Article
Nutrition & Dietetics
Octavia-Laura Moldovan, Camil-Eugen Vari, Amelia Tero-Vescan, Ovidiu Simion Cotoi, Iuliu Gabriel Cocuz, Flaviu Alexandru Tabaran, Romelia Pop, Ibolya Fulop, Rafael Florin Chis, Ioana-Andreea Lungu, Aura Rusu
Summary: This study investigates the effects of sub-chronic consumption of monosodium glutamate (MSG) on aged rats. The results suggest that the positive effects of glutamic acid (GLA) appear to be more pronounced after MSG consumption, potentially due to the protective effects of low-level reactive oxygen species and the hormesis effect of GLA metabolism.
Article
Multidisciplinary Sciences
Mahfoudh A. M. Abdulghani, Salah Abdulrazak Alshehade, Sareh Kamran, Mohammed Abdullah Alshawsh
Summary: The study investigated the toxic effects of MSG on the uterus in rats, revealing alterations in hormone levels and changes in uterine structure. Therefore, caution should be exercised when using MSG, especially for females at risk of hormonal abnormalities.
Article
Food Science & Technology
Sangsu Park, Jeongin Lim, Kyung Tae Lee, Myung Sook Oh, Dae Sik Jang
Summary: The study found that KP-1 did not exhibit toxicity in oral and genotoxicity tests, with no significant adverse effects observed in rats and mice, suggesting that butterbur leaves may be safe for human consumption.
Article
Food Science & Technology
Ting Lyu, Hongyuan Zhou, Yihui Wang, Minyan Jiang, Qian Tao, Juanlin Chen, Yitong Guo, Qiuping Zhang, Xu Wang, Xihan Guo
Summary: This study demonstrates that metformin can suppress cancer cell proliferation and colony formation by increasing genotoxic stress. The effect is dependent on the glucose environment and is weakened in high glucose conditions. Additionally, metformin can increase genotoxicity in non-cancer cells, suggesting that its effects may vary in different cell types.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hansol Won, Da Hye Jeong, Hyo-Sook Shin, Jin Hee Lee, Jeong Pyo Lee, Jun-Young Yang, Kikyung Jung, Jayoung Jeong, Jae Ho Oh
Summary: The study evaluated the genotoxicity and toxicity of BCP in Sprague-Dawley rats. BCP showed no genotoxic effects but caused mortality at high doses, with significant increases in cholesterol levels and treatment-related histopathological changes in the pancreas. The ALD of BCP was estimated to be over 1,000 mg/kg b.w., and the NOAEL was considered to be 250 mg/kg b.w. for male and female rats after repeated oral administration for 28 days.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mahmoud Abd-Elkareem, Mahmoud Soliman, Mokhless A. M. Abd El-Rahman, Nasser S. Abou Khalil
Summary: The study found that Nigella sativa seeds can alleviate MSG-induced renal toxicity in rats. Nigella sativa seeds improved oxidative stress and histopathological damage caused by MSG through their antioxidant and anti-apoptotic effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Green & Sustainable Science & Technology
Mingyan Liu, Ze Yu, Liqun Jiang, Qingjie Hou, Zhen Xie, Meng Ma, Siteng Yu, Haiyan Pei
Summary: Using seawater supplemented with waste sources to cultivate freshwater algae is a promising approach for biomass production. By adding anaerobically digested effluent from kitchen waste or monosodium glutamate wastewater as nutrient sources, the growth of algae, biomass concentration, and lipid productivity can be optimized.
Article
Food Science & Technology
Ben Wu, Xirui Zhou, Imre Blank, Yuan Liu
Summary: This study used EEG technology to investigate the responsive regions of the brain to umami taste. The results showed that the most responsive frequency to umami taste was 2 Hz, and the most responsive brain regions were T4CzA2, F8CzA2, and Fp2CzA2. The study also found higher sensitivity to umami taste in the right brain region. This research provides potential for further exploring the relevance between different brain responses to umami taste.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Electrochemistry
Zhengyang Chen, Jing Cao, Yanzhao Rao, Ling An, Yali Yang, Shengquan Zhou, Lei Wu
Summary: In this study, sodium glutamate (MSG) was used as an electrolyte additive for lead-acid batteries to improve the deposition process and crystal morphology of lead sulfate, which had a positive effect on battery performance. Electrochemical tests and material characterization showed that MSG promoted the formation of uniform lead sulfate deposition with a stacked flakes-like structure, enabling the formation of active lead and preventing the generation of irreversible sulfate during fast charging and discharging.
ELECTROCHIMICA ACTA
(2023)
Review
Environmental Sciences
Gabriel Souza-Silva, Clessius Ribeiro de Souza, Cintia Aparecida de Jesus Pereira, Walter Dos Santos Lima, Marcos Paulo Gomes Mol, Micheline Rosa Silveira
Summary: This study conducted a systematic review of the use of Biomphalaria glabrata as a biological model for ecotoxicological studies in aquatic environments contaminated with human pollutants. Several assays were performed to assess the toxicity, embryotoxicity, cytotoxicity, genotoxicity, and bioaccumulation of various substances using B. glabrata. The findings highlight the importance of using this species as a representative model for tropical environmental monitoring and call for further standardization of the model.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Food Science & Technology
Jinzhao Xu, Mengqi Tang, Yini Liu, Jinghan Xu, Xiaoxi Xu
Summary: This study investigated the effects of different doses of monosodium glutamate (MSG) on mice and found that low doses of MSG were safe and may provide some health benefits by promoting intestinal development and regulating the intestinal flora.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Chemistry, Analytical
Heba M. Ali, Sherin F. Hammad, Samah F. El-Malla
Summary: Two novel and simple spectrophotometric methods have been developed for the determination of monosodium glutamate, showing excellent greenness and wide application potential.
MICROCHEMICAL JOURNAL
(2021)
Article
Environmental Sciences
Bai-Yun Zhao, Xiao-Kai Liu, Xi-Lin Li, Li-Juan Zhou, Li Wang
Summary: A group of Bacillus sp. was extracted from monosodium glutamate wastewater and immobilized using lignocellulose/montmorillonite composite. The microspheres were used to treat monosodium glutamate wastewater, resulting in significantly reduced ammonia nitrogen and chemical oxygen demand concentrations. The study investigated the optimal preparation conditions for the microspheres, and identified the removal capacities of ammonia nitrogen and chemical oxygen demand. The results showed that the microspheres were successfully prepared and contributed to the treatment of ammonia nitrogen and chemical oxygen demand in monosodium glutamate wastewater, providing a potential strategy for industrial wastewater treatment.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Chi Be Hlaing, Arpamas Chariyakornkul, Chalermchai Pilapong, Charatda Punvittayagul, Somdet Srichairatanakool, Rawiwan Wongpoomchai
Summary: The study assessed the toxicity of Fe-TA NPs and found no obvious signs of toxicity, genotoxicity, and early phase hepatocarcinogenicity in rats.
Article
Chemistry, Medicinal
Cheng-Xiang Wang, Yue Zhang, Qing-Feng Li, Hong-Liang Sun, Hai-Ling Chong, Jian-Xi Jiang, Qing-Chun Li
Summary: This study evaluated the effect of monosodium glutamate on testicular spermatogenesis in mice, finding that it damages GnRH neurons and leads to reproductive toxicity in male mice. This toxic effect does not alleviate spontaneously over time, as supported by observed histological changes.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)