Article
Biochemistry & Molecular Biology
Henry Velazquez-Soto, Sergio Groman-Lupa, Marisa Cruz-Aguilar, Alberto L. Salazar, Juan C. Zenteno, Maria C. Jimenez-Martinez
Summary: Age-related macular degeneration (AMD) is a complex retinal disease that results in progressive irreversible degeneration of photoreceptors. Oxidative stress, chronic inflammation, and genetic factors, such as the CFH Y402H polymorphism, contribute to AMD pathogenesis. In this study, it was found that ARPE-19 cells with the CFH Y402H variant were more susceptible to oxidative stress-induced damage and exhibited increased levels of inflammatory mediators and pro-apoptotic factors. However, pretreatment with exogenous CFH protected the cells from damage and cell death, possibly through negative regulation of pro-inflammatory cytokines.
Article
Virology
Petlada Yongpitakwattana, Atthapan Morchang, Aussara Panya, Nunghathai Sawasdee, Pa-thai Yenchitsomanus
Summary: Dengue virus is transmitted by Aedes mosquitoes and infects various types of cells in the human skin, leading to diseases like dengue fever. Inhibiting virus production and the cytokine storm is critical for effective treatment of DENV infection.
ARCHIVES OF VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Raghul Murugan, B. Haridevamuthu, Rajendran Saravana Kumar, Bader O. Almutairi, Selvaraj Arokiyaraj, Jesu Arockiaraj
Summary: This study investigates the potential of neem-derived semi natural deacetyl epoxyazadiradione (DEA) against the oxidative stress and inflammatory response induced by BPA exposure. The results showed that DEA can protect zebrafish larvae from BPA toxicity by ameliorating oxidative stress and inflammatory responses.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Environmental Sciences
Mingquan Huang, Xingjie Li, Shengjun Jia, Shuang Liu, Li Fu, Xue Jiang, Meng Yang
Summary: The study reveals that BPAF can induce apoptosis of KGN cells in a concentration- and time-dependent manner by increasing the expression of pro-apoptotic proteins and decreasing the expression of anti-apoptotic proteins. Additionally, BPAF exposure leads to a significant increase in intracellular ROS levels, which mediates KGN cell apoptosis through the ROS-ASK1-JNK axis.
ENVIRONMENTAL POLLUTION
(2021)
Article
Chemistry, Multidisciplinary
Shuang Liu, Guofeng Xu, Mingquan Huang, Li Fu, Xue Jiang, Meng Yang
Summary: The study revealed that co-exposure to BPA and BPAF induced intracellular stress in KGN cells, leading to apoptosis. The mixture of BPA and BPAF was found to promote KGN cell apoptosis through the ASK1-JNK signaling pathway.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Immunology
Muhammad Usman Saleem, Faqir Muhammad, Ali Sharif, Muhammad Imran Arshad, Kanwal Akhtar, Yasir Javed, Bushra Akhtar
Summary: This study validates the use of methotrexate-loaded chitosan nanoparticles in treating Freund's complete adjuvant arthritis in rats. The results suggest that MTX nanoparticles can reduce inflammation, improve oxidative stress, and alleviate pathological changes such as necrosis and cellular infiltration.
INFLAMMOPHARMACOLOGY
(2022)
Article
Cell Biology
Alireza Bastin, Asie Sadeghi, Mohammad Hadi Nematollahi, Moslem Abolhassani, Abbas Mohammadi, Hamed Akbari
Summary: Malvidin inhibits inflammation and oxidative stress in LPS-induced THP-1 cells, significantly affecting cytokine secretion, reducing oxidative stress levels, and increasing antioxidant activity.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sudarsanan Drishya, Suresh Sulekha Dhanisha, Paramu Raghukumar, Chandrasekharan Guruvayoorappan
Summary: The study demonstrates the radioprotective efficacy of methanolic extract of Amomum subulatum dry fruits in mice, showing its potential in enhancing antioxidant defense mechanisms, preventing hematopoietic damages, and reducing inflammatory responses.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Adrian Schmalen, Lea Lorenz, Antje Grosche, Diana Pauly, Cornelia A. Deeg, Stefanie M. Hauck
Summary: Muller cells play a crucial role in maintaining retinal homeostasis, but can become gliotic upon pathological changes, with both protective and detrimental consequences. Research suggests their pivotal role in diabetic retinopathy and their important signaling capacity in chronic retinal inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anne Bollmann, Hans Christian Sons, Jennifer Lynn Schiefer, Paul C. Fuchs, Joachim Windolf, Christoph Viktor Suschek
Summary: Adipose tissue-derived stromal cells (ASCs) and dedifferentiated fat cells (DFATs) have similar osteogenic potential in bone regeneration. DFATs show lower decrease in osteogenic differentiation potential under oxidative stress compared to ASCs. Exogenous application of catalase can significantly increase osteogenesis in both cell types.
Review
Biochemistry & Molecular Biology
Dorina Lauritano, Filiberto Mastrangelo, Cristian D'Ovidio, Gianpaolo Ronconi, Alessandro Caraffa, Carla E. Gallenga, Ilias Frydas, Spyros K. Kritas, Matteo Trimarchi, Francesco Carinci, Pio Conti
Summary: Mast cells (MCs) are tissue cells derived from bone marrow stem cells and play a role in various diseases and disorders. They communicate with microglia in the brain through the production of mediators and can have pathological effects. MCs release preformed chemical mediators and cytokines, and can interact with neuropeptides, leading to inflammation in the central nervous system. This article explores the activation of MCs by neuropeptides and the therapeutic potential of anti-inflammatory cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Paul Ademola Adeleke, Abayomi Mayowa Ajayi, Benneth Ben-Azu, Solomon Umukoro
Summary: Epidemiological studies have identified copper as an important environmental risk factor for the pathogenesis of depression. This study aimed to investigate the effects of copper sulfate on depression-like behaviors in mice and found that exposure to copper sulfate led to depression-like effects, increased oxidative stress and pro-inflammatory cytokines.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Food Science & Technology
Wenjuan Zhang, Tao Huang, Zhangbei Sun, Haibin Kuang, Yangyang Yuan, Weiying Zou, Fangming Liu, Fan Zhang, Bei Yang, Lei Wu, Dalei Zhang
Summary: This study demonstrates that exposure to BPS can cause cytotoxicity to Leydig cells through inducing oxidative stress, mitochondrial impairment, autophagic disturbance, and apoptosis.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Ewelina Wozniak, Marlena Broncel, Mateusz Niedzielski, Agnieszka Wozniak, Paulina Gorzelak-Pabis
Summary: The study compared the pleiotropic effects of two commonly-used statins (atorvastatin, rosuvastatin), ezetimibe, and their combinations, on the mRNA expression of pro-inflammatory and anti-inflammatory genes in endothelial cells damaged by 25-OHC. The results showed that rosuvastatin had the strongest anti-inflammatory effects and was most effective at reducing the effect of oxysterols. Both statins had stronger anti-inflammatory effects compared to ezetimibe. The combination therapies' anti-inflammatory effects seemed to be based on the statins alone, rather than their combination with ezetimibe.
Article
Environmental Sciences
Sarah Easson, Radha Dutt Singh, Liam Connors, Taylor Scheidl, Larissa Baker, Anshul Jadli, Hai-Lei Zhu, Jennifer Thompson
Summary: This study found that the commonly used BPA substitute BPS can disturb redox balance and increase the production of reactive oxygen species (ROS), leading to impaired endothelial function.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Arnab Banerjee, Debasmita Das, Rajarshi Paul, Sandipan Roy, Ujjal Das, Samrat Saha, Sanjit Dey, Arghya Adhikary, Sandip Mukherjee, Bithin Kumar Maji
SCIENTIFIC REPORTS
(2020)
Review
Medicine, Research & Experimental
Arnab Banerjee, Sandip Mukherjee, Bithin K. Maji
Summary: In the unprecedented pandemic of 2020 caused by COVID-19, the CRISPR/Cas system has been suggested as a potential tool to target and inhibit the replication of SARS-CoV-2 by destroying its RNA sequence. This approach is seen as a promising alternative strategy in global pandemic management.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Toxicology
Arnab Banerjee, Sandip Mukherjeee, Bithin Kumar Maji
Summary: Coccinia grandis has been traditionally used for treating various diseases, and ethanol extract of its leaves demonstrated significant antioxidant and free radical-scavenging properties. This extract showed protective effects against MSG-induced hepato-cardiac damage by reducing inflammation, oxidative stress, and apoptosis in liver and heart tissues.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Article
Toxicology
Arnab Banerjee, Sandip Mukherjee, Bithin Kumar Maji
Summary: People in the fast-food era tend to rely on packaged foods while engaging in limited physical activities, leading to a shift in dietary patterns. Monosodium glutamate (MSG) has been found to have negative effects on the liver and heart, particularly at high doses.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Arnab Banerjee, Sandip Mukherjee, Bithin Kumar Maji
Summary: This study demonstrates the harmful effects of consuming flavor-enhanced high-lipid diets and suggests the use of Coccinia grandis as a dietary supplement to counteract these effects.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Biology
Debasmita Das, Arnab Banerjee, Ankita Bhattacharjee, Sandip Mukherjee, Bithin Kumar Maji
Summary: Globally, the use of food additives and consumption of ready-made fast food has had a negative impact on immune organs. Monosodium glutamate (MSG), as a food additive in a high-fat diet, has been found to harm immune cells. This study evaluated the role of MSG in a high-fat diet on spleen injury in rats. The findings showed that MSG causes splenomegaly and promotes inflammatory responses, while also inducing oxidative stress and reducing mitochondrial membrane potential in immune cells. The study suggests that MSG has more detrimental effects on the spleen compared to MSG in a high-fat diet due to the presence of antioxidants in the diet. These findings highlight the importance of understanding the effects of food additives on immune health.
OPEN LIFE SCIENCES
(2022)
Article
Plant Sciences
Aparna Shil, Arnab Banerjee, Bithin Kumar Maji, Biswadev Bishayi, Mausumi Sikdar (ne'e Bhakta)
Summary: This study evaluated the effectiveness of Catharanthus roseus (CR) root extract in killing multiple antibiotic-resistant Staphylococcus aureus (SA) by inhibiting the efflux pump activity of SA. The extract showed significant improvement in redox equilibrium and inflammation induced by SA, and provided hepatoprotective effects against SA-induced hepatocellular anomalies.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Toxicology
Arnab Banerjee, Sandip Mukherjee, Bithin Kumar Maji
Summary: In today's fast-food era, reliance on ready-made foods and minimal physical activity has led to changes in dietary habits, with high lipid diets and monosodium glutamate potentially causing systemic anomalies. It is recommended to consume more natural foods rich in antioxidants to counteract these effects.
TOXICOLOGY REPORTS
(2021)
Article
Environmental Sciences
Siddhartha Singh, Oly Banerjee, Ankita Bhattacharjee, Shilpi Kumari Prasad, Ananya Bose, Bithin Kumar Maji, Sandip Mukherjee
TOXICOLOGY AND ENVIRONMENTAL HEALTH SCIENCES
(2020)