wen Chang, Chi-Jiun Peng
Summary: Antibodies conjugated with diagnostic/therapeutic radionuclides, such as TE-1132, show promise for treating inoperable cancers like pancreatic cancer. TE-1132, composed of α-CA19-9 scFv-Fc conjugated to 3 DOTA chelators, demonstrated high radioactivity and selective tumor accumulation in mouse models. The administration of [Lu-177]Lu-TE-1132 effectively inhibited tumor growth and improved survival without adverse effects.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Neurosciences
Chun-Yi Wu, Hsin-Hua Hsieh, Sheng-Min Huang, Shao-Chieh Chiu, Shin-Lei Peng
Summary: This study investigated the potential effect of ovariohysterectomy on brain integrity in rat model using diffusion tensor imaging (DTI) technique for the first time. The results showed that ovariohysterectomy caused neuronal injury in various brain regions and demyelination, as indicated by significantly lower fractional anisotropy. Therefore, neuroimaging should be performed to monitor brain alterations in women after hysterectomy with bilateral oophorectomy in clinical settings.
Article
Cell Biology
Yao-Wen Chang, Huey-Wen Hsiao, Ju-Pei Chen, Sheue-Fen Tzeng, Chin-Hsien Tsai, Chun-Yi Wu, Hsin-Hua Hsieh, Santiago J. Carmona, Massimo Andreatta, Giusy Di Conza, Mei-Tzu Su, Pandelakis A. Koni, Ping-Chih Ho, Hung-Kai Chen, Muh-Hwa Yang
Summary: This study generated a bifunctional protein by fusing IL-10 to a CSF-1R-blocking antibody, increasing the intratumoral concentrations of an anticancer agent. The bifunctional protein showed significant antitumor activity and altered the tumor microenvironment to an immune-active state. This research provides an efficient strategy for designing immunotherapeutic agents.
CELL REPORTS MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chun-Yi Wu, Sheng-Min Huang, Yu-Hsin Lin, Hsin-Hua Hsieh, Lok Wang Lauren Chu, Hui-Chieh Yang, Shao-Chieh Chiu, Shin-Lei Peng
Summary: This study systematically assessed the test-retest reproducibility of DTI techniques in animals and applied them to a longitudinal animal model of diabetes. The results demonstrated good reliability of DTI in animal studies and showed that the longitudinal setting is beneficial for detecting small changes in the brain due to diseases.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2023)
Article
Polymer Science
Hui-Wen Chan, Yi-Hsuan Lo, Deng-Yuan Chang, Jia-Je Li, Wen-Yi Chang, Chih-Hao Chen, Chih-Hsien Chang, Chuan-Lin Chen, Hsin-Ell Wang, Ren-Shyan Liu, Chun-Yi Wu
Summary: This study successfully developed radiometal-labeled chitosan microspheres (In-111/Lu-177-DTPA-CMS) for transarterial radioembolization (TARE) treatment of hepatocellular carcinoma (HCC). The results demonstrated that Lu-177-DTPA-CMS effectively reduced the size of hepatoma and showed potential as a superior theranostic pair for clinical hepatoma treatment.
Review
Biochemistry & Molecular Biology
M. T. Ciubuc-Batcu, N. J. C. Stapelberg, J. P. Headrick, G. M. C. Renshaw
Summary: The nervous system relies on mitochondria, and impaired mitochondrial function is associated with major depressive disorder. Modulating mitochondrial function may be a therapeutic target for treating MDD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Correction
Biochemistry & Molecular Biology
Saowaluk Saisomboon, Ryusho Kariya, Piyanard Boonnate, Kanlayanee Sawanyawisuth, Ubon Cha'on, Vor Luvira, Yaovalux Chamgramol, Chawalit Pairojkul, Wunchana Seubwai, Atit Silsirivanit, Sopit Wongkham, Seiji Okada, Sarawut Jitrapakdee, Kulthida Vaeteewoottacharn
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Pavan Thapak, Zhe Ying, Victoria Palafox-Sanchez, Guanglin Zhang, Xia Yang, Fernando Gomez-Pinilla
Summary: Traumatic brain injury (TBI) impairs cellular energy demand, compromising neuronal function and plasticity. This study demonstrates that the mitochondrial activator humanin (HN) can counteract the reduction in mitochondrial bioenergetics caused by TBI, restore memory function and synaptic protein levels, and suppress inflammation and astrocyte proliferation. HN plays an integral role in normalizing fundamental aspects of TBI pathology.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Paul Murphy, Valeria A. Buzinova, Carrie E. Johnson
Summary: Progress has been made in the treatment of Alzheimer's disease through the development of anti-A beta therapeutics, which have shown modest efficacy in slowing the progression of the disease. However, the puzzling issue remains as to why completely removing A beta does not fully stop the disease.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Mengxin Li, Xuanzhong Wang, Xuyang Chen, Jinghui Hong, Ye Du, Dong Song
Summary: Pancreatic adenocarcinoma (PAAD) is a common digestive malignant tumor with limited treatment options. This study demonstrates that TGM2 may serve as a marker for treatment and prognosis in pancreatic cancer patients. Co-treatment of low dose cisplatin (DDP) and the TGM2 inhibitor GK921 effectively inhibits PAAD cell viability and proliferation in vitro and in vivo, by inhibiting epithelial-to-mesenchymal transition (EMT) induced by TGM2 and enhancing cell cycle arrest and apoptosis caused by DDP. These findings suggest that the combination of GK921 and DDP holds promise as a treatment for PAAD patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Liaoran Niu, Qi Wang, Fan Feng, Wanli Yang, Zhenyu Xie, Gaozan Zheng, Wei Zhou, Lili Duan, Kunli Du, Yiding Li, Ye Tian, Junfeng Chen, Qibin Xie, Aqiang Fan, Hanjun Dan, Jinqiang Liu, Daiming Fan, Liu Hong, Jian Zhang, Jianyong Zheng
Summary: This review provides a comprehensive summary of the interaction between cancer cells and macrophages in the tumor microenvironment, and discusses the role of small extracellular vesicles (sEVs) in this process. It also explores the various effects of macrophage-secreted sEVs on tumor malignant transformation, and addresses the therapeutic advancements and challenges associated with these vesicles.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Neha Sawant, Sudhir Kshirsagar, P. Hemachandra Reddy, Arubala P. Reddy
Summary: Depression is a common neuropsychiatric comorbidity in Alzheimer's disease (AD) and other Tauopathies. Selective serotonin reuptake inhibitor (SSRI) treatment, such as Citalopram, not only has anti-depressive and anxiolytic effects, but also helps improve neurogenesis, reduce amyloid burden & Tau pathologies, and neuroinflammation in AD. In this study, Citalopram was found to reduce pathologically pTau level, increase synaptic gene expression and cytoskeletal structure, as well as improve cell survival, mitochondrial respiration, and mitochondrial morphology in cells expressing mutant APP and Tau. These findings suggest that Citalopram could be a promising therapeutic drug for treating depression and AD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Yueqi Chen, Jiulin Tan, Chuan Yang, Zhiguo Ling, Jianzhong Xu, Dong Sun, Fei Luo
Summary: Bone is a self-healing organ that undergoes continuous regeneration through the cooperation of osteoclasts and osteoblasts. This study used ATAC-seq and RNA-Seq techniques to investigate the chromatin accessibility and transcriptomic landscape of osteoblast differentiation and mineralization. The results showed that global chromatin accessibility was extensively improved during osteoblastogenesis. Additionally, several transcription factors including MEF2A, PRRX1, Shox2, and HOXB13 were found to modulate the promoter accessibility of target genes during osteoblast differentiation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Zi-Ran Kang, Shanshan Jiang, Ji-Xuan Han, Yaqi Gao, Yile Xie, Jinxian Chen, Qiang Liu, Jun Yu, Xin Zhao, Jie Hong, Haoyan Chen, Ying-Xuan Chen, Huimin Chen, Jing-Yuan Fang
Summary: The study demonstrates that BCAA metabolism is involved in the development of colorectal cancer (CRC). BCAT2 deficiency promotes CRC progression by inhibiting BCAA metabolism and chronically activating the mTORC1 pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Chao Zheng, Lingling Liu, Caiyun Liu, Fengna Chu, Yue Lang, Shan Liu, Yan Mi, Jie Zhu, Tao Jin
Summary: Inducing tolerogenic dendritic cells (tDCs) with low RelB expression could effectively alleviate symptoms and reduce immune cell infiltration and demyelination in experimental autoimmune encephalomyelitis (EAE) mouse model.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Hang Lam Li, Simei Go, Jung-Chin Chang, Arthur Verhoeven, Ronald Oude Elferink
Summary: This review highlights the distinct characteristics and crucial role of soluble adenylyl cyclase (sAC) in cellular processes, as well as recent significant advancements in the field of sAC research.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Seco-Cervera, D. Ortiz-Masia, D. C. Macias-Ceja, S. Coll, L. Gisbert-Ferrandiz, J. Cosin-Roger, C. Bauset, M. Ortega, B. Heras-Moran, F. Navarro-Vicente, M. Millan, J. V. Esplugues, S. Calatayud, M. D. Barrachina
Summary: The study revealed the presence of resistance to apoptosis in complicated ileal Crohn's disease, with PDGFB inducing an ETS1-mediated resistance to apoptosis associated with an inflammatory and fibrogenic pattern of expression in intestinal fibroblasts. Potential targets against ileal fibrosis include PDGFRB, IL1R1, or MCL1.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yunmeng Wang, Ping Cheng
Summary: Oncolytic viruses (OVs) are emerging as therapeutically relevant anticancer agents, especially when combined with genetically modified bispecific T cell engagers (BiTEs). This combination strategy can overcome the limitations of BiTEs alone and provide targeted cytotoxicity to solid tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Stephanie Tannous, Hassan Y. Naim
Summary: Congenital sucrase-isomaltase deficiency (CSID) is an autosomal recessive disorder caused by variants in the SI gene. A frameshift mutation called c.273_274delAG (p.Gly92Leufs*8) has been identified in CSID patients in Greenlandic population, which leads to loss of digestive function of SI. Surprisingly, the truncated mutant can still be located on the cell surface and interacts with wild type SI, negatively affecting its enzymatic function. Furthermore, heterozygote carriers of this mutation may also exhibit CSID symptoms.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)